Kuffdac Syrup: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or shortness of breath
- Swelling of the face, lips, tongue, or throat
- Severe drowsiness or confusion
- Hallucinations or unusual behavior
- Rapid, irregular, or pounding heartbeat
- Inability to urinate
- Cough lasting more than 7 days or accompanied by fever, rash, or persistent headache
If experiencing severe symptoms, call emergency services immediately.
What is kuffdac syrup used for?
This medicine is a combination cough syrup containing dextromethorphan (cough suppressant) and chlorpheniramine (antihistamine). It treats dry cough and cold or allergy symptoms. It is for short-term use and may cause drowsiness.
- Generic Name: Dextromethorphan Hydrobromide (10mg/10ml) + Chlorpheniramine Maleate (2mg/10ml)
- Manufacturer: Daksh Pharma Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 kuffdac syrup के बारे में (Hindi Summary)
उपयोग: यह दवा सूखी खांसी, नाक बहना, छींक आना और आंखों में पानी आना जैसे लक्षणों के इलाज के लिए इस्तेमाल की जाती है। यह डेक्सट्रोमेथोर्फन और क्लोरफेनिरामाइन का संयोजन है। यह खांसी को कम करने और एलर्जी के लक्षणों को शांत करने में मदद करती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, मुंह सूखना, चक्कर आना और धुंधली दृष्टि शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन यदि सांस लेने में कठिनाई, चेहरे या गले में सूजन, या तेज दिल की धड़कन हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर की सलाह के अनुसार ही लें। शराब का सेवन न करें। गाड़ी चलाने या मशीन चलाने से बचें क्योंकि इससे नींद आ सकती है। 7 दिनों से अधिक इसका उपयोग न करें। बच्चों और बुजुर्गों में सावधानी बरतें।
💊 kuffdac syrup Uses & Benefits
[{"condition":"Dry cough","description":"Provides temporary relief of non-productive cough due to colds or inhaled irritants.","evidence":"Well-established"},{"condition":"Allergic rhinitis","description":"Helps relieve runny nose, sneezing, and itchy, watery eyes associated with allergies.","evidence":"Well-established"},{"condition":"Common cold symptoms","description":"Reduces cough and nasal symptoms in uncomplicated upper respiratory tract infections.","evidence":"Well-established"}]
Off-label uses: []
Primary treatment for: Dry cough
Also treats: Allergic rhinitis, Common cold
📋 Drug Information
| Generic Name(s) | Dextromethorphan Hydrobromide (10mg/10ml) + Chlorpheniramine Maleate (2mg/10ml) |
| Brand Name | kuffdac syrup |
| Manufacturer | Daksh Pharma Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Do not freeze. Keep the bottle tightly closed. |
| Shelf Life | 24 months from the date of manufacture or as indicated on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Dextromethorphan acts centrally by suppressing the cough reflex in the medulla oblongata, likely through agonism at sigma-1 receptors and antagonism at NMDA receptors. Chlorpheniramine is a first-generation antihistamine that competitively blocks histamine H1 receptors, reducing allergic symptoms and producing sedation due to central H1 blockade.
Mechanism Steps
💡 How to Take kuffdac syrup
Strength: Each 10 ml contains Dextromethorphan Hydrobromide 10 mg and Chlorpheniramine Maleate 2 mg.
Dosage Information
| Adult Dosage | The usual adult dose is 10 ml (2 teaspoons) every 6 to 8 hours as needed for cough and cold symptoms. Do not exceed 4 doses (40 ml) in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially drowsiness, confusion, and anticholinergic effects. Use with caution and consult a doctor for appropriate dosing. |
| Renal Impairment | Not established from the available information. Consult your doctor for dose adjustment in renal impairment. |
| Hepatic Impairment | Not established from the available information. Consult your doctor for dose adjustment in hepatic impairment. |
| Maximum Daily Dose | 40 ml in 24 hours for adults. Do not exceed the recommended dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of kuffdac syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| Alcohol | Major | |
| Benzodiazepines | Major | |
| Opioids | Major | |
| Fluoxetine | Moderate | |
| Paroxetine | Moderate | |
| Quinidine | Moderate | |
| Tricyclic antidepressants | Moderate | |
| Atropine | Moderate | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Alcohol
- Other CNS depressants (e.g., benzodiazepines, opioids, sedatives)
⚡ Moderate Interactions
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
- Anticholinergic drugs (e.g., tricyclic antidepressants, atropine)
🍷 Alcohol Interaction
Alcohol increases the sedative and CNS depressant effects of this medicine. Avoid alcohol completely while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Children under 4 years of age","Known hypersensitivity to dextromethorphan, chlorpheniramine, or any component of the formulation","Concurrent use with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping MAOIs","Chronic cough associated with asthma, COPD, or emphysema","Cough with excessive phlegm","Narrow-angle glaucoma","Urinary retention or prostatic hypertrophy","Severe liver disease"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery.","Avoid alcohol and other CNS depressants.","Do not exceed recommended dose.","Do not use for more than 7 days without medical advice.","Use with caution in elderly patients due to increased risk of confusion, constipation, and urinary retention.","Consult a doctor before use if pregnant or breastfeeding.","Keep out of reach of children.","Do not use if you have a chronic cough or cough with excessive mucus unless directed by a doctor."]
🤱 Lactation Safety
Not established from the available information. Consult your doctor before use.
💊 Overdose Management
Overdose may cause severe drowsiness, confusion, hallucinations, seizures, respiratory depression, and cardiac arrhythmias. Seek emergency medical attention immediately. Treatment is supportive and symptomatic. There is no specific antidote for dextromethorphan or chlorpheniramine overdose. Gastric lavage may be considered if within 1-2 hours of ingestion. Monitor vital signs and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Do not exceed the recommended dose. Avoid alcohol and other central nervous system depressants while taking this medicine. Do not drive or operate heavy machinery until you know how this medicine affects you. Do not use this medicine for chronic cough or cough with excessive phlegm unless directed by a doctor. Keep out of reach of children. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before use. Do not use for more than 7 days without medical advice. Inform your doctor if you have glaucoma, difficulty urinating, asthma, or liver disease.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the side effects of this medicine, especially drowsiness, confusion, dry mouth, and urinary retention. Use with caution and consult a doctor for appropriate dosing.
🤰 Pregnancy Planning (TTC)
Consult your doctor before taking this medicine if you are pregnant, planning to become pregnant, or breastfeeding. The safety of this combination during pregnancy is not well established.
🏥 Post-Surgery Considerations
Consult your doctor before taking this medicine after surgery, as it may interact with other medications and affect recovery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may cause dry mouth and interact with other medications used during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise while taking this medicine due to possible drowsiness and dizziness. Light activity is fine if you feel well.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness and impair your ability to drive or operate machinery. Avoid these activities until you know how it affects you. It may also reduce your alertness, affecting work performance.
🛑 When to Stop This Medicine
Stop taking this medicine if your symptoms improve or after 7 days of use, whichever is earlier. If symptoms persist or worsen, consult a doctor before continuing.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended. Prolonged use may lead to tolerance, dependence, and increased risk of side effects. Use only for short-term relief of symptoms. If symptoms persist beyond 7 days, consult a doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Warm fluids, honey, and steam inhalation can help soothe cough.
Evidence: LimitedHelps relieve nasal congestion without medication.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of the prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing intervals as advised by your doctor. Check customs regulations for carrying medications.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30 minutes to relieve cough and cold symptoms.
A: Do not take with other cough and cold medicines without consulting your doctor, as they may contain similar ingredients and increase the risk of side effects.
A: This medicine is not recommended for children under 4 years. For children above 4 years, consult a pediatrician for appropriate dosing.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of cough.
Fact: This medicine is only for dry, non-productive cough. It is not effective for cough with phlegm. - Myth: It is safe to take this medicine with alcohol.
Fact: Alcohol increases the sedative effects and should be avoided. - Myth: More medicine will work faster.
Fact: Taking more than the recommended dose can cause serious side effects and does not improve efficacy.