ivabrad c 6.25mg/5mg tablet - Carvedilol (6.25mg) + Ivabradine (5mg) medicine

Ivanode C 6.25mg/5mg Tablet: Comprehensive Medicine Guide

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🏭 Lupin Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 26, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate to well-established for individual components; combination evidence is limited.
Reviewed by
SaathiMed Expert Panel | Sep 26, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Severe dizziness or fainting
  • Chest pain or difficulty breathing
  • Irregular heartbeat
  • Swelling in legs or ankles
  • Sudden weight gain
  • Yellowing of skin or eyes

If experiencing severe symptoms, call emergency services immediately.

What is ivabrad c 6.25mg/5mg tablet used for?

This medicine is a combination of Carvedilol and Ivabradine used to treat chronic heart failure and stable angina by reducing heart rate and improving cardiac function.

  • Generic Name: Carvedilol (6.25mg) + Ivabradine (5mg)
  • Manufacturer: Lupin Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 ivabrad c 6.25mg/5mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा कैर्वेडिलोल और आइवाब्राडीन का संयोजन है, जिसका उपयोग हृदय विफलता और एंजाइना के इलाज में किया जाता है। यह हृदय की गति को कम करके हृदय की कार्यक्षमता में सुधार करती है।

साइड इफेक्ट्स: सामान्य दुष्प्रभावों में चक्कर आना, थकान, सिरदर्द और निम्न रक्तचाप शामिल हैं। गंभीर दुष्प्रभावों में गंभीर ब्रैडीकार्डिया, हृदय ब्लॉक और हृदय विफलता का बिगड़ना शामिल है। किसी भी असामान्य लक्षण को तुरंत डॉक्टर को बताएं।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे अचानक बंद न करें। शराब से बचें। गाड़ी चलाने से पहले सावधानी बरतें। नियमित रूप से हृदय गति और रक्तचाप की जांच कराएं।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 ivabrad c 6.25mg/5mg tablet Uses & Benefits

[{"condition":"Chronic heart failure with reduced ejection fraction","description":"Used to reduce heart rate and improve cardiac output in patients with systolic heart failure who remain symptomatic despite standard therapy.","evidence":"Well-established"},{"condition":"Stable angina pectoris","description":"Helps reduce angina attacks by lowering heart rate and myocardial oxygen demand.","evidence":"Moderate"},{"condition":"Inappropriate sinus tachycardia","description":"Ivabradine component may be used to control heart rate when beta-blockers are insufficient or not tolerated.","evidence":"Limited"}]

Off-label uses: [{"condition":"Postural orthostatic tachycardia syndrome (POTS)","description":"Ivabradine has been used off-label to reduce heart rate in POTS, but evidence is limited.","evidence":"Limited"}]

Primary treatment for: Chronic heart failure with reduced ejection fraction

Also treats: Stable angina pectoris, Inappropriate sinus tachycardia

📋 Drug Information

Generic Name(s)Carvedilol (6.25mg) + Ivabradine (5mg)
Brand Nameivabrad c 6.25mg/5mg tablet
ManufacturerLupin Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always take this medicine with food to reduce stomach upset.
2
Do not stop this medicine abruptly without consulting your doctor.
3
Monitor your heart rate and blood pressure regularly.
4
Avoid alcohol while taking this medicine.
5
Inform your doctor if you experience dizziness or fainting.
6
Keep all follow-up appointments for monitoring.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chronic heart failure
This medicine is commonly prescribed for this.
Likely Use
✅
Stable angina
This medicine helps reduce angina attacks.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionCarvedilol is rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations occurring 1-2 hours after oral administration. Ivabradine is also rapidly absorbed, with peak plasma levels reached in about 1 hour. Food delays absorption but does not significantly affect bioavailability.
DistributionCarvedilol is highly lipophilic and distributes widely into tissues. It is approximately 98% bound to plasma proteins. Ivabradine is moderately bound to plasma proteins (about 70%) and has a volume of distribution of approximately 100 L.
Protein BindingCarvedilol: approximately 98%. Ivabradine: approximately 70%.
MetabolismCarvedilol is extensively metabolized in the liver, primarily by CYP2D6 and CYP2C9, with some involvement of CYP3A4. Ivabradine is metabolized in the liver and intestines by CYP3A4 and is subject to first-pass metabolism.
Half-LifeCarvedilol: 7-10 hours. Ivabradine: approximately 2 hours (effective half-life 11 hours).
ExcretionCarvedilol is excreted mainly in bile and feces, with less than 2% excreted unchanged in urine. Ivabradine metabolites are excreted in urine and feces.
BioavailabilityCarvedilol: approximately 25-35% due to first-pass metabolism. Ivabradine: approximately 40% due to first-pass metabolism.
Onset of ActionCarvedilol: within 1-2 hours. Ivabradine: within 1-2 hours.
Peak Plasma TimeCarvedilol: 1-2 hours. Ivabradine: approximately 1 hour.
Duration of ActionCarvedilol: 12-24 hours. Ivabradine: approximately 12 hours.

How It Works

This medicine combines two active ingredients with complementary mechanisms. Carvedilol blocks beta-1, beta-2, and alpha-1 adrenergic receptors, reducing heart rate, contractility, and vascular resistance. Ivabradine selectively inhibits the If (funny) current in the sinoatrial node, slowing the rate of diastolic depolarization and thereby reducing heart rate without affecting myocardial contractility or blood pressure.

Mechanism Steps

1
Carvedilol blocks beta-adrenergic receptors: Carvedilol binds to beta-1 and beta-2 receptors in the heart and lungs, reducing sympathetic stimulation, which lowers heart rate and contractility.
2
Carvedilol blocks alpha-1 receptors: This leads to peripheral vasodilation, reducing blood pressure and afterload.
3
Ivabradine inhibits If current: Ivabradine enters the sinoatrial node cells and blocks HCN channels, slowing the spontaneous depolarization phase of the action potential.
4
Combined effect on heart rate: Both agents reduce heart rate through different mechanisms, leading to improved diastolic filling and reduced myocardial oxygen demand.

💡 How to Take ivabrad c 6.25mg/5mg tablet

Strength: Tablet containing Carvedilol 6.25 mg and Ivabradine 5 mg.

1Take this medicine with food to reduce stomach upset.
2Swallow the tablet whole with a glass of water.
3Do not crush or chew the tablet.
4Take it at the same time each day.
5If you miss a dose, follow the missed dose instructions.

Dosage Information

Adult DosageThe dose of this medicine must be individualized by a qualified clinician based on the patient's condition, heart rate, blood pressure, and renal/hepatic function. Typically, one tablet is taken twice daily with food. The dose may be adjusted gradually. Do not self-adjust the dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of this medicine. Dose adjustment may be required based on renal and hepatic function. Close monitoring is advised.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be necessary. Monitor renal function regularly.
Hepatic ImpairmentContraindicated in severe hepatic impairment. Use with caution in mild to moderate hepatic impairment. Dose adjustment may be required.
Maximum Daily DoseThe maximum daily dose should not exceed the prescribed amount. Typically, carvedilol up to 25 mg twice daily and ivabradine up to 7.5 mg twice daily, but individual limits apply.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and improves absorption.
Grapefruit
Avoid
May increase drug levels and risk of side effects.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of ivabrad c 6.25mg/5mg tablet

✅ Common Side Effects

Dizziness (Common (5-10%))
Rise slowly from sitting or lying position. If persistent, consult your doctor.
Fatigue (Common (5-10%))
Ensure adequate rest. If severe, consult your doctor.
Headache (Common (5-10%))
Usually resolves. Use paracetamol if needed, but consult doctor if persistent.
Low blood pressure (Common (5-10%))
Monitor blood pressure. Report symptoms like fainting to your doctor.
Blurred vision or phosphenes (Common (5-10%))
Usually transient. Avoid driving if affected. Consult doctor if persistent.

🚨 Serious Side Effects

Severe bradycardia (Uncommon (0.1-1%))
Seek immediate medical attention if you experience fainting, severe dizziness, or confusion.
Heart block (Rare (<0.1%))
Requires urgent medical evaluation. Report symptoms like palpitations or fainting.
Worsening heart failure (Uncommon (0.1-1%))
Contact your doctor if you experience increased breathlessness, swelling, or fatigue.
Bronchospasm (Rare (<0.1%))
Seek immediate medical help if you have difficulty breathing, especially if you have asthma.

⚠️ Rare Side Effects

Atrial fibrillation
Report palpitations or irregular heartbeat to your doctor.
Severe allergic reactions
Seek emergency care if you develop rash, swelling, or difficulty breathing.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Verapamil Major
Clonidine Major
Ketoconazole Major
Digoxin Moderate
Insulin Moderate
NSAIDs Moderate
Antacids Minor
Grapefruit juice Minor

🚨 Major Interactions

  • Verapamil, Diltiazem
  • Clonidine
  • CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)

⚡ Moderate Interactions

  • Digoxin
  • Insulin, oral hypoglycemics
  • NSAIDs

🍷 Alcohol Interaction

Alcohol may enhance the blood pressure-lowering effects of this medicine, leading to dizziness and fainting. It is advisable to avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Severe bradycardia (heart rate < 50 bpm)","Sick sinus syndrome","Sinoatrial block","Severe hypotension","Decompensated heart failure requiring IV inotropic support","Severe hepatic impairment","Hypersensitivity to carvedilol or ivabradine"]

⚠️ Warnings & Precautions

["Do not stop this medicine abruptly as it can worsen heart failure or cause chest pain.","Use with caution in patients with asthma or COPD due to risk of bronchospasm.","May mask symptoms of hypoglycemia in diabetic patients.","Avoid driving or operating machinery until you know how this medicine affects you.","Inform your doctor if you have liver or kidney disease.","Regular monitoring of heart rate and blood pressure is required."]

🤱 Lactation Safety

Not established from the available information. Consult your doctor before breastfeeding.

💊 Overdose Management

Overdose may cause severe bradycardia, hypotension, and heart failure. Seek immediate medical attention. Treatment is supportive and symptomatic, including atropine for bradycardia and intravenous fluids for hypotension.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Additional Safety Advice

General Safety

Always take this medicine exactly as prescribed by your doctor. Do not stop or change the dose without medical advice, as abrupt withdrawal of Carvedilol can worsen heart failure or cause chest pain. Avoid driving or operating heavy machinery until you know how this medicine affects you. Inform your doctor if you have asthma, liver disease, or kidney problems. Avoid alcohol as it may enhance the blood pressure-lowering effect. Regular monitoring of heart rate, blood pressure, and kidney function is essential. Do not take this medicine if you are pregnant or planning pregnancy without consulting your doctor.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the effects of this medicine. Dose adjustment and close monitoring are advised.

🤰 Pregnancy Planning (TTC)

Consult your doctor before planning pregnancy. This medicine may not be safe during pregnancy.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist about this medicine before any surgery. It may interact with anesthetic agents.

🦷 Dental Procedures

Inform your dentist about this medicine before any dental procedure. It may affect blood pressure and heart rate.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight.
🥗
Regular low-impact exercise like walking or swimming.
😴
Practice good posture.
💧
Include heart-healthy foods in your diet.
🧘
Get adequate sleep.
🌞
Manage stress through relaxation techniques.

🏋️ Exercise Considerations

Avoid strenuous exercise until you know how this medicine affects you. It may cause dizziness or fatigue. Consult your doctor before starting any exercise program.

🥗 Diet Recommendations

Include omega-3 rich foods
Reduce processed food intake
Stay well hydrated
Limit salt intake

💼 Impact on Daily Work & Life

This medicine may cause dizziness or fatigue, affecting your ability to drive or operate machinery. Avoid these activities until you know how it affects you.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. If you experience severe side effects, contact your doctor immediately.

📅 Long-Term Use Effects

Long-term use requires regular monitoring of heart rate, blood pressure, and renal/hepatic function. It may reduce heart failure hospitalizations and improve survival. Do not stop without medical advice.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Lifestyle modifications

Diet, exercise, and stress management can complement medicine.

Evidence: Well-established
Cardiac rehabilitation

Structured exercise and education programs for heart patients.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are established. Consult your doctor before any vaccination.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and avoid extreme heat. Adjust dosing times if crossing time zones, but consult your doctor first. Keep enough supply for your trip.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 60-year-old man with chronic heart failure
Started this medicine as prescribed. After a few weeks, his heart rate stabilized and he could walk longer distances without breathlessness. He emphasized taking it with meals to avoid stomach upset.
💡 Lesson: Consistency and regular monitoring are key to managing heart failure.
👤 A 55-year-old woman with stable angina
She experienced fewer angina attacks after starting this medicine. She learned to avoid alcohol and to monitor her heart rate daily.
💡 Lesson: Lifestyle modifications enhance the effectiveness of this medicine.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine starts working within 1-2 hours, but full benefits may take several weeks.

Q: Can I stop taking this medicine if I feel better?

A: No, do not stop without consulting your doctor. Abrupt withdrawal can worsen your condition.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for ivabrad c 6.25mg/5mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken without a prescription.
    Fact: This medicine is a prescription drug and must only be taken under medical supervision.
  • Myth: It is safe to stop this medicine abruptly.
    Fact: Abrupt withdrawal can worsen heart failure or cause chest pain. Always consult your doctor before stopping.

🔄 Alternative Options

Generic Alternatives

  • Carvedilol + Ivabradine generic tablets

Brand Alternatives

  • Ivanode C 6.25mg/5mg tablet

📊 Comparison with Similar Medicines

[{"medicine":"Carvedilol alone","difference":"Lacks Ivabradine, may not control heart rate as effectively."},{"medicine":"Ivabradine alone","difference":"Lacks Carvedilol, may not provide beta-blockade benefits."}]

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