lemolate plus  tablet - Paracetamol (500mg) + Caffeine (32mg) medicine

Lemolate Plus Tablet: Complete Guide To Uses, Dosage, And Safety

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🏭 Morepen Laboratories Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 26, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for Paracetamol; Caffeine as adjunct has moderate evidence.
Reviewed by
SaathiMed Expert Panel | Oct 26, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Yellowing of skin or eyes
  • Dark urine or pale stools
  • Severe abdominal pain
  • Blood in vomit or stool
  • Swelling of face, lips, or throat
  • Difficulty breathing
  • Severe rash or blistering
  • Unusual bleeding or bruising

If experiencing severe symptoms, call emergency services immediately.

What is lemolate plus tablet used for?

This medicine is a combination of Paracetamol 500 mg and Caffeine 32 mg used for relief of mild to moderate pain and fever. It works by reducing pain and fever in the brain, while caffeine enhances the pain-relieving effect and reduces fatigue. It is usually taken every 4-6 hours as needed, but do not exceed 8 tablets in 24 hours.

  • Generic Name: Paracetamol (500mg) + Caffeine (32mg)
  • Manufacturer: Morepen Laboratories Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 lemolate plus tablet के बारे में (Hindi Summary)

उपयोग: यह दवा पैरासिटामोल 500 मिलीग्राम और कैफीन 32 मिलीग्राम का संयोजन है। इसका उपयोग हल्के से मध्यम दर्द जैसे सिरदर्द, माइग्रेन, दांत दर्द, मांसपेशियों में दर्द, मासिक धर्म में होने वाले दर्द और बुखार को कम करने के लिए किया जाता है। कैफीन दर्द निवारक प्रभाव को बढ़ाता है और थकान को कम करता है।

साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, पेट में परेशानी, बेचैनी, अनिद्रा, घबराहट और धड़कन शामिल हो सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन जिगर की क्षति, त्वचा पर गंभीर प्रतिक्रियाएं और एलर्जी हो सकती हैं। यदि आंखों या त्वचा का पीलापन, गहरे रंग का मूत्र, गंभीर पेट दर्द, दाने, चेहरे या गले में सूजन या सांस लेने में कठिनाई हो तो तुरंत चिकित्सा सहायता लें।

सुरक्षा सलाह: इस दवा को अपने डॉक्टर के निर्देशानुसार ही लें। अनुशंसित खुराक से अधिक न लें। इस दवा के साथ शराब का सेवन न करें क्योंकि इससे जिगर की क्षति का खतरा बढ़ जाता है। पैरासिटामोल युक्त अन्य उत्पादों के साथ इसका सेवन न करें। यदि आपको जिगर या गुर्दे की समस्या है, या आप गर्भवती या स्तनपान करा रही हैं, तो उपयोग से पहले अपने डॉक्टर से परामर्श करें। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 lemolate plus tablet Uses & Benefits

[{"condition":"Tension headache","description":"Relieves mild to moderate headache pain and associated tension.","evidence":"Well-established"},{"condition":"Migraine","description":"Provides symptomatic relief of migraine pain; caffeine may enhance analgesic effect.","evidence":"Well-established"},{"condition":"Fever","description":"Reduces elevated body temperature due to various causes.","evidence":"Well-established"},{"condition":"Musculoskeletal pain","description":"Relieves mild to moderate pain from muscle strains, sprains, and arthritis.","evidence":"Well-established"},{"condition":"Dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Well-established"},{"condition":"Toothache","description":"Provides temporary relief of dental pain.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Post-operative pain","description":"Sometimes used as an adjunct for mild post-operative pain.","evidence":"Limited"},{"condition":"Cancer pain","description":"May be used as part of multimodal analgesia for mild cancer pain.","evidence":"Limited"}]

Primary treatment for: Pain and fever

Also treats: Headache, Migraine, Musculoskeletal pain, Dysmenorrhea, Toothache

📋 Drug Information

Generic Name(s)Paracetamol (500mg) + Caffeine (32mg)
Brand Namelemolate plus tablet
ManufacturerMorepen Laboratories Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food or milk to reduce stomach upset.
2
Do not exceed 8 tablets in 24 hours to avoid liver damage.
3
Avoid alcohol completely while taking this medicine.
4
Do not take other Paracetamol-containing products concurrently.
5
If pain persists beyond 5 days or fever beyond 3 days, consult your doctor.
6
Take the last dose at least 4-6 hours before bedtime to avoid insomnia.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Headache
This medicine is commonly used for tension headaches and migraines.
Likely Use
✅
Fever
This medicine helps reduce fever.
Likely Use
✅
Muscle pain
This medicine provides relief from mild to moderate musculoskeletal pain.
Likely Use
❌
Chest pain
This medicine is not appropriate for chest pain; seek immediate medical attention.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionParacetamol is rapidly and almost completely absorbed from the gastrointestinal tract. Caffeine is also rapidly absorbed. Food may delay absorption slightly.
DistributionParacetamol distributes widely into body tissues; it crosses the placenta and is excreted in breast milk. Caffeine distributes throughout body water and crosses the placenta and blood-brain barrier.
Protein BindingParacetamol: approximately 10-25% bound to plasma proteins. Caffeine: approximately 10-35% bound to plasma proteins.
MetabolismParacetamol is metabolized in the liver primarily by glucuronidation and sulfation, with a small fraction via CYP2E1 to N-acetyl-p-benzoquinone imine (NAPQI), which is detoxified by glutathione. Caffeine is metabolized in the liver by CYP1A2, CYP2E1, and CYP3A4.
Half-LifeParacetamol: 2-3 hours in adults. Caffeine: 3-7 hours, prolonged in liver disease and in neonates.
ExcretionParacetamol metabolites are excreted primarily in urine. Caffeine metabolites are excreted in urine.
BioavailabilityParacetamol: 80-100% oral bioavailability. Caffeine: approximately 99% oral bioavailability.
Onset of ActionParacetamol: 30-60 minutes for analgesia and antipyresis. Caffeine: 15-45 minutes for stimulant effects.
Peak Plasma TimeParacetamol: 0.5-2 hours. Caffeine: 0.5-2 hours.
Duration of ActionParacetamol: 4-6 hours. Caffeine: 3-5 hours.

How It Works

Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis, likely through COX-3 inhibition and modulation of descending serotonergic pathways, leading to reduced pain perception and fever. Caffeine is a methylxanthine that blocks adenosine receptors, causing central nervous system stimulation, vasoconstriction, and enhanced analgesic effect of Paracetamol. The combination provides additive pain relief.

Mechanism Steps

1
Paracetamol central action: Paracetamol inhibits prostaglandin synthesis in the brain and spinal cord, reducing pain and fever.
2
Caffeine adenosine blockade: Caffeine blocks adenosine receptors, leading to increased neuronal firing and release of neurotransmitters.
3
Enhanced analgesia: Caffeine potentiates the analgesic effect of Paracetamol by increasing its bioavailability and central effects.

💡 How to Take lemolate plus tablet

Strength: Tablet: Paracetamol 500 mg + Caffeine 32 mg

1Take this medicine by mouth with a full glass of water.
2Take with or without food. If stomach upset occurs, take with food or milk.
3Do not crush, chew, or break the tablet unless instructed by your doctor.
4Follow the dose and duration recommended by your doctor.
5Do not take more than the recommended dose.

Dosage Information

Adult DosageThe usual adult dose is 1-2 tablets every 4-6 hours as needed for pain or fever, not to exceed 8 tablets in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not use for more than 5 days for pain or 3 days for fever without medical advice.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of Caffeine and may have reduced liver or kidney function. Use with caution and consult a doctor for appropriate dosing.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be needed. Consult a doctor.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose reduction or avoidance may be necessary. Consult a doctor.
Maximum Daily DoseFor adults: maximum 8 tablets (4000 mg Paracetamol and 256 mg Caffeine) in 24 hours. Do not exceed the recommended dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases risk of liver damage.
Caffeine-containing beverages
Limit
May increase stimulant side effects.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of lemolate plus tablet

✅ Common Side Effects

Nausea (Common (1-10%))
Take with food or milk to reduce stomach upset. If persistent, consult your doctor.
Insomnia (Common (1-10%))
Avoid taking close to bedtime. If it interferes with sleep, consult your doctor.
Restlessness (Common (1-10%))
Usually temporary. If severe, consult your doctor.
Palpitations (Uncommon (0.1-1%))
Limit caffeine intake from other sources. If persistent or bothersome, consult your doctor.

🚨 Serious Side Effects

Severe skin reactions (e.g., Stevens-Johnson syndrome) (Rare (<0.1%))
Seek immediate medical attention if you develop rash, blisters, or peeling skin.
Liver damage (Rare (<0.1%) with recommended doses; higher with overdose)
Seek immediate medical attention if you experience yellowing of eyes or skin, dark urine, or severe abdominal pain.
Anaphylaxis (Very rare (<0.01%))
Seek emergency help if you have difficulty breathing, swelling of face or throat, or severe dizziness.

⚠️ Rare Side Effects

Thrombocytopenia
Report unusual bleeding or bruising to your doctor immediately.
Agranulocytosis
Report fever, sore throat, or mouth ulcers to your doctor promptly.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Alcohol Major
Other Paracetamol products Major
Ciprofloxacin Moderate
Fluvoxamine Moderate
Rifampicin Moderate
Oral contraceptives Moderate
Antacids Minor
Food Minor

🚨 Major Interactions

  • Warfarin
  • Alcohol
  • Other Paracetamol-containing products

⚡ Moderate Interactions

  • CYP1A2 inhibitors (e.g., ciprofloxacin, fluvoxamine)
  • CYP1A2 inducers (e.g., rifampicin, smoking)
  • Oral contraceptives

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol increases the risk of Paracetamol-induced liver damage and may worsen caffeine-related side effects such as palpitations and insomnia.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to Paracetamol or Caffeine","Severe liver disease or active liver disease","Severe kidney impairment","Chronic alcohol abuse"]

⚠️ Warnings & Precautions

["Do not exceed the recommended dose.","Avoid alcohol during treatment.","Do not use with other Paracetamol-containing products.","Use with caution in patients with liver or kidney disease.","May cause insomnia; avoid taking close to bedtime.","Consult a doctor if pain persists for more than 5 days or fever for more than 3 days."]

🤱 Lactation Safety

Paracetamol and Caffeine are excreted in breast milk in small amounts. Short-term use at recommended doses is generally considered compatible with breastfeeding. Consult your doctor.

💊 Overdose Management

Overdose of Paracetamol can cause severe liver damage. Symptoms may include nausea, vomiting, abdominal pain, and confusion. Seek immediate medical attention. Treatment includes activated charcoal, N-acetylcysteine, and supportive care. Caffeine overdose may cause restlessness, palpitations, and seizures; manage symptomatically.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Additional Safety Advice

General Safety

Take this medicine exactly as directed by your doctor. Do not exceed the recommended dose or duration. Avoid consuming alcohol while taking this medicine, as it increases the risk of liver damage. Do not take other products containing Paracetamol without consulting your doctor, as this can lead to overdose. If you have liver or kidney problems, or if you are pregnant or breastfeeding, consult your doctor before use. Keep out of reach of children. Store in a cool, dry place away from direct sunlight.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the effects of caffeine and may have reduced liver or kidney function. Use with caution and consult a doctor for appropriate dosing.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor before taking this medicine. Paracetamol is generally considered safe, but caffeine should be limited.

🏥 Post-Surgery Considerations

This medicine may be used for mild post-operative pain, but follow your surgeon's instructions. It may interact with other medications used after surgery.

🦷 Dental Procedures

This medicine can be taken for dental pain, but inform your dentist if you are taking it before any dental procedure. It may be used for pain relief after dental work.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce stress on joints and muscles.
🥗
Stay hydrated by drinking plenty of water.
😴
Get regular exercise to improve overall health and reduce pain.
💧
Practice stress-reduction techniques like deep breathing or meditation.
🧘
Ensure adequate sleep to help your body recover.
🌞
Limit caffeine intake from other sources to avoid stimulant side effects.

🏋️ Exercise Considerations

This medicine may cause dizziness or restlessness in some people. Avoid strenuous exercise if you feel unsteady. Listen to your body and rest if needed.

🥗 Diet Recommendations

Include anti-inflammatory foods like fruits, vegetables, and omega-3 rich fish.
Avoid excessive caffeine and alcohol.
Eat regular balanced meals to support overall health.

💼 Impact on Daily Work & Life

This medicine may cause insomnia or restlessness, which could affect your sleep and work performance. Avoid driving or operating heavy machinery if you feel dizzy or drowsy. Take the last dose well before bedtime.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your pain or fever persists beyond the recommended duration, if you experience any serious side effects, or if you develop new symptoms. Do not stop abruptly if you have been taking it regularly for a long time without medical advice.

📅 Long-Term Use Effects

Long-term use of this medicine at high doses can lead to liver damage, kidney problems, and medication-overuse headaches. Regular monitoring of liver and kidney function may be needed if used for extended periods. Consult your doctor for alternative treatments if pain persists.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can help manage chronic pain conditions through exercises and manual techniques.

Evidence: Well-established
Relaxation techniques

May reduce tension headaches and stress-related pain.

Evidence: Moderate
Acupuncture

May provide relief for certain types of pain.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

This medicine does not interact with vaccines. It can be taken before or after vaccination if needed for pain or fever, but consult your doctor.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, adjust dosing intervals as advised by your doctor. Check customs regulations for carrying medications.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with frequent tension headaches
She was prescribed this medicine for her headaches. She found that taking it at the first sign of headache provided quick relief. She was advised not to take it more than twice a week to avoid medication-overuse headache.
💡 Lesson: Early use can be effective, but frequent use may lead to rebound headaches. Follow your doctor's advice.
👤 A 50-year-old man with fever and body ache
He took this medicine as directed for fever and body pain. His symptoms improved within an hour. He was reminded not to take additional Paracetamol from other sources.
💡 Lesson: Always check labels for Paracetamol to avoid accidental overdose.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving pain within 30-60 minutes after taking it.

Q: Can I take it on an empty stomach?

A: It can be taken with or without food, but taking it with food may reduce stomach upset.

Q: Is it safe to take every day?

A: It is intended for short-term use. Prolonged daily use should only be done under medical supervision.

Q: What should I do if I miss a dose?

A: Take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for lemolate plus tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: Lemolate Plus Tablet is a strong painkiller and can be taken for any pain.
    Fact: It is effective for mild to moderate pain but not for severe pain. It should be used only for approved indications.
  • Myth: It is safe to take Lemolate Plus Tablet with alcohol.
    Fact: Alcohol increases the risk of liver damage and should be avoided.
  • Myth: You can take Lemolate Plus Tablet along with other Paracetamol medicines.
    Fact: Doing so can lead to Paracetamol overdose and liver damage.

🔄 Alternative Options

Generic Alternatives

  • Paracetamol 500 mg + Caffeine 32 mg tablet

Brand Alternatives

  • Lemolate Plus Tablet

📊 Comparison with Similar Medicines

[{"medicine":"Lemolate Plus Tablet","composition":"Paracetamol 500 mg + Caffeine 32 mg","uses":"Pain and fever","notes":"Caffeine enhances analgesia"},{"medicine":"Paracetamol 500 mg Tablet","composition":"Paracetamol 500 mg","uses":"Pain and fever","notes":"No caffeine"},{"medicine":"Ibuprofen 400 mg + Paracetamol 500 mg Tablet","composition":"Ibuprofen 400 mg + Paracetamol 500 mg","uses":"Pain and inflammation","notes":"NSAID combination"}]

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