Durox-P 8mg/500mg Tablet: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is lexicam plus 8mg/500mg tablet used for?
This medicine is a combination of Lornoxicam 8 mg and Paracetamol 500 mg used for short-term relief of acute pain and inflammation. It works by reducing prostaglandins that cause pain and swelling. Take it with food to avoid stomach upset and never exceed the prescribed dose.
- Generic Name: Lornoxicam (8mg) + Paracetamol (500mg)
- Manufacturer: Cipla Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 lexicam plus 8mg/500mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा लॉर्नोक्सिकैम 8 मिलीग्राम और पैरासिटामोल 500 मिलीग्राम का संयोजन है। इसका उपयोग तीव्र दर्द और सूजन के इलाज के लिए किया जाता है, जैसे कि मांसपेशियों में चोट, दांत दर्द, ऑपरेशन के बाद का दर्द, और गठिया के दर्द में। यह दर्द और सूजन को कम करने में मदद करती है। इसे डॉक्टर के निर्देशानुसार ही लें। इसे खाने के साथ लें ताकि पेट में जलन न हो। शराब के साथ इसका सेवन न करें। गर्भावस्था के तीसरे महीने में इसका उपयोग न करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, अपच, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट में रक्तस्राव, अल्सर, गुर्दे की समस्या, यकृत की क्षति, और एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि आपको काला मल, खून की उल्टी, सांस लेने में कठिनाई, या चेहरे पर सूजन हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक से अधिक न लें। इसे भोजन के साथ लें। शराब का सेवन न करें। अन्य दर्द निवारक दवाओं के साथ इसका सेवन न करें। यदि आपको पेट अल्सर, गुर्दे या यकृत की बीमारी, या रक्तस्राव विकार है तो डॉक्टर को बताएं। गर्भावस्था के तीसरे महीने में इसका उपयोग न करें। स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। दवा को ठंडी, सूखी जगह पर रखें।
💊 lexicam plus 8mg/500mg tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in muscles, joints, and soft tissues after injury or strain.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of moderate to severe pain after surgery.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from toothache and pain following dental procedures.","evidence":"Well-established"},{"condition":"Osteoarthritis flare-up","description":"Reduces pain and improves joint function during acute exacerbations.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Helps control pain and swelling in inflammatory joint disease.","evidence":"Well-established"},{"condition":"Dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used for acute migraine attacks, but not first-line.","evidence":"Limited"},{"condition":"Renal colic","description":"May be used for pain relief in kidney stones, but other options are preferred.","evidence":"Limited"}]
Primary treatment for: Acute pain and inflammation
Also treats: Osteoarthritis, Rheumatoid arthritis, Dysmenorrhea, Post-operative pain, Dental pain
📋 Drug Information
| Generic Name(s) | Lornoxicam (8mg) + Paracetamol (500mg) |
| Brand Name | lexicam plus 8mg/500mg tablet |
| Manufacturer | Cipla Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a cool, dry place away from direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Lornoxicam is a non-steroidal anti-inflammatory drug that reversibly inhibits both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, leading to decreased synthesis of prostaglandins, prostacyclin, and thromboxane. This results in analgesic, anti-inflammatory, and antipyretic effects. Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis and possibly activating descending serotonergic pathways, producing analgesia and fever reduction. The combination provides enhanced pain relief through different pathways.
Mechanism Steps
💡 How to Take lexicam plus 8mg/500mg tablet
Strength: Each tablet contains Lornoxicam 8 mg and Paracetamol 500 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet two to three times daily as prescribed by your doctor. The maximum daily dose should not exceed three tablets in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-medicate. Take with food or milk to reduce stomach upset. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding and kidney problems. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with kidney impairment. Dose reduction may be necessary. Consult your doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with liver impairment. Dose reduction may be necessary. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose is three tablets in 24 hours. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of lexicam plus 8mg/500mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Corticosteroids | Major | |
| Methotrexate | Major | |
| Lithium | Major | |
| ACE inhibitors | Moderate | |
| Diuretics | Moderate | |
| SSRIs | Moderate | |
| Beta-blockers | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, diclofenac)
- Corticosteroids
- Methotrexate
- Lithium
⚡ Moderate Interactions
- ACE inhibitors
- Diuretics
- SSRIs
- Beta-blockers
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding, ulceration, and liver damage, especially when combined with paracetamol and NSAIDs.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to lornoxicam, paracetamol, or any other NSAID","Active peptic ulcer or history of recurrent ulcers","Severe liver disease","Severe kidney disease","Severe heart failure","Bleeding disorders","Third trimester of pregnancy","Children under 18 years (safety not established)","Concurrent use with other NSAIDs"]
⚠️ Warnings & Precautions
["Take with food to reduce stomach upset.","Avoid alcohol while taking this medicine.","Do not exceed the recommended dose or duration.","Use with caution in the elderly.","Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, asthma, or bleeding disorders.","Do not use during the third trimester of pregnancy.","Consult your doctor before use if you are breastfeeding.","Avoid driving or operating machinery if you feel dizzy or drowsy.","Do not take other paracetamol-containing products simultaneously.","Report any unusual bleeding, bruising, or persistent symptoms to your doctor."]
🤱 Lactation Safety
Lornoxicam and paracetamol are excreted in breast milk in small amounts. Paracetamol is generally considered safe during breastfeeding. Lornoxicam is not recommended during breastfeeding due to lack of safety data. Consult your doctor before use.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage, kidney failure, gastrointestinal bleeding, and blood disorders. Seek immediate medical attention. Treatment includes activated charcoal if within 1-2 hours, N-acetylcysteine for paracetamol toxicity, and supportive care. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it increases the risk of stomach bleeding and liver damage. Do not take other NSAIDs or paracetamol-containing products simultaneously. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, asthma, or bleeding disorders. Use with caution in the elderly. Do not use during the third trimester of pregnancy. If you are breastfeeding, consult your doctor before use. Store in a cool, dry place away from direct sunlight. Keep out of reach of children. If you miss a dose, take it as soon as you remember unless it is almost time for the next dose; do not double dose. If you experience signs of stomach bleeding such as black stools or vomiting blood, seek emergency help immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function regularly.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. NSAIDs may affect ovulation and are best avoided around conception. Paracetamol is generally considered safe but should be used at the lowest effective dose for the shortest time.
🏥 Post-Surgery Considerations
This medicine may be prescribed for post-operative pain. Follow your surgeon's instructions carefully. Inform your surgeon about all medicines you are taking. Avoid alcohol and other NSAIDs.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may increase bleeding risk. Your dentist may advise stopping it temporarily before surgery.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that may increase pain while taking this medicine. Gentle stretching and low-impact exercises are generally safe. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is advisable to rest and avoid strenuous activities while taking this medicine.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if you experience severe side effects such as stomach bleeding, allergic reactions, or if your pain does not improve within 7 days. Do not stop abruptly if you have been taking it for a long time without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of gastrointestinal bleeding, ulcers, kidney impairment, liver damage, and cardiovascular events. Regular monitoring of liver and kidney function is recommended. Use the lowest effective dose for the shortest duration. Consult your doctor if you need to take it for more than 7 days.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain.
Evidence: Well-establishedMay help reduce localized pain and inflammation.
Evidence: ModerateSome evidence for pain relief in certain conditions.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. Consult your doctor regarding vaccination timing while taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying prescription medicines. Keep enough supply for your trip and carry a list of your medications.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it.
A: It is best taken with food or milk to reduce the risk of stomach upset.
A: Do not take other NSAIDs or paracetamol-containing products without consulting your doctor.
A: Avoid during the third trimester. Consult your doctor before use in any trimester.
A: Take it as soon as you remember unless it is almost time for the next dose. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for lexicam plus 8mg/500mg tablet
View AllAlternative brands with exact same active ingredient:
-
loranibee plus tabletBonsai Pharma ₹12.38 48.1% CHEAPER
-
univer p 8 mg/500 mg tabletElder Pharmaceuticals Ltd ₹36.56 53.2% COSTLIER
-
lorup plus 8 mg/500 mg tabletFDC Ltd ₹37.73 58.1% COSTLIER
-
lornasafe plus tabletMankind Pharma Ltd ₹41.25 72.9% COSTLIER
-
loxcam p tabletAkesiss Pharma Pvt Ltd ₹43.40 81.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken for any type of pain.
Fact: It is only for specific types of acute pain and inflammation as prescribed by a doctor. - Myth: It is safe to take long-term without monitoring.
Fact: Long-term use requires monitoring of liver, kidney, and stomach health. - Myth: It can be taken with alcohol without any risk.
Fact: Alcohol increases the risk of stomach bleeding and liver damage. - Myth: More tablets mean faster relief.
Fact: Taking more than the recommended dose can cause serious harm.
🔄 Alternative Options
Generic Alternatives
- Lornoxicam 8 mg + Paracetamol 500 mg tablet (various manufacturers)
Brand Alternatives
- Durox-P 8mg/500mg Tablet