Ahabir 250mg Tablet (Abiraterone Acetate): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of the skin or eyes, dark urine, or severe tiredness (possible liver damage)
- Severe weakness, dizziness, low blood pressure, or vomiting (possible adrenal insufficiency)
- Chest pain, shortness of breath, palpitations, or sudden swelling (possible heart problem)
- Severe muscle pain, weakness, or dark urine (possible rhabdomyolysis)
- Rash with swelling of the face, lips, or throat, or difficulty breathing (possible severe allergic reaction)
- Seizures or loss of consciousness
- Blood in stool or vomit, or severe abdominal pain
If experiencing severe symptoms, call emergency services immediately.
What is krypton abiraterone tablet used for?
This medicine is a 250 mg abiraterone acetate tablet used to treat advanced prostate cancer in adults. It works by blocking an enzyme called CYP17A1 to reduce androgen production. It must be taken on an empty stomach once daily with a corticosteroid such as prednisone or prednisolone, and it requires regular blood tests to monitor liver function, blood pressure, and potassium.
- Generic Name: Abiraterone Acetate (250mg)
- Manufacturer: Krypton Global Health
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 krypton abiraterone tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एबिरेटेरोन एसीटेट 250 मिलीग्राम की गोली है, जिसका उपयोग वयस्कों में प्रोस्टेट कैंसर के इलाज के लिए किया जाता है, खासकर जब कैंसर शरीर के अन्य हिस्सों में फैल चुका हो या हार्मोन थेरेपी के बाद भी बढ़ रहा हो। यह दवा शरीर में टेस्टोस्टेरोन और अन्य एंड्रोजन बनाने वाले एंजाइम को रोकती है, जिससे कैंसर कोशिकाओं की वृद्धि धीमी हो सकती है। इसे हमेशा प्रेडनिसोन या प्रेडनिसोलोन जैसी स्टेरॉयड दवा के साथ लेना जरूरी है। इस दवा को खाली पेट लेना चाहिए, खाने से कम से कम एक घंटा पहले या दो घंटे बाद। इसका सेवन केवल कैंसर रोग विशेषज्ञ की सलाह से ही करें।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में थकान, जोड़ों में दर्द या सूजन, उच्च रक्तचाप, गर्मी लगना, दस्त, जी मिचलाना, अपच और पैरों में सूजन शामिल हैं। कुछ मरीजों में पोटैशियम की कमी हो सकती है, जिससे मांसपेशियों में कमजोरी या ऐंठन हो सकती है। गंभीर दुष्प्रभावों में लिवर को नुकसान, हृदय की समस्या, और स्टेरॉयड दवा बंद करने पर एड्रेनल संकट शामिल हैं। अगर आपको पीलिया, गहरे रंग का पेशाब, सीने में दर्द, सांस लेने में तकलीफ, या बहुत ज्यादा कमजोरी महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को केवल कैंसर रोग विशेषज्ञ की देखरेख में ही लें और हमेशा प्रेडनिसोन या प्रेडनिसोलोन के साथ लें। स्टेरॉयड दवा को अचानक बंद न करें, क्योंकि इससे गंभीर समस्या हो सकती है। इस दवा को खाली पेट लें, खाने से एक घंटा पहले या दो घंटे बाद। गोली को पानी के साथ पूरा निगलें, चबाएं नहीं। डॉक्टर समय-समय पर लिवर, किडनी, पोटैशियम और ब्लड प्रेशर की जांच करेंगे, इसलिए सभी जांचें समय पर कराएं। अंगूर और अंगूर के जूस से बचें। अगर आपके साथी गर्भवती हो सकती हैं, तो गर्भनिरोधक का उपयोग करें। इस दवा को लेते समय और आखिरी खुराक के एक महीने बाद तक रक्तदान न करें।
💊 krypton abiraterone tablet Uses & Benefits
[{"condition":"Metastatic castration-resistant prostate cancer","description":"Used together with prednisone or prednisolone to treat adults with prostate cancer that has spread and is no longer controlled by androgen deprivation therapy alone.","evidence":"Well-established"},{"condition":"Newly diagnosed high-risk metastatic hormone-sensitive prostate cancer","description":"Used in combination with androgen deprivation therapy and a corticosteroid to treat adults with newly diagnosed high-risk prostate cancer that has spread.","evidence":"Well-established"},{"condition":"High-risk non-metastatic castration-resistant prostate cancer","description":"Used in some adults with prostate cancer that has not spread but is at high risk of progressing despite low testosterone levels.","evidence":"Established in selected patients"}]
Off-label uses: [{"condition":"Salivary gland and other androgen receptor-positive tumours","description":"Sometimes used in specialised centres for cancers that express androgen receptors, such as some salivary gland cancers.","evidence":"Limited"},{"condition":"Congenital adrenal hyperplasia","description":"Rarely used in specialist settings to reduce androgen production in certain forms of congenital adrenal hyperplasia.","evidence":"Limited"}]
Primary treatment for: Prostate cancer
Also treats: Metastatic castration-resistant prostate cancer, Metastatic hormone-sensitive prostate cancer, Non-metastatic castration-resistant prostate cancer
📋 Drug Information
| Generic Name(s) | Abiraterone Acetate (250mg) |
| Brand Name | krypton abiraterone tablet |
| Manufacturer | Krypton Global Health |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Anticancer-others |
| Route of Administration | Oral |
| Storage | Store at room temperature between 20°C and 25°C (68°F to 77°F). Keep the tablets in the original container, tightly closed, and protect them from moisture and light. Do not store in the bathroom. |
| Shelf Life | The shelf life is usually 24 months from the date of manufacture, but check the expiry date printed on the pack. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. Treatment guidelines should be consulted through your treating oncologist. |
| ICMR Guideline | Not established from the available information. Treatment guidelines should be consulted through your treating oncologist. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by selectively and irreversibly blocking the enzyme CYP17A1, which is also known as 17-alpha-hydroxylase/C17,20-lyase. This enzyme is needed for the production of testosterone and other androgens in the testes, adrenal glands, and prostate cancer tissue. By blocking this enzyme, the medicine reduces the amount of androgens available to stimulate prostate cancer cells. Because it also blocks cortisol production, a corticosteroid such as prednisone or prednisolone must be taken at the same time to replace the missing cortisol and to reduce the rise in mineralocorticoids that would otherwise cause high blood pressure and low potassium.
Mechanism Steps
💡 How to Take krypton abiraterone tablet
Strength: 250 mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 1000 mg (four 250 mg tablets) taken by mouth once daily on an empty stomach, together with prednisone or prednisolone 5 mg twice daily. The dose and schedule must be individualized by a qualified clinician based on the indication, liver function, and other medicines you take. Do not change the dose without talking to your doctor. If you have liver problems, your doctor may start you on a lower dose or stop treatment. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | Older adults can usually take the same dose as younger adults, but they may be more sensitive to side effects such as high blood pressure, low potassium, and heart problems. Your doctor will monitor you closely and adjust other medicines as needed. |
| Renal Impairment | No dose adjustment is needed for patients with kidney problems. However, kidney function should be monitored because low potassium and high blood pressure can affect the kidneys. |
| Hepatic Impairment | For patients with mild liver problems (Child-Pugh class A), the usual dose may be used, but liver tests must be checked often. For moderate liver problems (Child-Pugh class B), the starting dose is usually reduced to 250 mg once daily, and liver tests must be checked frequently. This medicine should not be used in severe liver disease (Child-Pugh class C). Your doctor will decide the exact dose. |
| Maximum Daily Dose | The maximum recommended daily dose is 1000 mg (four 250 mg tablets) once daily, unless your doctor prescribes a lower dose because of liver problems. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of krypton abiraterone tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Rifampicin | Major | |
| Ketoconazole | Major | |
| Warfarin | Moderate | |
| Metoprolol | Moderate | |
| Theophylline | Moderate | |
| Prednisone | Moderate | |
| Spironolactone | Moderate | |
| Furosemide | Moderate | |
| Carbamazepine | Major | |
| St John's wort | Major |
🚨 Major Interactions
- Strong CYP3A4 inducers (for example rifampicin, carbamazepine, phenytoin, St John's wort)
- Strong CYP3A4 inhibitors (for example ketoconazole, clarithromycin, ritonavir)
- Medicines that can lower potassium or raise blood pressure (for example some diuretics, corticosteroids)
⚡ Moderate Interactions
- CYP2D6 substrates (for example metoprolol, codeine, tramadol)
- CYP1A2 substrates (for example theophylline, caffeine)
- Warfarin and other blood thinners
🍷 Alcohol Interaction
Alcohol may worsen liver stress and increase the risk of liver problems while taking this medicine. It is best to avoid alcohol or limit it strictly, and to discuss any alcohol use with your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Women who are pregnant or may become pregnant","Severe liver disease (Child-Pugh class C)","Known severe allergy to abiraterone acetate or any ingredient in the tablet","Use without a corticosteroid such as prednisone or prednisolone"]
⚠️ Warnings & Precautions
["This medicine must always be taken with a corticosteroid to prevent adrenal insufficiency and mineralocorticoid side effects.","Do not stop the corticosteroid suddenly; your doctor will give you a tapering schedule if needed.","Take this medicine on an empty stomach, at least 1 hour before or 2 hours after food.","Avoid grapefruit and grapefruit juice while taking this medicine.","Tell your doctor if you have a history of liver disease, heart disease, low potassium, or high blood pressure.","Use effective contraception if your partner could become pregnant, because this medicine can harm a developing baby.","Do not donate blood while taking this medicine and for at least 1 month after the last dose.","Keep all appointments for blood tests and check-ups.","Tell your doctor about all other medicines, supplements, and herbal products you take."]
🤱 Lactation Safety
This medicine is not for use in women and is not recommended during breastfeeding. It is not known whether abiraterone passes into breast milk, but because of the risk to the baby, it should not be used by breastfeeding women.
💊 Overdose Management
There is no specific antidote for an overdose of this medicine. If you take too much, contact your doctor or a poison control centre immediately. Treatment is supportive, with close monitoring of liver function, blood pressure, potassium, and heart rhythm. Do not try to make yourself vomit unless told to do so by a medical professional.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember on the same day, but only if you have not eaten. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you are unsure, contact your doctor or pharmacist.
Additional Safety Advice
This medicine must only be taken under the supervision of a cancer specialist and always together with a corticosteroid such as prednisone or prednisolone as prescribed. Do not stop or change the dose of either medicine on your own, because stopping the corticosteroid suddenly can cause serious adrenal problems. Take this medicine on an empty stomach, at least one hour before or two hours after food, because food increases the amount of medicine absorbed and can raise side effects. Swallow the tablet whole with water; do not crush or chew it. Your doctor will check your liver function, blood pressure, potassium, and kidney function regularly, so keep all appointments and blood tests. Tell your doctor if you have a history of liver disease, heart disease, low potassium, or high blood pressure. Avoid grapefruit and grapefruit juice while taking this medicine. Use effective contraception if you have a partner who could become pregnant, because this medicine can harm a developing baby. Do not donate blood while taking this medicine and for at least one month after the last dose. Keep all medicines out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults can usually take the same dose as younger adults, but they may be more sensitive to side effects such as high blood pressure, low potassium, heart problems, and falls. Regular monitoring of blood pressure, potassium, liver, and kidney function is especially important. Your doctor may adjust other medicines to reduce the risk of interactions.
🤰 Pregnancy Planning (TTC)
This medicine is not for use in women and can harm a developing baby. Male patients should use effective contraception during treatment and for at least 3 weeks after the last dose if their partner could become pregnant. If you are planning a pregnancy with your partner, talk to your doctor first.
🏥 Post-Surgery Considerations
Tell your surgeon and anaesthetist that you are taking this medicine and the corticosteroid before any surgery. Do not stop the corticosteroid suddenly, as this can cause adrenal crisis during or after surgery. Your doctor may give extra steroid cover during the procedure. Follow your cancer specialist's advice about when to restart the medicine after surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine and a corticosteroid before any dental procedure. You may need extra steroid cover for dental work, especially if it is invasive. Do not stop your medicines without talking to your doctor first.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Gentle exercise is usually safe, but avoid heavy lifting or strenuous activity if you have bone pain or are at risk of fractures. Talk to your doctor before starting any new exercise programme.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause tiredness, dizziness, or high blood pressure, which can affect your ability to drive or operate machinery. Avoid driving or using heavy machines if you feel unwell. Most patients can continue their usual daily activities, but listen to your body and rest when needed.
🛑 When to Stop This Medicine
Do not stop this medicine or your corticosteroid without talking to your doctor. Treatment is usually continued as long as it is helping and side effects are manageable. Your doctor may stop or change treatment if the cancer progresses, if serious side effects occur, or if liver tests become severely abnormal. Always discuss any decision to stop with your cancer specialist.
📅 Long-Term Use Effects
Long-term use of this medicine may continue to control prostate cancer, but it can also cause ongoing side effects such as high blood pressure, low potassium, tiredness, and joint pain. Regular monitoring of liver function, blood pressure, potassium, and kidney function is needed for as long as you take it. Some patients may develop resistance over time, and your doctor will check PSA levels to decide if treatment should continue. Do not stop the medicine or the corticosteroid without medical advice.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Standard hormone treatment that lowers testosterone levels.
Evidence: Well-establishedMedicines such as enzalutamide, apalutamide, or darolutamide that block androgen receptors.
Evidence: Well-establishedMedicines such as docetaxel or cabazitaxel may be used in certain stages.
Evidence: Well-establishedMay be used for local control or pain relief.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions established for this medicine. However, because it is used in cancer patients who may have weakened immunity, talk to your doctor about which vaccines are safe and when to receive them. Avoid live vaccines unless approved by your doctor.
📦 Storage Guide
✅ DO
Store at room temperature between 20°C and 25°C
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in the original container, tightly closed
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with the prescription label visible. Bring a copy of your prescription and a letter from your doctor explaining that you need this medicine for cancer treatment. Keep enough supply for your entire trip, plus extra in case of delays. Store at room temperature and protect from moisture and heat; do not leave in a hot car. If you are crossing time zones, take your dose at the same time each day according to your home schedule or ask your doctor how to adjust. Declare the medicine at customs if required and check the rules of your destination country before travelling.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: A fall in PSA levels is usually seen within the first few weeks to months. Your doctor will check your PSA regularly to see how well it is working.
A: No. This medicine must be taken on an empty stomach, at least 1 hour before or 2 hours after food, because food increases absorption and side effects.
A: Yes. This medicine must always be taken with a corticosteroid such as prednisone or prednisolone to prevent serious adrenal problems.
A: If you remember on the same day and have not eaten, take the missed dose. If it is almost time for the next dose, skip it. Do not double dose.
A: No. This medicine is not for use in women, especially during pregnancy, because it can harm a developing baby.
🤔 Common Patient Concerns
🔄 Substitutes for krypton abiraterone tablet
View AllAlternative brands with exact same active ingredient:
-
abtmed 250mg tabletMedicamen Biotech Ltd ₹6,496.88 76.9% CHEAPER
-
zelgor 250mg tabletSun Pharmaceutical Industries Ltd ₹12,187.50 56.7% CHEAPER
-
mytera 250 tabletMylan Pharmaceuticals Pvt Ltd ₹13,125.00 53.3% CHEAPER
-
abura 250mg tabletMSN Laboratories ₹14,229.94 49.4% CHEAPER
-
abitate 250mg tabletRPG Life Sciences Ltd ₹15,600.00 44.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken without a corticosteroid.
Fact: This medicine must always be taken with a corticosteroid such as prednisone or prednisolone to prevent serious adrenal problems. - Myth: This medicine can be taken with food to reduce stomach upset.
Fact: This medicine must be taken on an empty stomach because food increases absorption and side effects. - Myth: This medicine is a chemotherapy medicine.
Fact: This medicine is not chemotherapy; it is a targeted androgen biosynthesis inhibitor. - Myth: Once you feel better, you can stop this medicine.
Fact: Do not stop this medicine or the corticosteroid without talking to your doctor, as this can cause serious problems.
🔄 Alternative Options
Generic Alternatives
- Abiraterone acetate 250 mg tablet
Brand Alternatives
- Ahabir 250 mg tablet