Zac 10mg Tablet (Clobazam): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe drowsiness or difficulty staying awake
- Slow or shallow breathing
- Confusion or hallucinations
- Suicidal thoughts or behavior
- Seizures that worsen or new types of seizures
- Signs of severe allergic reaction (rash, swelling, difficulty breathing)
- Yellowing of skin or eyes, dark urine, or severe abdominal pain
- Unusual bruising or bleeding
If experiencing severe symptoms, call emergency services immediately.
What is keolax 10mg tablet used for?
This medicine contains clobazam, a benzodiazepine used as an add-on treatment for seizures in Lennox-Gastaut syndrome and other types of epilepsy. It works by enhancing the calming effect of GABA in the brain, reducing abnormal electrical activity. It is available as a 10mg immediate-release tablet and must be taken under medical supervision.
- Generic Name: Clobazam (10mg)
- Manufacturer: Fawn Incorporation
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 keolax 10mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोबाज़म 10mg टैबलेट है, जिसका उपयोग मिर्गी के दौरों के इलाज में किया जाता है, विशेष रूप से लेनोक्स-गैस्टॉट सिंड्रोम में। यह दौरों की आवृत्ति और गंभीरता को कम करने में मदद करती है। यह दवा मस्तिष्क में GABA नामक रसायन के प्रभाव को बढ़ाकर काम करती है, जिससे मस्तिष्क की असामान्य विद्युत गतिविधि कम होती है। यह दवा केवल डॉक्टर की सलाह पर ही लेनी चाहिए और इसे अचानक बंद नहीं करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, थकान, अस्थिरता, लार बहना, कब्ज और चिड़चिड़ापन शामिल हैं। गंभीर दुष्प्रभावों में तेज नींद, सांस लेने में कठिनाई, भ्रम, मतिभ्रम, आत्महत्या के विचार और गंभीर एलर्जी प्रतिक्रिया शामिल हो सकते हैं। यदि आपको कोई भी असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के बताए अनुसार ही लें। इसे अचानक बंद न करें, क्योंकि इससे दौरे पड़ सकते हैं। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन चलाने या मशीनरी चलाने से बचें। शराब का सेवन बिल्कुल न करें। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं जो आप ले रहे हैं। इस दवा को बच्चों की पहुंच से दूर रखें।
💊 keolax 10mg tablet Uses & Benefits
[{"condition":"Lennox-Gastaut syndrome","description":"Used as adjunctive therapy to reduce the frequency and severity of seizures in patients aged 2 years and older.","evidence":"Well-established"},{"condition":"Epilepsy (adjunctive treatment)","description":"May be used as add-on therapy for partial-onset seizures, generalized tonic-clonic seizures, and other seizure types when standard treatments are inadequate.","evidence":"Established"},{"condition":"Anxiety (short-term)","description":"Sometimes prescribed for short-term management of anxiety disorders, although this is not the primary approved use in many countries.","evidence":"Limited"}]
Off-label uses: [{"condition":"Catamenial epilepsy","description":"May be used off-label for seizures that worsen around the menstrual cycle.","evidence":"Limited"},{"condition":"Insomnia","description":"Occasionally used off-label for short-term management of insomnia, but not recommended due to dependence risk.","evidence":"Limited"}]
Primary treatment for: Lennox-Gastaut syndrome
Also treats: Epilepsy, Partial-onset seizures, Generalized tonic-clonic seizures, Anxiety disorders
📋 Drug Information
| Generic Name(s) | Clobazam (10mg) |
| Brand Name | keolax 10mg tablet |
| Manufacturer | Fawn Incorporation |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Benzodiazepines |
| Route of Administration | Oral |
| Storage | Store at room temperature between 20°C and 25°C (68°F to 77°F). Keep away from moisture, heat, and direct sunlight. Keep in the original container tightly closed. Do not refrigerate unless specified by the manufacturer. |
| Shelf Life | 24 months from the date of manufacture, unless otherwise stated on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Clobazam enhances the inhibitory effect of gamma-aminobutyric acid (GABA) in the brain by binding to the benzodiazepine site on the GABA-A receptor. This increases the frequency of chloride channel opening, leading to hyperpolarization of neurons and reduced neuronal excitability. The 1,5-benzodiazepine structure of clobazam gives it a slightly different pharmacological profile compared to 1,4-benzodiazepines, with potentially less sedation and muscle relaxation at therapeutic doses. Its active metabolite, N-desmethylclobazam, also contributes to the anticonvulsant effect and may accumulate with long-term use.
Mechanism Steps
💡 How to Take keolax 10mg tablet
Strength: This medicine is available as an immediate-release tablet containing 10 mg of clobazam.
Dosage Information
| Adult Dosage | The usual starting dose of this medicine for adults with epilepsy is 5 mg to 10 mg once daily, which may be gradually increased based on clinical response and tolerability. The maximum recommended daily dose is 40 mg, but doses up to 80 mg per day have been used in some patients under close supervision. For Lennox-Gastaut syndrome, the dose is typically titrated slowly to minimize side effects. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and concomitant medications. Do not adjust the dose without consulting your doctor. |
| Pediatric Dosage | Pediatric dosing of this medicine is not established from available information for all age groups. For Lennox-Gastaut syndrome, it is approved for children aged 2 years and older, with dosing based on body weight (typically 0.5 mg/kg/day initially, titrated up to a maximum of 40 mg/day). However, pediatric dosing must be determined by a pediatric neurologist. Consult a pediatrician for individualized dosing. |
| Elderly Dosage | Elderly patients (65 years and older) may be more sensitive to the effects of this medicine, especially sedation and cognitive impairment. The starting dose should be lower, and dose increases should be made more gradually. Regular monitoring for falls, confusion, and excessive sedation is recommended. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Clobazam is primarily excreted by the kidneys. In patients with severe renal impairment (creatinine clearance less than 30 mL/min), dose reduction may be necessary. However, specific dosing guidelines are not well established. Use with caution and monitor closely. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | In patients with mild to moderate hepatic impairment, the dose of this medicine should be reduced and titrated slowly. It is contraindicated in severe hepatic impairment. Regular monitoring of liver function is recommended. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose of this medicine is 40 mg for adults, but doses up to 80 mg per day have been used in some patients under close supervision. The maximum daily dose for children is 40 mg. Do not exceed the prescribed dose without medical advice. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of keolax 10mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Opioids | Major | |
| Alcohol | Major | |
| Fluconazole | Major | |
| Rifampin | Major | |
| Valproic acid | Moderate | |
| Cimetidine | Moderate | |
| Oral contraceptives | Moderate | |
| Antacids | Minor | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- Opioids (e.g., morphine, oxycodone)
- CNS depressants (e.g., alcohol, barbiturates, antipsychotics)
- CYP2C19 inhibitors (e.g., fluconazole, fluoxetine, omeprazole)
- CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin)
⚡ Moderate Interactions
- Valproic acid
- Cimetidine
- Oral contraceptives
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Both alcohol and clobazam are central nervous system depressants, and their combined use can lead to severe drowsiness, respiratory depression, coma, and even death. Alcohol can also increase the risk of seizures and worsen the side effects of this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to clobazam or other benzodiazepines","Severe hepatic impairment","Severe respiratory insufficiency","Myasthenia gravis","Sleep apnea syndrome","Acute narrow-angle glaucoma","Concomitant use with opioids in patients without access to a healthcare setting"]
⚠️ Warnings & Precautions
["Concomitant use with opioids may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing for patients for whom alternative treatment options are inadequate.","This medicine can cause physical and psychological dependence. Withdrawal symptoms may occur if stopped abruptly. Taper gradually under medical supervision.","May impair mental and physical abilities required for driving or operating machinery. Avoid these activities until you know how the medicine affects you.","Use with caution in elderly patients due to increased risk of falls, cognitive impairment, and prolonged sedation.","Use with caution in patients with hepatic or renal impairment. Dose adjustment may be necessary.","May cause paradoxical reactions such as agitation, aggression, and hallucinations, especially in children and elderly.","Antiepileptic drugs, including clobazam, increase the risk of suicidal thoughts or behavior. Monitor patients for mood changes.","Do not use during pregnancy unless clearly necessary. May cause fetal harm.","Caution when used in patients with a history of substance abuse."]
🤱 Lactation Safety
Clobazam and its metabolites are excreted in human breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the medicine, taking into account the importance of the medicine to the mother. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose of clobazam can cause severe drowsiness, confusion, coma, respiratory depression, and hypotension. If overdose is suspected, seek emergency medical attention immediately. Treatment is supportive and may include gastric lavage if within 1-2 hours of ingestion, administration of activated charcoal, and monitoring of vital signs. Flumazenil, a benzodiazepine antagonist, may be used with caution in cases of severe respiratory depression, but it can precipitate seizures in patients with epilepsy. Contact a poison control center for guidance.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you miss multiple doses, contact your doctor for advice. Never stop taking this medicine abruptly without medical supervision.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it suddenly, as this can cause withdrawal seizures or other serious symptoms. Avoid driving or operating heavy machinery until you know how this medicine affects you. Do not drink alcohol while taking this medicine because it can increase drowsiness and breathing problems. Inform your doctor about all other medicines you are taking, especially opioids, antidepressants, and other seizure medicines. Keep this medicine out of reach of children. Store it at room temperature away from moisture and heat. If you miss a dose, follow your doctor's instructions; do not double the dose. If you experience any unusual symptoms, contact your doctor immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the sedative and cognitive effects of this medicine. They are at higher risk of falls, confusion, and prolonged sedation. Lower starting doses and slower titration are recommended. Regular monitoring for these effects is essential.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before conception. This medicine may increase the risk of congenital malformations. Your doctor may adjust your treatment or recommend alternative therapies. Use effective contraception while taking this medicine unless otherwise advised.
🏥 Post-Surgery Considerations
After surgery, inform your anesthesiologist and surgeon that you are taking this medicine. It may interact with anesthetic agents and increase sedation. Your dose may need to be adjusted during the perioperative period. Do not stop the medicine abruptly.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may interact with sedatives or anesthetics used during dental work. Your dentist may need to adjust medications or take extra precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness and unsteadiness, which may affect your ability to exercise safely. Avoid activities that require balance or coordination, such as cycling or swimming, until you know how the medicine affects you. Consult your doctor before starting any new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, dizziness, and difficulty concentrating, which may affect your ability to work, drive, or operate machinery. Avoid these activities until you know how the medicine affects you. Inform your employer if your job requires alertness. Adjustments to your work schedule may be needed.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects or your doctor decides to discontinue it, the dose will be tapered gradually to prevent withdrawal seizures. If you wish to stop for any reason, discuss it with your doctor first.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to tolerance, meaning the dose may need to be increased to achieve the same effect. Physical and psychological dependence can develop, and withdrawal symptoms may occur if the medicine is stopped abruptly. Regular monitoring of liver function, blood counts, and seizure control is recommended. Some patients may experience cognitive impairment, especially with high doses. Periodic review of the risk-benefit balance is essential.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A high-fat, low-carbohydrate diet that can help reduce seizures in some patients with epilepsy, especially children.
Evidence: Well-established for certain epilepsy syndromesA device implanted under the skin that sends electrical impulses to the vagus nerve to reduce seizures.
Evidence: Established for refractory epilepsySurgical removal of the brain area causing seizures, considered for some patients with drug-resistant epilepsy.
Evidence: Well-established for selected patients💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you have epilepsy, fever from vaccination can sometimes trigger seizures. Consult your doctor about fever management after vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Check the laws of your destination country regarding controlled substances, as clobazam may be regulated. If crossing time zones, consult your doctor about adjusting the dosing schedule. Store the medicine at room temperature and protect it from extreme heat or moisture.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 1-2 hours, but the full effect on seizure control may take several days to weeks as the dose is adjusted.
A: No, you should never stop this medicine suddenly. Stopping abruptly can cause withdrawal seizures. Always consult your doctor before making any changes.
A: Avoid alcohol, driving, and operating heavy machinery until you know how this medicine affects you. Also avoid other CNS depressants unless prescribed.
A: This medicine is approved for children aged 2 years and older for Lennox-Gastaut syndrome. Dosing must be determined by a pediatric neurologist.
🤔 Common Patient Concerns
🔄 Substitutes for keolax 10mg tablet
View AllAlternative brands with exact same active ingredient:
-
epiford 10mg tabletOxford Pharmaceuticals Pvt Ltd ₹12.68 83.1% CHEAPER
-
davaindia clobazam 10mg tabletDavaindia Generic Pharmacy ₹25.00 66.6% CHEAPER
-
stayhappi clobazam 10mg tabletSarvagunaushdhi Pvt Ltd ₹42.19 43.7% CHEAPER
-
c baz 10mg tabletReliance Formulation Pvt Ltd ₹44.75 40.3% CHEAPER
-
gabazam 10mg tabletPulse Pharmaceuticals ₹45.94 38.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a cure for epilepsy.
Fact: This medicine helps control seizures but does not cure epilepsy. It should be used as part of a comprehensive treatment plan. - Myth: It is safe to stop this medicine once seizures are controlled.
Fact: Stopping this medicine suddenly can cause withdrawal seizures. Always taper gradually under medical supervision. - Myth: This medicine is not addictive.
Fact: This medicine can cause physical and psychological dependence, especially with long-term use. It should be used with caution. - Myth: You can drink alcohol while taking this medicine.
Fact: Alcohol should be avoided as it increases the risk of severe sedation and respiratory depression.
🔄 Alternative Options
Generic Alternatives
- Clobazam 10mg tablet
Brand Alternatives
- Zac 10mg tablet
- Frisium 10mg tablet
- Cloban 10mg tablet