Itom Plus Tablet: Complete Guide to Uses, Dosage, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of skin or eyes (jaundice)
- Dark urine or pale stools
- Severe abdominal pain or persistent vomiting
- Sudden weight gain, swelling of legs, or shortness of breath
- Palpitations, fainting, or irregular heartbeat
- Severe skin rash with blisters or peeling
- Numbness or tingling in hands or feet
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is itrapro t 100mg/250mg tablet used for?
This medicine is a combination antifungal tablet containing itraconazole 100 mg and terbinafine 250 mg. It is used to treat serious fungal infections of the skin, nails, and hair. It works by attacking the fungal cell membrane through two different mechanisms. It must be taken with food and under a doctor's supervision due to risks of liver and heart side effects.
- Generic Name: Itraconazole (100mg) + Terbinafine (250mg)
- Manufacturer: Progressive Life Care
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 itrapro t 100mg/250mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा इट्राकोनाज़ोल और टर्बिनाफाइन का संयोजन है, जिसका उपयोग त्वचा, नाखून और बालों के गंभीर फंगल संक्रमण के इलाज के लिए किया जाता है। यह दवा फंगस की कोशिका झिल्ली को दो अलग-अलग तरीकों से नष्ट करती है, जिससे संक्रमण जल्दी ठीक होता है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, पेट दर्द, सिरदर्द, और हल्के दाने शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन लिवर की समस्या, गंभीर त्वचा प्रतिक्रियाएं, और दिल की धड़कन में बदलाव हो सकते हैं। अगर आंखों या त्वचा का रंग पीला पड़े, गहरे रंग का पेशाब आए, या सांस लेने में तकलीफ हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को हमेशा भोजन के साथ लें ताकि अवशोषण बेहतर हो और पेट की परेशानी कम हो। इलाज के दौरान शराब बिल्कुल न पिएं क्योंकि इससे लिवर को नुकसान हो सकता है। एंटासिड या एसिड कम करने वाली दवाएं इस दवा से 2 घंटे पहले या बाद में लें। अपने डॉक्टर को सभी दवाओं के बारे में बताएं। गर्भवती महिलाएं और गर्भधारण की योजना बना रही महिलाएं इस दवा का सेवन न करें।
💊 itrapro t 100mg/250mg tablet Uses & Benefits
[{"condition":"Extensive tinea corporis (ringworm of the body)","description":"Used for widespread or stubborn ringworm infections that have not responded to topical treatment alone.","evidence":"Well-established for itraconazole and terbinafine individually; combination use is based on clinical practice."},{"condition":"Tinea cruris (jock itch)","description":"Prescribed for extensive or recurrent jock itch when topical agents are insufficient.","evidence":"Well-established for individual components; combination use is based on clinical practice."},{"condition":"Onychomycosis (fungal nail infection)","description":"Used to treat fungal infections of the fingernails and toenails, especially when multiple nails are involved.","evidence":"Well-established for individual components; combination use is based on clinical practice."},{"condition":"Tinea capitis (fungal scalp infection)","description":"May be used for scalp ringworm, particularly when oral therapy is required.","evidence":"Well-established for individual components; combination use is based on clinical practice."},{"condition":"Tinea pedis (athlete's foot)","description":"Used for severe or resistant athlete's foot that has not improved with topical antifungals.","evidence":"Well-established for individual components; combination use is based on clinical practice."}]
Off-label uses: [{"condition":"Seborrheic dermatitis","description":"Sometimes prescribed off-label when Malassezia yeast is suspected to play a role.","evidence":"Limited"},{"condition":"Cutaneous candidiasis","description":"May be used off-label for skin yeast infections not responding to standard treatment.","evidence":"Limited"}]
Primary treatment for: Fungal infections of skin, nails, and hair
Also treats: Tinea corporis, Tinea cruris, Tinea pedis, Onychomycosis, Tinea capitis
📋 Drug Information
| Generic Name(s) | Itraconazole (100mg) + Terbinafine (250mg) |
| Brand Name | itrapro t 100mg/250mg tablet |
| Manufacturer | Progressive Life Care |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the pack. |
| WHO Guideline | Not established from the available information. Guidelines generally recommend topical therapy first for uncomplicated dermatophyte infections. Oral therapy is reserved for extensive, resistant, or nail/scalp infections. Combination antifungal therapy is not routinely recommended by WHO for common fungal infections. |
| ICMR Guideline | Not established from the available information. ICMR guidelines for dermatophytosis recommend oral antifungals for extensive or recalcitrant cases, but combination therapy should be used judiciously due to drug interactions and liver toxicity. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antifungal agents with different mechanisms. Itraconazole, an azole, inhibits the fungal cytochrome P450 enzyme lanosterol 14-alpha-demethylase, which blocks the conversion of lanosterol to ergosterol, a key component of the fungal cell membrane. This leads to a defective membrane and accumulation of toxic sterol precursors. Terbinafine, an allylamine, inhibits squalene epoxidase, causing squalene accumulation and ergosterol deficiency, which disrupts membrane function and leads to fungal cell death. The combination provides a broader and more potent antifungal effect against dermatophytes.
Mechanism Steps
💡 How to Take itrapro t 100mg/250mg tablet
Strength: Immediate-release tablet containing itraconazole 100 mg and terbinafine 250 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once daily with a full meal, or as prescribed by your doctor. The exact dose and duration depend on the type and severity of the fungal infection. For skin infections, treatment may last 2 to 4 weeks; for nail infections, several months may be needed. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and other medicines you are taking. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially heart and liver effects. Dose adjustment may be needed based on kidney and liver function. Consult your doctor. |
| Renal Impairment | Dose adjustment may be needed in patients with severe kidney impairment. Itraconazole and terbinafine are not significantly removed by dialysis. Consult your doctor for individualized dosing. |
| Hepatic Impairment | This medicine is contraindicated in patients with severe liver disease. In mild to moderate liver impairment, dose reduction or alternative therapy may be necessary. Close monitoring of liver function is required. Consult your doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet containing itraconazole 100 mg and terbinafine 250 mg, unless otherwise directed by your doctor. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of itrapro t 100mg/250mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Simvastatin | Major | |
| Amiodarone | Major | |
| Midazolam | Major | |
| Rifampicin | Major | |
| Omeprazole | Moderate | |
| Metformin | Moderate | |
| Amlodipine | Moderate | |
| Dexamethasone | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin and other anticoagulants
- Statins (e.g., simvastatin, atorvastatin)
- QT-prolonging drugs (e.g., amiodarone, sotalol, quinidine)
- Midazolam and triazolam
- Rifampicin, rifabutin, carbamazepine, phenytoin
⚡ Moderate Interactions
- Proton pump inhibitors (omeprazole, esomeprazole)
- H2 blockers (ranitidine, famotidine)
- Oral hypoglycemics (sulfonylureas)
- Calcium channel blockers (nifedipine, amlodipine)
- Corticosteroids (dexamethasone, methylprednisolone)
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Both itraconazole and terbinafine can stress the liver, and alcohol increases the risk of liver damage. Alcohol may also worsen stomach upset and dizziness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to itraconazole, terbinafine, or other azole/allylamine antifungals","Severe liver disease or active liver injury","Heart failure or ventricular dysfunction","Pregnancy (unless absolutely necessary and under specialist care)","Women planning to become pregnant","Concurrent use with certain QT-prolonging drugs (e.g., quinidine, dofetilide)","Concurrent use with simvastatin or lovastatin"]
⚠️ Warnings & Precautions
["Take with food to improve absorption and reduce stomach upset.","Avoid alcohol completely during treatment.","Do not take antacids or acid reducers within 2 hours of this medicine.","Inform your doctor about all other medicines, especially blood thinners, heart drugs, and diabetes drugs.","Use effective contraception during treatment and for one cycle after the last dose.","Avoid driving or operating machinery if you feel dizzy.","Report any signs of liver problems (yellowing of eyes/skin, dark urine, severe fatigue) immediately.","Report any signs of heart failure (swelling, weight gain, shortness of breath) immediately.","Do not stop treatment early without consulting your doctor, even if symptoms improve."]
🤱 Lactation Safety
Itraconazole and terbinafine are excreted in breast milk. Breastfeeding is not recommended while taking this medicine. Consult your doctor for guidance.
💊 Overdose Management
Overdose of this medicine may cause severe nausea, vomiting, abdominal pain, dizziness, and liver or heart toxicity. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if taken recently. Monitor liver function, electrolytes, and cardiac rhythm.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop treatment early, even if you feel better, because the fungal infection may return. Take each dose with a full meal to improve absorption and reduce stomach upset. Avoid alcohol completely while on this medicine because it increases the risk of liver problems. Do not take antacids, acid reducers, or sucralfate within two hours of this medicine, as they reduce its absorption. Inform your doctor about all other medicines, supplements, and herbal products you are taking, especially blood thinners, heart medicines, and diabetes drugs. Your doctor may order blood tests to check your liver and kidney function before and during treatment. If you develop yellowing of the skin or eyes, dark urine, severe nausea, or unusual tiredness, stop the medicine and contact your doctor immediately. Women of childbearing age must use effective contraception during treatment and for at least one menstrual cycle after the last dose. This medicine may cause dizziness; avoid driving or operating heavy machinery until you know how it affects you.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of liver, kidney, and heart side effects. Dose adjustment may be needed based on organ function. Close monitoring is recommended. Falls due to dizziness should be prevented.
🤰 Pregnancy Planning (TTC)
This medicine should be avoided during pregnancy and in women planning to become pregnant. Both itraconazole and terbinafine may harm the developing fetus. Use effective contraception during treatment and for at least one menstrual cycle after the last dose. Consult your doctor for alternative treatments if you are planning pregnancy.
🏥 Post-Surgery Considerations
Not established from the available information. Inform your surgeon and anesthesiologist if you are taking this medicine, as it can interact with many drugs used during surgery. It may need to be stopped before elective surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. It can interact with certain antibiotics and antifungals used in dentistry. It may also increase bleeding risk if you are on blood thinners. Your dentist may recommend postponing non-urgent procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause dizziness or fatigue. Avoid strenuous exercise if you feel unsteady. If you have heart failure or are at risk, consult your doctor before starting any exercise program. Moderate activity is generally safe.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, fatigue, or changes in taste, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also require time off for blood tests and doctor visits. Discuss any work-related concerns with your doctor.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience serious side effects such as jaundice, severe rash, palpitations, or signs of heart failure, stop the medicine and seek immediate medical attention. Your doctor will decide whether to stop treatment or switch to an alternative.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of liver toxicity, heart failure, and peripheral neuropathy. Regular monitoring of liver function, electrolytes, and cardiac status is recommended. The duration of treatment should be as short as necessary to clear the infection. Prolonged use should be avoided unless clearly indicated by a specialist.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For mild to moderate skin infections, topical creams may be sufficient and have fewer systemic side effects.
Evidence: Well-establishedUsing either itraconazole or terbinafine alone may be effective for many infections, reducing the risk of drug interactions.
Evidence: Well-establishedKeeping skin clean and dry, avoiding sharing personal items, and wearing breathable clothing can help prevent and manage fungal infections.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. There are no known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in the original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If crossing time zones, continue taking your dose at approximately the same interval as prescribed; consult your doctor for specific advice. Check customs regulations for carrying prescription medicines into your destination country. Do not stop treatment during travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Improvement in skin infections may be seen within 1-2 weeks. Nail infections may take several months to clear completely.
A: Yes, take it with a full meal to improve absorption and reduce stomach upset.
A: Avoid alcohol, grapefruit juice, and antacids within 2 hours of the dose. Also avoid driving if you feel dizzy.
A: It can affect the liver. Your doctor will monitor liver function tests before and during treatment. Report any signs of liver problems immediately.
A: No, complete the full course as prescribed to prevent the infection from returning.
🤔 Common Patient Concerns
🔄 Substitutes for itrapro t 100mg/250mg tablet
View AllAlternative brands with exact same active ingredient:
-
duofaze 100mg/250mg tabletMegha Healthcare Pvt Ltd ₹194.20 18.8% CHEAPER
-
itrav-t tabletNarvs Pharma ₹206.25 13.7% CHEAPER
-
itradac t 100mg/250mg tabletIkon Remedies Pvt Ltd ₹229.69 3.9% CHEAPER
-
Torabest IT 100mg/250mg TabletBiochemix Health Care Pvt. Ltd. ₹229.69 3.9% CHEAPER
-
itroteb 100mg/250mg tabletNukind Healthcare Pvt Ltd ₹248.44 3.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be stopped as soon as symptoms improve.
Fact: You must complete the full course as prescribed to prevent the infection from returning. - Myth: This medicine is safe to take without any blood tests.
Fact: Liver function tests are often needed before and during treatment because this medicine can affect the liver. - Myth: It is okay to drink alcohol while taking this medicine.
Fact: Alcohol should be completely avoided as it increases the risk of liver damage. - Myth: This medicine can be taken with antacids for stomach upset.
Fact: Antacids reduce the absorption of this medicine. They should be taken at least 2 hours apart.
🔄 Alternative Options
Generic Alternatives
- Itraconazole 100 mg + Terbinafine 250 mg tablet (generic)