Listril Plus Tablet: Comprehensive Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of face, lips, tongue, or throat
- Difficulty breathing or swallowing
- Severe dizziness or fainting
- Decreased urine output or swelling in legs
- Irregular heartbeat or palpitations
- Severe abdominal pain
- Yellowing of skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is lispro h 5mg/12.5mg tablet used for?
This medicine is a combination of lisinopril and hydrochlorothiazide used to treat high blood pressure. It works by relaxing blood vessels and removing excess fluid from the body.
- Generic Name: Lisinopril (5mg) + Hydrochlorothiazide (12.5mg)
- Manufacturer: Johnlee Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 lispro h 5mg/12.5mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा उच्च रक्तचाप (हाइपरटेंशन) के इलाज के लिए इस्तेमाल की जाती है। यह लिसिनोप्रिल और हाइड्रोक्लोरोथियाजाइड का संयोजन है, जो रक्त वाहिकाओं को आराम देकर और शरीर से अतिरिक्त तरल पदार्थ निकालकर रक्तचाप को कम करती है। यह उन रोगियों के लिए दी जाती है जिनका रक्तचाप एक दवा से नियंत्रित नहीं हो पाता।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में चक्कर आना, सिरदर्द, थकान, और सूखी खांसी शामिल हैं। कुछ रोगियों में पेशाब बार-बार आना, प्यास लगना, और इलेक्ट्रोलाइट असंतुलन हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, सूजन, या गुर्दे की समस्या हो सकती है। कोई भी असामान्य लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। दवा की खुराक बदलें या बंद करें नहीं। चक्कर आ सकते हैं, इसलिए वाहन चलाने या मशीन चलाने से बचें। पर्याप्त पानी पिएं। शराब से बचें। गुर्दे की कार्यप्रणाली और इलेक्ट्रोलाइट की नियमित जांच कराएं। गर्भवती होने पर तुरंत डॉक्टर को बताएं।
💊 lispro h 5mg/12.5mg tablet Uses & Benefits
- [{"condition":"Hypertension","description":"This medicine is used to treat high blood pressure when monotherapy is inadequate.
- It lowers blood pressure by combining the effects of an ACE inhibitor and a thiazide diuretic.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Heart failure with reduced ejection fraction","description":"Sometimes used off-label in combination for heart failure, but not a standard first-line approach.","evidence":"Limited"},{"condition":"Diabetic nephropathy","description":"ACE inhibitors are used to protect kidneys in diabetes, but the combination with hydrochlorothiazide is not standard for this indication.","evidence":"Limited"}]
Primary treatment for: Hypertension
Also treats: Heart failure, Diabetic nephropathy
📋 Drug Information
| Generic Name(s) | Lisinopril (5mg) + Hydrochlorothiazide (12.5mg) |
| Brand Name | lispro h 5mg/12.5mg tablet |
| Manufacturer | Johnlee Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and light. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antihypertensive agents with complementary mechanisms. Lisinopril, an ACE inhibitor, blocks the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby reducing peripheral vascular resistance and lowering blood pressure. It also decreases aldosterone secretion, leading to reduced sodium and water retention. Hydrochlorothiazide, a thiazide diuretic, inhibits sodium reabsorption in the distal convoluted tubule of the kidney, increasing excretion of sodium, chloride, and water. This reduces plasma volume and cardiac output initially, and later reduces peripheral resistance. Together, they produce a synergistic antihypertensive effect.
Mechanism Steps
💡 How to Take lispro h 5mg/12.5mg tablet
Strength: Tablet containing Lisinopril 5 mg and Hydrochlorothiazide 12.5 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally once daily. The dose may be adjusted by your doctor based on your blood pressure response and tolerance. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, particularly dizziness and hypotension. Start with a lower dose and monitor closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with renal impairment, dose adjustments may be necessary. Lisinopril and hydrochlorothiazide are excreted by the kidneys. Monitor renal function regularly. Consult a clinician for specific dosing. |
| Hepatic Impairment | In patients with hepatic impairment, use with caution. Hydrochlorothiazide may precipitate hepatic coma in patients with cirrhosis. Dose adjustment may be required. Consult a clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet of Lisinopril 5 mg and Hydrochlorothiazide 12.5 mg. Do not exceed without medical advice. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of lispro h 5mg/12.5mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Potassium supplements | Major | |
| NSAIDs | Major | |
| Lithium | Major | |
| Corticosteroids | Moderate | |
| Diabetes medications | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Potassium supplements
- NSAIDs
- Lithium
⚡ Moderate Interactions
- Corticosteroids
- Diabetes medications
🍷 Alcohol Interaction
Alcohol may enhance the blood pressure-lowering effect of this medicine, leading to dizziness, lightheadedness, and fainting. It is advisable to avoid or limit alcohol consumption while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["History of angioedema related to ACE inhibitors","Anuria","Hypersensitivity to lisinopril, hydrochlorothiazide, or sulfonamide-derived drugs","Pregnancy","Concomitant use with aliskiren in patients with diabetes"]
⚠️ Warnings & Precautions
["May cause symptomatic hypotension, especially in volume-depleted patients.","Regular monitoring of renal function and electrolytes is required.","Can cause dry cough; if persistent, consider alternative.","May increase blood glucose and worsen diabetes control.","Can cause hyperkalemia, especially with potassium supplements.","Avoid in patients with severe hepatic impairment.","Use with caution in patients with gout or hyperuricemia.","May cause photosensitivity; use sun protection."]
🤱 Lactation Safety
Lisinopril and hydrochlorothiazide are excreted in breast milk. Due to the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or discontinue the medicine, taking into account the importance of the medicine to the mother.
💊 Overdose Management
Overdose may cause severe hypotension, electrolyte disturbances, and renal failure. Treatment is supportive and symptomatic. If ingestion is recent, consider activated charcoal. Monitor vital signs, electrolytes, and renal function. Hemodialysis may be considered for lisinopril removal.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without consulting your doctor. This medicine can cause dizziness, so avoid driving or operating heavy machinery until you know how it affects you. Stand up slowly from a sitting or lying position to prevent dizziness. Drink adequate fluids to stay hydrated, especially if you experience increased urination. Avoid alcohol as it can intensify dizziness and low blood pressure. Inform your doctor if you have a history of kidney disease, liver disease, diabetes, or gout. Regular monitoring of blood pressure, kidney function, and electrolyte levels is essential. Do not take potassium supplements or salt substitutes containing potassium without your doctor's approval. If you become pregnant or plan to become pregnant, contact your doctor immediately as this medicine can harm the fetus.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to dizziness and electrolyte imbalances. Start with a lower dose and monitor closely.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated in pregnancy. If you are planning pregnancy, consult your doctor to switch to a safer alternative.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may need to be temporarily stopped before surgery to avoid hypotension.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may cause dry mouth or dizziness during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is generally safe, but avoid strenuous activities in hot weather as it may cause dehydration and hypotension. Stay hydrated and monitor how you feel.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, especially when starting treatment. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their daily activities with caution.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience serious side effects like angioedema, seek immediate medical attention and your doctor will advise on discontinuation.
📅 Long-Term Use Effects
Long-term use may require regular monitoring of kidney function, electrolytes, and blood pressure. It can increase the risk of electrolyte imbalances and may affect blood sugar and uric acid levels. Periodic check-ups are essential to adjust the dose and detect any complications early.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, and stress reduction can help lower blood pressure.
Evidence: Well-establishedCalcium channel blockers, ARBs, or beta-blockers may be alternatives.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, consult your doctor before any vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If traveling across time zones, consult your doctor about adjusting the timing. Carry enough supply for the entire trip plus extra in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The blood pressure-lowering effect begins within hours, but full effect may take several weeks.
A: No, do not stop without consulting your doctor. High blood pressure often requires lifelong treatment.
🤔 Common Patient Concerns
🔄 Substitutes for lispro h 5mg/12.5mg tablet
View AllAlternative brands with exact same active ingredient:
-
redihope 5mg/12.5mg tabletDr Reddy's Laboratories Ltd ₹15.00 68.8% CHEAPER
-
listen d 5mg/12.5mg tabletTwilight Mercantiles Ltd ₹35.00 27.1% CHEAPER
-
lisoril 5 ht tabletIpca Laboratories Ltd ₹49.69 3.5% COSTLIER
-
cipril-h 5mg/12.5mg tabletCipla Ltd ₹57.00 18.8% COSTLIER
-
angiotensin h 5mg/12.5mg tabletHealing Pharma India Pvt Ltd ₹70.31 46.5% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be stopped once blood pressure is normal.
Fact: High blood pressure often requires lifelong treatment. Stopping suddenly can cause a dangerous rise in blood pressure. - Myth: This medicine causes kidney damage in everyone.
Fact: While it can affect kidney function, regular monitoring helps prevent serious issues. Many patients take it safely for years.
🔄 Alternative Options
Generic Alternatives
- Lisinopril and Hydrochlorothiazide generic tablets
Brand Alternatives
- Listril Plus Tablet