Allerhin D Plus Syrup: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or shortness of breath
- Swelling of the face, lips, tongue, or throat
- Severe rash or blistering of the skin
- Hallucinations or confusion
- Rapid heart rate with agitation or fever
- Cough lasting more than 7 days or worsening
- Cough with blood or rust-colored sputum
- Severe drowsiness or inability to stay awake
If experiencing severe symptoms, call emergency services immediately.
What is kofno-ad syrup used for?
This medicine is a combination cough syrup containing ambroxol (15 mg/5 ml) and dextromethorphan hydrobromide (10 mg/5 ml). It is used to treat productive cough by loosening mucus and suppressing the cough reflex. It is for adults and children over 12 years, and should be taken as prescribed.
- Generic Name: Ambroxol (15mg/5ml) + Dextromethorphan Hydrobromide (10mg/5ml)
- Manufacturer: Mediquest Inc.
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 kofno-ad syrup के बारे में (Hindi Summary)
उपयोग: यह दवा एक संयुक्त कफ सिरप है जिसमें एम्ब्रोक्सोल (15 मिलीग्राम/5 मिली) और डेक्सट्रोमेथोर्फन हाइड्रोब्रोमाइड (10 मिलीग्राम/5 मिली) शामिल हैं। इसका उपयोग बलगम वाली खांसी के इलाज के लिए किया जाता है। यह बलगम को पतला करके बाहर निकालने में मदद करती है और खांसी की तीव्रता को कम करती है। यह दवा 12 वर्ष से अधिक उम्र के बच्चों और वयस्कों के लिए है। इसे डॉक्टर के निर्देशानुसार ही लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, जी मिचलाना, उल्टी, पेट में असहजता और मुंह सूखना शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर आपको त्वचा पर चकत्ते, सूजन, सांस लेने में कठिनाई, या मतिभ्रम जैसे लक्षण दिखें तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक से अधिक न लें। उपयोग से पहले बोतल को अच्छी तरह हिलाएं और मापने वाले कप से सही मात्रा लें। अगर आपको नींद या चक्कर आते हैं तो वाहन चलाने या मशीन चलाने से बचें। इस दवा के साथ शराब न पिएं। अगर आपको लीवर या किडनी की समस्या है, अस्थमा है, या नशीली दवाओं का सेवन किया है तो डॉक्टर को बताएं। 7 दिनों से अधिक इस दवा का उपयोग बिना डॉक्टर की सलाह के न करें।
💊 kofno-ad syrup Uses & Benefits
[{"condition":"Productive cough with thick mucus","description":"Helps loosen mucus and reduce cough frequency in acute or chronic bronchitis.","evidence":"Well-established"},{"condition":"Acute bronchitis","description":"Provides symptomatic relief of cough and mucus congestion.","evidence":"Moderate"},{"condition":"Chronic bronchitis","description":"Used to ease cough and improve mucus clearance in chronic obstructive pulmonary disease.","evidence":"Moderate"},{"condition":"Tracheobronchitis","description":"Reduces cough and helps expectoration in inflammation of the trachea and bronchi.","evidence":"Limited"}]
Off-label uses: [{"condition":"Post-operative cough","description":"Sometimes used to suppress cough after surgery to prevent strain on surgical sites.","evidence":"Limited"}]
Primary treatment for: Productive cough
Also treats: Acute bronchitis, Chronic bronchitis, Tracheobronchitis
📋 Drug Information
| Generic Name(s) | Ambroxol (15mg/5ml) + Dextromethorphan Hydrobromide (10mg/5ml) |
| Brand Name | kofno-ad syrup |
| Manufacturer | Mediquest Inc. |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a cool, dry place. Protect from direct sunlight and moisture. Do not freeze. Keep the bottle tightly closed. |
| Shelf Life | 24 months from the date of manufacture. Do not use after the expiry date printed on the pack. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Ambroxol is a mucolytic that increases serous bronchial secretion, reduces mucus viscosity, and promotes ciliary clearance, making it easier to cough out mucus. Dextromethorphan hydrobromide is a centrally acting cough suppressant that acts on the cough center in the medulla oblongata to raise the threshold for coughing. Together, they provide both mucus clearance and cough suppression.
Mechanism Steps
💡 How to Take kofno-ad syrup
Strength: Each 5 ml of syrup contains Ambroxol 15 mg and Dextromethorphan Hydrobromide 10 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 10 ml (two teaspoons) taken orally three times a day, or as directed by your doctor. The dose may be adjusted based on the severity of your symptoms and your response to treatment. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. This medicine is not recommended for children under 12 years of age. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially drowsiness and dizziness. Use with caution. Dose adjustment may be necessary based on kidney and liver function. Consult your doctor for appropriate dosing. |
| Renal Impairment | Use with caution in patients with severe kidney impairment. Dose adjustment may be needed. Consult your doctor for appropriate dosing. |
| Hepatic Impairment | Use with caution in patients with severe liver impairment. Dose adjustment may be needed. Consult your doctor for appropriate dosing. |
| Maximum Daily Dose | The maximum recommended daily dose for adults is 30 ml (6 teaspoons) in divided doses. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of kofno-ad syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| SSRIs | Major | |
| CYP2D6 inhibitors | Major | |
| Antihistamines | Moderate | |
| Opioids | Moderate | |
| Alcohol | Moderate | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- MAO inhibitors (e.g., phenelzine, tranylcypromine)
- SSRIs (e.g., fluoxetine, paroxetine)
- CYP2D6 inhibitors (e.g., quinidine, terbinafine)
⚡ Moderate Interactions
- Antihistamines (e.g., diphenhydramine)
- Opioid analgesics (e.g., codeine, morphine)
- Alcohol
🍷 Alcohol Interaction
Alcohol should be strictly avoided while taking this medicine. Both dextromethorphan and alcohol cause drowsiness and can depress the central nervous system. Combining them can lead to excessive sedation, impaired coordination, and difficulty breathing. It also increases the risk of liver damage.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to ambroxol, dextromethorphan, or any component of the formulation","Children under 12 years of age","Respiratory depression or severe respiratory insufficiency","Concurrent use with MAO inhibitors or within 14 days of stopping them","First trimester of pregnancy","Breastfeeding without medical advice","Chronic cough associated with smoking, asthma, or emphysema without diagnosis","Cough with excessive secretions where suppression could be harmful"]
⚠️ Warnings & Precautions
["Do not exceed the recommended dose. High doses of dextromethorphan can cause hallucinations and dissociation.","Avoid driving or operating machinery until you know how this medicine affects you.","Do not use for chronic cough or cough with excessive mucus without consulting a doctor.","Use with caution in patients with liver or kidney disease.","Use with caution in patients with a history of drug abuse or addiction.","Do not use in children under 12 years.","Consult a doctor if cough persists for more than 7 days, or if it is accompanied by fever, rash, or persistent headache.","Keep out of reach of children. In case of accidental overdose, seek medical help immediately."]
🤱 Lactation Safety
Not established from the available information. Dextromethorphan and ambroxol may pass into breast milk. Consult your doctor before use if you are breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, dizziness, nausea, vomiting, hallucinations, agitation, rapid heart rate, and difficulty breathing. In case of overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if the patient presents early. Monitor vital signs and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Shake the bottle well before each use and measure the dose with the provided measuring cup or spoon. Avoid driving or operating heavy machinery if you feel drowsy or dizzy after taking this medicine. Do not drink alcohol while taking this medicine, as it can increase drowsiness and other side effects. Inform your doctor if you have liver or kidney problems, asthma, or a history of drug abuse. Do not use this medicine for more than 7 days without consulting your doctor. Keep it out of reach of children. Store in a cool, dry place away from direct sunlight. Do not use this medicine if the seal is broken or the expiry date has passed.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, particularly drowsiness, dizziness, and confusion. They may also have reduced liver and kidney function, which can affect drug clearance. Use with caution and consider dose reduction. Monitor for falls and cognitive changes.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this medicine during pregnancy is not well established. It is generally recommended to avoid use in the first trimester. Discuss alternative treatments for cough with your doctor.
🏥 Post-Surgery Considerations
After surgery, cough can be painful and may strain surgical sites. This medicine can help suppress cough and loosen mucus, but use only under medical supervision. Inform your surgeon and anesthesiologist about all medicines you are taking. Dextromethorphan may interact with anesthetic agents.
🦷 Dental Procedures
If you are undergoing dental procedures, inform your dentist that you are taking this medicine. Dry mouth is a common side effect, which can increase the risk of dental problems. Stay hydrated and maintain good oral hygiene. The cough suppressant effect may be beneficial if you have a cough that could interfere with dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise while taking this medicine, especially if you feel drowsy or dizzy. Light activity like walking may be fine, but listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause nausea or stomach discomfort, which can impact your work. Take it with food to minimize these effects. If your job requires mental alertness, discuss with your doctor about timing your doses.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your cough persists for more than 7 days, if it worsens, or if you develop new symptoms like fever, rash, or difficulty breathing. Do not stop abruptly if you have been taking it for a long time without consulting your doctor, as withdrawal symptoms may occur.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended without medical supervision. Prolonged use of dextromethorphan can lead to tolerance, dependence, and withdrawal symptoms. Ambroxol is generally well tolerated, but long-term effects are not well studied. If your cough persists for more than 7 days, consult a doctor to determine the underlying cause. Regular monitoring of liver and kidney function may be advised if used for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps loosen mucus and soothe airways.
Evidence: Well-establishedCan help clear nasal congestion and postnasal drip.
Evidence: ModerateSoothes throat and reduces cough frequency.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider that you are taking this medicine. It is generally safe to continue, but your doctor will advise based on your condition.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging with the prescription label intact. Bring a copy of your prescription to avoid issues at customs. Store it in a cool, dry place away from direct sunlight. If traveling across time zones, continue taking the medicine at regular intervals as prescribed. Do not leave it in a hot car or checked luggage. If you need to take a dose during travel, ensure you have access to safe water to take it with.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 30 to 60 minutes. Cough suppression may begin within 15 to 30 minutes, while mucus loosening takes about 30 to 60 minutes.
A: Yes, you can take this medicine with or without food. Taking it with food may help reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: The safety of this medicine during pregnancy is not well established. It should be used only if clearly needed and prescribed by a doctor. Avoid use in the first trimester.
A: No, you should avoid alcohol while taking this medicine as it can increase drowsiness and the risk of central nervous system depression.
🤔 Common Patient Concerns
🔄 Substitutes for kofno-ad syrup
View AllAlternative brands with exact same active ingredient:
-
allerhin d plus syrupEmbiotic Laboratories Pvt Ltd ₹37.13 47.2% CHEAPER
-
cetmet tcf syrupAlmet Corporation Ltd ₹39.38 44% CHEAPER
-
lariz dm oral suspensionDatla Laboratories ₹40.00 43.1% CHEAPER
-
brozine syrupMHS Pharmaceuticals Pvt Ltd ₹48.00 31.7% CHEAPER
-
tune time syrupShrinivas Gujarat Laboratories Pvt Ltd ₹56.08 20.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of cough.
Fact: This medicine is only for productive cough with thick mucus. It is not effective for dry cough or cough due to other causes. - Myth: More medicine means faster relief.
Fact: Taking more than the recommended dose can cause serious side effects like hallucinations and respiratory depression. Always follow the prescribed dose. - Myth: It is safe to take this medicine with alcohol.
Fact: Alcohol increases the sedative effects and can be dangerous. Avoid alcohol completely while taking this medicine.
🔄 Alternative Options
Generic Alternatives
- Ambroxol + Dextromethorphan Hydrobromide syrup (various manufacturers)
Brand Alternatives
- Allerhin D Plus Syrup