Angiotensin H 5mg/12.5mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, tongue, or throat, or difficulty breathing or swallowing.
- Fainting, severe dizziness, or a sudden drop in blood pressure.
- Chest pain, irregular heartbeat, or shortness of breath.
- Severe upper stomach pain spreading to the back, with nausea or vomiting.
- Yellowing of the eyes or skin, dark urine, or severe tiredness.
- A big drop in urine output or swelling in the legs and feet.
- Fever, sore throat, or frequent infections that do not improve.
- Severe muscle cramps, weakness, or confusion.
If experiencing severe symptoms, call emergency services immediately.
What is angiotensin h 5mg/12.5mg tablet used for?
This medicine is a combination of lisinopril 5 mg and hydrochlorothiazide 12.5 mg used to treat high blood pressure. It works by relaxing blood vessels and helping the kidneys remove extra salt and water. It is taken once daily by mouth, usually in the morning, and must be prescribed and monitored by a doctor.
- Generic Name: Lisinopril + Hydrochlorothiazide
- Manufacturer: Healing Pharma India Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 angiotensin h 5mg/12.5mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा लिसिनोप्रिल 5 मिलीग्राम और हाइड्रोक्लोरोथियाजाइड 12.5 मिलीग्राम का संयोजन है, जिसका उपयोग मुख्य रूप से उच्च रक्तचाप (हाई ब्लड प्रेशर) के इलाज के लिए किया जाता है। यह रक्त वाहिकाओं को आराम देकर और शरीर से अतिरिक्त नमक और पानी निकालकर रक्तचाप को कम करती है। यह दवा उन रोगियों के लिए दी जाती है जिनका रक्तचाप एक दवा से पूरी तरह नियंत्रित नहीं होता। यह दवा केवल डॉक्टर के पर्चे पर ही लेनी चाहिए और डोज़ डॉक्टर द्वारा तय की जाती है। गर्भवती महिलाओं, एसीई इंजीबिटर से एलर्जी वाले लोगों और गुर्दे की गंभीर बीमारी वाले मरीजों को यह दवा नहीं लेनी चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में चक्कर आना, सिरदर्द, थकान, खड़े होने पर ब्लड प्रेशर गिरना, सूखी खांसी और बार-बार पेशाब आना शामिल हैं। कुछ लोगों में मांसपेशियों में ऐंठन, जी मिचलाना या हल्के दाने भी हो सकते हैं। गंभीर लेकिन दुर्लभ दुष्प्रभावों में चेहरे, होंठ, गले या जीभ में सूजन (एंजियोएडेमा), गुर्दे की समस्या, पोटैशियम या सोडियम का असंतुलन और अग्न्याशय की सूजन शामिल हैं। अगर सांस लेने में तकलीफ, चेहरे या गले में सूजन, बेहोशी, सीने में दर्द या पेशाब कम आना हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: यह दवा डॉक्टर के बताए अनुसार ही लें, आमतौर पर सुबह एक बार। इसे अपने आप बंद या कम-ज्यादा न करें। चक्कर आने पर धीरे-धीरे उठें। पर्याप्त पानी पिएं जब तक डॉक्टर ने तरल पदार्थ कम करने को न कहा हो। शराब से बचें क्योंकि इससे चक्कर और ब्लड प्रेशर गिरना बढ़ सकता है। पोटैशियम सप्लीमेंट या नमक के विकल्प डॉक्टर की सलाह के बिना न लें। ब्लड प्रेशर, गुर्दे की कार्यप्रणाली और इलेक्ट्रोलाइट्स की नियमित जांच कराते रहें। गर्भावस्था में यह दवा सुरक्षित नहीं है, इसलिए गर्भनिरोधक का उपयोग करें और गर्भवती होने पर तुरंत डॉक्टर को बताएं।
💊 angiotensin h 5mg/12.5mg tablet Uses & Benefits
[{"condition":"Hypertension (high blood pressure)","description":"Used to lower blood pressure in adults when a single medicine is not enough, reducing the risk of stroke, heart attack, and kidney damage over time.","evidence":"Well-established"},{"condition":"Heart failure with reduced ejection fraction","description":"May be used as part of a treatment plan to reduce symptoms and hospitalizations in some patients with heart failure, as determined by a clinician.","evidence":"Established for ACE inhibitor component; combination use individualized"},{"condition":"Diabetic nephropathy with hypertension","description":"ACE inhibitor component can help protect kidney function in people with diabetes and high blood pressure, while the diuretic helps control blood pressure.","evidence":"Established for ACE inhibitor component; combination use individualized"}]
Off-label uses: [{"condition":"Post-transplant hypertension","description":"Sometimes used off-label when blood pressure control is needed after organ transplant, but only under specialist supervision because of interactions with immunosuppressants.","evidence":"Limited"},{"condition":"Proteinuria in non-diabetic kidney disease","description":"ACE inhibitor component may be used off-label to reduce protein in urine in some kidney diseases, with careful monitoring.","evidence":"Limited"}]
Primary treatment for: Hypertension (high blood pressure)
Also treats: Heart failure with reduced ejection fraction, Diabetic nephropathy with hypertension, Chronic kidney disease with hypertension (selected patients)
📋 Drug Information
| Generic Name(s) | Lisinopril + Hydrochlorothiazide |
| Brand Name | Angiotensin H 5mg/12.5mg Tablet |
| Manufacturer | Healing Pharma India Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | ACE inhibitor + Thiazide diuretic |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C, away from direct sunlight, heat, and moisture. Keep the tablets in their original container with the lid tightly closed. Do not store in the bathroom. Keep out of reach of children and pets. |
| Shelf Life | Refer to the expiry date printed on the pack. Do not use after the expiry date. Once opened, follow the manufacturer's instructions on the pack. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two blood-pressure-lowering mechanisms. Lisinopril blocks the angiotensin-converting enzyme, which reduces the formation of angiotensin II, a powerful vessel-narrowing substance, and lowers aldosterone levels. This relaxes blood vessels and reduces salt and water retention. Hydrochlorothiazide inhibits the sodium-chloride symporter in the distal convoluted tubule of the kidney, increasing the excretion of sodium, chloride, and water. The result is lower blood volume and reduced vascular resistance, which together lower blood pressure.
Mechanism Steps
💡 How to Take angiotensin h 5mg/12.5mg tablet
Strength: Tablet containing lisinopril 5 mg and hydrochlorothiazide 12.5 mg, immediate release, for oral use.
Dosage Information
| Adult Dosage | The usual adult starting dose is one tablet of lisinopril 5 mg with hydrochlorothiazide 12.5 mg taken by mouth once daily. Your doctor may adjust the dose based on your blood pressure response, kidney function, and other medicines you take. Some patients may need a different strength or a different combination. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not change the dose on your own. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Older adults may be more sensitive to the blood pressure-lowering and diuretic effects of this medicine. Dizziness and falls are more likely. Doctors often start with a lower dose and monitor blood pressure, kidney function, and electrolytes more closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Kidney function affects how this medicine is cleared from the body. In people with reduced kidney function, doctors may start with a lower dose, avoid the combination, or choose different medicines. Regular monitoring of kidney function and electrolytes is needed. Dose must be individualized by a qualified clinician based on renal function. |
| Hepatic Impairment | Liver function is not a major route of elimination for this medicine, but people with liver disease may be more sensitive to blood pressure changes and fluid shifts. Doctors may start with a lower dose and monitor carefully. Dose must be individualized by a qualified clinician based on hepatic function. |
| Maximum Daily Dose | The maximum recommended daily dose of this combination is generally lisinopril 20 mg with hydrochlorothiazide 25 mg once daily, but the exact maximum depends on your condition and kidney function. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of angiotensin h 5mg/12.5mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Potassium supplements | Major | |
| Lithium | Major | |
| NSAIDs | Major | |
| Other ACE inhibitors or ARBs | Major | |
| Sacubitril/valsartan | Major | |
| Corticosteroids | Moderate | |
| Diabetes medicines | Moderate | |
| Cholestyramine | Moderate | |
| Digoxin | Moderate | |
| Other blood pressure medicines | Moderate |
🚨 Major Interactions
- Potassium supplements or potassium-sparing diuretics
- Lithium
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
- Other ACE inhibitors or angiotensin receptor blockers (ARBs)
- Sacubitril/valsartan
⚡ Moderate Interactions
- Corticosteroids
- Diabetes medicines (insulin, sulfonylureas)
- Cholestyramine and colestipol
- Digoxin
- Other blood pressure-lowering medicines
🍷 Alcohol Interaction
Alcohol can increase the blood pressure-lowering effect of this medicine and worsen dizziness, lightheadedness, and the risk of fainting. It is best to avoid alcohol or keep it to a minimum while taking this medicine. If you choose to drink, do so only occasionally and in small amounts, and never drive or operate machinery afterward.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Pregnancy","History of angioedema related to ACE inhibitors","Anuria (no urine output)","Allergy to lisinopril, hydrochlorothiazide, or any ingredient","Severe kidney disease with no urine output","Use with sacubitril/valsartan (within 36 hours)","Breastfeeding (usually avoided)"]
⚠️ Warnings & Precautions
["May cause dizziness or fainting, especially when standing up quickly.","Can cause high potassium or low sodium levels; regular blood tests are needed.","May harm the kidneys, especially with dehydration or NSAID use.","Can cause a dry cough that may need a medicine change.","Rarely causes severe allergic swelling (angioedema); stop and seek emergency help if it occurs.","May raise blood sugar and worsen diabetes control.","May raise uric acid and trigger gout attacks.","Avoid potassium supplements and salt substitutes unless approved by your doctor.","Do not stop suddenly without medical advice.","Use effective contraception during treatment."]
🤱 Lactation Safety
Small amounts of lisinopril and hydrochlorothiazide pass into breast milk. Hydrochlorothiazide can reduce milk production in some women. Because of possible effects on the baby, this medicine is usually avoided during breastfeeding. Discuss safer options with your doctor if you are breastfeeding.
💊 Overdose Management
Overdose can cause very low blood pressure, dizziness, fainting, dehydration, and electrolyte imbalance. If you suspect an overdose, seek emergency medical help immediately. Treatment is supportive, including close monitoring of blood pressure, heart rate, kidney function, and electrolytes, and intravenous fluids if needed. Do not try to treat yourself at home.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember on the same day. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed, usually once daily in the morning, with or without food. Do not stop or change the dose on your own, because stopping suddenly can raise your blood pressure. Stand up slowly to avoid dizziness, especially in the first few weeks. Drink enough water unless your doctor has told you to limit fluids. Avoid alcohol, as it can worsen dizziness and low blood pressure. Do not use potassium supplements or salt substitutes containing potassium unless your doctor approves. Tell every doctor, dentist, and pharmacist that you take this medicine, especially before starting new medicines such as pain relievers (NSAIDs), other blood pressure medicines, or lithium. Have your blood pressure, kidney function, and electrolyte levels checked regularly as advised. This medicine is not safe during pregnancy; use effective contraception and inform your doctor immediately if you become pregnant or plan to become pregnant.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults are more likely to experience dizziness, low blood pressure, falls, and electrolyte imbalances with this medicine. Doctors often start with a lower dose and monitor blood pressure, kidney function, and electrolytes more closely. Take extra care when standing up, and avoid driving if you feel dizzy.
🤰 Pregnancy Planning (TTC)
This medicine is not safe during pregnancy and can harm the developing baby. If you are planning pregnancy, talk to your doctor before you conceive so they can switch you to a safer blood pressure medicine. Use effective contraception while taking this medicine. If you become pregnant, stop the medicine and contact your doctor immediately.
🏥 Post-Surgery Considerations
Tell your surgeon and anesthesiologist that you take this medicine before any surgery. It may need to be stopped for a short time before surgery because of the risk of low blood pressure during anesthesia. Do not stop it on your own; follow your doctor's instructions. After surgery, your doctor will decide when it is safe to restart.
🦷 Dental Procedures
Tell your dentist that you take this medicine, especially if you are having a procedure that may cause bleeding or if you need local anesthesia. This medicine can cause dizziness when you sit up after lying in the dental chair, so rise slowly. Keep taking your medicine as usual unless your doctor advises otherwise.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Regular exercise is good for blood pressure, but this medicine can cause dizziness or low blood pressure, especially when you start treatment or increase the dose. Warm up slowly, avoid sudden intense bursts of activity, and drink enough water. If you feel dizzy, lightheaded, or very tired during exercise, stop and rest. Talk to your doctor before starting a new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or tiredness, especially in the first few weeks or when the dose changes. Avoid driving or operating heavy machinery until you know how it affects you. The diuretic component increases urination, so plan bathroom breaks during work or travel. Most people can continue their usual work and daily activities once their body adjusts, but always follow your doctor's advice.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. Your doctor may stop or change it if you develop serious side effects such as angioedema, severe kidney problems, very low blood pressure, or electrolyte imbalances, or if you become pregnant. If you experience any red-flag symptoms, seek medical help immediately. Always discuss any decision to stop with your doctor so your blood pressure remains controlled.
📅 Long-Term Use Effects
Long-term use of this medicine can effectively control blood pressure and reduce the risk of stroke, heart attack, and kidney damage. However, it can also cause ongoing electrolyte changes, reduced kidney function in some people, raised blood sugar, and raised uric acid. Regular blood tests for kidney function, potassium, sodium, and blood sugar are important. Your doctor may adjust the dose or change the medicine if side effects or laboratory changes occur. Do not stop the medicine on your own.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A low-salt diet, regular exercise, weight loss, and limiting alcohol can lower blood pressure and may reduce the dose of medicine needed.
Evidence: Well-establishedYour doctor may choose a different class, such as an ARB, calcium channel blocker, or beta-blocker, depending on your condition and side effects.
Evidence: Well-establishedSome patients do well with just lisinopril or just hydrochlorothiazide instead of the combination.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known vaccine interactions with this medicine. Keep your routine vaccinations up to date, including flu and pneumonia vaccines if your doctor recommends them. Tell the vaccination provider about all medicines you take.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C.
❌ DON'T
Do not refrigerate unless the label says so.
✅ DO
Keep the tablets in their original container with the lid tightly closed.
❌ DON'T
Do not transfer them to unmarked containers.
✅ DO
Keep away from direct sunlight, heat, and moisture.
❌ DON'T
Do not store in the bathroom cabinet.
✅ DO
Keep out of reach of children and pets.
❌ DON'T
Do not use after the expiry date printed on the pack.
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with the prescription label visible. Bring a copy of your prescription and a doctor's note listing your medicines, especially for international travel. Keep enough supply in your hand luggage in case checked baggage is delayed. Store it at room temperature, away from heat and direct sunlight. If you travel across time zones, take your once-daily dose at the same local time each day unless your doctor advises otherwise. Check local customs rules for carrying prescription medicines before you travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Blood pressure may start to fall within 1 to 2 hours after a dose, but the full effect usually develops over 2 to 4 weeks of regular use. Keep taking it as prescribed and attend follow-up visits.
A: It is usually taken in the morning because the diuretic component increases urination. If you take it at night, you may need to wake up to urinate. Follow your doctor's instructions.
A: Avoid potassium supplements and salt substitutes unless approved, limit high-salt foods, avoid or limit alcohol, and check with your doctor before taking pain relievers like ibuprofen or naproxen.
A: Yes, a dry cough is a known side effect of the ACE inhibitor component. Tell your doctor if it bothers you; a different medicine may be needed.
A: No. This medicine is not recommended during pregnancy because it can harm the developing baby. Use effective contraception and tell your doctor right away if you become pregnant or plan to become pregnant.
A: No. High blood pressure often has no symptoms, and stopping the medicine can cause blood pressure to rise again. Always talk to your doctor before stopping or changing your dose.
🤔 Common Patient Concerns
🔄 Substitutes for angiotensin h 5mg/12.5mg tablet
View AllAlternative brands with exact same active ingredient:
-
redihope 5mg/12.5mg tabletDr Reddy's Laboratories Ltd ₹15.00 78.7% CHEAPER
-
listen d 5mg/12.5mg tabletTwilight Mercantiles Ltd ₹35.00 50.2% CHEAPER
-
lispro h 5mg/12.5mg tabletJohnlee Pharmaceuticals Pvt Ltd ₹48.00 31.7% CHEAPER
-
lisoril 5 ht tabletIpca Laboratories Ltd ₹49.69 29.3% CHEAPER
-
cipril-h 5mg/12.5mg tabletCipla Ltd ₹57.00 18.9% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be stopped once blood pressure is normal.
Fact: High blood pressure usually has no symptoms, and stopping the medicine can cause blood pressure to rise again. Always talk to your doctor before stopping. - Myth: This medicine damages the kidneys in everyone.
Fact: This medicine can affect kidney function in some people, but with regular monitoring and proper use, it can also help protect the kidneys in certain conditions. - Myth: A dry cough means you are allergic to the medicine.
Fact: A dry cough is a known side effect of ACE inhibitors, not necessarily an allergy. Tell your doctor if it bothers you; a different medicine may be needed. - Myth: You can take potassium supplements freely with this medicine.
Fact: This medicine can raise potassium levels, so potassium supplements should only be taken if your doctor approves.
🔄 Alternative Options
Generic Alternatives
- Lisinopril and hydrochlorothiazide combination tablets from other manufacturers
- Separate tablets of lisinopril and hydrochlorothiazide taken together as prescribed
Brand Alternatives
- Angiotensin H 5mg/12.5mg Tablet