Alimta 500mg Injection - Uses, Price, Side Effects
What is alimta 500mg injection used for?
Alimta 500mg Injection contains Pemetrexed, an antineoplastic agent used to treat malignant pleural mesothelioma and non-small cell lung cancer. It works by inhibiting enzymes involved in folate metabolism, thereby disrupting DNA synthesis and cancer cell growth. It is administered intravenously under medical supervision.
- Generic Name: Pemetrexed
- Manufacturer: Eli Lilly and Company India Pvt Ltd
- Form: Allopathy
- Pregnancy Category: D
- Prescription Required: Yes
๐ alimta 500mg injection Uses & Benefits
Malignant pleural mesothelioma (in combination with cisplatin), non-small cell lung cancer (first-line and maintenance).
Off-label uses: Bladder cancer, Breast cancer, Colorectal cancer
๐ Drug Information
| Generic Name(s) | Pemetrexed |
| Brand Name | Alimta |
| Manufacturer | Eli Lilly and Company India Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Antimetabolites |
| Route of Administration | Intravenous infusion. |
| Storage | Store at 25ยฐC (77ยฐF); excursions permitted to 15-30ยฐC. Protect from light. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), disrupting folate-dependent synthesis of purines and pyrimidines.
Mechanism Steps
๐ก How to Take alimta 500mg injection
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of alimta 500mg injection
โ Common Side Effects
- Nausea
- Fatigue
- Anemia
- Neutropenia
- Thrombocytopenia
- Stomatitis
- Anorexia
๐จ Serious Side Effects
- Myelosuppression
- Renal failure
- Interstitial pneumonitis
- Severe skin reactions
โ ๏ธ Rare Side Effects
- Radiation recall
- Colitis
- Pancreatitis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| NSAIDs | Moderate | Increased risk of kidney toxicity |
| Nephrotoxic drugs | Major | Additive nephrotoxicity |
| Live vaccines | Major | Risk of disseminated infection |
๐จ Major Interactions
- NSAIDs
- Nephrotoxic drugs
- Live vaccines
โก Moderate Interactions
- Warfarin
- Aspirin
- Probenecid
โน๏ธ Minor Interactions
- Folic acid
- Vitamin B12
๐ฝ๏ธ Food Interactions
No significant food interactions.
๐ท Alcohol Interaction
Avoid alcohol due to potential hepatotoxicity.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, severe renal impairment (CrCl <45 mL/min), pregnancy, breastfeeding.
๐ Monitoring Parameters
Complete blood count, renal function, liver function, folic acid and vitamin B12 levels.
๐คฑ Lactation Safety
Contraindicated; discontinue breastfeeding.
๐ Overdose Management
Supportive care; leucovorin may be considered.
โฐ Missed Dose
Do not double dose; consult physician.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for alimta 500mg injection
View AllAlternative brands with exact same active ingredient (Pemetrexed (500mg)):
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pemnat 500mg injectionNatco Pharma Ltd โน2,289.00 92.2% CHEAPER
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pemetero 500 injectionHetero Drugs Ltd โน2,505.00 91.5% CHEAPER
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es peme 500 injectionEsperer Bioresearch Pvt Ltd โน2,700.00 90.9% CHEAPER
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pempro 500mg injectionZydus Cadila โน3,023.21 89.8% CHEAPER
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pemzonex 500mg injectionMetta Life Sciences Private Limited โน3,808.00 87.1% CHEAPER
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antifol 500mg injectionZuvius Life Sciences โน3,905.17 86.8% CHEAPER
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zupemed 500mg injectionZuventus Healthcare Ltd โน4,246.00 85.6% CHEAPER
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kabipem 500mg injectionFresenius Kabi India Pvt Ltd โน4,738.00 84% CHEAPER
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Relitrexed 500mg InjectionReliance Life Sciences โน5,120.00 82.7% CHEAPER
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pemmet 500 injectionIntas Pharmaceuticals Ltd โน5,125.00 82.6% CHEAPER
Medical Note: Always consult your doctor before switching medications.