Koflab Syrup: Complete Guide to Uses, Dosage, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or shortness of breath
- Swelling of face, lips, tongue, or throat
- Severe dizziness or fainting
- Rapid or irregular heartbeat
- Hallucinations or confusion
- Seizures
- Severe nausea or vomiting
- Blood in vomit or stool
If experiencing severe symptoms, call emergency services immediately.
What is koflab syrup used for?
This medicine is a combination of cetirizine (an antihistamine) and dextromethorphan (a cough suppressant) used to treat dry cough and allergic symptoms like runny nose and sneezing. It is available as a syrup and is usually taken every 4-6 hours as needed, but not more than 60 ml in 24 hours. It may cause drowsiness, so avoid driving. Always use as prescribed by your doctor.
- Generic Name: Cetirizine (5mg/5ml) + Dextromethorphan Hydrobromide (5mg/5ml)
- Manufacturer: Helplab Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 koflab syrup के बारे में (Hindi Summary)
उपयोग: यह दवा सेटिरिज़िन और डेक्सट्रोमेथोर्फन का संयोजन है, जिसका उपयोग सूखी खांसी और एलर्जी के लक्षणों जैसे नाक बहना, छींक आना और आंखों में खुजली के इलाज के लिए किया जाता है। यह सिरप के रूप में उपलब्ध है और इसे डॉक्टर के निर्देशानुसार लेना चाहिए। यह दवा खांसी को कम करने और एलर्जी से राहत देने में मदद करती है। इसे 12 वर्ष से कम उम्र के बच्चों को बिना डॉक्टर की सलाह के नहीं देना चाहिए। गर्भवती और स्तनपान कराने वाली महिलाओं को इसका उपयोग करने से पहले डॉक्टर से परामर्श लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, मुंह सूखना, थकान और हल्का पेट दर्द शामिल हैं। कुछ लोगों को मतली, सिरदर्द या बेचैनी हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर आपको त्वचा पर चकत्ते, सूजन, सांस लेने में कठिनाई, या दिल की धड़कन तेज होने जैसे लक्षण दिखें, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक से अधिक न लें। शराब और अन्य नींद लाने वाली दवाओं के साथ इसका सेवन न करें क्योंकि इससे नींद और चक्कर बढ़ सकते हैं। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन न चलाएं या मशीनरी न चलाएं। अगर आपको लीवर या किडनी की बीमारी, अस्थमा या किसी दवा से एलर्जी है, तो डॉक्टर को बताएं। बच्चों की पहुंच से दूर रखें।
💊 koflab syrup Uses & Benefits
[{"condition":"Dry cough","description":"Relieves non-productive, irritating cough by suppressing the cough reflex in the brain.","evidence":"Well-established"},{"condition":"Allergic rhinitis","description":"Reduces sneezing, runny nose, itchy and watery eyes, and nasal itching due to allergic response.","evidence":"Well-established"},{"condition":"Common cold with cough","description":"Provides symptomatic relief of cough and allergic symptoms associated with the common cold.","evidence":"Well-established"},{"condition":"Allergic cough","description":"Helps control cough triggered by allergic reactions, especially when associated with postnasal drip.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Chronic idiopathic cough","description":"Sometimes prescribed off-label for persistent dry cough after other causes are ruled out.","evidence":"Limited"},{"condition":"Pruritus (itching) due to various causes","description":"Cetirizine component may help relieve itching, though the combination is not primarily indicated for this.","evidence":"Limited"}]
Primary treatment for: Dry cough and allergic rhinitis
Also treats: Common cold, Allergic cough, Postnasal drip, Sneezing and runny nose due to allergies
📋 Drug Information
| Generic Name(s) | Cetirizine (5mg/5ml) + Dextromethorphan Hydrobromide (5mg/5ml) |
| Brand Name | koflab syrup |
| Manufacturer | Helplab Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep the bottle tightly closed when not in use. Do not freeze. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture, or as indicated on the packaging. Do not use after the expiry date printed on the bottle. |
| WHO Guideline | Not established from the available information. The World Health Organization does not have specific guidelines for this fixed-dose combination. Cough and cold medicines should be used judiciously, and symptomatic treatment should be based on individual assessment. |
| ICMR Guideline | Not established from the available information. The Indian Council of Medical Research does not have specific guidelines for this combination. Use should be based on clinical judgment and national treatment protocols for cough and allergic rhinitis. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Cetirizine is a selective peripheral H1-receptor antagonist that blocks histamine from binding to H1 receptors on blood vessels and nerve endings, reducing allergic symptoms such as sneezing, runny nose, and itching. Dextromethorphan hydrobromide is a centrally acting cough suppressant that acts on the cough center in the medulla oblongata. It is a dextro-isomer of levorphanol but lacks analgesic and addictive properties at therapeutic doses. Dextromethorphan suppresses the cough reflex by reducing the sensitivity of cough receptors in the brain to stimuli. Together, they provide relief from cough and allergic symptoms.
Mechanism Steps
💡 How to Take koflab syrup
Strength: Each 5 ml of syrup contains cetirizine 5 mg and dextromethorphan hydrobromide 5 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 10 ml (2 teaspoons) orally every 4 to 6 hours as needed for cough and allergic symptoms, not to exceed 60 ml in 24 hours. However, the exact dose and frequency must be individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, renal and hepatic function, and response to treatment. Do not self-medicate or exceed the prescribed dose. Follow your doctor's instructions carefully. |
| Pediatric Dosage | Pediatric dosing is not established from available information. This medicine is not recommended for children under 12 years of age unless specifically prescribed by a pediatrician. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the side effects of this medicine, especially drowsiness, dizziness, and confusion. Dose adjustment may be necessary based on renal and hepatic function. Use with caution and under medical supervision. The dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with renal impairment, the clearance of cetirizine is reduced, and dose adjustment may be necessary. For creatinine clearance between 11-31 mL/min, the dose of cetirizine should be reduced. For creatinine clearance less than 10 mL/min, cetirizine is contraindicated. Dextromethorphan metabolites may also accumulate. Consult your doctor for appropriate dose adjustment based on your kidney function. |
| Hepatic Impairment | In patients with hepatic impairment, the metabolism of dextromethorphan may be reduced, leading to increased levels and side effects. Dose adjustment may be necessary. Use with caution and under medical supervision. The dose must be individualized by a qualified clinician based on the degree of hepatic impairment. |
| Maximum Daily Dose | The maximum recommended daily dose for adults is 60 ml of this syrup in 24 hours, providing 60 mg of cetirizine and 60 mg of dextromethorphan hydrobromide. Do not exceed this dose. Higher doses can increase the risk of serious side effects. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of koflab syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| SSRIs | Major | |
| CYP2D6 inhibitors | Major | |
| Alcohol | Moderate | |
| Opioids | Moderate | |
| Other antihistamines | Moderate | |
| Anticholinergics | Minor | |
| Grapefruit juice | Moderate |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Selective serotonin reuptake inhibitors (SSRIs)
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
⚡ Moderate Interactions
- Alcohol
- Other antihistamines or sedatives
- Opioid analgesics
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can increase drowsiness, dizziness, and the risk of central nervous system depression. Combining alcohol with cetirizine and dextromethorphan can impair your ability to drive or operate machinery and may increase the risk of falls or accidents. It is best to avoid alcohol until you have finished the course of treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to cetirizine, dextromethorphan, or any component of the formulation","Use within 14 days of stopping an MAOI","Children under 12 years of age (unless specifically prescribed by a pediatrician)","Chronic cough associated with asthma, COPD, or excessive mucus production","Severe hepatic impairment","Severe renal impairment (creatinine clearance
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol and other CNS depressants while taking this medicine.","Do not exceed the recommended dose; high doses of dextromethorphan can cause hallucinations, dissociation, and serotonin syndrome.","Use with caution in patients with a history of drug abuse or dependence.","Consult a doctor before use in patients with asthma, chronic bronchitis, or emphysema.","Do not use for chronic cough or cough with excessive mucus unless advised by a doctor.","Use with caution in elderly patients who may be more sensitive to side effects.","Consult a doctor before use if you are pregnant, planning pregnancy, or breastfeeding.","Keep out of reach of children; accidental overdose can be dangerous.","Do not use if the seal is broken or the solution is discolored."]
🤱 Lactation Safety
Not established from the available information. Cetirizine and dextromethorphan may pass into breast milk. It is not known whether this combination is safe during breastfeeding. Consult your doctor before using this medicine if you are breastfeeding. Your doctor may recommend an alternative or advise you to pump and discard breast milk during treatment.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, dizziness, hallucinations, agitation, rapid heartbeat, high blood pressure, nausea, vomiting, and in severe cases, respiratory depression, seizures, and coma. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and symptomatic. There is no specific antidote for cetirizine or dextromethorphan. Activated charcoal may be administered if the patient presents within 1-2 hours of ingestion. Naloxone may be used if opioid-like effects are present. Monitor vital signs, cardiac rhythm, and mental status. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Avoid alcohol and other central nervous system depressants because they can increase drowsiness and dizziness. Do not drive or operate heavy machinery until you know how this medicine affects you. Inform your doctor if you have liver or kidney disease, asthma, or a history of drug abuse. Do not use this medicine for a chronic cough or cough with a lot of mucus unless your doctor advises. Keep out of reach of children. Store at room temperature away from direct sunlight and moisture. Do not use after the expiry date. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before use. Do not share this medicine with others, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially drowsiness, dizziness, confusion, and urinary retention. The dose may need to be reduced based on kidney and liver function. Use with caution and under medical supervision. Avoid driving or operating machinery.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this combination during pregnancy is not well established. Cetirizine is generally considered safe, but dextromethorphan should be used with caution, especially during the first trimester. Your doctor may recommend an alternative treatment.
🏥 Post-Surgery Considerations
After surgery, the use of this medicine should be discussed with your surgeon or anesthesiologist. Dextromethorphan can interact with certain anesthetic agents and may increase the risk of serotonin syndrome. Cetirizine may cause drowsiness, which can interfere with post-operative recovery. Do not take this medicine without medical advice after surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. The dry mouth caused by cetirizine may increase the risk of dental caries and oral discomfort. Dextromethorphan may interact with anesthetics. Your dentist may recommend adjusting your medication or taking preventive measures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness and dizziness. Avoid strenuous exercise or activities that require alertness until you know how it affects you. If you feel dizzy or sleepy, do not exercise. Consult your doctor before resuming exercise if you have been unwell.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may affect your ability to drive, operate machinery, or perform tasks requiring mental alertness. It is best to avoid these activities until you know how the medicine affects you. Inform your employer if your job involves such tasks. You may need to adjust your work schedule or take sick leave if symptoms are severe.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your cough persists for more than 7 days, if it worsens, or if you develop a fever, rash, or difficulty breathing. Do not stop abruptly if you have been taking it for a long time without consulting your doctor. Always follow your doctor's advice on when to stop.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended without medical supervision. Prolonged use of dextromethorphan can lead to tolerance and dependence. Cetirizine may cause dry mouth, drowsiness, and rarely urinary retention. Regular monitoring of kidney and liver function may be advised if used for extended periods. Always consult your doctor before using this medicine for more than 7 days.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps loosen mucus and soothe irritated airways.
Evidence: Traditional remedy with some supportive evidence.Soothes throat and may reduce cough frequency.
Evidence: Some evidence for cough relief.Helps clear nasal congestion and postnasal drip.
Evidence: Well-established for allergic rhinitis.💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are unwell with a cough or cold, it is best to postpone vaccination until you recover, as your immune response may be affected. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate or freeze
✅ DO
Keep in original container with cap tightly closed
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case of customs checks. Store it in a cool, dry place away from direct sunlight. If traveling across time zones, continue your regular dosing schedule as prescribed. Do not leave it in a hot car or checked luggage. If you need to take it during travel, ensure you have enough for the trip. Avoid alcohol during travel as it can increase drowsiness.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Cetirizine starts working within 1 hour, while dextromethorphan's cough-suppressant effect begins in about 15-30 minutes.
A: Yes, you can take it with or without food. If it upsets your stomach, take it with a meal or snack.
A: It is not recommended for children under 12 years unless prescribed by a pediatrician.
A: No, alcohol should be avoided as it can increase drowsiness and dizziness.
A: Take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose. Do not double dose.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of cough.
Fact: This medicine is only for dry, non-productive cough. It is not effective for cough with phlegm and may be harmful in such cases. - Myth: It is safe to take this medicine with alcohol.
Fact: Alcohol increases the risk of drowsiness, dizziness, and CNS depression. It should be avoided. - Myth: This medicine is safe for children of all ages.
Fact: It is not recommended for children under 12 years unless prescribed by a pediatrician. - Myth: You can take this medicine for as long as you want.
Fact: It should be used for the shortest duration necessary. Prolonged use without medical advice is not recommended.
🔄 Alternative Options
Generic Alternatives
- Cetirizine + Dextromethorphan generic syrup
Brand Alternatives
- Koflab Syrup