kofrlf ls kid syrup - Levosalbutamol (0.25mg/5ml) + Ambroxol (7.5mg/5ml) medicine

Axaril LS Oral Drops: Complete Medicine Guide

No reviews yet
🏭 Gracia Life Science India Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 22, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for combination in respiratory conditions.
Reviewed by
SaathiMed Expert Panel | Oct 22, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Difficulty breathing or worsening of breathing after taking the medicine
  • Chest pain or irregular heartbeat
  • Severe allergic reaction (rash, swelling of face, lips, or throat)
  • Severe dizziness or fainting
  • Blood in sputum or vomit
  • Persistent high fever
  • Yellowing of skin or eyes

If experiencing severe symptoms, call emergency services immediately.

What is kofrlf ls kid syrup used for?

This medicine is a combination of levosalbutamol (a bronchodilator) and ambroxol (a mucolytic) used to treat respiratory conditions with wheezing and thick mucus. It helps open airways and loosen mucus, making breathing easier.

  • Generic Name: Levosalbutamol (0.25mg/5ml) + Ambroxol (7.5mg/5ml)
  • Manufacturer: Gracia Life Science India Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 kofrlf ls kid syrup के बारे में (Hindi Summary)

उपयोग: यह दवा लेवोसाल्बुटामोल और एम्ब्रोक्सोल का संयोजन है, जिसका उपयोग श्वसन संबंधी समस्याओं जैसे ब्रोंकाइटिस, घरघराहट और बलगम वाली खांसी के इलाज में किया जाता है। यह श्वास नलियों को फैलाकर सांस लेना आसान बनाती है और गाढ़े बलगम को पतला करके बाहर निकालने में मदद करती है। यह दवा केवल डॉक्टर के पर्चे पर ही लेनी चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में हाथ-पैर कांपना, घबराहट, सिरदर्द, धड़कन तेज होना और जी मिचलाना शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि सांस लेने में कठिनाई, चक्कर आना, या त्वचा पर चकत्ते दिखें तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक से अधिक न लें। उपयोग से पहले बोतल को अच्छी तरह हिलाएं और ड्रॉपर से सही मात्रा नापें। यदि आपको दिल, थायरॉइड, या मधुमेह की समस्या है तो डॉक्टर को बताएं। अन्य दवाओं के साथ लेने से पहले डॉक्टर से सलाह लें। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 kofrlf ls kid syrup Uses & Benefits

[{"condition":"Acute bronchitis with bronchospasm","description":"Helps relieve bronchospasm and loosen thick mucus, making breathing easier and cough more productive.","evidence":"Well-established for the combination in respiratory conditions."},{"condition":"Productive cough associated with respiratory tract infections","description":"Ambroxol thins mucus while levosalbutamol opens airways, facilitating expectoration.","evidence":"Commonly used in clinical practice."},{"condition":"Pediatric respiratory conditions with wheeze and mucus plugging","description":"Oral drops are convenient for children who cannot use inhalers effectively.","evidence":"Accepted use in pediatric practice."}]

Off-label uses: [{"condition":"Post-operative atelectasis prevention","description":"Sometimes used to help clear secretions and prevent lung collapse after surgery.","evidence":"Limited"}]

Primary treatment for: Respiratory conditions with bronchospasm and thick mucus

Also treats: Acute bronchitis, Productive cough, Asthma (adjunct), COPD (adjunct)

📋 Drug Information

Generic Name(s)Levosalbutamol (0.25mg/5ml) + Ambroxol (7.5mg/5ml)
Brand Namekofrlf ls kid syrup
ManufacturerGracia Life Science India Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep the container tightly closed. Do not freeze.
Shelf LifeNot established from the available information. Refer to the product packaging for expiry date.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always prescribe this medicine after confirming the presence of bronchospasm and thick mucus; it is not for dry cough.
2
Advise patients to shake the bottle well and use the dropper for accurate dosing.
3
Warn patients about the possibility of tremors and palpitations, especially at higher doses.
4
Monitor potassium levels in patients on concomitant diuretics or corticosteroids.
5
Use with caution in patients with cardiovascular disease; consider baseline ECG if risk factors present.
6
Instruct patients not to exceed the prescribed dose and to report if symptoms persist beyond 7 days.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Wheezing
This medicine is commonly prescribed for wheezing associated with bronchospasm.
Likely Use
✅
Productive cough
Ambroxol helps thin mucus, making cough more productive.
Likely Use
❌
Dry cough
This medicine is not effective for dry cough.
Not Primary
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionLevosalbutamol is rapidly absorbed from the gastrointestinal tract after oral administration. Ambroxol is also well absorbed orally. However, oral bioavailability of levosalbutamol is reduced due to first-pass metabolism. Specific pharmacokinetic parameters for this combination oral drop are not established from the available information.
DistributionLevosalbutamol distributes widely into body tissues, including the lungs. Ambroxol crosses the blood-brain barrier and placenta. Protein binding information for this specific combination is not established from the available information.
Protein BindingNot established from the available information.
MetabolismLevosalbutamol undergoes extensive first-pass metabolism in the liver, primarily by sulfation. Ambroxol is metabolized in the liver by conjugation. Specific metabolic data for this combination product are not established from the available information.
Half-LifeNot established from the available information.
ExcretionLevosalbutamol and its metabolites are excreted mainly in urine. Ambroxol is excreted in urine as conjugates. Specific excretion data for this combination are not established from the available information.
BioavailabilityNot established from the available information.
Onset of ActionBronchodilation from levosalbutamol typically begins within 5-15 minutes after oral administration, but the exact onset for this oral drop formulation is not established from the available information.
Peak Plasma TimeNot established from the available information.
Duration of ActionBronchodilation usually lasts 4-6 hours, but the exact duration for this oral drop formulation is not established from the available information.

How It Works

Levosalbutamol selectively stimulates beta-2 adrenergic receptors in the bronchial smooth muscle, leading to relaxation and bronchodilation. Ambroxol increases serous bronchial secretion, reduces mucus viscosity, and enhances ciliary clearance, thereby aiding expectoration. Together, they improve airway patency and mucus clearance.

Mechanism Steps

1
Beta-2 receptor stimulation: Levosalbutamol binds to beta-2 receptors on bronchial smooth muscle, activating adenylate cyclase and increasing cyclic AMP.
2
Smooth muscle relaxation: Increased cyclic AMP leads to relaxation of bronchial smooth muscle, resulting in bronchodilation.
3
Mucus modification: Ambroxol alters the composition of mucus, reducing its viscosity and elasticity.
4
Enhanced mucociliary clearance: Thinner mucus is more easily moved by cilia and expelled through coughing.

💡 How to Take kofrlf ls kid syrup

Strength: Oral drops: Levosalbutamol 0.25 mg/5 ml + Ambroxol 7.5 mg/5 ml

1Shake the bottle well before each use.
2Use the dropper provided to measure the exact dose prescribed.
3Administer the drops directly into the mouth or mix with a small amount of water or juice if needed.
4Take with food to reduce stomach upset, unless your doctor advises otherwise.
5Wash the dropper after each use and close the bottle tightly.
6Do not exceed the prescribed dose.

Dosage Information

Adult DosageThe dosage of this medicine must be individualized by a qualified clinician based on the indication, age, weight, and renal and hepatic function. Typically, for adults, the dose may range from 5-10 ml orally 2-3 times a day, but this is for educational reference only. Do not self-medicate. Always follow your doctor's prescription.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing based on the child's age and weight.
Elderly DosageElderly patients may be more sensitive to the cardiovascular effects of levosalbutamol. Use with caution and individualized dosing by a clinician.
Renal ImpairmentDose adjustment may be required in patients with renal impairment. Consult a doctor for individualized dosing.
Hepatic ImpairmentDose adjustment may be required in patients with hepatic impairment. Consult a doctor for individualized dosing.
Maximum Daily DoseNot established from the available information. Do not exceed the dose prescribed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Caffeine
Limit
May increase nervousness and palpitations.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of kofrlf ls kid syrup

✅ Common Side Effects

Tremors (Common (5-10%))
Usually resolves with continued use. If bothersome, consult your doctor.
Nervousness (Common (5-10%))
May decrease over time. Avoid caffeine. Consult doctor if severe.
Headache (Common (5-10%))
Stay hydrated. Use acetaminophen if needed, but consult doctor first.
Palpitations (Uncommon (1-5%))
Report to your doctor if persistent or accompanied by chest pain.
Nausea (Uncommon (1-5%))
Take with food to reduce stomach upset.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience rash, swelling, or difficulty breathing.
Paradoxical bronchospasm (Rare (<0.1%))
Stop the medicine and seek immediate medical help if breathing worsens.
Cardiac arrhythmias (Rare (<0.1%))
Seek immediate medical attention if you experience irregular heartbeat, chest pain, or fainting.

⚠️ Rare Side Effects

Hypokalemia
Monitor potassium levels if on long-term therapy. Consult doctor.
Hyperglycemia
Monitor blood sugar if diabetic. Consult doctor.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Propranolol Major
Furosemide Moderate
Digoxin Moderate
MAOIs Major
Tricyclic antidepressants Major
Corticosteroids Moderate
Theophylline Moderate
Other beta-2 agonists Moderate
Diuretics (thiazide) Moderate
Anticholinergics Minor

🚨 Major Interactions

  • Non-selective beta-blockers (e.g., propranolol)
  • Monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants

⚡ Moderate Interactions

  • Diuretics (e.g., furosemide)
  • Corticosteroids
  • Digoxin

🍷 Alcohol Interaction

Alcohol may increase the risk of dizziness, drowsiness, and cardiovascular side effects. It is advisable to avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to levosalbutamol, ambroxol, or any component of the formulation","Severe cardiovascular disorders","Hyperthyroidism","Severe hepatic or renal impairment (relative contraindication)"]

⚠️ Warnings & Precautions

["Use with caution in patients with cardiovascular diseases, including coronary insufficiency, cardiac arrhythmias, and hypertension.","May cause hypokalemia; monitor potassium levels, especially in patients on diuretics or corticosteroids.","May cause hyperglycemia; monitor blood glucose in diabetic patients.","Not recommended for children under 2 years without medical advice.","Avoid use in patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption, or sucrase-isomaltase insufficiency (if formulation contains sorbitol).","Do not exceed the recommended dose.","Consult a doctor if symptoms persist or worsen."]

🤱 Lactation Safety

It is not known whether levosalbutamol and ambroxol are excreted in human milk. Caution should be exercised when used by breastfeeding mothers. Consult your doctor.

💊 Overdose Management

Overdose may cause severe tachycardia, tremors, palpitations, and hypokalemia. In case of overdose, seek immediate medical attention. Treatment is symptomatic and supportive. Monitor cardiac and electrolyte status.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

This medicine should be taken exactly as prescribed by a qualified clinician. Do not exceed the recommended dose or frequency. Shake the bottle well before each use and measure the dose accurately using the dropper provided. Inform your doctor about all other medicines, especially beta-blockers, diuretics, or other bronchodilators, as interactions may occur. Avoid using this medicine if you have a known allergy to levosalbutamol or ambroxol. Patients with heart disease, high blood pressure, diabetes, or thyroid disorders should use this medicine with caution and under medical supervision. Do not stop or change the dose without consulting your doctor. Keep this medicine out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the cardiovascular effects of levosalbutamol. Use with caution and monitor heart rate and blood pressure. Dose adjustment may be needed.

🤰 Pregnancy Planning (TTC)

Consult your doctor if you are planning pregnancy or are pregnant. The safety of this medicine during pregnancy is not fully established. Use only if clearly needed and prescribed.

🏥 Post-Surgery Considerations

If you have recently had surgery, inform your surgeon and anesthesiologist about this medicine. It may interact with anesthetic agents and affect heart rate.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may cause dry mouth or interact with certain medications used in dental procedures.

💚 Lifestyle Tips for Better Results

🏃
Avoid smoking and exposure to secondhand smoke.
🥗
Stay well hydrated to help thin mucus.
😴
Use a humidifier to keep airways moist.
💧
Practice deep breathing exercises as advised.
🧘
Get adequate rest to support recovery.
🌞
Avoid known allergens and pollutants.

🏋️ Exercise Considerations

Avoid strenuous exercise if you have breathing difficulties. Consult your doctor before starting any exercise program. If exercise-induced bronchospasm occurs, follow your doctor's advice.

🥗 Diet Recommendations

Include warm fluids like soups and herbal teas.
Avoid cold and processed foods that may worsen mucus.
Eat a balanced diet rich in fruits and vegetables.
Limit caffeine intake as it may increase side effects.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or tremors, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is advisable to rest and recover.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. If you experience severe side effects or your symptoms worsen, contact your doctor immediately. The duration of treatment should be determined by your healthcare provider.

📅 Long-Term Use Effects

Long-term use of this medicine should be under medical supervision. Prolonged use of beta-2 agonists may lead to tolerance and reduced effectiveness. Regular monitoring of cardiovascular and respiratory status is advised. Do not use for longer than prescribed without consulting your doctor.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Steam inhalation

Can help loosen mucus and ease breathing.

Evidence: Traditional, supportive.
Chest physiotherapy

Techniques to help clear secretions.

Evidence: Well-established for mucus clearance.

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

Ensure vaccinations are up to date, especially influenza and pneumococcal vaccines, to prevent respiratory infections. Consult your doctor about timing.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of the prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 4-year-old child with acute bronchitis and wheezing
The child was prescribed this medicine by a pediatrician. After two days, the parents noticed that the child's cough became more productive and breathing was easier. They ensured the child took the medicine with food to avoid stomach upset.
💡 Lesson: This medicine can effectively relieve bronchospasm and loosen mucus in children when taken as prescribed.
👤 An adult with COPD exacerbation
A 60-year-old man with COPD was given this medicine as part of his treatment. He experienced mild tremors initially, which subsided after a few days. His breathing improved significantly, and he was able to expectorate more easily.
💡 Lesson: Side effects like tremors are usually transient, and the benefits often outweigh the risks when used under medical supervision.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Bronchodilation typically begins within 5-15 minutes after oral administration, but the full effect may take longer. The mucolytic effect may take a few days to become noticeable.

Q: Can I take this medicine with food?

A: Yes, taking it with food can reduce stomach upset. Follow your doctor's advice.

Q: Is it safe for children?

A: It is used in children but only under a pediatrician's supervision. The dose is individualized based on age and weight.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my heart?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for kofrlf ls kid syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be used for any type of cough.
    Fact: It is specifically for cough associated with bronchospasm and thick mucus. It is not effective for dry cough or cough due to other causes.
  • Myth: It is safe to increase the dose if symptoms don't improve.
    Fact: Increasing the dose can lead to serious side effects. Always follow the prescribed dose.

🔄 Alternative Options

Generic Alternatives

  • Levosalbutamol + Ambroxol oral drops (generic)

📊 Comparison with Similar Medicines

[{"medicine":"Levosalbutamol + Ambroxol","composition":"Levosalbutamol 0.25mg/5ml + Ambroxol 7.5mg/5ml","route":"Oral","key_feature":"Combination of bronchodilator and mucolytic"},{"medicine":"Salbutamol + Ambroxol","composition":"Salbutamol + Ambroxol","route":"Oral","key_feature":"Similar but uses racemic salbutamol"}]

😊 Was this information helpful?

Browse Medicines A-Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Back to Medicines Directory