Keflex BD 375 mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, tongue, or throat, or difficulty breathing
- Severe, watery, or bloody diarrhea with fever and abdominal cramps
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain
- Unusual bruising or bleeding, or signs of infection such as fever and sore throat
- Decreased urine output, swelling in the legs, or blood in the urine
- Seizures or sudden loss of consciousness
- Chest pain, palpitations, or severe dizziness
If experiencing severe symptoms, call emergency services immediately.
What is keflex bd 375 mg tablet used for?
This medicine is an oral antibiotic containing Cefalexin 375 mg, used to treat bacterial infections of the respiratory tract, urinary tract, skin, and bones. It works by killing bacteria and should be taken exactly as prescribed for the full course.
- Generic Name: Cefalexin (375mg)
- Manufacturer: Eli Lilly and Company India Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 keflex bd 375 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा सेफालेक्सिन 375 मिलीग्राम की एक एंटीबायोटिक गोली है, जिसका उपयोग बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है। यह श्वसन तंत्र, मूत्र मार्ग, त्वचा और हड्डियों के संक्रमण में प्रभावी है। यह बैक्टीरिया को मारकर काम करती है और डॉक्टर के बताए अनुसार पूरा कोर्स करना बहुत जरूरी है।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में जी मिचलाना, उल्टी, दस्त, पेट में दर्द, और त्वचा पर चकत्ते शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर सांस लेने में कठिनाई, चेहरे या गले में सूजन, या खूनी दस्त हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। पूरा कोर्स पूरा करें, भले ही आप बेहतर महसूस करें। इसे भोजन के साथ लेने से पेट की परेशानी कम हो सकती है। अगर आपको किडनी की बीमारी है या पेनिसिलिन से एलर्जी है, तो डॉक्टर को बताएं। इस दवा के साथ शराब न लें। कोई भी असामान्य लक्षण होने पर तुरंत डॉक्टर से मिलें।
💊 keflex bd 375 mg tablet Uses & Benefits
[{"condition":"Respiratory tract infections","description":"Used to treat bacterial pharyngitis, tonsillitis, and otitis media caused by susceptible streptococci and other organisms.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Effective against uncomplicated cystitis and other urinary tract infections caused by susceptible bacteria such as Escherichia coli and Klebsiella species.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Prescribed for impetigo, cellulitis, and other skin infections caused by susceptible staphylococci and streptococci.","evidence":"Well-established"},{"condition":"Bone and joint infections","description":"Used in the treatment of osteomyelitis and septic arthritis when the causative organism is susceptible to Cefalexin.","evidence":"Established"},{"condition":"Dental infections","description":"Sometimes used for dental abscesses and post-extraction prophylaxis in patients who are allergic to penicillin.","evidence":"Established"}]
Off-label uses: [{"condition":"Acne vulgaris","description":"Occasionally prescribed off-label for inflammatory acne, but this is not a first-line treatment and resistance is a concern.","evidence":"Limited"},{"condition":"Prophylaxis before dental procedures","description":"May be used off-label as an alternative to other antibiotics for preventing infective endocarditis in high-risk patients allergic to penicillin.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Respiratory tract infections, Urinary tract infections, Skin and soft tissue infections, Bone and joint infections, Dental infections
📋 Drug Information
| Generic Name(s) | Cefalexin (375mg) |
| Brand Name | keflex bd 375 mg tablet |
| Manufacturer | Eli Lilly and Company India Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporins: 1st generation |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep the tablets in their original container, tightly closed, and protect them from moisture, heat, and direct sunlight. Do not store in the bathroom. Keep out of reach of children and pets. |
| Shelf Life | Typically 24 to 36 months from the date of manufacture, depending on the manufacturer. Check the expiry date on the packaging before use. Do not use the medicine after the expiry date. |
| WHO Guideline | Cefalexin is included in the World Health Organization Model List of Essential Medicines as a first-generation cephalosporin antibiotic. It is recommended for the treatment of various bacterial infections, including respiratory tract infections, urinary tract infections, and skin infections, when susceptible organisms are involved. Always follow local guidelines and your doctor's advice. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) recognizes Cefalexin as a first-generation cephalosporin for the treatment of susceptible bacterial infections. It is included in the National List of Essential Medicines (NLEM) of India. ICMR guidelines emphasize the importance of rational antibiotic use and completing the full course to prevent resistance. Consult your doctor for specific recommendations. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a first-generation cephalosporin antibiotic that kills bacteria by interfering with the synthesis of the bacterial cell wall. It binds to specific penicillin-binding proteins located inside the bacterial cell wall and blocks the final step of peptidoglycan cross-linking. Without proper cross-linking, the bacterial cell wall becomes weak and cannot withstand the internal osmotic pressure, leading to cell lysis and death. This medicine is bactericidal, meaning it actively kills susceptible bacteria rather than just stopping their growth. It is active against many gram-positive bacteria, including streptococci and staphylococci that do not produce beta-lactamase, and against some gram-negative bacteria such as Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis. It is not effective against methicillin-resistant Staphylococcus aureus, Enterococcus species, Pseudomonas aeruginosa, or anaerobic bacteria.
Mechanism Steps
💡 How to Take keflex bd 375 mg tablet
Strength: Immediate-release tablet containing 375 mg of Cefalexin.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine for most infections is 250 mg to 500 mg taken every 6 to 12 hours, depending on the type and severity of the infection. For example, uncomplicated urinary tract infections may be treated with 250 mg every 6 hours or 500 mg every 12 hours. Skin infections may require 500 mg every 12 hours. The maximum recommended daily dose is 4 grams. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Always follow your doctor's prescription exactly. |
| Pediatric Dosage | Pediatric dosing is not established from available information for this specific 375 mg tablet. Cefalexin is available in other formulations and strengths for children, and dosing is based on body weight and the type of infection. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may have reduced kidney function, which can affect how this medicine is cleared from the body. Your doctor may need to adjust the dose based on your kidney function. Regular monitoring of kidney function is recommended during treatment. Elderly patients should stay well hydrated and report any side effects to their doctor promptly. |
| Renal Impairment | In patients with kidney impairment, the dose of this medicine may need to be reduced or the dosing interval lengthened. For patients with a creatinine clearance of 30 to 59 mL/min, a maximum daily dose of 1 gram may be appropriate. For creatinine clearance of 15 to 29 mL/min, a maximum daily dose of 500 mg may be appropriate. For creatinine clearance less than 15 mL/min, a maximum daily dose of 250 mg may be appropriate. Dose must be individualized by a qualified clinician based on renal function. |
| Hepatic Impairment | No specific dose adjustment is usually required for patients with liver disease alone, as this medicine is not significantly metabolized by the liver. However, if you have both liver and kidney disease, your doctor will individualize your dose based on your overall condition. |
| Maximum Daily Dose | The maximum recommended adult daily dose is 4 grams (4000 mg), divided into several doses. Doses above this are not recommended. In patients with kidney impairment, the maximum daily dose is lower and must be determined by a doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of keflex bd 375 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Gentamicin | Major | |
| Furosemide | Moderate | |
| Oral contraceptives | Moderate | |
| Probenecid | Moderate | |
| Metformin | Moderate | |
| Antacids | Minor | |
| Iron supplements | Minor |
🚨 Major Interactions
- Warfarin
- Aminoglycosides (e.g., gentamicin)
- Loop diuretics (e.g., furosemide)
⚡ Moderate Interactions
- Oral contraceptives
- Probenecid
- Metformin
🍷 Alcohol Interaction
It is best to avoid alcohol while taking this medicine. Alcohol can increase the risk of stomach upset, nausea, and dizziness. It may also make it harder for your body to fight the infection and can worsen dehydration if you have diarrhea. If you do drink alcohol, do so in moderation and never skip doses of your antibiotic.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe allergy to Cefalexin or any other cephalosporin antibiotic","Previous severe allergic reaction to penicillin antibiotics (cross-reactivity possible)","Use in patients with a history of anaphylaxis to beta-lactam antibiotics"]
⚠️ Warnings & Precautions
["Before starting this medicine, tell your doctor if you are allergic to penicillin or other antibiotics.","Use with caution in patients with kidney disease. Dose adjustment may be needed.","Prolonged use may lead to overgrowth of non-susceptible bacteria or fungi, such as Candida.","If severe diarrhea develops, consider Clostridioides difficile infection and seek medical advice.","This medicine may interfere with some urine glucose tests, causing false-positive results.","Do not use this medicine to treat viral infections such as colds or flu.","Complete the full course as prescribed, even if you feel better, to prevent resistance."]
🤱 Lactation Safety
Cefalexin passes into breast milk in small amounts. It is generally considered safe for breastfeeding mothers, but it may cause diarrhea or thrush in the nursing infant. Monitor your baby for any signs of stomach upset or diaper rash. If you notice any unusual symptoms in your baby, contact your pediatrician. Always consult your doctor before taking this medicine while breastfeeding.
💊 Overdose Management
If you take more than the prescribed dose of this medicine, seek medical attention immediately. Symptoms of overdose may include nausea, vomiting, stomach pain, diarrhea, and in severe cases, seizures or blood in the urine. There is no specific antidote for Cefalexin overdose. Treatment is supportive and may include activated charcoal if the overdose is recent, and measures to maintain hydration and electrolyte balance. In patients with kidney disease, hemodialysis can remove Cefalexin from the blood. Always keep the medicine out of reach of children and contact a poison control center or emergency room if an overdose is suspected.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you are unsure what to do, contact your doctor or pharmacist for advice.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop early, even if your symptoms improve, because incomplete treatment can allow the infection to return and can promote antibiotic resistance. Swallow the tablet whole with a full glass of water. You may take it with or without food, but taking it with a meal can reduce stomach upset. If you have kidney problems, your doctor may need to adjust your dose, so tell your doctor about any kidney disease before starting this medicine. Inform your doctor if you are allergic to penicillin or other antibiotics, or if you have ever had a severe allergic reaction. This medicine can reduce the effectiveness of oral contraceptives in some people, so use an additional barrier method while taking it. Avoid alcohol while taking this medicine because it can worsen stomach upset and dizziness. Do not share this medicine with anyone else, even if they have similar symptoms. Keep all follow-up appointments so your doctor can check whether the infection is clearing. If you develop a rash, swelling, or difficulty breathing, seek emergency medical help immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function, which can affect how this medicine is cleared from the body. Your doctor may need to adjust your dose based on your kidney function. Regular monitoring of kidney function is recommended during treatment. Elderly patients should stay well hydrated and report any side effects to their doctor promptly. Falls and dizziness should be monitored, especially if you take other medicines.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before taking this medicine. Cefalexin is generally considered safe during pregnancy, but it is important to use it only when clearly needed and under medical supervision. If you become pregnant while taking this medicine, inform your doctor immediately.
🏥 Post-Surgery Considerations
This medicine may be prescribed after surgery to prevent or treat surgical site infections. Take it exactly as directed by your surgeon. Inform your surgeon if you have any allergies or kidney problems. Complete the full course to prevent infection. If you notice increased redness, swelling, pain, or discharge from the surgical wound, contact your doctor immediately.
🦷 Dental Procedures
This medicine may be used before dental procedures in patients with certain heart conditions who are allergic to penicillin, to prevent infective endocarditis. Inform your dentist if you are taking this medicine or have any allergies. Do not stop taking this medicine before a dental procedure without consulting your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
You can continue light to moderate exercise if you feel well enough. However, if you have a fever, severe fatigue, or are feeling unwell, it is best to rest and avoid strenuous activities. Listen to your body and do not push yourself too hard while recovering from an infection. Consult your doctor before resuming intense workouts.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness in some people. If you experience dizziness, avoid driving or operating heavy machinery until you know how the medicine affects you. Most people can continue their normal daily activities while taking this medicine, but it is important to rest if you feel unwell. Stay hydrated and take the medicine at regular intervals as prescribed.
🛑 When to Stop This Medicine
Do not stop taking this medicine before completing the full course prescribed by your doctor, even if you feel better. Stopping early can allow the infection to return and can promote antibiotic resistance. If you experience severe side effects, such as a severe allergic reaction or bloody diarrhea, stop the medicine and seek immediate medical attention. Always consult your doctor before stopping this medicine for any reason.
📅 Long-Term Use Effects
This medicine is usually prescribed for short courses, typically 7 to 14 days. Long-term use is not recommended unless specifically directed by a doctor for a chronic infection. Prolonged use can lead to overgrowth of non-susceptible bacteria or fungi, such as Candida, and may increase the risk of antibiotic resistance. If you need to take this medicine for an extended period, your doctor will monitor your kidney and liver function, as well as your blood counts. Always follow your doctor's instructions and do not self-medicate for long periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the infection and your allergy profile, your doctor may prescribe a different antibiotic such as amoxicillin or cefuroxime.
Evidence: Well-establishedRest, hydration, and pain relievers can help manage symptoms while the antibiotic works.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, if you are due for a vaccination, inform your healthcare provider that you are taking this antibiotic. In general, antibiotics do not interfere with the effectiveness of most vaccines. Always consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging with the prescription label clearly visible. Bring a copy of your prescription or a letter from your doctor, especially if you are traveling internationally. Store the medicine at room temperature and protect it from extreme heat or moisture. If you are crossing time zones, adjust your dosing schedule gradually to maintain even intervals, but consult your doctor or pharmacist for specific advice. Keep the medicine in your carry-on luggage to avoid loss or temperature extremes in checked baggage. Check local customs regulations regarding antibiotics before you travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 48 hours, but it is important to complete the full course as prescribed.
A: Yes, you can take it with or without food. Taking it with a meal can help reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: Cefalexin is generally considered safe during pregnancy when prescribed by a doctor. Always consult your doctor before taking any medicine during pregnancy.
A: It is best to avoid alcohol as it can worsen stomach upset and dizziness.
🤔 Common Patient Concerns
🔄 Substitutes for keflex bd 375 mg tablet
View AllAlternative brands with exact same active ingredient:
-
mexef 375mg tablet srAbbott ₹77.55 17.3% CHEAPER
-
axin-la 375mg tabletAllenge India ₹120.94 29% COSTLIER
-
sporidex af 375 tablet erSun Pharmaceutical Industries Ltd ₹248.44 165% COSTLIER
-
phexin bd 375mg tabletGlaxo SmithKline Pharmaceuticals Ltd ₹254.30 171.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Antibiotics can cure the common cold and flu.
Fact: This medicine is effective only against bacterial infections. Colds and flu are caused by viruses, so this medicine will not help. - Myth: You can stop taking antibiotics as soon as you feel better.
Fact: You must complete the full course prescribed by your doctor, even if you feel better, to ensure the infection is fully cleared and to prevent resistance. - Myth: Antibiotics can be shared with family members who have similar symptoms.
Fact: Never share antibiotics. They are prescribed for a specific infection and person. Sharing can lead to incorrect treatment and resistance. - Myth: Taking antibiotics with alcohol is always dangerous.
Fact: While it is best to avoid alcohol while taking this medicine, it does not cause a severe reaction like some other antibiotics. However, alcohol can worsen side effects like stomach upset and dizziness.
🔄 Alternative Options
Generic Alternatives
- Cefalexin 375 mg tablet
Brand Alternatives
- Keflex BD 375 mg tablet