ivables od 10mg tablet - Ivabradine (10mg) medicine

Inapure ER 10 Tablet (Ivabradine 10mg): Complete Medicine Guide

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🏭 Lloyd Healthcare Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for stable angina and chronic heart failure with reduced ejection fraction.
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Fainting or severe dizziness
  • Heart rate below 50 beats per minute
  • Chest pain that is new or worsening
  • Shortness of breath or sudden weight gain
  • Swelling of face, lips, or throat
  • Irregular heartbeat or palpitations
  • Yellowing of skin or eyes (jaundice)

If experiencing severe symptoms, call emergency services immediately.

What is ivables od 10mg tablet used for?

This medicine is a prescription heart medicine that slows the heart rate to treat stable angina and certain types of heart failure. It works by blocking the funny current in the heart's pacemaker. It is taken twice daily and should not be stopped without medical advice.

  • Generic Name: Ivabradine (10mg)
  • Manufacturer: Lloyd Healthcare Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 ivables od 10mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा इवाब्राडीन 10 मिलीग्राम की एक प्रिस्क्रिप्शन टैबलेट है, जिसका उपयोग स्थिर एनजाइना (दिल की धमनियों में रक्त के प्रवाह में कमी के कारण सीने में दर्द) और कुछ प्रकार के दिल की विफलता के इलाज के लिए किया जाता है। यह दिल की धड़कन को धीमा करके दिल पर दबाव कम करती है और ऑक्सीजन की मांग को कम करती है। यह बीटा-ब्लॉकर दवाओं को सहन न कर पाने वाले मरीजों के लिए एक विकल्प है। इसे डॉक्टर के निर्देशानुसार ही लें और बिना सलाह के बंद न करें।

साइड इफेक्ट्स: आम दुष्प्रभावों में दृष्टि में अस्थायी चमक (फॉस्फीन), धुंधली दृष्टि, सिरदर्द, चक्कर आना और दिल की धड़कन धीमी होना शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अत्यधिक धीमी हृदय गति, हृदय रुकावट, या एलर्जी प्रतिक्रिया हो सकती है। यदि आपको बेहोशी, गंभीर सीने में दर्द, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। टैबलेट को चबाएं या तोड़ें नहीं, पूरा निगल लें। इस दवा के साथ अंगूर का जूस या अंगूर न खाएं, क्योंकि इससे दवा का स्तर बढ़ सकता है और दुष्प्रभावों का खतरा हो सकता है। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं। दिल की धड़कन और रक्तचाप की नियमित निगरानी करें। गर्भवती महिलाओं को इस दवा से बचना चाहिए।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 ivables od 10mg tablet Uses & Benefits

[{"condition":"Stable angina pectoris","description":"Used to reduce the frequency of angina attacks in patients with chronic stable angina who have a contraindication or intolerance to beta-blockers, or in combination with beta-blockers when optimal control is not achieved.","evidence":"Well-established"},{"condition":"Chronic heart failure with reduced ejection fraction","description":"Used in combination with standard therapy to reduce the risk of hospitalization for worsening heart failure in patients with systolic dysfunction and heart rate ≥70 beats per minute.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Inappropriate sinus tachycardia","description":"Sometimes prescribed off-label to control elevated heart rate in patients with inappropriate sinus tachycardia when other treatments fail.","evidence":"Limited"}]

Primary treatment for: Stable angina pectoris and chronic heart failure with reduced ejection fraction.

Also treats: Inappropriate sinus tachycardia (off-label), Coronary artery disease

📋 Drug Information

Generic Name(s)Ivabradine (10mg)
Brand Nameivables od 10mg tablet
ManufacturerLloyd Healthcare Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action ClassI F sodium channel (sinoatrial node) current blockers
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Keep in the original container, tightly closed, away from moisture and direct sunlight. Do not refrigerate or freeze.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always measure resting heart rate before initiating and during treatment; adjust dose to maintain heart rate between 50-60 bpm.
2
Avoid concomitant use with strong CYP3A4 inhibitors like ketoconazole or clarithromycin.
3
Instruct patients to avoid grapefruit juice while on this medicine.
4
Monitor for visual disturbances; advise caution while driving until effects are known.
5
In moderate hepatic impairment, start with a lower dose (2.5 mg twice daily) and titrate slowly.
6
Do not use for acute angina attacks; it is for chronic stable angina.
7
Consider alternative therapy in patients with severe renal impairment.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chronic stable angina
This medicine is commonly prescribed for this condition.
Likely Use
✅
Heart failure with reduced ejection fraction
This medicine may be added to standard therapy.
Likely Use
❌
Acute angina attack
This medicine is not for immediate relief of acute angina.
Not Primary
❌
High blood pressure
This medicine does not significantly lower blood pressure.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionIvabradine is rapidly and almost completely absorbed after oral administration, with peak plasma concentrations reached in about 1 hour under fasting conditions. Food delays absorption by approximately 1 hour and increases plasma exposure by 20-40%. Bioavailability is estimated to be around 40% due to first-pass metabolism in the gut and liver.
DistributionIvabradine is approximately 70% bound to plasma proteins. It has a large volume of distribution (around 100 L), indicating extensive distribution into tissues. It does not accumulate significantly with repeated dosing.
Protein BindingApproximately 70% bound to plasma proteins.
MetabolismIvabradine is extensively metabolized in the liver and intestines, primarily by the cytochrome P450 enzyme CYP3A4. The main active metabolite is N-desmethylivabradine, which is pharmacologically active but less potent. The metabolite is further glucuronidated.
Half-LifeThe effective elimination half-life is approximately 11 hours, but it can range from 6 to 12 hours. In patients with hepatic impairment, the half-life may be prolonged.
ExcretionIvabradine and its metabolites are excreted mainly in the feces (about 80%) and urine (about 20%). Unchanged ivabradine accounts for a small fraction of the excreted drug.
BioavailabilityApproximately 40% due to first-pass metabolism.
Onset of ActionHeart rate reduction begins within 1-2 hours after oral administration, with peak effect occurring around 3-4 hours.
Peak Plasma TimeAbout 1 hour under fasting conditions; delayed by food.
Duration of ActionThe heart rate-lowering effect lasts for approximately 12 hours, but with twice-daily dosing, a sustained effect is maintained.

How It Works

This medicine selectively inhibits the funny current (If) in the sinoatrial node of the heart. The funny current is a mixed sodium-potassium inward current that helps generate the spontaneous diastolic depolarization responsible for setting the heart's natural pace. By blocking this current, ivabradine slows the rate of diastolic depolarization, thereby reducing the heart rate. This effect is specific to the sinoatrial node and does not affect other cardiac tissues or blood vessels, leading to a pure heart-rate-lowering effect without negative inotropy or hypotension.

Mechanism Steps

1
Selective inhibition of the funny current: This medicine enters the sinoatrial node cells and binds to the HCN4 channels, blocking the inward funny current (If) that normally contributes to the spontaneous depolarization phase of the action potential.
2
Slowing of diastolic depolarization: By reducing the funny current, the rate of diastolic depolarization is slowed, delaying the time it takes for the membrane potential to reach the threshold for firing an action potential.
3
Reduction in heart rate: The net effect is a decrease in the firing rate of the sinoatrial node, resulting in a lower heart rate. This reduces cardiac workload and oxygen demand.
4
Improved myocardial oxygen balance: The reduced heart rate prolongs diastole, enhancing coronary blood flow and oxygen delivery to the heart muscle, which helps relieve angina and improve heart failure symptoms.

💡 How to Take ivables od 10mg tablet

Strength: Ivabradine 10 mg immediate-release tablet.

1Take this medicine exactly as prescribed by your doctor.
2Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet.
3You may take it with or without food, but try to take it at the same times each day.
4Avoid drinking grapefruit juice while taking this medicine.
5If you miss a dose, follow the missed dose instructions provided by your doctor.
6Do not stop taking this medicine without consulting your doctor first.

Dosage Information

Adult DosageThe usual starting dose for stable angina is 5 mg twice daily, which may be increased to 7.5 mg twice daily after 3-4 weeks based on heart rate and symptoms. For chronic heart failure, the starting dose is 5 mg twice daily, with adjustments based on heart rate and tolerability. The maximum dose is 7.5 mg twice daily. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageNo specific dose adjustment is required for elderly patients, but they may be more sensitive to the heart rate-lowering effects. Monitor heart rate closely and adjust dose as needed.
Renal ImpairmentNo dose adjustment is required for mild to moderate renal impairment. In severe renal impairment (creatinine clearance <15 mL/min), use with caution as safety and efficacy have not been established.
Hepatic ImpairmentIn mild hepatic impairment, no dose adjustment is needed. In moderate hepatic impairment (Child-Pugh B), the starting dose should be reduced to 2.5 mg twice daily and titrated carefully. In severe hepatic impairment (Child-Pugh C), the medicine is contraindicated.
Maximum Daily Dose15 mg per day (7.5 mg twice daily).

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With or without food
Take consistently
Food delays absorption but does not significantly affect overall exposure; consistency helps maintain stable levels.
Grapefruit
Avoid
Increases ivabradine levels and risk of side effects.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed (e.g., less than 6 hours for twice-daily dosing)
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed (e.g., more than 6 hours for twice-daily dosing)
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of ivables od 10mg tablet

✅ Common Side Effects

Phosphenes (temporary brightness in vision) (Common (10-15%))
Usually resolves on its own. If persistent or bothersome, consult your doctor.
Headache (Common (5-10%))
May improve with continued use. Use over-the-counter pain relief if needed, but consult your doctor if severe.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how this medicine affects you.
Blurred vision (Common (5-10%))
Usually transient. Report to your doctor if it persists.
Bradycardia (slow heart rate) (Common (5-10%))
Your doctor will monitor your heart rate. Report any symptoms like fainting or extreme fatigue.

🚨 Serious Side Effects

Severe bradycardia (heart rate below 50 bpm) (Uncommon (0.1-1%))
Seek immediate medical attention if you experience fainting, severe dizziness, or confusion.
Atrial fibrillation (Uncommon (0.1-1%))
Report palpitations, irregular heartbeat, or chest discomfort to your doctor promptly.
Heart block (Rare (<0.1%))
Seek emergency care if you experience fainting, severe fatigue, or shortness of breath.
Worsening heart failure (Uncommon (0.1-1%))
Contact your doctor if you notice increased swelling, weight gain, or shortness of breath.
Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Call emergency services if you experience rash, swelling of face/lips/throat, or difficulty breathing.

⚠️ Rare Side Effects

Erythema multiforme
Seek immediate medical attention if you develop skin rash, blisters, or sores.
Angioedema
Seek emergency care if you experience swelling of the face, lips, or tongue.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Ketoconazole Major
Diltiazem Moderate
Verapamil Moderate
Rifampicin Major
Beta-blockers Moderate
Grapefruit juice Moderate
St. John's wort Moderate
Clarithromycin Major
Ritonavir Major
Spironolactone Moderate

🚨 Major Interactions

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir)
  • Moderate CYP3A4 inhibitors (e.g., diltiazem, verapamil, grapefruit juice)
  • CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin, St. John's wort)

⚡ Moderate Interactions

  • Beta-blockers
  • Calcium channel blockers (e.g., diltiazem, verapamil)
  • Potassium-sparing diuretics (e.g., spironolactone)

🍷 Alcohol Interaction

Alcohol may increase the heart rate-lowering effect of this medicine and can worsen dizziness or lightheadedness. It is advisable to avoid or limit alcohol consumption while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Severe bradycardia (heart rate

⚠️ Warnings & Precautions

["This medicine should only be prescribed by a cardiologist or a physician experienced in treating heart failure or angina.","Do not use this medicine to treat acute angina attacks; it is for chronic stable angina.","Monitor heart rate regularly; if resting heart rate falls below 50 bpm, dose reduction or discontinuation may be needed.","Use with caution in patients with mild to moderate hepatic impairment; dose adjustment may be required.","Avoid concomitant use with strong CYP3A4 inhibitors.","Use effective contraception in women of childbearing potential.","May cause visual disturbances; caution when driving or operating machinery.","Do not stop abruptly without medical advice."]

🤱 Lactation Safety

It is not known whether ivabradine is excreted in human breast milk. Because many medicines are excreted in breast milk, a decision should be made whether to discontinue nursing or to discontinue the medicine, taking into account the importance of the medicine to the mother.

💊 Overdose Management

Overdose may cause severe bradycardia, hypotension, and other cardiac arrhythmias. There is no specific antidote. Treatment should be symptomatic and supportive, including close monitoring of heart rate and blood pressure. In case of severe bradycardia, atropine or temporary pacing may be required. Contact a poison control center or emergency services immediately if overdose is suspected.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember if less than half the dosing interval has passed. If more than half the interval has passed, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not crush, chew, or break the tablet; swallow it whole with water. Avoid grapefruit juice and grapefruit products while taking this medicine, as they can increase the levels of ivabradine in your blood and raise the risk of side effects. Inform your doctor about all other medicines you are taking, especially those for heart rhythm, blood pressure, or fungal infections. Do not stop taking this medicine suddenly without consulting your doctor. Regular monitoring of heart rate and blood pressure is important. Use effective contraception during treatment if you are a woman of childbearing potential, as this medicine may harm an unborn baby.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the heart rate-lowering effects of this medicine. Start with a lower dose and monitor heart rate closely. Falls due to dizziness or bradycardia are a concern; advise caution.

🤰 Pregnancy Planning (TTC)

This medicine is not recommended during pregnancy unless clearly necessary. Women of childbearing potential should use effective contraception while taking this medicine. If you are planning pregnancy, consult your doctor to discuss alternative treatments.

🏥 Post-Surgery Considerations

After surgery, inform your surgeon and anesthesiologist that you are taking this medicine. It may affect heart rate during surgery. Your doctor may advise temporary discontinuation or dose adjustment.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine. It may interact with certain local anesthetics or medications used during dental procedures. No routine adjustment is usually needed, but your dentist may consult your doctor.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce strain on your heart.
🥗
Engage in regular low-impact exercise like walking or swimming, as advised by your doctor.
😴
Follow a heart-healthy diet low in saturated fats and sodium.
💧
Avoid smoking and limit alcohol consumption.
🧘
Manage stress through relaxation techniques like deep breathing or meditation.
🌞
Get adequate sleep and rest.
🚭
Monitor your pulse regularly and report any significant changes to your doctor.

🏋️ Exercise Considerations

Moderate exercise is generally encouraged, but avoid strenuous activities that cause chest pain or shortness of breath. Always warm up and cool down. If you experience dizziness, palpitations, or chest discomfort during exercise, stop and consult your doctor.

🥗 Diet Recommendations

Include plenty of fruits, vegetables, and whole grains.
Choose lean proteins like fish and poultry.
Limit intake of saturated fats, trans fats, and cholesterol.
Reduce sodium intake to help manage blood pressure.
Avoid grapefruit and grapefruit juice.
Stay well hydrated unless fluid restriction is advised.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or visual disturbances, especially when starting treatment. Avoid driving or operating heavy machinery until you know how it affects you. Most patients can continue their normal work activities with caution. Inform your employer if your job involves safety-sensitive tasks.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience severe side effects like fainting, severe bradycardia, or allergic reactions, seek immediate medical attention. Your doctor may adjust the dose or switch to another medicine if needed.

📅 Long-Term Use Effects

Long-term use of this medicine is generally well-tolerated. Regular monitoring of heart rate, blood pressure, and symptoms is necessary. In some patients, prolonged use may lead to visual disturbances or bradycardia. Periodic assessment of liver and kidney function is advised. Do not stop the medicine without medical supervision.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Beta-blockers

First-line therapy for angina and heart failure; however, may not be suitable for patients with asthma or COPD.

Evidence: Well-established
Calcium channel blockers

Can be used for angina but may have additional blood pressure-lowering effects.

Evidence: Well-established
Lifestyle modifications

Diet, exercise, and stress management can complement medical therapy.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, always inform your healthcare provider about all medicines you are taking before receiving any vaccine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate or freeze

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight and moisture

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. If crossing time zones, adjust dosing times gradually under medical guidance. Store at room temperature and avoid leaving it in a hot car. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 62-year-old man with chronic stable angina unable to tolerate beta-blockers due to asthma.
He was started on this medicine 5 mg twice daily. After 4 weeks, his heart rate was 68 bpm and angina attacks reduced significantly. He was advised to avoid grapefruit juice and to monitor his pulse daily. He experienced mild visual brightness initially, which resolved after a few weeks.
💡 Lesson: This medicine can be an effective alternative for angina patients who cannot take beta-blockers, but regular monitoring and lifestyle adjustments are key.
👤 A 55-year-old woman with heart failure with reduced ejection fraction and a heart rate of 80 bpm.
She was already on standard heart failure therapy but remained symptomatic. This medicine was added at 5 mg twice daily. Over 3 months, her heart rate decreased to 65 bpm, and she reported improved exercise tolerance and less fatigue. She was reminded not to stop the medicine abruptly.
💡 Lesson: Adding this medicine to standard therapy can improve symptoms in heart failure patients with elevated heart rate, but adherence and follow-up are crucial.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine starts lowering heart rate within 1-2 hours, but full benefits for angina or heart failure may take several weeks.

Q: Can I stop taking this medicine if I feel better?

A: No, do not stop without consulting your doctor. Stopping suddenly can worsen your condition.

Q: What should I do if I miss a dose?

A: If less than half the dosing interval has passed, take it as soon as you remember. If more, skip it and continue your regular schedule. Do not double dose.

Q: Does this medicine cause weight gain?

A: Weight gain is not a common side effect. However, if you have heart failure, weight gain may indicate worsening condition and should be reported to your doctor.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my vision?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Is it safe during pregnancy?

🔄 Substitutes for ivables od 10mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken for any type of chest pain.
    Fact: This medicine is specifically for stable angina and certain heart failure; it is not for acute angina attacks or other types of chest pain.
  • Myth: This medicine can be stopped once symptoms improve.
    Fact: This medicine is usually a long-term treatment; stopping suddenly can worsen your condition. Always consult your doctor before stopping.
  • Myth: This medicine is safe to take with any other medicine.
    Fact: This medicine interacts with many drugs, especially those affecting CYP3A4. Always inform your doctor about all medicines you take.

🔄 Alternative Options

Generic Alternatives

  • Ivabradine 10 mg tablet

Brand Alternatives

  • Inapure ER 10 Tablet

📊 Comparison with Similar Medicines

[{"medicine":"Ivabradine","class":"If channel inhibitor","primary_use":"Stable angina, heart failure","heart_rate_effect":"Lowers heart rate","blood_pressure_effect":"Minimal","common_side_effects":"Phosphenes, headache, dizziness"},{"medicine":"Metoprolol","class":"Beta-blocker","primary_use":"Angina, heart failure, hypertension","heart_rate_effect":"Lowers heart rate","blood_pressure_effect":"Lowers blood pressure","common_side_effects":"Fatigue, cold extremities, bradycardia"}]

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