Epstat 150mg Tablet SR: Comprehensive Guide to Uses, Side Effects, and Safety
When to Call Your Doctor IMMEDIATELY
- Yellowing of skin or eyes
- Dark urine or pale stools
- Severe abdominal pain
- Persistent nausea and vomiting
- Difficulty breathing or swelling of face, lips, or throat
- Unusual bleeding or bruising
- Severe dizziness or fainting
If experiencing severe symptoms, call emergency services immediately.
What is listap 150 sr tablet used for?
This medicine contains Epalrestat 150 mg, an aldose reductase inhibitor used to manage diabetic peripheral neuropathy. It works by reducing sorbitol accumulation in nerves, helping to alleviate tingling, numbness, and pain. It is taken orally once daily with meals, and dose adjustments may be needed for liver or kidney problems.
- Generic Name: Epalrestat (150mg)
- Manufacturer: Vivid Biotek Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 listap 150 sr tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एपलरेस्टैट 150 मिलीग्राम युक्त है और मधुमेह के कारण होने वाली तंत्रिका समस्या (डायबिटिक न्यूरोपैथी) के इलाज में उपयोग की जाती है। यह हाथ-पैरों में झनझनाहट, सुन्नपन, जलन और दर्द को कम करने में मदद करती है। यह दवा एल्डोज रिडक्टेज एंजाइम को रोककर काम करती है, जिससे तंत्रिका कोशिकाओं में सोर्बिटोल का जमाव कम होता है और तंत्रिका क्षति धीमी होती है। इसे आमतौर पर दिन में एक बार भोजन के साथ लिया जाता है। यह दवा डॉक्टर के पर्चे के बिना नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के कुछ सामान्य दुष्प्रभाव हो सकते हैं जैसे मतली, उल्टी, दस्त, पेट में असहजता, सिरदर्द और चक्कर आना। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। दुर्लभ मामलों में यह लिवर की समस्या, त्वचा पर चकत्ते, या सांस लेने में कठिनाई पैदा कर सकती है। अगर आपको पीलिया, गहरे रंग का पेशाब, या लगातार पेट दर्द हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं और दवाओं के बारे में बताएं। गर्भावस्था या स्तनपान के दौरान इस दवा का उपयोग डॉक्टर की सलाह के बिना न करें। शराब का सेवन न करें क्योंकि इससे लिवर की समस्या बढ़ सकती है। दवा को डॉक्टर के बताए अनुसार ही लें, खुराक न बदलें। यदि खुराक छूट जाए तो याद आते ही ले लें, लेकिन अगली खुराक का समय नजदीक हो तो छूटी हुई खुराक न लें। दवा को ठंडी और सूखी जगह पर रखें। नियमित रूप से ब्लड शुगर की जांच कराएं।
💊 listap 150 sr tablet Uses & Benefits
[{"condition":"Diabetic peripheral neuropathy","description":"This medicine is used to improve symptoms such as tingling, numbness, burning, and pain in the hands and feet caused by nerve damage due to diabetes.","evidence":"Well-established in some regions; evidence varies"},{"condition":"Diabetic autonomic neuropathy","description":"May be used to help manage symptoms related to autonomic nerve damage, such as gastrointestinal issues, though evidence is limited.","evidence":"Limited"}]
Off-label uses: [{"condition":"Other neuropathic pain conditions","description":"Occasionally prescribed off-label for neuropathic pain not related to diabetes, but evidence is insufficient.","evidence":"Limited"}]
Primary treatment for: Diabetic peripheral neuropathy
Also treats: Diabetic autonomic neuropathy, Other neuropathic pain conditions
📋 Drug Information
| Generic Name(s) | Epalrestat (150mg) |
| Brand Name | listap 150 sr tablet |
| Manufacturer | Vivid Biotek Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | Aldose reductase inhibitor |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a cool, dry place away from direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting the enzyme aldose reductase, which is involved in the polyol pathway. Under high blood sugar conditions, this pathway becomes overactive, leading to the accumulation of sorbitol and fructose inside nerve cells. This accumulation causes osmotic stress and oxidative damage, contributing to nerve dysfunction. By blocking aldose reductase, this medicine reduces sorbitol production and helps protect nerve cells from damage.
Mechanism Steps
💡 How to Take listap 150 sr tablet
Strength: Sustained-release tablet, 150 mg
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 150 mg taken orally once daily, preferably with meals to reduce stomach upset. However, the dose may be adjusted by your doctor based on your condition, response to treatment, and kidney or liver function. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not change the dose without consulting your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Dose adjustments may be necessary based on kidney and liver function. Consult your doctor for appropriate dosing. |
| Renal Impairment | Dose adjustment may be needed in patients with kidney impairment. Consult your doctor for appropriate dosing. |
| Hepatic Impairment | Dose adjustment may be needed in patients with liver impairment. Consult your doctor for appropriate dosing. |
| Maximum Daily Dose | 150 mg per day, unless otherwise directed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of listap 150 sr tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Insulin | Moderate | |
| Sulfonylureas | Moderate | |
| Methotrexate | Moderate | |
| Isoniazid | Moderate | |
| Warfarin | Minor | |
| Diuretics | Minor | |
| ACE inhibitors | Minor | |
| NSAIDs | Minor | |
| Grapefruit juice | Minor | |
| Other aldose reductase inhibitors | Major |
🚨 Major Interactions
- Other aldose reductase inhibitors
⚡ Moderate Interactions
- Antidiabetic drugs (e.g., insulin, sulfonylureas)
- Hepatotoxic drugs (e.g., methotrexate, isoniazid)
🍷 Alcohol Interaction
Avoid consuming alcohol while taking this medicine, as it can increase the risk of liver damage and may worsen side effects such as nausea and dizziness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to Epalrestat or any component of the tablet","Pregnancy and breastfeeding (unless advised by doctor)","Severe liver disease","Severe kidney disease"]
⚠️ Warnings & Precautions
["Use with caution in patients with liver or kidney impairment.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol consumption.","Monitor blood sugar regularly as this medicine is used in diabetic patients.","Do not stop taking this medicine without consulting your doctor.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding."]
🤱 Lactation Safety
It is not known whether Epalrestat passes into breast milk. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
If you suspect an overdose, seek immediate medical attention. Symptoms of overdose may include severe nausea, vomiting, dizziness, and liver toxicity. Treatment is supportive and symptomatic.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Additional Safety Advice
Before starting this medicine, tell your doctor if you have any liver or kidney disease, as dose adjustments may be needed. Do not take this medicine if you are pregnant, planning to become pregnant, or breastfeeding without consulting your doctor, as the safety in these conditions is not well established. Avoid consuming alcohol while taking this medicine, as it may increase the risk of liver problems and worsen side effects. Take this medicine exactly as prescribed by your doctor, and do not change the dose or stop taking it without medical advice. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for a missed one. Keep this medicine out of reach of children and store it in a cool, dry place away from direct sunlight. Regularly monitor your blood sugar levels and attend follow-up appointments as scheduled. If you experience any unusual symptoms such as severe abdominal pain, yellowing of the eyes or skin, or difficulty breathing, seek immediate medical attention.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine. Dose adjustments may be needed based on kidney and liver function. Regular monitoring is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this medicine during pregnancy is not well established.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may need to be stopped temporarily.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. No specific precautions are known, but it is important for your dentist to know your medication history.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is generally safe while taking this medicine, but if you experience dizziness, avoid strenuous activities until you know how the medicine affects you. Always warm up and cool down.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you. Otherwise, it should not significantly impact your daily activities.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects like liver problems or severe allergic reactions, seek immediate medical advice. Your doctor will decide if and when to stop the medicine.
📅 Long-Term Use Effects
Long-term use of this medicine may require regular monitoring of liver and kidney function. It is generally well-tolerated, but rare liver toxicity can occur. Periodic blood tests are advised. Do not stop the medicine without consulting your doctor, as symptoms may return.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Maintaining optimal blood sugar levels is the cornerstone of managing diabetic neuropathy.
Evidence: Well-establishedCan help improve mobility and reduce pain.
Evidence: ModerateAn antioxidant that may help with neuropathic symptoms.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, inform your doctor about all medicines before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If crossing time zones, continue taking your dose at the same time each day as close as possible. Check customs regulations for carrying prescription medicines. Always carry enough supply for the duration of your trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: It may take several weeks to months to notice improvement in symptoms. Continue taking it as prescribed.
A: Yes, but inform your doctor as dose adjustments may be needed to avoid low blood sugar.
A: It can be used long-term under medical supervision with regular monitoring of liver and kidney function.
A: Take it as soon as you remember, but if it's almost time for the next dose, skip the missed dose. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for listap 150 sr tablet
View AllAlternative brands with exact same active ingredient:
-
Dinrest 150mg Tablet SRWalton Healthcare Pvt. Ltd ₹89.06 67.8% CHEAPER
-
epstat 150mg tablet srGlobus Labs ₹171.56 38% CHEAPER
-
epo 150 tablet srFrankfurt Pharma Pvt Ltd ₹186.56 32.5% CHEAPER
-
Alrista SR TabletMacleods Pharmaceuticals Pvt Ltd ₹191.80 30.6% CHEAPER
-
epalpex 150 sr tabletShilpex Pharmysis ₹236.00 14.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Epalrestat can cure diabetic neuropathy completely.
Fact: Epalrestat helps manage symptoms and slow progression but does not cure the condition. Good blood sugar control remains essential. - Myth: Epalrestat can be taken without a doctor's prescription.
Fact: Epalrestat is a prescription medicine and should only be taken under medical supervision. - Myth: Epalrestat works immediately.
Fact: It may take several weeks to months to notice improvement.
🔄 Alternative Options
Generic Alternatives
- Epalrestat 150 mg tablet
Brand Alternatives
- Epstat 150mg Tablet SR