Cetilistat 60 mg Tablet: Complete Guide to Uses, Dosage, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe or persistent abdominal pain
- Blood in stool or black, tarry stools
- Vomiting blood or material that looks like coffee grounds
- Signs of a severe allergic reaction such as swelling of the face, lips, or throat, or difficulty breathing
- Persistent greasy stools with weight loss despite eating, suggesting malabsorption
- Yellowing of the skin or eyes (jaundice)
- Severe diarrhoea with signs of dehydration such as dizziness, reduced urine, or dry mouth
- Flank pain or blood in urine, which may suggest kidney stones
If experiencing severe symptoms, call emergency services immediately.
What is kilfat tablet used for?
This medicine contains cetilistat 60 mg, a gastrointestinal lipase inhibitor used with a reduced-calorie, low-fat diet and exercise to help adults with obesity or overweight lose weight. It works by blocking the digestion and absorption of some dietary fat, which is then passed out in the stool. It is taken with main meals that contain fat and is not recommended during pregnancy or breastfeeding.
- Generic Name: Cetilistat (60mg)
- Manufacturer: Akumentis Healthcare Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 kilfat tablet के बारे में (Hindi Summary)
उपयोग: यह दवा सेटिलिस्टैट 60 मिलीग्राम से बनी है और इसे मोटापे तथा अधिक वजन के इलाज में इस्तेमाल किया जाता है। यह उन वयस्कों के लिए है जिनका वजन अधिक है और साथ में मधुमेह, उच्च रक्तचाप या कोलेस्ट्रॉल जैसी समस्याएँ भी हैं। यह दवा शरीर में वसा के पाचन और अवशोषण को कम करती है, जिससे कुछ चर्बी पाचन तंत्र से बाहर निकल जाती है। इसे कम कैलोरी और कम वसा वाले आहार तथा नियमित व्यायाम के साथ ही लेना चाहिए। यह दवा अकेले वजन कम करने का जादुई उपाय नहीं है। इसे डॉक्टर की सलाह के बिना शुरू या बंद नहीं करना चाहिए। गर्भवती और स्तनपान कराने वाली महिलाओं को यह दवा नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सबसे आम दुष्प्रभाव पेट और आंतों से जुड़े होते हैं। इनमें तैलीय या चिकनी मल, बार-बार शौच जाने की इच्छा, पेट में गैस, पेट फूलना और पेट में हल्का दर्द शामिल हैं। ये समस्याएँ तब अधिक होती हैं जब आप अधिक वसा वाला भोजन करते हैं। कम वसा वाला आहार लेने पर ये लक्षण कम हो जाते हैं। कुछ लोगों को सिरदर्द या हल्की मतली भी हो सकती है। गंभीर दुष्प्रभाव कम होते हैं, लेकिन तेज पेट दर्द, मल में खून, या बार-बार चिकनी मल आने पर तुरंत डॉक्टर से मिलें। लंबे समय तक दवा लेने पर शरीर में वसा में घुलनशील विटामिन की कमी हो सकती है, इसलिए डॉक्टर समय-समय पर जाँच कर सकते हैं।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, आमतौर पर हर उस मुख्य भोजन के साथ जिसमें वसा हो। अगर आप कोई भोजन छोड़ देते हैं या भोजन में वसा नहीं है, तो उस समय दवा न लें। कम कैलोरी और कम वसा वाला आहार लें, क्योंकि अधिक वसा वाला भोजन तैलीय मल और पेट की तकलीफ बढ़ा सकता है। दवा की मात्रा बढ़ाकर न लें। गर्भावस्था, गर्भधारण की योजना या स्तनपान के दौरान यह दवा न लें, जब तक डॉक्टर सलाह न दें। अपनी सभी दवाओं, विटामिन और हर्बल उत्पादों के बारे में डॉक्टर को बताएं। नियमित जाँच के लिए डॉक्टर के पास जाते रहें। दवा को ठंडी, सूखी जगह पर, धूप से दूर, बच्चों की पहुँच से बाहर रखें। यह दवा किसी और के साथ साझा न करें।
💊 kilfat tablet Uses & Benefits
[{"condition":"Obesity and overweight with weight-related comorbidities","description":"Used as an adjunct to a reduced-calorie, low-fat diet and exercise to promote weight loss in adults with obesity or overweight who have conditions such as type 2 diabetes, hypertension, or dyslipidaemia.","evidence":"Established in clinical studies as an adjunct to lifestyle modification"},{"condition":"Weight management in type 2 diabetes","description":"May help reduce body weight in overweight or obese adults with type 2 diabetes when combined with dietary and lifestyle measures, which can support better glycaemic control.","evidence":"Supported by clinical trial data in overweight or obese adults with type 2 diabetes"},{"condition":"Weight management in dyslipidaemia","description":"May assist with weight reduction in overweight or obese adults with high cholesterol or triglycerides as part of a comprehensive weight-management plan.","evidence":"Supported by clinical trial data in overweight or obese adults with dyslipidaemia"}]
Off-label uses: [{"condition":"Non-alcoholic fatty liver disease (NAFLD)","description":"Weight loss achieved with this medicine may indirectly improve liver fat, but this is not an approved indication and should only be considered under specialist supervision.","evidence":"Limited; not an approved indication"},{"condition":"Polycystic ovary syndrome (PCOS) with obesity","description":"Weight reduction may improve metabolic and reproductive outcomes in some women with PCOS, but this medicine is not approved specifically for PCOS.","evidence":"Limited; not an approved indication"}]
Primary treatment for: Obesity and overweight with weight-related comorbidities
Also treats: Type 2 diabetes mellitus, Hypertension, Dyslipidaemia, Metabolic syndrome
📋 Drug Information
| Generic Name(s) | Cetilistat (60mg) |
| Brand Name | kilfat tablet |
| Manufacturer | Akumentis Healthcare Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | OTHERS |
| Action Class | Lipase inhibitor |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C in a dry place, away from direct sunlight and moisture. Keep the tablets in their original blister pack or container until it is time to take them. |
| Shelf Life | Refer to the expiry date printed on the pack. Do not use the medicine after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works locally in the gastrointestinal tract by inhibiting pancreatic and gastric lipases, the enzymes responsible for breaking down dietary triglycerides into absorbable fatty acids and monoglycerides. When these enzymes are inhibited, a portion of the fat eaten in a meal is not digested and is excreted in the stool, reducing the net absorption of dietary fat and thereby lowering calorie intake. Because cetilistat acts in the gut lumen and is minimally absorbed into the bloodstream, its effects are largely confined to the digestive tract. The resulting reduction in fat absorption creates a modest energy deficit that, together with diet and exercise, supports gradual weight loss. The effect is dose-dependent and reversible when the medicine is stopped.
Mechanism Steps
💡 How to Take kilfat tablet
Strength: Immediate-release tablet containing cetilistat 60 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one 60 mg tablet taken orally with each main meal that contains fat, up to a maximum of three tablets (180 mg) per day. If a meal is skipped or contains no fat, the dose for that meal should be skipped. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to treatment. This medicine should always be used together with a reduced-calorie, low-fat diet and regular physical activity. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | There is no specific dose adjustment for elderly patients based on age alone. However, older adults may be more prone to dehydration from gastrointestinal side effects and may have other medical conditions or medicines that need consideration. Dose must be individualized by a qualified clinician based on renal and hepatic function and overall health status. |
| Renal Impairment | No specific dose adjustment is established for patients with mild to moderate renal impairment. This medicine is minimally absorbed and acts locally in the gut. Caution is advised in patients with a history of kidney stones or severe renal impairment, and dose must be individualized by a qualified clinician. |
| Hepatic Impairment | This medicine is contraindicated in patients with cholestasis and should be used with caution in patients with hepatic impairment. Dose must be individualized by a qualified clinician based on the severity of liver disease and monitoring of liver function. |
| Maximum Daily Dose | The maximum recommended daily dose is 180 mg (three 60 mg tablets) taken with main meals. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of kilfat tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Levothyroxine | Major | |
| Ciclosporin | Major | |
| Antiepileptics (valproate, lamotrigine) | Major | |
| Fat-soluble vitamin supplements | Moderate | |
| Oral contraceptives | Moderate | |
| Amiodarone | Moderate | |
| Beta-carotene | Minor | |
| Vitamin E | Minor | |
| Alcohol | Minor |
🚨 Major Interactions
- Warfarin and other anticoagulants
- Levothyroxine
- Antiepileptic medicines (for example, valproate, lamotrigine)
- Ciclosporin
⚡ Moderate Interactions
- Fat-soluble vitamin supplements (A, D, E, K)
- Oral contraceptives
- Amiodarone
🍷 Alcohol Interaction
There is no established direct interaction between this medicine and alcohol. However, alcohol adds extra calories and may reduce your motivation to follow a healthy diet and exercise plan, which can work against your weight-loss goals. It is advisable to limit or avoid alcohol while taking this medicine, especially if you have liver problems or are taking other medicines that affect the liver.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to cetilistat or any component of this medicine","Chronic malabsorption syndrome","Cholestasis (reduced bile flow)","Pregnancy and breastfeeding","Children and adolescents under 18 years of age","Severe hepatic impairment","Concurrent use with ciclosporin without specialist supervision"]
⚠️ Warnings & Precautions
["This medicine is intended only as an adjunct to a reduced-calorie, low-fat diet and increased physical activity, not as a standalone treatment.","Follow a low-fat diet to reduce the risk of oily stools, faecal urgency, and abdominal discomfort.","Long-term use may reduce the absorption of fat-soluble vitamins; your doctor may monitor vitamin levels and recommend supplements.","Tell your doctor if you take anticoagulants, thyroid medicines, antiepileptics, or ciclosporin, as dose adjustments or monitoring may be needed.","Do not use this medicine if you are pregnant, planning pregnancy, or breastfeeding.","Stop the medicine and seek medical help if you develop signs of a severe allergic reaction.","Use with caution in patients with a history of kidney stones, and stay well hydrated.","Do not share this medicine with others, even if they have similar weight-loss goals."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Because it acts locally in the gut and is minimally absorbed, systemic exposure to the baby is expected to be very low, but there is not enough reliable information to confirm safety. Breastfeeding is not recommended while taking this medicine unless your doctor specifically advises it.
💊 Overdose Management
There is limited information on overdose with this medicine. If you or someone else takes too much, seek immediate medical attention or contact a poison control centre. Treatment is supportive and directed at the symptoms that develop. Because the medicine acts locally in the gut, significant systemic toxicity is not expected, but gastrointestinal symptoms such as severe diarrhoea, abdominal pain, or dehydration may occur and should be managed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it with your next meal that contains fat, unless it is almost time for your next scheduled dose. If you skip a meal or your meal contains no fat, skip that dose. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, usually with each main meal that contains fat. If you skip a meal or your meal contains no fat, skip that dose. Follow a reduced-calorie, low-fat diet while taking this medicine, because a high-fat diet increases the chance of oily stools and urgent bowel movements. Do not take more than the prescribed dose. Do not use this medicine if you are pregnant, planning pregnancy, or breastfeeding unless your doctor specifically advises it. Tell your doctor about all other medicines, vitamins, and herbal supplements you take, especially anticoagulants, thyroid medicines, and anti-seizure medicines. Keep your follow-up appointments so your doctor can monitor your weight, nutritional status, and any side effects. Do not drive or operate heavy machinery if you feel dizzy or unwell. Store this medicine in its original packaging, away from moisture and direct sunlight, and keep it out of reach of children. Do not share this medicine with anyone else, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults may be more susceptible to dehydration and electrolyte imbalance from gastrointestinal side effects such as diarrhoea. They may also have reduced dietary intake and a higher risk of fat-soluble vitamin deficiency. Monitor hydration, nutrition, and kidney function, and review all other medicines for interactions. Dose must be individualized by a qualified clinician based on overall health, renal and hepatic function.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended if you are trying to conceive or are pregnant. Weight loss and reduced absorption of nutrients may affect fertility and early pregnancy. If you are planning pregnancy, stop this medicine and consult your doctor to discuss a safe weight-management plan before conception. Use effective contraception while taking this medicine unless your doctor advises otherwise.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon and anaesthetist that you are taking this medicine. There is no specific guidance on stopping this medicine before surgery, but your doctor may advise a temporary pause if you are on a restricted diet or have gastrointestinal symptoms. Follow your surgical team's instructions about eating, drinking, and taking medicines before and after the procedure.
🦷 Dental Procedures
There is no specific interaction between this medicine and dental procedures. However, if you are taking anticoagulants or have a bleeding disorder, inform your dentist before any dental work. Maintain good oral hygiene and follow your dentist's advice about eating and drinking after procedures. If you have severe diarrhoea or dehydration, you may wish to postpone non-urgent dental treatment until you have recovered.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Regular physical activity is encouraged while taking this medicine, but start gradually if you have been inactive. If you experience dizziness, dehydration from diarrhoea, or severe abdominal discomfort, stop exercising and seek medical advice. Choose low-impact activities such as walking, swimming, or cycling if you have joint problems. Stay well hydrated before, during, and after exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause oily stools, faecal urgency, or increased bowel frequency, especially after high-fat meals. These effects can be inconvenient at work or during travel. Planning lower-fat meals and knowing where toilets are located can help. This medicine is not sedating and does not usually affect your ability to drive or operate machinery, but avoid driving if you feel dizzy or unwell. Discuss any work-related concerns with your doctor.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Your doctor may advise stopping if you develop a serious side effect, if you become pregnant or plan pregnancy, if you develop a condition that makes continued use unsafe, or if the medicine is not providing benefit after an adequate trial. If you stop, continue your diet and exercise plan to help maintain weight loss. Seek immediate medical help and stop the medicine if you develop signs of a severe allergic reaction or severe abdominal symptoms.
📅 Long-Term Use Effects
Long-term use of this medicine may reduce the absorption of fat-soluble vitamins (A, D, E, and K), so your doctor may monitor vitamin levels and recommend supplements if needed. Some patients may experience persistent gastrointestinal symptoms such as oily stools or faecal urgency, especially if their diet remains high in fat. There is limited information on the effects of very long-term use. Regular follow-up is important to assess weight loss, nutritional status, and any new symptoms. Do not continue this medicine indefinitely without medical review.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A structured reduced-calorie, low-fat diet planned with a dietitian can support weight loss and improve tolerability of this medicine.
Evidence: Well-establishedRegular aerobic and resistance exercise complements weight-loss medicines and helps maintain muscle mass.
Evidence: Well-establishedCognitive and behavioural strategies can help with portion control, emotional eating, and long-term adherence.
Evidence: Well-establishedAlternatives such as orlistat or GLP-1 receptor agonists may be considered by your doctor depending on your health profile.
Evidence: Established for specific indicationsMay be considered for selected patients with severe obesity who meet eligibility criteria.
Evidence: Well-established for eligible patients💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. You can receive routine vaccinations while taking this medicine. If you have severe diarrhoea or vomiting, you may wish to postpone non-urgent vaccinations until you have recovered, and you should inform the vaccination provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not store in the refrigerator unless specifically instructed
✅ DO
Keep the tablets in their original blister pack or container
❌ DON'T
Do not transfer them to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children and pets
❌ DON'T
Do not use after the expiry date printed on the pack
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging with the prescription label clearly visible. Keep a copy of your prescription or a letter from your doctor, especially for international travel, as some countries may have restrictions on weight-management medicines. Store the tablets in a cool, dry place away from direct sunlight and moisture. If you are crossing time zones, continue to take the tablet with your main meals that contain fat rather than at a fixed clock time. Carry enough supply for the entire trip and keep it in your hand luggage so it is not lost with checked baggage. Check local customs rules before travelling with prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts reducing fat absorption with the first fatty meal you take it with, but noticeable weight loss usually develops gradually over weeks to months when combined with a reduced-calorie, low-fat diet and regular exercise.
A: No. This medicine is a prescription-only product and must be used under medical supervision. Do not start or stop it without consulting your doctor.
A: Oily stools are a common effect of this medicine and usually mean that some fat is passing through undigested. Reduce the fat content of your meals and maintain good hygiene. If the problem is severe or persistent, consult your doctor.
A: This medicine is not recommended during pregnancy because weight loss and reduced nutrient absorption may harm the developing baby. If you are pregnant or planning pregnancy, stop the medicine and consult your doctor immediately.
A: This medicine can interact with some medicines, including anticoagulants, thyroid medicines, antiepileptics, and ciclosporin. Always tell your doctor about all medicines, vitamins, and supplements you take.
A: Weight regain can happen after stopping any weight-loss medicine if healthy eating and physical activity habits are not maintained. Continue your diet and exercise plan and discuss a long-term strategy with your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for kilfat tablet
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a magic pill for weight loss.
Fact: This medicine only works as an adjunct to a reduced-calorie, low-fat diet and regular exercise. It produces modest weight loss and is not a substitute for lifestyle changes. - Myth: This medicine burns fat while you sleep.
Fact: This medicine does not burn fat. It reduces the absorption of some fat from the food you eat, and only when taken with fatty meals. - Myth: You can eat as much fatty food as you like while taking this medicine.
Fact: A high-fat diet increases the risk of oily stools, faecal urgency, and abdominal discomfort. A low-fat diet is essential for tolerability and effectiveness. - Myth: This medicine is safe to take during pregnancy for weight control.
Fact: This medicine is not recommended during pregnancy because weight loss and reduced nutrient absorption may harm the baby.
🔄 Alternative Options
Generic Alternatives
- Cetilistat 60 mg tablet
Brand Alternatives
- Kilfat Tablet