Antima 100mg Syrup: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blurred vision or vision loss
- Chest pain, palpitations, or irregular heartbeat
- Severe allergic reaction (swelling of face, lips, throat, difficulty breathing)
- Seizures or convulsions
- Severe abdominal pain with vomiting
- Yellowing of skin or eyes (jaundice)
- Unusual bleeding or bruising
- Severe dizziness or fainting
If experiencing severe symptoms, call emergency services immediately.
What is leoquin p ec tablet used for?
This medicine contains chloroquine, an antimalarial and immunomodulatory drug. It is used to treat and prevent malaria, and to manage autoimmune conditions like rheumatoid arthritis and lupus. It works by killing malaria parasites and reducing inflammation. It should be taken exactly as prescribed by a doctor.
- Generic Name: Chloroquine (100mg)
- Manufacturer: Leo Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 leoquin p ec tablet के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोरोक्वीन नामक सक्रिय तत्व से बनी है और मुख्य रूप से मलेरिया के इलाज और रोकथाम के लिए उपयोग की जाती है। यह रूमेटॉइड आर्थराइटिस और ल्यूपस जैसी ऑटोइम्यून बीमारियों में भी प्रभावी है। यह मलेरिया परजीवी को मारती है और सूजन को कम करती है। इसका उपयोग डॉक्टर की सलाह के अनुसार ही करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, सिरदर्द, चक्कर आना और धुंधली दृष्टि शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें आंखों की समस्या, दिल की धड़कन में गड़बड़ी, और एलर्जी प्रतिक्रिया हो सकती है। यदि कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं के बारे में बताएं, खासकर यदि आपको लीवर, किडनी, मिर्गी या आंखों की कोई बीमारी है। लंबे समय तक उपयोग के दौरान नियमित आंखों की जांच कराएं। इस दवा के साथ शराब न लें। बिना डॉक्टर की सलाह के दवा न लें और न ही बंद करें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।
💊 leoquin p ec tablet Uses & Benefits
[{"condition":"Malaria (treatment)","description":"Used to treat uncomplicated malaria caused by chloroquine-sensitive Plasmodium species.","evidence":"Well-established"},{"condition":"Malaria (prophylaxis)","description":"Used for prevention of malaria in travelers to endemic areas with susceptible parasites.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Used as a disease-modifying antirheumatic drug (DMARD) in mild to moderate cases.","evidence":"Established"},{"condition":"Systemic lupus erythematosus","description":"Used to manage skin and joint symptoms and reduce flares.","evidence":"Established"},{"condition":"Extraintestinal amebiasis","description":"Used as an adjunct in treating liver abscess caused by Entamoeba histolytica.","evidence":"Limited"}]
Off-label uses: [{"condition":"Porphyria cutanea tarda","description":"Sometimes used to reduce skin lesions by lowering iron levels.","evidence":"Limited"},{"condition":"Sarcoidosis","description":"Occasionally used for skin and joint involvement.","evidence":"Limited"},{"condition":"Chronic urticaria","description":"Rarely used when other treatments fail.","evidence":"Limited"}]
Primary treatment for: Malaria
Also treats: Rheumatoid arthritis, Systemic lupus erythematosus, Extraintestinal amebiasis
📋 Drug Information
| Generic Name(s) | Chloroquine (100mg) |
| Brand Name | leoquin p ec tablet |
| Manufacturer | Leo Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | OPHTHAL |
| Action Class | Antimalarial- Aminoquinolines |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep the bottle tightly closed. Do not refrigerate unless specified. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization recommends chloroquine for the treatment of uncomplicated malaria caused by chloroquine-sensitive Plasmodium species. However, due to widespread resistance, its use is limited to areas where the parasite is known to be susceptible. For prophylaxis, it is recommended only for travelers to areas with chloroquine-sensitive malaria. |
| ICMR Guideline | The Indian Council of Medical Research recommends chloroquine for the treatment of malaria in areas where Plasmodium falciparum is chloroquine-sensitive. It is also recommended for prophylaxis in specific high-risk groups. For autoimmune conditions, it is used as a second-line agent. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Chloroquine works by concentrating in the acidic food vacuole of the malaria parasite, where it inhibits the enzyme heme polymerase. This prevents the conversion of toxic heme into harmless hemozoin, leading to the accumulation of toxic heme that kills the parasite. In autoimmune conditions, chloroquine modulates the immune system by interfering with antigen processing and presentation, and by inhibiting the production of inflammatory cytokines such as tumor necrosis factor-alpha and interleukin-6. It also stabilizes lysosomal membranes and reduces the release of inflammatory mediators.
Mechanism Steps
💡 How to Take leoquin p ec tablet
Strength: Syrup, 100 mg per 5 mL (as chloroquine phosphate or sulfate equivalent).
Dosage Information
| Adult Dosage | The dosage of this medicine must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function. For malaria treatment, a typical adult dose might be an initial loading dose followed by maintenance doses over several days. For malaria prophylaxis, a weekly dose is often used. For autoimmune conditions, a lower daily dose is typically prescribed. Always follow your doctor's prescription exactly and do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing based on weight and indication. |
| Elderly Dosage | Elderly patients may be more susceptible to side effects, especially cardiac and ocular toxicity. Dose should be adjusted based on renal and hepatic function. Regular monitoring is recommended. |
| Renal Impairment | In patients with renal impairment, dose reduction may be necessary. Consult your doctor for specific dosing adjustments based on creatinine clearance. |
| Hepatic Impairment | In patients with hepatic impairment, dose reduction may be necessary. Monitor liver function closely. Consult your doctor for specific dosing adjustments. |
| Maximum Daily Dose | The maximum daily dose varies by indication and should not exceed the prescribed amount. For malaria treatment, the total dose over the treatment course is typically 25 mg base/kg. For prophylaxis, 5 mg base/kg weekly. Always follow your doctor's prescription. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of leoquin p ec tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Amiodarone | Major | |
| Mefloquine | Major | |
| Digoxin | Major | |
| Metformin | Moderate | |
| Cimetidine | Moderate | |
| Rifampicin | Moderate | |
| Antacids | Moderate | |
| Kaolin | Minor | |
| Phenylbutazone | Minor | |
| Alcohol | Moderate |
🚨 Major Interactions
- Amiodarone
- Mefloquine
- Digoxin
- Metformin
⚡ Moderate Interactions
- Cimetidine
- Rifampicin
- Antacids
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol may increase the risk of liver toxicity and worsen side effects such as dizziness and nausea.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to chloroquine or any component of the formulation","Pre-existing retinopathy or visual field changes","Epilepsy or history of seizures","Severe hepatic impairment","Severe renal impairment (unless benefits outweigh risks)","G6PD deficiency (relative contraindication; use with caution)","Concurrent use with mefloquine"]
⚠️ Warnings & Precautions
["Use with caution in patients with liver or kidney disease; dose adjustment may be needed.","Regular eye exams are recommended for patients on long-term therapy.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol during treatment.","Do not use for malaria prophylaxis in areas with chloroquine-resistant malaria.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Keep out of reach of children; overdose can be fatal."]
🤱 Lactation Safety
Chloroquine is excreted in breast milk in small amounts. It is generally considered safe during breastfeeding, but consult your doctor before use, especially if the infant is premature or has G6PD deficiency.
💊 Overdose Management
Overdose of chloroquine is a medical emergency and can be fatal. Symptoms include severe headache, drowsiness, visual disturbances, convulsions, and cardiac arrhythmias. If overdose is suspected, seek immediate medical attention. Treatment is supportive and may include gastric lavage, activated charcoal, and management of cardiac arrhythmias. There is no specific antidote, but early intervention is critical.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Before taking this medicine, inform your doctor about all your medical conditions, especially if you have liver or kidney disease, epilepsy, psoriasis, or a history of eye problems. Regular eye examinations are recommended during long-term therapy. Avoid alcohol while taking this medicine as it may increase the risk of liver problems. Do not take this medicine without a prescription, and never exceed the prescribed dose. If you are pregnant or breastfeeding, consult your doctor before use. This medicine may cause dizziness; avoid driving or operating heavy machinery until you know how it affects you. Keep this medicine out of reach of children and store it as directed on the label.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of chloroquine-related side effects, particularly cardiac toxicity, retinopathy, and neuromuscular weakness. Dose adjustment based on renal function is often necessary. Regular monitoring of heart, eyes, and kidney function is recommended. Falls risk may increase due to dizziness.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. Chloroquine is generally considered safe for malaria prevention and treatment during pregnancy, but for autoimmune conditions, the risk-benefit should be carefully evaluated. Effective contraception is advised while on therapy if the medicine is not considered safe for the fetus.
🏥 Post-Surgery Considerations
After surgery, inform your surgeon and anesthesiologist if you are taking this medicine, as it can affect heart rhythm and interact with anesthetic agents. Your doctor may recommend monitoring during the perioperative period. Do not stop the medicine without medical advice.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. It may cause dry mouth or increase bleeding risk if you are also on blood thinners. Your dentist may take precautions during procedures. Maintain good oral hygiene.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
If you experience dizziness or blurred vision while taking this medicine, avoid exercises that require balance or coordination, such as cycling or using heavy machinery. For patients with autoimmune conditions, low-impact exercises are generally safe, but consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, blurred vision, or nausea, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. For office work, take regular breaks and stay hydrated. If you have autoimmune conditions, fatigue may impact your work; pace yourself and prioritize tasks.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. For malaria treatment, complete the full course even if you feel better. For autoimmune conditions, your doctor will determine the duration of therapy based on your response and side effects. If you experience serious side effects like vision changes or heart problems, contact your doctor immediately; they may advise you to stop.
📅 Long-Term Use Effects
Long-term use of this medicine, especially at high doses, can lead to irreversible eye damage (retinopathy) and heart problems. Regular monitoring with eye exams and cardiac assessments is essential. It may also cause muscle weakness and skin pigmentation changes. The risk increases with cumulative dose and duration of therapy. Your doctor will periodically assess the benefit-risk ratio and may adjust or discontinue therapy if needed.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A safer alternative for autoimmune conditions with a better side effect profile.
Evidence: Well-establishedFirst-line treatment for malaria in many regions due to resistance.
Evidence: Well-establishedCan complement medicine for chronic pain and joint stiffness.
Evidence: Well-establishedUsing nets, repellents, and protective clothing to prevent malaria.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, if you are traveling to a malaria-endemic area, ensure you are up to date with routine vaccinations and any travel-specific vaccines. This medicine does not replace the need for other preventive measures.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. If you are crossing time zones, adjust your dosing schedule accordingly, especially for weekly prophylaxis. Store the syrup at room temperature and protect it from extreme heat or cold. Check the customs regulations of your destination regarding prescription medications. Always carry enough supply for your entire trip and a little extra in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: For malaria, fever may improve within 24-48 hours, but full recovery takes a few days. For autoimmune conditions, it may take several weeks to months to see full benefits.
A: Yes, taking it with food or milk can help reduce stomach upset.
A: Take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: Avoid grapefruit and alcohol. Also, separate antacids by at least 4 hours.
A: No, you must complete the full course as prescribed to prevent relapse and resistance.
🤔 Common Patient Concerns
🔄 Substitutes for leoquin p ec tablet
View AllAlternative brands with exact same active ingredient:
-
malargo 100mg syrupEastern Drug ₹11.40 272.5% COSTLIER
-
mosqun 100mg syrupCiron Drugs & Pharmaceuticals Pvt Ltd ₹11.86 287.6% COSTLIER
-
maligon suspensionUnijules Life Science Ltd ₹12.62 312.4% COSTLIER
-
antima 100mg syrupV.S. Healthcare Ltd ₹13.63 345.4% COSTLIER
-
emquin 100mg syrupMerck Ltd ₹15.81 416.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Chloroquine is safe for everyone.
Fact: Chloroquine can cause serious side effects and is not suitable for people with certain conditions like retinopathy or epilepsy. - Myth: Chloroquine can be used to prevent all types of malaria.
Fact: Chloroquine is only effective against chloroquine-sensitive malaria parasites; resistance is widespread in many regions. - Myth: You can stop taking chloroquine once you feel better.
Fact: You must complete the full course as prescribed to prevent relapse and resistance. - Myth: Chloroquine is a safe treatment for COVID-19.
Fact: Clinical trials have not shown chloroquine to be effective for COVID-19, and it can cause serious side effects.
🔄 Alternative Options
Generic Alternatives
- Chloroquine phosphate syrup
- Chloroquine sulfate syrup
Brand Alternatives
- Lariago Syrup
- Resochin Syrup
- Malarquin Syrup