Opipramol 100mg Tablet (Jolivel): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, tongue, or throat, or difficulty breathing.
- Severe dizziness, fainting, or a sudden drop in blood pressure.
- Chest pain, palpitations, or irregular heartbeat.
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain.
- Unusual bleeding or bruising, or signs of infection such as fever and sore throat.
- Seizures or sudden confusion.
- Worsening depression or suicidal thoughts.
If experiencing severe symptoms, call emergency services immediately.
What is jolivel 100mg tablet used for?
This medicine is a prescription medication containing Opipramol 100 mg, used to treat generalised anxiety disorder and anxiety associated with depression. It works by modulating sigma receptors in the brain to reduce anxiety and tension. It is taken orally, usually once or twice daily, and must be used under medical supervision.
- Generic Name: Opipramol (100mg)
- Manufacturer: Torrent Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 jolivel 100mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा ओपिप्रामोल 100 मिलीग्राम टैबलेट के रूप में उपलब्ध है और मुख्य रूप से चिंता विकार (एंग्जायटी डिसऑर्डर) और अवसाद (डिप्रेशन) के इलाज में उपयोग की जाती है। यह मस्तिष्क में सिग्मा रिसेप्टर्स को प्रभावित करके चिंता, तनाव और घबराहट को कम करने में मदद करती है। यह दवा उन रोगियों के लिए है जिन्हें डॉक्टर द्वारा चिंता या अवसाद का निदान किया गया है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, मुँह सूखना, चक्कर आना, थकान और खड़े होने पर रक्तचाप कम होना शामिल है। कुछ रोगियों को कब्ज, धुंधली दृष्टि, पेशाब में कठिनाई या पसीना आना भी हो सकता है। ये प्रभाव आमतौर पर हल्के होते हैं और शरीर के सामान्य होने पर कम हो जाते हैं। यदि कोई गंभीर या लगातार लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें और अपनी मर्जी से मात्रा न बदलें। यह दवा नींद और चक्कर ला सकती है, इसलिए जब तक आपको इसका असर समझ न आ जाए, वाहन चलाने या मशीन चलाने से बचें। बैठने या लेटने से उठते समय धीरे-धीरे उठें। इस दवा के साथ शराब न लें। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं जो आप ले रहे हैं। इस दवा को अचानक बंद न करें, क्योंकि इससे withdrawal के लक्षण हो सकते हैं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।
💊 jolivel 100mg tablet Uses & Benefits
[{"condition":"Generalised anxiety disorder","description":"This medicine is used to reduce excessive and persistent worry, tension, and the physical symptoms of anxiety such as restlessness, palpitations, and sweating.","evidence":"Well-established"},{"condition":"Anxiety with somatic complaints","description":"It helps relieve anxiety that presents with bodily symptoms such as headache, muscle tension, and gastrointestinal discomfort.","evidence":"Well-established"},{"condition":"Depressive disorders with anxiety","description":"This medicine is prescribed for depressive states in which anxiety is a prominent feature, helping to improve mood and reduce nervousness.","evidence":"Moderate"},{"condition":"Psychosomatic disorders","description":"It may be used as part of a comprehensive treatment plan for conditions where psychological factors contribute to physical symptoms.","evidence":"Limited"}]
Off-label uses: [{"condition":"Insomnia associated with anxiety","description":"Sometimes prescribed off-label to help with sleep difficulties that occur alongside anxiety, due to its sedating properties.","evidence":"Limited"},{"condition":"Chronic pain with anxiety component","description":"Occasionally used off-label when chronic pain is accompanied by significant anxiety, but this is not a standard approved use.","evidence":"Limited"}]
Primary treatment for: Generalised anxiety disorder
Also treats: Anxiety with somatic complaints, Depressive disorders with anxiety, Psychosomatic disorders
📋 Drug Information
| Generic Name(s) | Opipramol (100mg) |
| Brand Name | jolivel 100mg tablet |
| Manufacturer | Torrent Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Anxiety disorder- Opipramol |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | Not established from the available information. Refer to the packaging for the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works primarily by binding to sigma receptors in the brain, particularly sigma-1 receptors, which are involved in the regulation of emotional responses and stress. Unlike typical tricyclic antidepressants, it has weak effects on serotonin and norepinephrine reuptake and relatively low affinity for muscarinic and histamine receptors. Through sigma receptor modulation, it helps to normalise the activity of brain regions that control anxiety and mood. It also has mild antagonistic effects at certain serotonin and dopamine receptors, which may contribute to its calming effect. The overall result is a reduction in anxiety, tension, and associated physical symptoms without the strong anticholinergic effects seen with some older antidepressants.
Mechanism Steps
💡 How to Take jolivel 100mg tablet
Strength: Immediate-release tablet, 100 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 100 mg to 200 mg per day, taken in divided doses or as a single dose at bedtime, depending on the condition being treated and the doctor's assessment. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to treatment. Do not adjust the dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially drowsiness, dizziness, and low blood pressure. Treatment should be started at a low dose and increased gradually under close medical supervision. |
| Renal Impairment | Dose adjustment may be necessary in patients with impaired kidney function. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Dose adjustment may be necessary in patients with impaired liver function. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose is not established from the available information. The dose should not exceed the limit prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of jolivel 100mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| Benzodiazepines | Major | |
| Opioids | Major | |
| Antihypertensives | Moderate | |
| Anticholinergics | Moderate | |
| CYP2D6 inhibitors | Moderate | |
| QT-prolonging drugs | Major | |
| Antacids | Minor | |
| Caffeine | Minor | |
| Alcohol | Major |
🚨 Major Interactions
- MAO inhibitors
- Other central nervous system depressants (e.g., benzodiazepines, opioids, alcohol)
- QT-prolonging drugs (e.g., certain antiarrhythmics, antipsychotics, some antibiotics)
⚡ Moderate Interactions
- Antihypertensive drugs
- Anticholinergic drugs (e.g., atropine, some antihistamines)
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can increase drowsiness, dizziness, and impair your ability to think and react. Combining them can also increase the risk of low blood pressure and falls.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Allergy to Opipramol or any other ingredient in this medicine.","Untreated narrow-angle glaucoma.","Acute urinary retention.","Recent myocardial infarction (heart attack).","Concurrent use with MAO inhibitors.","Severe liver disease.","Pregnancy and breastfeeding, unless specifically advised by a doctor."]
⚠️ Warnings & Precautions
["This medicine may cause drowsiness and dizziness. Avoid driving or operating machinery until you know how it affects you.","Do not stop this medicine suddenly, as withdrawal symptoms may occur. Taper gradually under medical supervision.","Use with caution in elderly patients, who may be more sensitive to side effects such as confusion, falls, and low blood pressure.","Inform your doctor if you have a history of heart disease, liver disease, kidney disease, epilepsy, or thyroid problems.","This medicine may increase the risk of suicidal thoughts, especially in young adults. Close monitoring is required during the initial phase of treatment.","Avoid alcohol while taking this medicine.","Tell your doctor about all other medicines you are taking, including over-the-counter products and herbal supplements."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Breastfeeding is not recommended while taking this medicine unless the doctor advises otherwise after weighing the benefits and risks.
💊 Overdose Management
Overdose of this medicine may cause severe drowsiness, confusion, agitation, hallucinations, low blood pressure, rapid or irregular heartbeat, and seizures. If you suspect an overdose, seek emergency medical care immediately. Treatment is supportive and symptomatic, including monitoring of vital signs, cardiac rhythm, and respiratory function. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor and do not change the dose on your own. Because this medicine can cause drowsiness and dizziness, avoid driving or operating heavy machinery until you know how it affects you. Stand up slowly from a sitting or lying position to reduce the risk of dizziness or fainting due to low blood pressure. Avoid drinking alcohol while taking this medicine, as it can increase sedation and impair your ability to think clearly. Tell your doctor about all other medicines you are taking, especially blood pressure medicines, antidepressants, antipsychotics, and drugs that affect heart rhythm. Do not stop this medicine suddenly, as withdrawal symptoms such as nausea, headache, and restlessness may occur. If you are pregnant, planning to become pregnant, or breastfeeding, inform your doctor before taking this medicine. Keep this medicine out of the reach of children and store it in its original packaging.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the side effects of this medicine, especially drowsiness, dizziness, confusion, and low blood pressure. Falls are a particular risk. Treatment should be started at a low dose and increased slowly under close supervision.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before taking this medicine. The safety of this medicine during pregnancy is not well established, and alternative treatments may be considered.
🏥 Post-Surgery Considerations
Inform your surgeon and anaesthesiologist that you are taking this medicine before any surgery. It may interact with anaesthetic agents and affect blood pressure and heart rate. Your doctor may advise you to stop it temporarily before surgery.
🦷 Dental Procedures
Tell your dentist that you are taking this medicine before any dental procedure. It may cause dry mouth, which can increase the risk of dental problems. Also, it may interact with certain local anaesthetics or sedatives used during dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness and dizziness, so avoid activities that require full alertness, such as heavy lifting or high-intensity workouts, until you know how it affects you. Light to moderate exercise like walking or yoga is generally safe and can help reduce anxiety.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness and dizziness, which can affect your ability to drive, operate machinery, or perform tasks requiring concentration. It is best to avoid these activities until you know how the medicine affects you. Discuss with your doctor if your work involves such tasks.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects or your doctor decides to discontinue it, the dose will be reduced gradually over time to prevent withdrawal reactions. Seek immediate medical advice if you develop serious symptoms such as allergic reactions or heart rhythm changes.
📅 Long-Term Use Effects
Long-term use of this medicine may require periodic monitoring of liver function, blood counts, and blood pressure. Some patients may develop tolerance to the sedative effects, but the anxiolytic benefits usually persist. Regular follow-up with your doctor is important to assess continued need and to taper the dose gradually when stopping.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A talking therapy that can be effective for anxiety disorders and may complement or reduce the need for medication.
Evidence: Well-establishedPractices such as meditation and deep breathing can help manage anxiety symptoms.
Evidence: ModeratePhysical activity has been shown to reduce anxiety and improve mood.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are feeling unwell, consult your doctor before receiving any vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your hand luggage to avoid loss or exposure to extreme temperatures. If crossing time zones, consult your doctor about how to adjust your dosing schedule. Store it at room temperature and away from direct sunlight. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The calming effects may begin within a few hours, but the full benefits for anxiety usually take one to two weeks of regular use.
A: No, you should not stop this medicine suddenly. Your doctor will gradually reduce the dose to prevent withdrawal symptoms.
A: It can be used long-term under medical supervision. Regular follow-up is needed to monitor for side effects and adjust the dose.
A: Weight changes are not a commonly reported side effect, but individual responses vary. Consult your doctor if you notice significant weight changes.
🤔 Common Patient Concerns
🔄 Substitutes for jolivel 100mg tablet
View AllAlternative brands with exact same active ingredient:
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stayhappi opipramol 100mg tabletSarvagunaushdhi Pvt Ltd ₹66.56 28.3% CHEAPER
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opiprex 100mg tabletStrides shasun Ltd ₹98.44 6.1% COSTLIER
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opipran 100mg tabletRyon Pharma ₹103.13 11.1% COSTLIER
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opirest 100mg tabletIcon Life Sciences ₹126.56 36.4% COSTLIER
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opimol 100mg tabletIshjas Pharma Pvt Ltd ₹126.56 36.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a sleeping pill.
Fact: This medicine is an anxiolytic and antidepressant, not a primary sleep aid. It may cause drowsiness as a side effect, but it is not used solely for sleep. - Myth: This medicine works immediately.
Fact: The full therapeutic effects usually take one to two weeks to appear. It is not a rapid-acting medicine. - Myth: This medicine is addictive.
Fact: This medicine has a low potential for dependence compared to benzodiazepines, but it should still be stopped gradually under medical supervision. - Myth: I can stop this medicine once I feel better.
Fact: Stopping suddenly can cause withdrawal symptoms. Always consult your doctor before stopping.
🔄 Alternative Options
Generic Alternatives
- Opipramol 100 mg tablet
Brand Alternatives
- Jolivel 100mg Tablet