Kofrid D Syrup: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swallowing
- Swelling of face, lips, or throat
- Severe dizziness or fainting
- Hallucinations or confusion
- Chest pain or rapid heartbeat
- Cough persists for more than 7 days or worsens
- Fever, rash, or persistent headache accompanying cough
If experiencing severe symptoms, call emergency services immediately.
What is kofrid d syrup used for?
This medicine is a combination cough syrup containing dextromethorphan hydrobromide (a cough suppressant) and menthol (a soothing agent). It is used for temporary relief of dry, irritating coughs. It works by suppressing the cough reflex in the brain and providing a cooling sensation to the throat. It should not be used for cough with excessive phlegm or chronic cough without medical advice.
- Generic Name: Dextromethorphan Hydrobromide (10mg) + Menthol (1.5mg)
- Manufacturer: Meridian Medicare Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 kofrid d syrup के बारे में (Hindi Summary)
उपयोग: यह दवा सूखी खांसी और गले में खराश के इलाज के लिए इस्तेमाल की जाती है। इसमें डेक्सट्रोमेथोर्फन हाइड्रोब्रोमाइड और मेंथॉल होते हैं। डेक्सट्रोमेथोर्फन खांसी को दबाने का काम करता है और मेंथॉल गले को ठंडक पहुंचाकर आराम देता है। यह दवा 12 साल से बड़े बच्चों और वयस्कों के लिए है। ध्यान रखें कि यह दवा बलगम वाली खांसी के लिए नहीं है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, जी मिचलाना और पेट खराब होना शामिल हैं। ये आमतौर पर हल्के और अस्थायी होते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें एलर्जी, सांस लेने में कठिनाई, या मतिभ्रम शामिल हो सकते हैं। अगर ऐसा कुछ हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा की अनुशंसित खुराक से अधिक न लें। जब तक आपको पता न चले कि यह दवा आप पर कैसे असर करती है, तब तक वाहन चलाने या मशीनरी चलाने से बचें। इस दवा के साथ शराब न लें। अगर आप गर्भवती हैं, गर्भवती होने की योजना बना रही हैं, या स्तनपान करा रही हैं, तो इस दवा का उपयोग करने से पहले अपने डॉक्टर से सलाह लें। बच्चों की पहुंच से दूर रखें।
💊 kofrid d syrup Uses & Benefits
[{"condition":"Dry cough","description":"Provides temporary relief from dry, irritating cough due to colds or inhaled irritants.","evidence":"Well-established"},{"condition":"Throat irritation","description":"Menthol provides a soothing cooling effect that helps relieve throat irritation associated with cough.","evidence":"Well-established"}]
Off-label uses: []
Primary treatment for: Dry cough
Also treats: Throat irritation
📋 Drug Information
| Generic Name(s) | Dextromethorphan Hydrobromide (10mg) + Menthol (1.5mg) |
| Brand Name | kofrid d syrup |
| Manufacturer | Meridian Medicare Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a cool, dry place. Protect from direct sunlight. |
| Shelf Life | Not established from the available information. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Dextromethorphan hydrobromide acts on the central nervous system by suppressing the cough reflex through its action on the cough center in the medulla oblongata. It is a non-opioid agent that raises the threshold for cough stimulation. Menthol, when inhaled or ingested, activates TRPM8 receptors, producing a cooling sensation that helps soothe the throat and may also have mild local anesthetic properties.
Mechanism Steps
💡 How to Take kofrid d syrup
Strength: Each 5 mL contains Dextromethorphan Hydrobromide 10 mg and Menthol 1.5 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 10 mL (2 teaspoons) every 4 hours as needed, not to exceed 6 doses in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Use with caution and consult a doctor for appropriate dosing. |
| Renal Impairment | Not established from the available information. Consult a doctor for dose adjustment in renal impairment. |
| Hepatic Impairment | Not established from the available information. Consult a doctor for dose adjustment in hepatic impairment. |
| Maximum Daily Dose | 60 mL in 24 hours for adults. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of kofrid d syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| SSRIs | Major | |
| CYP2D6 inhibitors | Moderate | |
| CNS depressants | Moderate | |
| Antihistamines | Minor |
🚨 Major Interactions
- MAO inhibitors (e.g., phenelzine, tranylcypromine)
- SSRIs (e.g., fluoxetine, sertraline)
⚡ Moderate Interactions
- CYP2D6 inhibitors (e.g., quinidine, paroxetine)
- CNS depressants (e.g., alcohol, benzodiazepines, opioids)
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine as it can increase drowsiness, dizziness, and the risk of other side effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to dextromethorphan, menthol, or any component of the formulation.","Concurrent use with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping MAOI therapy.","Chronic cough associated with smoking, asthma, or emphysema.","Cough with excessive mucus or phlegm."]
⚠️ Warnings & Precautions
["Do not exceed the recommended dose.","Avoid driving or operating heavy machinery until you know how this medicine affects you.","Avoid alcohol while taking this medicine.","Consult a doctor if cough persists for more than 7 days, tends to recur, or is accompanied by fever, rash, or persistent headache.","Use with caution in patients with liver or kidney disease.","Keep out of reach of children."]
🤱 Lactation Safety
Not established from the available information. Consult your doctor before use.
💊 Overdose Management
If overdose is suspected, seek immediate medical attention. Symptoms of overdose may include nausea, vomiting, drowsiness, dizziness, hallucinations, and difficulty breathing. Treatment is supportive and symptomatic.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
Additional Safety Advice
Do not exceed the recommended dose of this medicine. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it may cause drowsiness. Do not use this medicine for a chronic cough or cough with excessive phlegm unless advised by a doctor. Avoid alcohol while taking this medicine as it can increase drowsiness and other side effects. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Keep out of reach of children. Do not use this medicine if you are taking a monoamine oxidase inhibitor (MAOI) or have taken one in the last 14 days.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially drowsiness and dizziness. Use with caution and consult a doctor for appropriate dosing.
🤰 Pregnancy Planning (TTC)
Consult your doctor before using this medicine if you are pregnant, planning to become pregnant, or breastfeeding.
🏥 Post-Surgery Considerations
Consult your doctor before using this medicine after surgery, as it may interact with other medications or affect recovery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise if you are feeling unwell. This medicine may cause drowsiness, so avoid activities that require alertness until you know how it affects you.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is generally safe to work if you are not operating heavy machinery.
🛑 When to Stop This Medicine
Stop taking this medicine and consult a doctor if your cough persists for more than 7 days, worsens, or is accompanied by fever, rash, or persistent headache. Do not stop prescribed medications without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended without medical supervision. Prolonged use may lead to dependence or other side effects. Consult your doctor if you need to use it for more than 7 days.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Warm fluids, honey, and humidifiers can help soothe a dry cough.
Evidence: LimitedMenthol lozenges can provide temporary relief from throat irritation.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from direct sunlight. If traveling across time zones, continue with your regular dosing schedule as needed for cough relief. Check customs regulations for carrying medications into your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine typically starts working within 15-30 minutes after taking it.
A: Do not take this medicine with other cough medicines without consulting your doctor, as it may lead to overdose or increased side effects.
A: This medicine is not recommended for children under 12 years without a doctor's advice.
🤔 Common Patient Concerns
🔄 Substitutes for kofrid d syrup
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of cough.
Fact: This medicine is only for dry cough and is not effective for cough with phlegm. - Myth: It is safe to take more than the recommended dose for faster relief.
Fact: Taking more than the recommended dose can lead to serious side effects and is not safer or more effective.