Kapocin 750 Injection (Capreomycin 750 mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Decreased urine output or swelling in the legs
- Ringing in the ears or hearing loss
- Severe dizziness or balance problems
- Muscle cramps, weakness, or irregular heartbeat
- Rash, itching, or swelling of the face or throat
- Difficulty breathing
- Yellowing of skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is kapocin 750 injection used for?
Capreomycin 750 mg injection is a second-line antibiotic used to treat multidrug-resistant tuberculosis (MDR-TB). It is given by a healthcare professional as an intramuscular or intravenous injection, usually once daily for 2-4 months, then two to three times weekly. It requires regular monitoring of kidney function and hearing.
- Generic Name: Capreomycin (750mg)
- Manufacturer: Macleods Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 kapocin 750 injection के बारे में (Hindi Summary)
उपयोग: यह दवा कैप्रियोमाइसिन 750 मिलीग्राम इंजेक्शन के रूप में उपलब्ध है और यह मल्टीड्रग-रेसिस्टेंट ट्यूबरकुलोसिस (MDR-TB) के इलाज के लिए इस्तेमाल की जाती है। यह एक दूसरी पंक्ति की एंटीबायोटिक है जो बैक्टीरिया के प्रोटीन संश्लेषण को रोककर उन्हें मारती है। यह दवा केवल डॉक्टर या नर्स द्वारा इंजेक्शन के माध्यम से दी जाती है और इसे अकेले नहीं, बल्कि अन्य टीबी दवाओं के साथ मिलाकर दिया जाता है। इलाज के दौरान किडनी की कार्यप्रणाली और सुनने की क्षमता की नियमित जांच आवश्यक है।
साइड इफेक्ट्स: आम दुष्प्रभावों में इंजेक्शन वाली जगह पर दर्द, जी मिचलाना, उल्टी, भूख न लगना और चक्कर आना शामिल हैं। गंभीर दुष्प्रभावों में किडनी को नुकसान, सुनने में कमी, कान में घंटी बजना, संतुलन की समस्या और इलेक्ट्रोलाइट असंतुलन (जैसे पोटेशियम, मैग्नीशियम, कैल्शियम की कमी) हो सकते हैं। किसी भी असामान्य लक्षण को तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल अस्पताल या क्लिनिक में प्रशिक्षित स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। खुद से इंजेक्शन न लगाएं। इलाज से पहले और दौरान किडनी फंक्शन टेस्ट, इलेक्ट्रोलाइट टेस्ट और हियरिंग टेस्ट कराना जरूरी है। अगर आपको किडनी की कोई समस्या, सुनने में दिक्कत या चक्कर आते हैं तो डॉक्टर को बताएं। शराब न पिएं। बिना डॉक्टर की सलाह के इलाज बंद न करें।
💊 kapocin 750 injection Uses & Benefits
[{"condition":"Multidrug-resistant tuberculosis (MDR-TB)","description":"Used as part of a combination regimen for MDR-TB when resistance to first-line drugs is confirmed.","evidence":"Well-established"},{"condition":"Extensively drug-resistant tuberculosis (XDR-TB)","description":"May be included in combination therapy for XDR-TB under specialist guidance.","evidence":"Limited"}]
Off-label uses: [{"condition":"Mycobacterium avium complex (MAC) infections","description":"Occasionally used off-label in combination regimens for MAC in immunocompromised patients, but evidence is limited.","evidence":"Limited"}]
Primary treatment for: Multidrug-resistant tuberculosis (MDR-TB)
Also treats: Extensively drug-resistant tuberculosis (XDR-TB), Mycobacterium avium complex infections (off-label)
📋 Drug Information
| Generic Name(s) | Capreomycin (750mg) |
| Brand Name | kapocin 750 injection |
| Manufacturer | Macleods Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Aminoglycosides |
| Route of Administration | Parenteral (intramuscular or intravenous) |
| Storage | Store at 20°C to 25°C (68°F to 77°F). Protect from light. Do not freeze. After reconstitution, the solution should be used immediately or stored as directed by the manufacturer. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization (WHO) includes Capreomycin as a second-line injectable agent for the treatment of MDR-TB in its guidelines, but its use should be based on drug susceptibility testing and in combination with other effective agents. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) recommends Capreomycin as part of combination therapy for MDR-TB under the National TB Elimination Program, with close monitoring for adverse effects. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Capreomycin binds to the 30S ribosomal subunit of Mycobacterium tuberculosis, specifically to the 16S rRNA, and inhibits protein synthesis by causing misreading of mRNA and blocking translocation. This leads to bacterial cell death. It is a bactericidal antibiotic effective against several mycobacterial species.
Mechanism Steps
💡 How to Take kapocin 750 injection
Strength: 750 mg lyophilized powder for injection
Dosage Information
| Adult Dosage | The usual adult dose of Capreomycin is 15 mg/kg per day (maximum 1 gram) given intramuscularly or intravenously once daily for 2 to 4 months, followed by 15 mg/kg two to three times per week. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Renal function should be monitored closely and dose adjusted accordingly. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function and are at higher risk of nephrotoxicity and ototoxicity. Dose should be adjusted based on renal function. Close monitoring is required. |
| Renal Impairment | In patients with renal impairment, the dose and/or frequency should be reduced. For creatinine clearance 10-50 mL/min, the dose may be reduced to 15 mg/kg two to three times per week. For creatinine clearance less than 10 mL/min, the dose may be reduced further. Therapeutic drug monitoring may be beneficial. |
| Hepatic Impairment | No specific dosage adjustment is established for hepatic impairment. Use with caution and monitor liver function. |
| Maximum Daily Dose | 1 gram per day |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of kapocin 750 injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Gentamicin | Major | |
| Furosemide | Major | |
| Amphotericin B | Major | |
| Warfarin | Moderate | |
| NSAIDs | Moderate | |
| Cyclosporine | Moderate | |
| Neuromuscular blockers | Major | |
| Ethacrynic acid | Major | |
| Vancomycin | Moderate | |
| Cisplatin | Major |
🚨 Major Interactions
- Aminoglycosides (e.g., gentamicin, amikacin)
- Loop diuretics (e.g., furosemide)
- Amphotericin B
- Neuromuscular blocking agents
⚡ Moderate Interactions
- NSAIDs
- Cyclosporine
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine because it can increase the risk of liver and kidney toxicity and may worsen side effects such as dizziness and nausea.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to Capreomycin or any component of the formulation","Severe renal impairment without dose adjustment","Pre-existing hearing loss or vestibular dysfunction","Concurrent use with other nephrotoxic or ototoxic drugs unless absolutely necessary"]
⚠️ Warnings & Precautions
["Nephrotoxicity: Monitor renal function closely; dose adjust in renal impairment.","Ototoxicity: May cause hearing loss, tinnitus, and balance disorders; monitor with audiometry.","Electrolyte imbalances: May cause hypokalemia, hypomagnesemia, and hypocalcemia; monitor and supplement as needed.","Neuromuscular blockade: May potentiate neuromuscular blocking agents; use with caution.","Pregnancy: Use only if clearly needed; risk to fetus cannot be ruled out.","Lactation: Excreted in breast milk; consider alternative or discontinue nursing.","Elderly: Increased risk of nephrotoxicity and ototoxicity; monitor closely.","Pediatric: Safety and efficacy not established."]
🤱 Lactation Safety
Capreomycin is excreted in breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
💊 Overdose Management
There is no specific antidote for Capreomycin overdose. Management should be symptomatic and supportive. Hemodialysis may be considered to remove the drug from the bloodstream in cases of severe toxicity, especially in patients with renal failure. Monitor renal function, electrolytes, and hearing closely.
⏰ Missed Dose
If you miss a dose, contact your healthcare provider as soon as possible. Do not double the dose to catch up. The dosing schedule is usually managed by a healthcare professional, so follow their instructions.
Additional Safety Advice
This medicine must only be given by a trained healthcare professional in a clinical setting. Do not attempt to self-administer. Regular blood tests to check kidney function, electrolyte levels, and hearing tests are essential before and during treatment. Inform your doctor if you have any kidney problems, hearing loss, or balance issues. Avoid other medicines that can harm the kidneys or ears, such as aminoglycosides or loop diuretics, unless specifically prescribed. Stay well hydrated unless your doctor advises otherwise. Do not stop treatment without consulting your doctor, as incomplete treatment can lead to resistant TB. Use effective contraception during treatment if you are of childbearing age. Avoid alcohol as it may increase the risk of liver and kidney problems. Report any signs of hearing changes, dizziness, or decreased urination immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of nephrotoxicity and ototoxicity due to age-related decline in renal function. Dose adjustment based on creatinine clearance is essential. Close monitoring of kidney function and hearing is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor. Capreomycin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Effective contraception is recommended during treatment.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are receiving Capreomycin, as it may interact with neuromuscular blocking agents used during surgery. Close monitoring is advised.
🦷 Dental Procedures
Inform your dentist that you are on Capreomycin. No specific precautions are required, but maintain good oral hygiene to prevent infections.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but avoid strenuous activities if you feel dizzy or weak. If you experience muscle cramps or irregular heartbeat, consult your doctor before exercising.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness and fatigue, which can affect your ability to drive or operate machinery. Avoid driving until you know how the medicine affects you. You may need to take time off work for regular clinic visits and monitoring.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping early can lead to treatment failure and drug resistance. Your doctor will decide when to stop based on your response to treatment and test results.
📅 Long-Term Use Effects
Long-term use of Capreomycin can lead to cumulative kidney damage and permanent hearing loss. Regular monitoring of renal function and audiometry is essential. Electrolyte imbalances may persist and require ongoing supplementation. Patients should be reviewed periodically to assess the risk-benefit of continuing therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Amikacin, kanamycin, or streptomycin may be used as alternatives based on susceptibility testing.
Evidence: Well-establishedNewer all-oral regimens (e.g., bedaquiline, pretomanid, linezolid) are increasingly used and may replace injectables.
Evidence: Emerging💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. However, live vaccines should be avoided in immunocompromised patients. Consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label intact. Keep a copy of your prescription and a letter from your doctor explaining the medical need for injectable Capreomycin. Since it requires administration by a healthcare professional, arrange for a clinic or hospital at your destination to administer the injection. Store the powder at room temperature (20-25°C) and protect from light. For air travel, carry it in your hand luggage with proper documentation. Check customs regulations for controlled medications in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Improvement in TB symptoms may take several weeks. However, the full course of treatment usually lasts 6 to 12 months or longer, depending on the regimen.
A: No, Capreomycin must be administered by a healthcare professional in a clinic or hospital setting.
A: Report any hearing changes immediately to your doctor. Early detection can prevent permanent damage.
🤔 Common Patient Concerns
🔄 Substitutes for kapocin 750 injection
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Capreomycin can be taken orally.
Fact: Capreomycin is not effective orally and must be given by injection. - Myth: Capreomycin is a first-line treatment for TB.
Fact: Capreomycin is a second-line agent used only for drug-resistant TB. - Myth: Capreomycin has no serious side effects.
Fact: Capreomycin can cause kidney damage and hearing loss, requiring regular monitoring.
🔄 Alternative Options
Generic Alternatives
- Capreomycin 750 mg injection (generic)
Brand Alternatives
- Kapocin 750 injection