Embriz-L Injection (Levosulpiride 12.5mg): Complete Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- High fever with muscle stiffness and confusion
- Irregular or rapid heartbeat
- Severe allergic reaction with swelling of face, lips, or throat
- Difficulty breathing
- Uncontrollable muscle spasms or tremors
- Yellowing of skin or eyes
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is losrest 12.5mg injection used for?
This medicine is a prescription injection containing Levosulpiride 12.5 mg. It is used to treat severe nausea and vomiting and to improve stomach emptying. It works by blocking dopamine receptors in the brain and gut. It is given by a healthcare professional and should not be self-administered.
- Generic Name: Levosulpiride (12.5mg)
- Manufacturer: Arlak Biotech Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 losrest 12.5mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा लेवोसल्पिराइड 12.5 मिलीग्राम इंजेक्शन है, जिसका उपयोग तीव्र मतली और उल्टी के इलाज के लिए किया जाता है। यह पेट की खाली होने की गति को सुधारती है और अपच, पेट फूलने और जल्दी पेट भरने जैसी समस्याओं में राहत देती है। यह दवा डॉक्टर द्वारा इंजेक्शन के रूप में दी जाती है, इसलिए इसे घर पर स्वयं नहीं लगाया जाना चाहिए। यह मस्तिष्क और आंतों में डोपामाइन रिसेप्टर्स को ब्लॉक करके काम करती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, सिरदर्द, मुँह सूखना और कब्ज शामिल हैं। कभी-कभी यह हार्मोनल बदलाव कर सकती है जिससे स्तनों में दर्द या दूध का स्राव हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें तेज बुखार, मांसपेशियों में अकड़न, धड़कन अनियमित होना या गंभीर एलर्जी शामिल हो सकती है। अगर ऐसा कुछ हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल डॉक्टर या स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। इसे स्वयं न लगाएं। अगर आप गर्भवती हैं, स्तनपान करा रही हैं या गर्भधारण की योजना बना रही हैं तो डॉक्टर को बताएं। अपनी सभी दवाओं के बारे में डॉक्टर को जानकारी दें। इस दवा को लेने के बाद नींद आ सकती है, इसलिए वाहन चलाने या मशीन चलाने से बचें। शराब का सेवन न करें। डॉक्टर के बताए अनुसार नियमित जांच कराते रहें।
💊 losrest 12.5mg injection Uses & Benefits
[{"condition":"Severe nausea and vomiting","description":"This medicine is used to control severe nausea and vomiting from various causes, including chemotherapy, surgery, or other medicines.","evidence":"Well-established"},{"condition":"Delayed gastric emptying (gastroparesis)","description":"It helps improve stomach emptying and reduces symptoms like bloating, nausea, and early fullness.","evidence":"Moderate"},{"condition":"Functional dyspepsia","description":"Used to relieve symptoms of indigestion such as upper abdominal pain, bloating, and nausea when other treatments fail.","evidence":"Moderate"},{"condition":"Irritable bowel syndrome (IBS)","description":"May help with abdominal pain and altered bowel habits, particularly in IBS with constipation.","evidence":"Limited"}]
Off-label uses: [{"condition":"Premature ejaculation","description":"Sometimes prescribed off-label due to its effect on dopamine receptors, but evidence is limited.","evidence":"Limited"},{"condition":"Tourette syndrome","description":"Rarely used off-label for tics, but not a first-line treatment.","evidence":"Limited"}]
Primary treatment for: Nausea and vomiting
Also treats: Gastroparesis, Functional dyspepsia, Irritable bowel syndrome
📋 Drug Information
| Generic Name(s) | Levosulpiride (12.5mg) |
| Brand Name | losrest 12.5mg injection |
| Manufacturer | Arlak Biotech Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Atypical Antipsychotics |
| Route of Administration | Parenteral (intramuscular or intravenous injection) |
| Storage | Store in a cool, dry place, protected from light. Do not freeze. Keep out of reach of children. |
| Shelf Life | Not established from the available information. Refer to the product label. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by selectively blocking dopamine D2 receptors in the brain and gastrointestinal tract. In the brain, this action in the chemoreceptor trigger zone suppresses nausea and vomiting. In the gut, it enhances the movement of the stomach and intestines, promoting gastric emptying and reducing reflux. It also has some effect on serotonin receptors, which may contribute to its prokinetic action.
Mechanism Steps
💡 How to Take losrest 12.5mg injection
Strength: Injection: 12.5 mg
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 12.5 mg given by intramuscular or intravenous injection, typically once or twice daily. However, the exact dose and frequency depend on the condition being treated, the patient's response, and other medical factors. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-administer; this medicine must be given by a healthcare professional. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially drowsiness and extrapyramidal symptoms. Lower doses may be appropriate. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose adjustment may be necessary. Consult a doctor. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose adjustment may be necessary. Consult a doctor. |
| Maximum Daily Dose | Not established from the available information. The maximum dose should be determined by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of losrest 12.5mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Metoclopramide | Major | |
| Amiodarone | Major | |
| Levodopa | Major | |
| Diazepam | Moderate | |
| Amlodipine | Moderate | |
| Alcohol | Moderate |
🚨 Major Interactions
- Other dopamine antagonists (e.g., metoclopramide, haloperidol)
- QT-prolonging drugs (e.g., amiodarone, sotalol, haloperidol)
- Levodopa
⚡ Moderate Interactions
- CNS depressants (e.g., benzodiazepines, opioids, alcohol)
- Antihypertensives
🍷 Alcohol Interaction
Avoid alcohol while receiving this medicine. Alcohol can increase drowsiness, dizziness, and the risk of low blood pressure. It may also worsen the sedative effects of this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to levosulpiride or any component of the formulation","Pheochromocytoma","Severe renal impairment","Severe hepatic impairment","Concurrent use with levodopa","History of QT prolongation or arrhythmias"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Use with caution in elderly patients due to increased risk of side effects.","May increase prolactin levels; monitor for signs like breast tenderness or discharge.","Avoid alcohol while taking this medicine.","Use with caution in patients with Parkinson's disease as it may worsen symptoms.","May lower seizure threshold; use with caution in patients with epilepsy."]
🤱 Lactation Safety
Levosulpiride may pass into breast milk. It is not recommended during breastfeeding unless the benefit outweighs the risk. Consult your doctor.
💊 Overdose Management
Overdose may cause severe drowsiness, dizziness, extrapyramidal symptoms, and low blood pressure. There is no specific antidote. Treatment is supportive and symptomatic. If overdose is suspected, seek immediate medical attention.
⏰ Missed Dose
This medicine is given by a healthcare professional, so missed doses are unlikely. If you miss an appointment for your injection, contact your doctor to reschedule as soon as possible. Do not try to self-administer.
Additional Safety Advice
This medicine must only be given by a qualified healthcare professional. Do not attempt to self-administer it. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Tell your doctor about all other medicines you are taking, especially those for heart problems, depression, or Parkinson's disease. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it can cause drowsiness. Do not drink alcohol while receiving this medicine, as it can increase drowsiness and dizziness. If you have kidney or liver problems, your doctor may need to adjust the dose or monitor you more closely. Keep all follow-up appointments so your doctor can check your response and watch for side effects.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the side effects of this medicine, especially drowsiness, dizziness, and extrapyramidal symptoms. Lower doses may be needed. Close monitoring is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor. The safety of this medicine in pregnancy is not well established. It should only be used if clearly needed.
🏥 Post-Surgery Considerations
This medicine is often used after surgery to treat nausea and vomiting. It should be given under medical supervision. Inform your surgeon and anesthesiologist if you are taking this medicine.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine, as it may interact with other medications used during dental procedures. It may also cause drowsiness, so arrange for someone to drive you home.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness and dizziness. Avoid strenuous exercise or activities that require alertness until you know how it affects you.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may affect your ability to drive or operate machinery. It is best to avoid these activities until you know how the medicine affects you. Inform your employer if your job requires alertness.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Your doctor will decide when to stop based on your condition and response to treatment.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of extrapyramidal symptoms, tardive dyskinesia, and hyperprolactinemia. Regular monitoring by a doctor is required. It is not recommended for prolonged use without clear medical need.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For mild nausea, oral medicines may be sufficient.
Evidence: Well-establishedSmall, frequent meals and avoiding trigger foods can help with gastroparesis.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
This medicine is given by a healthcare professional, so travel is not a concern for self-administration. If you are traveling and need to receive this medicine, carry a copy of your prescription and a letter from your doctor explaining the need for the injection. Store the medicine in its original packaging, protected from light and extreme temperatures. Check with airlines and customs about carrying injectable medicines. It is best to have your doctor arrange for administration at your destination.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30 to 60 minutes after injection.
A: No, this medicine must be given by a healthcare professional in a clinic or hospital setting.
A: The safety of this medicine in pregnancy is not well established. It should only be used if clearly needed and under medical supervision.
🤔 Common Patient Concerns
🔄 Substitutes for losrest 12.5mg injection
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levazeo 12.5mg injectionTorrent Pharmaceuticals Ltd ₹50.63 68.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken at home like a pill.
Fact: This medicine is an injection and must be given by a healthcare professional. - Myth: This medicine is safe to use without a prescription.
Fact: This medicine is a prescription-only medicine and should only be used under medical supervision.
🔄 Alternative Options
Generic Alternatives
- Levosulpiride injection
Brand Alternatives
- Embriz-L Injection