Axime CV Oral Suspension: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction: swelling of face, lips, throat, difficulty breathing.
- Bloody diarrhea or severe abdominal cramps.
- Yellowing of skin or eyes, dark urine, severe abdominal pain.
- Signs of superinfection: oral thrush, vaginal yeast infection.
- Seizures or severe dizziness.
- Decreased urine output or swelling in legs.
If experiencing severe symptoms, call emergency services immediately.
What is kefclav 50mg/31.25mg tablet dt used for?
This medicine is a combination antibiotic containing cefixime and clavulanic acid. It is used to treat bacterial infections of the respiratory tract, urinary tract, skin, and ears. It works by killing bacteria and preventing their growth. Take it exactly as prescribed, and complete the full course.
- Generic Name: Cefixime (50mg) + Clavulanic Acid (31.25mg)
- Manufacturer: Macleods Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 kefclav 50mg/31.25mg tablet dt के बारे में (Hindi Summary)
उपयोग: यह दवा सेफिक्सिम और क्लैवुलैनिक एसिड का संयोजन है, जिसका उपयोग बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है। यह श्वसन तंत्र, मूत्र पथ, त्वचा और कान के संक्रमणों में प्रभावी है। यह बैक्टीरिया को मारकर और उनकी वृद्धि को रोककर काम करती है। इसे डॉक्टर के निर्देशानुसार पूरा कोर्स करें।
साइड इफेक्ट्स: आम दुष्प्रभावों में दस्त, जी मिचलाना, पेट दर्द और सिरदर्द शामिल हैं। ये आमतौर पर हल्के होते हैं और अपने आप ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि आपको चेहरे या गले में सूजन, सांस लेने में कठिनाई, या गंभीर दाने हों तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। उपयोग से पहले बोतल को अच्छी तरह हिलाएं। सही मात्रा मापने के लिए मापने वाला कप या सिरिंज का उपयोग करें। एंटासिड या आयरन सप्लीमेंट के साथ इस दवा को न लें, कम से कम 2 घंटे का अंतराल रखें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर से सलाह लें।
💊 kefclav 50mg/31.25mg tablet dt Uses & Benefits
[{"condition":"Acute bacterial exacerbation of chronic bronchitis","description":"This medicine is used to treat flare-ups of chronic bronchitis caused by susceptible bacteria, helping to reduce cough and sputum production.","evidence":"Well-established"},{"condition":"Uncomplicated urinary tract infections","description":"It is effective against common bacteria like Escherichia coli that cause urinary tract infections, relieving symptoms such as burning during urination and frequent urination.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"This medicine treats bacterial skin infections, including cellulitis and abscesses, by stopping the growth of causative organisms.","evidence":"Well-established"},{"condition":"Otitis media","description":"It is used to treat middle ear infections in children, reducing ear pain and preventing complications.","evidence":"Well-established"},{"condition":"Pharyngitis and tonsillitis","description":"This medicine can be used for bacterial throat infections, including those caused by Streptococcus pyogenes, when other antibiotics are not suitable.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Traveler's diarrhea","description":"Sometimes prescribed off-label for severe traveler's diarrhea caused by susceptible bacteria, but it is not a first-line treatment.","evidence":"Limited"},{"condition":"Prophylaxis in dental procedures","description":"Rarely used off-label to prevent infection in patients with certain heart conditions undergoing dental work, but not routinely recommended.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Respiratory tract infections, Urinary tract infections, Skin infections, Otitis media
📋 Drug Information
| Generic Name(s) | Cefixime (50mg) + Clavulanic Acid (31.25mg) |
| Brand Name | kefclav 50mg/31.25mg tablet dt |
| Manufacturer | Macleods Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Do not freeze. Keep the bottle tightly closed. After reconstitution, store as directed on the label, usually for 7 to 14 days at room temperature or in the refrigerator. Discard any unused portion after the specified period. |
| Shelf Life | The shelf life of the unreconstituted powder is typically 2 years from the date of manufacture. After reconstitution, use within the time specified by the manufacturer, usually 7 to 14 days when stored properly. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients. Cefixime is a third-generation cephalosporin antibiotic that works by binding to penicillin-binding proteins inside bacteria, which inhibits the synthesis of the bacterial cell wall. This leads to bacterial cell death. Clavulanic acid is a beta-lactamase inhibitor that protects cefixime from being destroyed by beta-lactamase enzymes produced by certain bacteria. By blocking these enzymes, clavulanic acid extends the spectrum of cefixime to include bacteria that would otherwise be resistant.
Mechanism Steps
💡 How to Take kefclav 50mg/31.25mg tablet dt
Strength: Oral suspension containing cefixime 50 mg and clavulanic acid 31.25 mg per 5 mL (or as specified by the manufacturer).
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 200 mg to 400 mg per day, divided into one or two doses, depending on the type and severity of the infection. For uncomplicated urinary tract infections, a common dose is 200 mg once daily or 100 mg twice daily. For respiratory tract infections, 200 mg twice daily may be used. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Always follow your doctor's prescription. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. The dose is typically based on weight and the specific infection, and must be determined by a qualified clinician. |
| Elderly Dosage | Elderly patients may have reduced renal function, which can affect drug clearance. Dose adjustment may be necessary based on renal function. Consult a doctor for individualized dosing. |
| Renal Impairment | In patients with renal impairment, dose adjustment is required. For creatinine clearance (CrCl) between 20 and 40 mL/min, a reduced dose or increased dosing interval may be needed. For CrCl less than 20 mL/min, further reduction is necessary. Consult a doctor for specific guidance. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment. Use with caution and monitor liver function. Consult a doctor. |
| Maximum Daily Dose | The maximum recommended daily dose of cefixime is 400 mg. The maximum daily dose of clavulanic acid in this combination is not well established; follow prescribed dosing. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of kefclav 50mg/31.25mg tablet dt
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Carbamazepine | Major | |
| Methotrexate | Major | |
| Probenecid | Moderate | |
| Oral contraceptives | Moderate | |
| Allopurinol | Moderate | |
| Antacids | Minor | |
| Iron supplements | Minor |
🚨 Major Interactions
- Warfarin
- Carbamazepine
- Methotrexate
⚡ Moderate Interactions
- Probenecid
- Oral contraceptives
- Allopurinol
🍷 Alcohol Interaction
Alcohol may increase the risk of stomach upset and dizziness. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to cefixime, clavulanic acid, or other cephalosporin antibiotics","History of severe allergic reaction to penicillin","Use in patients with a history of Clostridium difficile-associated diarrhea","Concurrent use with live typhoid vaccine"]
⚠️ Warnings & Precautions
["Use with caution in patients with renal impairment; dose adjustment may be needed.","Use with caution in patients with a history of gastrointestinal disease, especially colitis.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi.","Do not use for viral infections; it is ineffective and may promote resistance.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Keep out of reach of children; store properly."]
🤱 Lactation Safety
Cefixime is excreted in breast milk in small amounts. Clavulanic acid is also excreted. Consult your doctor before breastfeeding while taking this medicine. Monitor the infant for diarrhea or thrush.
💊 Overdose Management
Overdose may cause nausea, vomiting, stomach pain, and diarrhea. In severe cases, seizures may occur. Treatment is symptomatic and supportive. Contact a poison control center or emergency room immediately if overdose is suspected. Hemodialysis may be considered in severe cases.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Shake the bottle well before each use to ensure the medicine is evenly mixed. Use a proper measuring device to get the correct dose. Do not skip doses or stop early, even if you feel better. Inform your doctor if you have kidney problems, liver problems, or a history of allergies to antibiotics. Avoid taking antacids or iron supplements within two hours of this medicine, as they can reduce its absorption. If you are pregnant or breastfeeding, consult your doctor before using this medicine. Keep this medicine out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced kidney function, which can affect drug clearance. Dose adjustment may be necessary. Monitor for signs of toxicity.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It is generally considered safe in pregnancy (Category B), but use only if clearly needed.
🏥 Post-Surgery Considerations
This medicine may be prescribed to prevent or treat surgical site infections. Follow your surgeon's instructions carefully.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. It may interact with other medications used during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
If you experience dizziness or fatigue, avoid strenuous exercise until you feel better. Listen to your body and rest as needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue in some people. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their daily activities with minimal disruption.
🛑 When to Stop This Medicine
Do not stop taking this medicine early unless your doctor advises. Complete the full course as prescribed. If you experience severe side effects, contact your doctor immediately.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance and superinfections. It is not intended for prolonged use unless directed by a doctor. Regular monitoring of kidney and liver function may be needed if used for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help prevent antibiotic-associated diarrhea.
Evidence: Well-establishedFor symptom relief while the antibiotic takes effect.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the effectiveness of live bacterial vaccines, such as the typhoid vaccine. Avoid receiving live vaccines during treatment and for a few days after.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label. Bring a copy of your prescription in case you need to show it at customs. Keep the suspension in a cool, dry place, and follow storage instructions. If traveling across time zones, adjust dosing times gradually, but consult your doctor for specific advice. Do not expose to extreme temperatures.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 2 to 3 days, but it is important to complete the full course as prescribed.
A: Yes, you can take it with or without food. If it upsets your stomach, take it with a meal or snack.
A: Take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
🤔 Common Patient Concerns
🔄 Substitutes for kefclav 50mg/31.25mg tablet dt
View AllAlternative brands with exact same active ingredient:
-
omnapil cv 50mg/31.25mg dry syrupPsychotropics India Ltd ₹22.48 39.4% CHEAPER
-
cefolac cv 50mg/31.25mg tablet dtMacleods Pharmaceuticals Pvt Ltd ₹35.53 4.2% CHEAPER
-
cefitaxe cv dry syrupLeeford Healthcare Ltd ₹42.00 13.3% COSTLIER
-
Respiclav 50 mg/31.25 mg Dry SyrupOrdain Health Care Global Pvt Ltd ₹53.56 44.4% COSTLIER
-
mahacef-cv kid tabletMankind Pharma Ltd ₹54.02 45.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Antibiotics can cure viral infections like the common cold.
Fact: Antibiotics only work against bacteria. They are ineffective against viruses. - Myth: You can stop taking antibiotics once you feel better.
Fact: You must complete the full course to prevent the infection from returning and to avoid antibiotic resistance. - Myth: Antibiotics weaken the immune system.
Fact: Antibiotics do not weaken the immune system; they target bacteria. However, they can disrupt healthy gut bacteria.
🔄 Alternative Options
Generic Alternatives
- Cefixime + Clavulanic Acid oral suspension
Brand Alternatives
- Axime CV Oral Suspension