Thiosol 1 gm Injection (Thiopental Sodium): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe difficulty breathing or stopped breathing
- Chest pain or irregular heartbeat
- Sudden severe drop in blood pressure
- Swelling, redness, or pain at the injection site
- Signs of allergic reaction such as rash, itching, or swelling of the face, lips, or throat
- Prolonged confusion or excessive drowsiness after the procedure
- Decreased urine output or no urine output
If experiencing severe symptoms, call emergency services immediately.
What is ithiofast injection used for?
Thiopental sodium 1 gram injection is a short-acting barbiturate used for the induction of general anesthesia and for short surgical procedures. It works rapidly to produce unconsciousness by enhancing the inhibitory effects of GABA in the brain. It must be administered only by trained anesthesia providers in a monitored setting.
- Generic Name: Thiopental Sodium (1gm)
- Manufacturer: 6ipain Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ithiofast injection के बारे में (Hindi Summary)
उपयोग: यह दवा थायोपेंटल सोडियम 1 ग्राम इंजेक्शन के रूप में उपलब्ध है, जिसका उपयोग सामान्य एनेस्थीसिया (बेहोशी) शुरू करने के लिए किया जाता है। यह छोटी सर्जरी के दौरान बेहोशी बनाए रखने में भी मदद करती है। यह दवा मस्तिष्क में गामा-एमिनोब्यूटिरिक एसिड (GABA) के प्रभाव को बढ़ाकर काम करती है, जिससे रोगी जल्दी बेहोश हो जाता है। यह केवल अस्पताल में प्रशिक्षित एनेस्थेसियोलॉजिस्ट द्वारा ही दी जानी चाहिए। इसे घर पर या बिना निगरानी के नहीं दिया जा सकता।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, मतली, उल्टी और हिचकी शामिल हैं। गंभीर दुष्प्रभावों में सांस की गंभीर कमी, निम्न रक्तचाप, हृदय गति रुकना, लैरिंगोस्पाज्म और एनाफिलेक्सिस हो सकते हैं। दुर्लभ मामलों में इंजेक्शन स्थल पर ऊतक क्षति हो सकती है। इन सभी का प्रबंधन अस्पताल में डॉक्टरों द्वारा किया जाता है।
सुरक्षा सलाह: यह दवा केवल अस्पताल या सर्जिकल सेंटर में प्रशिक्षित एनेस्थेसियोलॉजिस्ट द्वारा ही दी जानी चाहिए। इस दवा को देने से पहले रोगी को अपनी सभी एलर्जी, दवाओं और स्वास्थ्य समस्याओं के बारे में डॉक्टर को बताना चाहिए। गर्भावस्था और स्तनपान के दौरान इसका उपयोग सावधानी से किया जाना चाहिए। इस दवा को लेने के बाद कम से कम 24 घंटे तक वाहन न चलाएं और मशीनरी न चलाएं। शराब का सेवन बिल्कुल न करें।
💊 ithiofast injection Uses & Benefits
[{"condition":"Induction of general anesthesia","description":"This medicine is used to rapidly induce unconsciousness before other anesthetic agents are administered.","evidence":"Well-established"},{"condition":"Short surgical procedures","description":"It can be used as a sole anesthetic for brief procedures or as an adjunct to other agents.","evidence":"Well-established"},{"condition":"Refractory intracranial hypertension","description":"In critical care, this medicine may be used to reduce elevated intracranial pressure that has not responded to other measures.","evidence":"Limited"},{"condition":"Cerebral protection during neurosurgery","description":"It may be employed to reduce cerebral metabolic demand and protect the brain during certain neurosurgical procedures.","evidence":"Limited"}]
Off-label uses: [{"condition":"Status epilepticus","description":"Rarely used off-label for refractory seizures when other treatments fail.","evidence":"Limited"},{"condition":"Sedation in intensive care","description":"Occasionally used for long-term sedation in critically ill patients, though propofol is more common.","evidence":"Limited"}]
Primary treatment for: Induction of general anesthesia
Also treats: Short surgical procedures, Refractory intracranial hypertension, Cerebral protection during neurosurgery
📋 Drug Information
| Generic Name(s) | Thiopental Sodium (1gm) |
| Brand Name | ithiofast injection |
| Manufacturer | 6ipain Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Barbiturate |
| Route of Administration | Parenteral (intravenous) |
| Storage | Store below 25°C, protected from light. Do not freeze. Reconstituted solutions should be used immediately; discard any unused portion. |
| Shelf Life | Refer to the product label for the exact shelf life. Typically 24 to 36 months from the date of manufacture when stored as directed. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine acts by binding to the gamma-aminobutyric acid type A receptor-chloride channel complex in the central nervous system. This binding enhances the inhibitory effect of gamma-aminobutyric acid, leading to increased chloride ion influx and hyperpolarization of neurons. The result is a decrease in neuronal excitability and depression of the central nervous system, producing sedation, hypnosis, and anesthesia.
Mechanism Steps
💡 How to Take ithiofast injection
Strength: Thiopental sodium 1 gram injection (powder for solution)
Dosage Information
| Adult Dosage | The dose of this medicine must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and the patient's response. For induction of general anesthesia, a typical adult dose is 3 to 5 mg per kg of body weight administered intravenously over 10 to 15 seconds. For short surgical procedures, additional doses of 1 to 2 mg per kg may be given as needed. For refractory intracranial hypertension, doses are titrated to effect under close monitoring. This information is for educational purposes only and does not replace clinical judgment. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician or pediatric anesthesiologist for appropriate dosing. |
| Elderly Dosage | Elderly patients are more sensitive to the effects of this medicine due to decreased hepatic metabolism and decreased cardiac output. Lower doses should be used, and the dose should be titrated carefully. Close monitoring of vital signs is essential. |
| Renal Impairment | Thiopental sodium is metabolized in the liver and excreted by the kidneys. In patients with renal impairment, the dose should be reduced and the dosing interval extended. Close monitoring for prolonged sedation is advised. |
| Hepatic Impairment | In patients with hepatic impairment, the metabolism of thiopental sodium is reduced, leading to prolonged effects. The dose should be reduced, and the patient should be monitored closely for signs of excessive sedation. |
| Maximum Daily Dose | The maximum daily dose is not fixed and must be determined by a qualified clinician based on the patient's condition and response. There is no established maximum daily dose for this medicine when used in anesthesia. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ithiofast injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Opioids | Major | |
| Benzodiazepines | Major | |
| Alcohol | Major | |
| Antihypertensives | Major | |
| MAO inhibitors | Major | |
| Probenecid | Moderate | |
| Cimetidine | Moderate | |
| Valproic acid | Moderate | |
| Aspirin | Minor | |
| Diuretics | Minor |
🚨 Major Interactions
- Other central nervous system depressants (e.g., opioids, benzodiazepines, alcohol)
- Antihypertensive agents
- Monoamine oxidase inhibitors
⚡ Moderate Interactions
- Probenecid
- Cimetidine
- Valproic acid
🍷 Alcohol Interaction
Alcohol should be avoided before and after receiving this medicine because it can enhance the central nervous system depressant effects, leading to severe respiratory depression, hypotension, and prolonged sedation. Patients should not consume alcohol for at least 24 hours after anesthesia.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to barbiturates","Severe cardiovascular disease","Acute intermittent porphyria","Severe respiratory depression or airway obstruction","Status asthmaticus"]
⚠️ Warnings & Precautions
["This medicine should be administered only by trained personnel in a setting with resuscitation equipment.","Rapid injection can cause severe hypotension and cardiovascular collapse.","Extravasation can cause tissue necrosis; ensure proper intravenous placement.","Use with caution in elderly, debilitated, and obese patients.","Prolonged use can lead to accumulation and prolonged sedation.","Tolerance and dependence can develop with prolonged use.","Avoid in patients with porphyria.","Use with caution in patients with hepatic or renal impairment.","May cause paradoxical excitation in some patients.","Not for intrathecal or intra-arterial administration."]
🤱 Lactation Safety
Thiopental sodium is excreted in breast milk in small amounts. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Infant monitoring for sedation is advised if used during breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause profound central nervous system depression, respiratory depression, and cardiovascular collapse. Management includes immediate discontinuation of the drug, maintenance of a patent airway, assisted ventilation with oxygen, and support of circulation with fluids and vasopressors. There is no specific antidote. Hemodialysis and hemoperfusion are not effective due to the high lipid solubility and large volume of distribution. Supportive care in an intensive care unit is essential until the patient recovers.
⏰ Missed Dose
This medicine is administered by healthcare professionals in a controlled setting, so missed doses are not applicable. If a scheduled dose is missed, the medical team will determine the appropriate action based on the clinical situation.
Additional Safety Advice
This medicine must be administered only by a qualified anesthesia provider in a hospital or surgical center with continuous monitoring of heart rate, blood pressure, oxygen saturation, and respiratory function. Resuscitation equipment and medications must be immediately available. Patients should inform their doctor of any allergies, especially to barbiturates, and of any history of asthma, heart disease, liver disease, kidney disease, or porphyria. This medicine should not be used during pregnancy unless clearly necessary, and it is not recommended during breastfeeding. Avoid alcohol and other central nervous system depressants before and after receiving this medicine. Do not attempt to drive or operate machinery for at least 24 hours after administration. Report any signs of infection at the injection site, such as redness, swelling, or pain.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the effects of this medicine due to decreased hepatic metabolism, decreased cardiac output, and altered body composition. Lower doses should be used, and the dose should be titrated carefully. Close monitoring of vital signs is essential. The risk of prolonged sedation and cardiovascular depression is higher.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before receiving this medicine. Thiopental sodium crosses the placenta and may cause respiratory depression in the newborn. It should be used during pregnancy only if clearly needed. If you are pregnant and require surgery, your anesthesia team will choose the safest agent for you and your baby.
🏥 Post-Surgery Considerations
After surgery, you will be monitored in a recovery area until you are fully awake and your vital signs are stable. You may experience drowsiness, nausea, or dizziness. Follow your surgeon's instructions regarding activity, diet, and medications. Do not drive or operate machinery for at least 24 hours. Contact your doctor if you experience severe pain, bleeding, fever, or difficulty breathing.
🦷 Dental Procedures
This medicine is not typically used for dental procedures, which usually require local anesthesia or conscious sedation. If you are scheduled for dental work and have received this medicine recently, inform your dentist. You may need to postpone non-urgent dental procedures until you have fully recovered.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities requiring coordination for at least 24 hours after receiving this medicine. You may feel drowsy or dizzy, so take time to recover before resuming your normal routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and impair your ability to drive or operate machinery for up to 24 hours after administration. You should not return to work or perform any hazardous tasks until you have fully recovered and your doctor has cleared you. Plan to take the day off after your procedure.
🛑 When to Stop This Medicine
This medicine is given as a single dose or short infusion by a healthcare professional. You do not need to stop it yourself. If you experience any unusual symptoms after the procedure, contact your doctor immediately.
📅 Long-Term Use Effects
Long-term use of this medicine is not common, as it is typically used for short procedures. However, prolonged infusion in critical care can lead to accumulation in fat tissue, resulting in prolonged sedation and delayed recovery. Tolerance and dependence can develop with extended use. Regular monitoring of liver and kidney function is advised for patients receiving prolonged therapy. There is no evidence of long-term organ damage with occasional use.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
An alternative intravenous anesthetic with a faster recovery profile.
Evidence: Well-establishedAn alternative with minimal cardiovascular effects, suitable for hemodynamically unstable patients.
Evidence: Well-establishedAn alternative with analgesic properties, useful in certain patient populations.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, if you are scheduled for surgery, inform your doctor about any recent vaccinations. Live vaccines should be avoided around the time of surgery due to potential immune suppression from the stress of surgery and anesthesia.
📦 Storage Guide
✅ DO
Store below 25°C, protected from light
❌ DON'T
Do not freeze
✅ DO
Reconstitute immediately before use
❌ DON'T
Do not store reconstituted solution
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✈️ Traveling with This Medicine
This medicine is administered only in a hospital setting and is not for self-administration. Patients who have received this medicine should not travel alone immediately after the procedure. It is advisable to have a responsible adult accompany you for at least 24 hours. If you are traveling after a procedure, carry a copy of your prescription and medical records. Do not drive or operate heavy machinery. Store any remaining medication as directed by the hospital; do not carry it in personal luggage unless prescribed for emergency use, which is rare. Always declare controlled substances to customs if traveling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine works very quickly, usually within 30 to 60 seconds after intravenous injection.
A: You may feel a brief burning sensation at the injection site, but you will quickly become unconscious.
A: A single dose typically produces anesthesia for 5 to 20 minutes, but additional doses can prolong the effect.
A: No, you should not drive or operate machinery for at least 24 hours after receiving this medicine. Arrange for someone to drive you home.
A: Pediatric dosing is not established from available information. Consult a pediatric anesthesiologist.
🤔 Common Patient Concerns
🔄 Substitutes for ithiofast injection
View AllAlternative brands with exact same active ingredient:
-
anesthal 1gm injectionJagsonpal Pharmaceuticals Ltd ₹40.57 20.1% CHEAPER
-
thiosol 1 gm injectionNeon Laboratories Ltd ₹48.00 5.5% CHEAPER
-
Thipen 1gm InjectionSamarth Life Sciences Pvt Ltd ₹51.58 1.6% COSTLIER
-
Thioz 1gm InjectionBharat Serums & Vaccines Ltd ₹72.11 42% COSTLIER
-
thiopental 1gm injectionVhb Life Sciences Inc ₹72.90 43.6% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Thiopental sodium is used for execution by lethal injection.
Fact: While thiopental sodium has been used in lethal injection protocols in some countries, its medical use is for anesthesia and is strictly regulated. This information is not relevant to its clinical use. - Myth: Thiopental sodium is a painkiller.
Fact: Thiopental sodium is an anesthetic agent that induces unconsciousness; it does not provide pain relief after waking. Additional analgesics are needed for postoperative pain. - Myth: Thiopental sodium can be taken at home.
Fact: This medicine is a controlled substance and must be administered only by healthcare professionals in a hospital setting.
🔄 Alternative Options
Generic Alternatives
- Thiopental sodium
Brand Alternatives
- Thiosol 1 gm injection