Dextcof C Syrup: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or shortness of breath
- Swelling of the face, lips, tongue, or throat
- Severe dizziness or fainting
- Rapid, irregular heartbeat
- Hallucinations, confusion, or severe drowsiness
- Seizures
- Blood in vomit or stool
If experiencing severe symptoms, call emergency services immediately.
What is kofgir-d syrup used for?
This medicine is a combination syrup containing cetirizine (an antihistamine) and dextromethorphan (a cough suppressant). It is used to treat dry cough and allergic symptoms like runny nose and sneezing. It works by blocking histamine and suppressing the cough reflex. It should not be used for cough with mucus or for more than 7 days without medical advice.
- Generic Name: Cetirizine (5mg/5ml) + Dextromethorphan Hydrobromide (10mg/5ml)
- Manufacturer: Krishgir Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 kofgir-d syrup के बारे में (Hindi Summary)
उपयोग: यह दवा सूखी खांसी और एलर्जी के लक्षणों जैसे छींक, नाक बहना और आंखों में खुजली के इलाज के लिए इस्तेमाल की जाती है। इसमें सेटिरिज़िन और डेक्सट्रोमेथोर्फन दो सक्रिय तत्व हैं। सेटिरिज़िन एलर्जी को कम करता है और डेक्सट्रोमेथोर्फन खांसी को दबाता है। यह दवा केवल सूखी खांसी के लिए है, बल्कि कफ वाली खांसी के लिए नहीं। इसका इस्तेमाल डॉक्टर की सलाह के अनुसार ही करें।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में नींद आना, चक्कर आना, मुंह सूखना, जी मिचलाना और थकान शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर सांस लेने में तकलीफ, चेहरे या गले में सूजन, तेज धड़कन या दाने हों तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को बताएं कि आप गर्भवती हैं, गर्भधारण की योजना बना रही हैं या स्तनपान करा रही हैं। इस दवा को लेने के बाद गाड़ी न चलाएं या मशीन न चलाएं क्योंकि इससे नींद आ सकती है। शराब न पिएं क्योंकि इससे नींद और चक्कर बढ़ सकते हैं। बच्चों की पहुंच से दूर रखें। 7 दिनों से अधिक इसका इस्तेमाल न करें और अगर खांसी ठीक न हो तो डॉक्टर से मिलें।
💊 kofgir-d syrup Uses & Benefits
[{"condition":"Dry cough associated with allergic rhinitis or common cold","description":"This medicine suppresses the cough reflex and reduces allergic symptoms such as sneezing and runny nose.","evidence":"Well-established for short-term symptomatic relief."},{"condition":"Allergic rhinitis (hay fever)","description":"Cetirizine component relieves sneezing, rhinorrhea, and itchy, watery eyes.","evidence":"Well-established for cetirizine; dextromethorphan adds cough suppression."},{"condition":"Non-productive cough due to minor throat irritation","description":"Dextromethorphan acts centrally to reduce the cough reflex.","evidence":"Well-established for dextromethorphan as a cough suppressant."}]
Off-label uses: [{"condition":"Cough in patients with allergic asthma","description":"Sometimes used to control cough in allergic asthma, but not as a primary treatment.","evidence":"Limited; asthma requires specific controller therapy."}]
Primary treatment for: Dry cough and allergic rhinitis
Also treats: Common cold, Allergic cough, Postnasal drip
📋 Drug Information
| Generic Name(s) | Cetirizine (5mg/5ml) + Dextromethorphan Hydrobromide (10mg/5ml) |
| Brand Name | kofgir-d syrup |
| Manufacturer | Krishgir Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Do not freeze. Keep the bottle tightly closed. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different mechanisms. Cetirizine is a selective antagonist of peripheral histamine H1 receptors. By blocking these receptors, it prevents histamine from causing symptoms such as sneezing, runny nose, itching, and watery eyes. Dextromethorphan hydrobromide is a centrally acting cough suppressant that acts on the cough center in the medulla oblongata. It is a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors and also interacts with sigma-1 receptors, which contributes to its antitussive effect. Unlike opioid cough suppressants, dextromethorphan does not cause significant respiratory depression or dependence at therapeutic doses.
Mechanism Steps
💡 How to Take kofgir-d syrup
Strength: Each 5 ml contains cetirizine 5 mg and dextromethorphan hydrobromide 10 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 5 ml to 10 ml taken orally every 4 to 6 hours as needed, but the maximum should not exceed 30 ml in 24 hours. However, the exact dose and frequency must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and severity of symptoms. Do not self-medicate; always follow your doctor's prescription. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially drowsiness and dizziness. Dose adjustment may be necessary based on kidney and liver function. Consult a doctor for personalized dosing. |
| Renal Impairment | In patients with renal impairment, cetirizine clearance is reduced. Dose adjustment is recommended. Consult a doctor for specific dosing guidelines. |
| Hepatic Impairment | In patients with hepatic impairment, dextromethorphan metabolism may be affected. Use with caution and consult a doctor for dose adjustment. |
| Maximum Daily Dose | The maximum daily dose for adults is 30 ml of this syrup in 24 hours. Do not exceed this limit. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of kofgir-d syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| SSRIs | Major | |
| CYP2D6 inhibitors | Major | |
| Alcohol | Moderate | |
| Benzodiazepines | Moderate | |
| Opioids | Moderate | |
| Anticholinergics | Moderate | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Selective serotonin reuptake inhibitors (SSRIs)
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
⚡ Moderate Interactions
- Alcohol
- Other CNS depressants (e.g., benzodiazepines, opioids)
- Anticholinergic drugs
🍷 Alcohol Interaction
Avoid drinking alcohol while taking this medicine. Alcohol can increase the drowsiness and dizziness caused by cetirizine and dextromethorphan, and may also increase the risk of central nervous system depression. It is best to avoid alcohol completely until you know how this medicine affects you.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to cetirizine, dextromethorphan, or any component of the formulation.","Use within 14 days of monoamine oxidase inhibitor (MAOI) therapy.","Cough associated with excessive mucus production.","Chronic cough due to smoking, asthma, or emphysema.","Children under 2 years of age."]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol and other CNS depressants.","Do not use for chronic cough or cough with mucus without medical advice.","Use with caution in patients with liver or kidney disease.","Do not exceed the recommended dose; overdose can cause serious side effects.","Consult a doctor if symptoms persist beyond 7 days or worsen.","Keep out of reach of children."]
🤱 Lactation Safety
Cetirizine and dextromethorphan may pass into breast milk. Consult your doctor before using this medicine while breastfeeding. It is generally recommended to avoid or use with caution.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, dizziness, nausea, vomiting, rapid heartbeat, hallucinations, confusion, seizures, and respiratory depression. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and symptomatic. There is no specific antidote. Activated charcoal may be used if the overdose is recent. Monitor vital signs and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Before taking this medicine, tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not drive or operate heavy machinery until you know how this medicine affects you, as it can cause drowsiness. Avoid drinking alcohol while taking this medicine because it can increase drowsiness and dizziness. Do not take this medicine with other cough and cold products that contain dextromethorphan or cetirizine without consulting your doctor, as this can lead to overdose. If you have liver or kidney disease, asthma, or chronic bronchitis, inform your doctor before use. Keep this medicine out of the reach of children. Do not use it for a cough that produces mucus or for a chronic cough caused by smoking. If your cough does not improve within 7 days or if you develop a fever, rash, or persistent headache, stop the medicine and consult your doctor. Never share this medicine with others, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially drowsiness, dizziness, and confusion. They may also have reduced kidney and liver function, which can affect drug clearance. Dose adjustment may be necessary. Consult a doctor for personalized dosing and monitoring.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this combination during pregnancy is not well established. Your doctor will weigh the potential benefits and risks.
🏥 Post-Surgery Considerations
After surgery, the use of this medicine should be discussed with your surgeon or anesthesiologist. It may interact with other medications used during surgery and can increase the risk of sedation and respiratory depression. Do not take it without medical advice.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It can cause dry mouth, which may increase the risk of dental problems. Also, the sedative effect may interact with anesthetics used during dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness and dizziness. Avoid strenuous exercise or activities that require alertness until you know how it affects you. Light activities like walking are generally safe, but listen to your body and rest if you feel tired.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may affect your ability to drive, operate machinery, or perform tasks that require mental alertness. It is best to avoid these activities until you know how the medicine affects you. If your work involves such tasks, inform your employer or take necessary precautions. The sedative effect may also reduce productivity, so plan your tasks accordingly.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your cough persists for more than 7 days, if it is accompanied by fever, rash, or persistent headache, or if you experience any serious side effects. Do not stop abruptly if you have been taking it for a long time without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended without medical supervision. Prolonged use of dextromethorphan can lead to tolerance, dependence, and rare cases of toxicity. Cetirizine is generally safe for long-term use in allergic conditions, but regular monitoring is advised. If you need this medicine for more than 7 days, consult your doctor to evaluate the underlying cause.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps clear nasal passages and reduce postnasal drip that can cause cough.
Evidence: Well-established for allergic rhinitis.Adds moisture to the air, soothing dry throat and reducing cough.
Evidence: Supportive.A spoonful of honey can help suppress cough in adults and children over 1 year.
Evidence: Some evidence for cough relief.💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled to receive a vaccine, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case you need to show it at customs. Store it in a cool, dry place away from direct sunlight. If you are crossing time zones, continue taking your doses at the same intervals as prescribed, but consult your doctor if you are unsure. Do not leave it in a hot car or checked luggage. Always keep it in your carry-on bag.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Cetirizine starts working within 1 hour, and dextromethorphan suppresses cough within 15-30 minutes. You may feel relief from cough and allergy symptoms within an hour.
A: Yes, this medicine can be taken with or without food. Taking it with food may help reduce stomach upset.
A: This medicine is not recommended for children under 2 years. For children above 2 years, consult a pediatrician for appropriate dosing.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
🤔 Common Patient Concerns
🔄 Substitutes for kofgir-d syrup
View AllAlternative brands with exact same active ingredient:
-
quicktuss mint syrupIgniva Marketing Pvt Ltd ₹60.94 7.1% CHEAPER
-
dextcof c syrupCaddes Life Sciences ₹65.00 1% CHEAPER
-
planokuf d syrupShreya Life Sciences Pvt Ltd ₹149.05 127.1% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of cough.
Fact: It is only for dry cough and allergic symptoms. It is not effective for cough with mucus or chronic cough due to smoking. - Myth: It is safe to take this medicine for a long time.
Fact: It should only be used for short-term relief. Prolonged use without medical supervision can be harmful. - Myth: You can take this medicine with alcohol.
Fact: Alcohol increases drowsiness and dizziness and should be avoided.
🔄 Alternative Options
Generic Alternatives
- Cetirizine + Dextromethorphan syrup (various manufacturers)