itinil 100 mg/125 mg suspension - Ibuprofen (100mg) + Paracetamol (125mg) medicine

Anaflam P 100 mg/125 mg Suspension: Complete Medicine Guide

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🏭 Commonwealth Pharmaceuticals 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
12 min read
Evidence: Well-established for pain and fever.
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Unusual bleeding or bruising

If experiencing severe symptoms, call emergency services immediately.

What is itinil 100 mg/125 mg suspension used for?

This medicine is a combination of ibuprofen and paracetamol used for short-term relief of pain and fever in children and adults who cannot take tablets. It works by reducing inflammation and fever through two different mechanisms.

  • Generic Name: Ibuprofen (100mg) + Paracetamol (125mg)
  • Manufacturer: Commonwealth Pharmaceuticals
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 itinil 100 mg/125 mg suspension के बारे में (Hindi Summary)

उपयोग: यह दवा इबुप्रोफेन और पैरासिटामोल का संयोजन है, जिसका उपयोग बुखार और हल्के से मध्यम दर्द के इलाज के लिए किया जाता है। यह विशेष रूप से उन बच्चों और वयस्कों के लिए उपयुक्त है जो गोलियाँ निगल नहीं सकते। इसका उपयोग दांत निकलने का दर्द, कान का दर्द, गले में खराश, सिरदर्द, मांसपेशियों में दर्द और टीकाकरण के बाद होने वाले बुखार में किया जाता है। यह दवा सूजन को कम करने और दर्द तथा बुखार को शांत करने में मदद करती है।

साइड इफेक्ट्स: आम दुष्प्रभावों में पेट में परेशानी, जी मिचलाना, उल्टी, सीने में जलन और दस्त शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट में रक्तस्राव, गुर्दे की समस्या, यकृत की क्षति और एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को देने से पहले बोतल को अच्छी तरह हिलाएं। दवा को खाने के साथ या दूध के साथ दें ताकि पेट में परेशानी न हो। दवा की मात्रा से अधिक न दें। अन्य पैरासिटामोल या इबुप्रोफेन युक्त दवाओं के साथ इसका सेवन न करें। बच्चों की पहुंच से दूर रखें। यदि लक्षण तीन दिनों में ठीक न हों तो डॉक्टर से मिलें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 itinil 100 mg/125 mg suspension Uses & Benefits

[{"condition":"Fever","description":"Reduces fever associated with common infections, teething, and post-vaccination reactions.","evidence":"Well-established"},{"condition":"Mild to moderate pain","description":"Relieves pain from headache, toothache, earache, sore throat, muscle aches, and minor injuries.","evidence":"Well-established"},{"condition":"Inflammatory pain","description":"Reduces pain and inflammation" class="semantic-link" title="Medicines for swelling">swelling in conditions such as juvenile idiopathic arthritis and soft tissue injuries.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Migraine attacks in children","description":"Sometimes used off-label for acute migraine relief when other treatments are not suitable.","evidence":"Limited"},{"condition":"Post-operative pain in children","description":"May be used off-label for short-term pain management after minor surgical procedures.","evidence":"Limited"}]

Primary treatment for: Pain and fever

Also treats: Juvenile idiopathic arthritis, Teething, Earache, Sore throat, Post-immunization fever

📋 Drug Information

Generic Name(s)Ibuprofen (100mg) + Paracetamol (125mg)
Brand Nameitinil 100 mg/125 mg suspension
ManufacturerCommonwealth Pharmaceuticals
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place. Do not freeze. Keep the bottle tightly closed.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always shake the bottle well before measuring the dose.
2
Use the measuring cup or syringe provided with the product, not a household spoon.
3
Give this medicine with food or milk to reduce stomach upset.
4
Do not exceed the recommended dose or give it more often than directed.
5
Avoid combining with other paracetamol or ibuprofen-containing products.
6
Consult a doctor if symptoms do not improve within three days.
7
Keep the medicine out of reach of children.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Fever
This medicine is commonly used for fever.
Likely Use
✅
Headache
This medicine is used for mild to moderate headache.
Likely Use
✅
Toothache
This medicine provides relief from toothache.
Likely Use
❌
Chest pain
This medicine is not for chest pain. Seek emergency care.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionIbuprofen is rapidly absorbed from the gastrointestinal tract after oral administration. Paracetamol is also rapidly and almost completely absorbed from the small intestine. Food may slightly delay the absorption of both ingredients but does not significantly reduce the total amount absorbed.
DistributionIbuprofen is highly bound to plasma proteins and distributes into synovial fluid, cerebrospinal fluid, and breast milk. Paracetamol distributes widely into most body tissues and fluids, with a volume of distribution of approximately 0.9 to 1.0 L/kg.
Protein BindingIbuprofen is approximately 99% bound to plasma proteins. Paracetamol is only about 10% to 25% bound to plasma proteins.
MetabolismIbuprofen is metabolized in the liver by cytochrome P450 enzymes, mainly CYP2C9, to inactive metabolites. Paracetamol is metabolized in the liver primarily by glucuronidation and sulfation, with a small fraction oxidized by CYP2E1 to a toxic intermediate that is normally detoxified by glutathione.
Half-LifeThe elimination half-life of ibuprofen is approximately 2 hours. The elimination half-life of paracetamol is approximately 2 to 3 hours.
ExcretionIbuprofen metabolites are excreted mainly in the urine. Paracetamol metabolites are excreted in the urine, with about 90% of the dose eliminated within 24 hours.
BioavailabilityThe oral bioavailability of ibuprofen is approximately 80% to 90%. The oral bioavailability of paracetamol is approximately 80% to 90%.
Onset of ActionIbuprofen begins to relieve pain and fever within 30 to 60 minutes after oral administration. Paracetamol also starts working within 30 to 60 minutes.
Peak Plasma TimeIbuprofen reaches peak plasma concentration in about 1 to 2 hours. Paracetamol reaches peak plasma concentration in about 0.5 to 1 hour.
Duration of ActionThe analgesic and antipyretic effects of ibuprofen last about 4 to 6 hours. Paracetamol effects last about 4 to 6 hours.

How It Works

Ibuprofen reversibly inhibits cyclooxygenase-1 and cyclooxygenase-2 enzymes, reducing the synthesis of prostaglandins that mediate pain, inflammation, and fever. Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis and modulating pain pathways, though its exact mechanism is not fully established. The combination provides both peripheral anti-inflammatory action and central analgesic and antipyretic effects.

Mechanism Steps

1
Ibuprofen absorption and distribution: Ibuprofen is absorbed from the gastrointestinal tract and distributed to peripheral tissues where inflammation occurs.
2
COX enzyme inhibition: Ibuprofen binds reversibly to COX-1 and COX-2 enzymes, blocking the conversion of arachidonic acid to prostaglandin H2.
3
Reduced prostaglandin synthesis: Lower prostaglandin levels decrease pain receptor sensitization, swelling, and fever.
4
Paracetamol central action: Paracetamol acts in the brain and spinal cord to inhibit prostaglandin synthesis and modulate pain perception.
5
Combined analgesic and antipyretic effect: The two medicines together provide stronger pain relief and fever reduction than either alone at the same doses.

💡 How to Take itinil 100 mg/125 mg suspension

Strength: Suspension containing ibuprofen 100 mg and paracetamol 125 mg per 5 mL.

1Shake the bottle well before each use.
2Measure the dose using the provided measuring cup or syringe.
3Give with food or milk to reduce stomach upset.
4Do not exceed the recommended dose.
5Wash the measuring cup after each use.

Dosage Information

Adult DosageThe adult dose of this medicine is individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Typically, 5 to 10 mL of the suspension may be given every 4 to 6 hours as needed, not exceeding 4 doses in 24 hours. Do not exceed the recommended dose. Consult a doctor for proper dosing.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing based on the child's age and weight.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine. Use the lowest effective dose for the shortest duration. Consult a doctor for dosing.
Renal ImpairmentUse with caution in patients with kidney disease. Dose adjustment may be needed. Consult a doctor.
Hepatic ImpairmentUse with caution in patients with liver disease. Dose adjustment may be needed. Consult a doctor.
Maximum Daily DoseThe maximum daily dose should not exceed 4 doses of the recommended strength in 24 hours. Do not exceed the dose prescribed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases risk of liver damage and gastrointestinal bleeding.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of itinil 100 mg/125 mg suspension

✅ Common Side Effects

Stomach discomfort (Common (5-10%))
Give with food or milk to reduce discomfort. If it persists, consult a doctor.
Nausea (Common (5-10%))
Usually resolves on its own. Offer small sips of water. Consult a doctor if vomiting occurs.
Vomiting (Uncommon (1-5%))
Stop the medicine and consult a doctor if vomiting is persistent.
Heartburn (Uncommon (1-5%))
Give with food. Avoid lying down immediately after the dose.
Loose stools (Uncommon (1-5%))
Ensure adequate fluid intake. Consult a doctor if diarrhea persists.

🚨 Serious Side Effects

Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black stool, vomiting blood, or severe abdominal pain.
Kidney problems (Rare (<0.1%))
Seek medical attention if there is decreased urine output, swelling, or blood in urine.
Liver injury (Rare (<0.1%))
Stop the medicine and seek immediate care if you notice yellowing of skin or eyes, dark urine, or severe fatigue.
Severe skin reactions (Very rare (<0.01%))
Stop the medicine and seek emergency care if a rash with blisters, peeling skin, or fever develops.
Allergic reaction (Rare (<0.1%))
Seek emergency care if there is swelling of the face, lips, tongue, or throat, or difficulty breathing.

⚠️ Rare Side Effects

Aseptic meningitis
Seek immediate medical attention if severe headache, neck stiffness, or sensitivity to light occurs.
Pancreatitis
Seek immediate care if severe upper abdominal pain radiating to the back occurs.
Blood disorders
Consult a doctor if unusual bleeding, bruising, or persistent sore throat with fever occurs.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Methotrexate Major
Other NSAIDs Major
ACE inhibitors Major
Diuretics Major
Corticosteroids Moderate
SSRIs Moderate
Lithium Moderate
Zidovudine Moderate
Antacids Minor

🚨 Major Interactions

  • Warfarin
  • Methotrexate
  • Other NSAIDs
  • ACE inhibitors and angiotensin receptor blockers
  • Diuretics

⚡ Moderate Interactions

  • Corticosteroids
  • Antidepressants (SSRIs)
  • Lithium
  • Zidovudine

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol increases the risk of liver damage from paracetamol and gastrointestinal bleeding from ibuprofen.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Active gastrointestinal bleeding or ulcer","Severe kidney disease","Severe liver disease","Aspirin-sensitive asthma","Allergy to ibuprofen, paracetamol, or any ingredient","Third trimester of pregnancy","Children under 3 months of age unless directed by a doctor"]

⚠️ Warnings & Precautions

["Do not exceed the recommended dose.","Avoid other paracetamol or ibuprofen-containing products.","Use with caution in the elderly.","Use with caution in dehydration.","Consult a doctor if symptoms persist beyond 3 days.","Do not use for more than 3 days without medical advice.","Keep out of reach of children."]

🤱 Lactation Safety

Ibuprofen and paracetamol are considered compatible with breastfeeding in usual doses. Consult a doctor for guidance.

💊 Overdose Management

Overdose can cause severe liver damage from paracetamol and gastrointestinal bleeding, kidney failure, and central nervous system effects from ibuprofen. Seek immediate medical attention. Treatment includes activated charcoal, acetylcysteine for paracetamol toxicity, and supportive care.

⏰ Missed Dose

If a dose is missed, give it as soon as remembered if less than half the dosing interval has passed. Otherwise, skip the missed dose and continue with the regular schedule. Do not double the dose.

Additional Safety Advice

General Safety

Always shake the bottle well before measuring each dose. Use the measuring cup or syringe provided with the product, not a household spoon. Give this medicine with food or milk to reduce stomach upset. Do not exceed the recommended dose or give it more often than directed. Avoid combining with other paracetamol or ibuprofen-containing products. Keep out of reach of children. Store at room temperature and do not freeze. Consult a doctor if symptoms do not improve within three days or if new symptoms appear.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal bleeding, kidney problems, and cardiovascular events. Use the lowest effective dose for the shortest duration. Consult a doctor for appropriate dosing.

🤰 Pregnancy Planning (TTC)

Consult a doctor before taking this medicine if you are planning pregnancy. Ibuprofen is generally avoided in the third trimester. Paracetamol is considered safer but should be used only when necessary.

🏥 Post-Surgery Considerations

This medicine may be used for post-operative pain under a doctor's supervision. It should be used with caution due to the risk of bleeding and kidney problems. Follow your surgeon's instructions.

🦷 Dental Procedures

This medicine can be used for dental pain. Inform your dentist if you are taking this medicine before any dental procedure. It may increase bleeding risk during dental surgery.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce stress on joints.
🥗
Stay well hydrated throughout the day.
😴
Include anti-inflammatory foods like fruits and vegetables in your diet.
💧
Get adequate rest and sleep.
🧘
Avoid alcohol while taking this medicine.
🌞
Practice good hygiene to prevent infections.

🏋️ Exercise Considerations

Avoid strenuous exercise if you have pain or fever. Rest and gentle movement are recommended until symptoms improve. Consult a doctor before resuming intense physical activity.

🥗 Diet Recommendations

Include omega-3 rich foods like fish and flaxseeds.
Reduce processed and fried food intake.
Eat plenty of fruits and vegetables.
Stay well hydrated.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is usually safe for office work.

🛑 When to Stop This Medicine

Stop this medicine and consult a doctor if symptoms persist beyond 3 days, if new symptoms appear, or if you experience any serious side effects such as stomach bleeding, allergic reaction, or yellowing of the skin or eyes.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of gastrointestinal bleeding, kidney problems, liver injury, and cardiovascular events. It should only be used for short-term relief unless directed by a doctor. Regular monitoring of liver and kidney function may be needed with prolonged use.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can help manage chronic pain and improve mobility.

Evidence: Well-established
Cold or warm compresses

Can provide local pain relief for minor injuries.

Evidence: Well-established
Rest and hydration

Important for recovery from fever and infections.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

This medicine can be used to manage fever and pain after vaccination. It does not interfere with vaccine effectiveness. Consult a doctor if fever persists beyond 48 hours after vaccination.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with the prescription label intact. Bring a copy of the prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, continue with the usual dosing schedule as advised by your doctor. Check customs regulations for carrying medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 4-year-old child with fever and earache
The child was given this medicine as prescribed by the pediatrician. The fever reduced within an hour and the child was more comfortable. The parents were advised to give it with food and to complete the course.
💡 Lesson: This medicine effectively reduces fever and pain in children when taken as directed.
👤 An adult with post-vaccination fever and body ache
After receiving a vaccine, the adult developed fever and muscle pain. This medicine was taken with food, and symptoms improved within 45 minutes. No side effects were experienced.
💡 Lesson: This medicine provides rapid relief from fever and pain after vaccination.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts working within 30 to 60 minutes after taking it.

Q: Can I take it on an empty stomach?

A: It is best taken with food or milk to reduce stomach upset.

Q: Is it safe for children?

A: It can be used in children over 3 months of age under a doctor's supervision. The dose depends on the child's weight and age.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for itinil 100 mg/125 mg suspension

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is safe for everyone.
    Fact: It is not safe for people with certain conditions such as stomach ulcers, kidney disease, or liver disease.
  • Myth: More medicine means faster relief.
    Fact: Taking more than the recommended dose can cause serious harm, including liver damage and stomach bleeding.
  • Myth: It can be taken on an empty stomach.
    Fact: It should be taken with food or milk to reduce stomach upset.

🔄 Alternative Options

Generic Alternatives

  • Ibuprofen + Paracetamol suspension

Brand Alternatives

  • Anaflam P 100 mg/125 mg suspension

📊 Comparison with Similar Medicines

[{"medicine":"Ibuprofen alone","difference":"Only anti-inflammatory, no central analgesic."},{"medicine":"Paracetamol alone","difference":"Only analgesic and antipyretic, no anti-inflammatory."},{"medicine":"This medicine","difference":"Combines both for broader relief."}]

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