kolderon syrup - Paracetamol (125mg) + Phenylpropanolamine (12.5mg) medicine

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🏭 Hauz Pharma Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 26, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Limited for combination; paracetamol is well-established for fever and pain.
Reviewed by
SaathiMed Expert Panel | Sep 26, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Difficulty breathing or swelling of face, lips, or throat
  • Severe headache with blurred vision
  • Chest pain or irregular heartbeat
  • Yellowing of skin or eyes
  • Blood in vomit or stool
  • Decreased urine output
  • Severe dizziness or fainting

If experiencing severe symptoms, call emergency services immediately.

What is kolderon syrup used for?

This medicine is a combination syrup containing Paracetamol and Phenylpropanolamine used for temporary relief of nasal congestion, runny nose, and fever due to common cold or allergies. It works by reducing fever and pain and constricting nasal blood vessels. It should not be used in patients with high blood pressure or heart disease.

  • Generic Name: Paracetamol (125mg) + Phenylpropanolamine (12.5mg)
  • Manufacturer: Hauz Pharma Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 kolderon syrup के बारे में (Hindi Summary)

उपयोग: यह दवा पैरासिटामोल और फेनिलप्रोपेनॉलामाइन का संयोजन है, जिसका उपयोग सर्दी-जुकाम, एलर्जी और साइनसाइटिस में नाक बंद होने, बहती नाक और बुखार से राहत के लिए किया जाता है। यह बुखार और दर्द को कम करती है और नाक की रक्त वाहिकाओं को सिकोड़कर जमाव को कम करती है। इसका उपयोग डॉक्टर की सलाह के बिना 5 दिनों से अधिक नहीं करना चाहिए।

साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट दर्द, मुँह सूखना, सिरदर्द, चक्कर आना और घबराहट शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, सांस लेने में कठिनाई, अनियमित दिल की धड़कन और यकृत की क्षति शामिल हो सकते हैं। यदि कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर की सलाह के बिना 5 दिनों से अधिक न लें। अन्य पैरासिटामोल युक्त दवाओं के साथ न लें। शराब का सेवन न करें। उच्च रक्तचाप, हृदय रोग, मधुमेह या थायरॉइड की समस्या हो तो डॉक्टर से परामर्श करें। चक्कर आने पर वाहन न चलाएँ। बच्चों की पहुँच से दूर रखें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 kolderon syrup Uses & Benefits

[{"condition":"Common cold","description":"Provides temporary relief from nasal congestion, runny nose, and fever associated with common cold.","evidence":"Well-established for symptomatic relief"},{"condition":"Allergic rhinitis","description":"Helps reduce nasal stuffiness and sneezing due to allergies.","evidence":"Limited evidence for combination"},{"condition":"Sinusitis","description":"May relieve nasal congestion and pressure in sinusitis.","evidence":"Limited evidence for combination"}]

Off-label uses: []

Primary treatment for: Common cold

Also treats: Allergic rhinitis, Sinusitis

📋 Drug Information

Generic Name(s)Paracetamol (125mg) + Phenylpropanolamine (12.5mg)
Brand Namekolderon syrup
ManufacturerHauz Pharma Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a cool, dry place away from direct sunlight. Do not refrigerate.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always measure the dose accurately using a measuring cup or spoon.
2
Do not use this medicine for more than 5 days without consulting a doctor.
3
Avoid giving this medicine to children under 6 years without a doctor's advice.
4
Check for other paracetamol-containing products to avoid overdose.
5
Monitor blood pressure if you have hypertension.
6
Report any signs of allergic reaction immediately.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Nasal congestion
This medicine is commonly prescribed for this.
Likely Use
✅
Fever
Paracetamol component reduces fever.
Likely Use
✅
Runny nose
Phenylpropanolamine reduces nasal secretions.
Likely Use
❌
Chest pain
This medicine is not for chest pain; seek emergency care.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionParacetamol is rapidly and completely absorbed from the gastrointestinal tract. Phenylpropanolamine is also absorbed from the gastrointestinal tract. Food may delay absorption of paracetamol.
DistributionParacetamol distributes widely into body tissues. Phenylpropanolamine distribution is not well characterized but is expected to distribute into tissues.
Protein BindingParacetamol: 10-25% bound to plasma proteins. Phenylpropanolamine: Not established from the available information.
MetabolismParacetamol is metabolized in the liver primarily by glucuronidation and sulfation, with a small fraction via CYP2E1 to N-acetyl-p-benzoquinone imine (NAPQI), which is detoxified by glutathione. Phenylpropanolamine undergoes limited metabolism, primarily by monoamine oxidase.
Half-LifeParacetamol: 2-3 hours. Phenylpropanolamine: 3-6 hours.
ExcretionParacetamol is excreted in urine as metabolites. Phenylpropanolamine is excreted largely unchanged in urine.
BioavailabilityParacetamol: 80-100%. Phenylpropanolamine: Not established from the available information.
Onset of ActionParacetamol: 30-60 minutes. Phenylpropanolamine: 15-30 minutes.
Peak Plasma TimeParacetamol: 0.5-2 hours. Phenylpropanolamine: 1-2 hours.
Duration of ActionParacetamol: 4-6 hours. Phenylpropanolamine: 4-6 hours.

How It Works

Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis, which reduces fever and pain. Phenylpropanolamine is a sympathomimetic amine that stimulates alpha-adrenergic receptors, causing vasoconstriction in the nasal mucosa, thereby reducing swelling and congestion. The combination provides symptomatic relief of cold symptoms.

Mechanism Steps

1
Paracetamol central action: Paracetamol inhibits prostaglandin synthesis in the brain, reducing fever and pain perception.
2
Phenylpropanolamine alpha-adrenergic stimulation: Phenylpropanolamine binds to alpha-adrenergic receptors on nasal blood vessels, causing vasoconstriction.
3
Reduced nasal congestion: Vasoconstriction decreases blood flow and swelling in the nasal mucosa, relieving stuffiness.
4
Symptom relief: The combined effects alleviate fever, pain, and nasal congestion associated with colds and allergies.

💡 How to Take kolderon syrup

Strength: Each 5 mL contains Paracetamol 125 mg and Phenylpropanolamine 12.5 mg.

1Shake the bottle well before use.
2Use a measuring cup or spoon to measure the dose accurately.
3Take orally, with or without food.
4Follow the prescribed dose and frequency.
5Do not exceed the recommended dose.

Dosage Information

Adult DosageThe usual adult dose is 10-15 mL (2-3 teaspoons) every 4-6 hours as needed, not to exceed 60 mL in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of phenylpropanolamine. Use with caution and consult a doctor for appropriate dosing.
Renal ImpairmentNot established from the available information. Consult a doctor.
Hepatic ImpairmentUse with caution in patients with liver impairment. Consult a doctor for dose adjustment.
Maximum Daily DoseAdults: Do not exceed 60 mL in 24 hours. Children: As directed by a physician.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases risk of liver damage.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of kolderon syrup

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food or milk to reduce nausea. Consult doctor if persistent.
Dry mouth (Common (5-10%))
Sip water frequently. Usually resolves on its own.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how it affects you.
Headache (Common (5-10%))
Rest and stay hydrated. Consult doctor if severe or persistent.
Nervousness (Common (5-10%))
Limit caffeine intake. Consult doctor if bothersome.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience rash, itching, swelling, or difficulty breathing.
Hemorrhagic stroke (Rare (<0.1%))
Seek emergency care if you experience sudden severe headache, confusion, or weakness.
Liver damage (paracetamol overdose) (Rare (<0.1%))
Seek immediate medical attention if you suspect overdose, even if you feel well.
Severe skin reactions (Stevens-Johnson syndrome) (Very rare (<0.01%))
Stop medicine and seek immediate medical attention if you develop rash, blisters, or peeling skin.

⚠️ Rare Side Effects

Blood disorders (thrombocytopenia, agranulocytosis)
Report unusual bleeding, bruising, or infections to your doctor.
Hypertensive crisis
Seek emergency care if you experience severe headache, chest pain, or blurred vision.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
MAOIs Major
Warfarin Major
Beta-blockers Moderate
Tricyclic antidepressants Moderate
Caffeine Moderate
Antacids Minor
Cholestyramine Minor

🚨 Major Interactions

  • Monoamine oxidase inhibitors (MAOIs)
  • Other sympathomimetics
  • Warfarin

⚡ Moderate Interactions

  • Beta-blockers
  • Tricyclic antidepressants
  • Caffeine

🍷 Alcohol Interaction

Avoid alcohol consumption while taking this medicine as it increases the risk of liver damage, especially with paracetamol.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to paracetamol or phenylpropanolamine","Severe hypertension","Coronary artery disease","Hyperthyroidism","Concurrent use with MAOIs","Pheochromocytoma","Closed-angle glaucoma","Urinary retention"]

⚠️ Warnings & Precautions

["Do not exceed recommended dose.","Avoid use in patients with cardiovascular disease.","Use with caution in patients with diabetes, thyroid disorders, or glaucoma.","May cause drowsiness; avoid driving.","Do not use for more than 5 days without medical advice.","Keep out of reach of children."]

🤱 Lactation Safety

Not established from the available information. Consult a doctor before use.

💊 Overdose Management

Seek immediate medical attention. Paracetamol overdose can cause liver damage; antidote N-acetylcysteine may be administered. Phenylpropanolamine overdose can cause hypertension, tachycardia, and CNS stimulation; supportive care is required.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double dose.

Additional Safety Advice

General Safety

Do not exceed the recommended dose. Avoid using this medicine for more than 5 days without consulting a doctor. Do not take other products containing paracetamol while on this medicine to prevent overdose. Avoid alcohol consumption as it increases the risk of liver damage. Patients with high blood pressure, heart disease, diabetes, or thyroid disorders should use this medicine only under medical supervision. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Keep out of reach of children. Store in a cool, dry place away from direct sunlight. Pregnant and breastfeeding women should consult a doctor before use. If symptoms persist or worsen, seek medical advice.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more sensitive to the effects of phenylpropanolamine, especially on blood pressure and heart rate. Use with caution and under medical supervision.

🤰 Pregnancy Planning (TTC)

Consult your doctor before taking this medicine if you are pregnant, planning to become pregnant, or breastfeeding. The safety of this combination in pregnancy is not well established.

🏥 Post-Surgery Considerations

Consult your surgeon before taking this medicine after surgery, as it may interact with other medications or affect blood pressure.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may interact with anesthetics or other medications used during dental procedures.

💚 Lifestyle Tips for Better Results

🏃
Stay hydrated by drinking plenty of fluids.
🥗
Get adequate rest to help your body recover.
😴
Use a humidifier to ease nasal congestion.
💧
Avoid exposure to allergens and irritants.
🧘
Practice good hand hygiene to prevent infections.

🏋️ Exercise Considerations

Avoid strenuous exercise if you feel dizzy or weak. Light activity is fine if you feel up to it.

🥗 Diet Recommendations

Drink warm fluids like soups and herbal teas.
Include vitamin C-rich fruits and vegetables.
Avoid cold and sugary drinks that can worsen congestion.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how it affects you. It is advisable to rest at home when symptomatic.

🛑 When to Stop This Medicine

Stop taking this medicine if symptoms persist beyond 5 days or if you experience any serious side effects. Consult your doctor before stopping if you have been on it for a longer duration.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended. Prolonged use of phenylpropanolamine may increase the risk of cardiovascular events. Paracetamol long-term use at high doses can cause liver damage. Regular monitoring of liver and kidney function may be required if used for extended periods.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Saline nasal spray

Helps relieve nasal congestion without medication.

Evidence: Well-established
Steam inhalation

Can temporarily relieve nasal stuffiness.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

This medicine does not interact with vaccines. However, if you have a fever, consult your doctor before vaccination.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of the prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing intervals as advised by your doctor. Check customs regulations for carrying medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with common cold and nasal congestion
She took this medicine as directed by her doctor. Within 30 minutes, her nasal congestion improved and fever reduced. She experienced mild dry mouth but it resolved after drinking water. She was advised not to take it for more than 3 days.
💡 Lesson: This medicine provides quick relief but should be used short-term and under medical guidance.
👤 A 50-year-old man with hypertension
He took this medicine for cold without consulting his doctor. He experienced a severe headache and his blood pressure was elevated. He was advised to avoid phenylpropanolamine-containing products due to his hypertension.
💡 Lesson: Patients with high blood pressure should avoid this medicine unless prescribed by a doctor.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: It usually starts working within 30-60 minutes after taking a dose.

Q: Can I take it on an empty stomach?

A: It can be taken with or without food, but taking it with food may reduce stomach upset.

Q: Is it safe for children?

A: It should only be given to children under medical supervision. Consult a pediatrician for appropriate dosing.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my blood pressure?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for kolderon syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken for any type of cold.
    Fact: It is only for symptomatic relief of congestion and fever; it does not cure the underlying infection.
  • Myth: It is safe to take more than the recommended dose for faster relief.
    Fact: Exceeding the dose can cause serious side effects like liver damage and hypertensive crisis.

📊 Comparison with Similar Medicines

[{"medicine":"Paracetamol + Phenylpropanolamine","composition":"Paracetamol 125mg + Phenylpropanolamine 12.5mg per 5mL","uses":"Nasal congestion, fever, cold symptoms","notes":"Phenylpropanolamine has safety concerns."},{"medicine":"Paracetamol + Phenylephrine","composition":"Paracetamol 325mg + Phenylephrine 5mg","uses":"Nasal congestion, fever, cold symptoms","notes":"Phenylephrine is considered safer."}]

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