Afitra-SB 50 Capsule (Itraconazole 50 mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of the skin or eyes, or dark urine
- Severe tiredness or upper abdominal pain
- Shortness of breath or swelling of the legs
- Sudden weight gain or worsening heart failure symptoms
- Swelling of the face, lips, or throat, or difficulty breathing
- Widespread blistering rash or fever with rash
- Numbness, tingling, or burning in the hands or feet
- Ringing in the ears or reduced hearing
If experiencing severe symptoms, call emergency services immediately.
What is it-mac sb capsule used for?
This medicine is a prescription antifungal capsule containing itraconazole 50 mg. It treats fungal infections of the skin, nails, mouth, and internal organs by weakening the fungal cell membrane. It is taken orally with food, usually once or twice daily, and the dose depends on the infection being treated.
- Generic Name: Itraconazole (50mg)
- Manufacturer: Macleods Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 it-mac sb capsule के बारे में (Hindi Summary)
उपयोग: यह दवा एक प्रिस्क्रिप्शन एंटीफंगल कैप्सूल है जिसमें इट्राकोनाज़ोल 50 मिलीग्राम होता है। यह त्वचा, नाखून, मुँह और शरीर के अंदर होने वाले फंगल संक्रमणों के इलाज के लिए इस्तेमाल की जाती है। यह फंगस की कोशिका की दीवार को कमजोर करके उसे बढ़ने से रोकती है। इसे खाने के साथ लेना चाहिए ताकि यह अच्छी तरह से अवशोषित हो सके। इस दवा का सेवन डॉक्टर के बताए अनुसार ही करें और कोर्स पूरा करें, भले ही लक्षण ठीक हो जाएँ।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, पेट दर्द, सिरदर्द और हल्का दाना शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। कभी-कभी चक्कर आना, स्वाद में बदलाव या पैरों में सूजन हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन लीवर की समस्या, दिल की विफलता बढ़ना या गंभीर एलर्जी हो सकती है। अगर आँखों या त्वचा का रंग पीला पड़े, पेशाब गहरा हो, या साँस लेने में तकलीफ हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें और कोर्स पूरा करें। इसे भोजन के साथ पूरे पानी के साथ निगलें। इस दवा के साथ अंगूर या अंगूर का जूस न लें, क्योंकि इससे दवा का स्तर बढ़ सकता है। शराब न पिएँ, क्योंकि इससे लीवर को नुकसान का खतरा बढ़ता है। अपने डॉक्टर को अपनी सभी दवाओं, सप्लीमेंट्स और हर्बल उत्पादों के बारे में बताएं। अगर आप गर्भवती हैं या गर्भधारण की योजना बना रही हैं, तो यह दवा न लें। इलाज के दौरान और आखिरी खुराक के बाद कम से कम दो महीने तक प्रभावी गर्भनिरोधक का इस्तेमाल करें।
💊 it-mac sb capsule Uses & Benefits
[{"condition":"Onychomycosis (fungal nail infection)","description":"This medicine is used in pulsed or continuous regimens to clear dermatophyte infections of the fingernails and toenails.","evidence":"Well-established"},{"condition":"Tinea corporis, cruris, and pedis","description":"This medicine treats persistent or extensive ringworm infections of the body, groin, and feet when topical therapy is inadequate.","evidence":"Well-established"},{"condition":"Oral candidiasis","description":"This medicine is used for oropharyngeal candidiasis, especially in immunocompromised patients or when topical agents fail.","evidence":"Well-established"},{"condition":"Vulvovaginal candidiasis","description":"This medicine may be prescribed for recurrent or complicated vaginal yeast infections that do not respond to topical treatment.","evidence":"Well-established"},{"condition":"Systemic fungal infections","description":"This medicine is used in histoplasmosis, blastomycosis, and aspergillosis in selected patients, often under specialist care.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Seborrheic dermatitis","description":"Sometimes prescribed off-label when Malassezia yeast is thought to play a role in persistent cases.","evidence":"Limited"},{"condition":"Fungal keratitis","description":"Rarely used off-label as part of combination therapy for certain corneal fungal infections under ophthalmology supervision.","evidence":"Limited"}]
Primary treatment for: Fungal infections
Also treats: Onychomycosis, Tinea corporis, Tinea cruris, Tinea pedis, Oral candidiasis, Vulvovaginal candidiasis, Histoplasmosis, Blastomycosis, Aspergillosis
📋 Drug Information
| Generic Name(s) | Itraconazole (50mg) |
| Brand Name | it-mac sb capsule |
| Manufacturer | Macleods Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | OPHTHAL |
| Action Class | Fungal ergosterol synthesis inhibitor |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature between 15°C and 30°C, away from direct sunlight and moisture. Keep it in its original container and out of reach of children. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture. Check the expiry date on the pack before use. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting the fungal cytochrome P450 enzyme 14-alpha-demethylase, which is needed to convert lanosterol into ergosterol. Ergosterol is an essential building block of the fungal cell membrane. When this step is blocked, the membrane becomes weak and leaky, and the fungus cannot grow or divide. Because human cells use cholesterol instead of ergosterol, this medicine has a much greater effect on fungal cells than on human cells, which is why it is relatively selective. However, the same enzyme family is involved in many human drug pathways, which explains why this medicine interacts with so many other medicines.
Mechanism Steps
💡 How to Take it-mac sb capsule
Strength: This medicine is available as an immediate-release capsule containing 50 mg of itraconazole.
Dosage Information
| Adult Dosage | The dose of this medicine depends on the type and severity of the fungal infection. For skin infections, a common regimen is 100 to 200 mg once daily for one to two weeks. For nail infections, a pulsed regimen of 200 mg twice daily for one week per month for two to three months is often used. For systemic infections, higher doses and longer durations may be needed. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially heart and liver effects. The dose should be individualized by a qualified clinician, and liver and heart function should be monitored closely. |
| Renal Impairment | Mild to moderate kidney impairment usually does not require a dose adjustment. In severe kidney impairment, this medicine should be used with caution, and the dose may need to be individualized by a qualified clinician. |
| Hepatic Impairment | This medicine should be used with caution in patients with liver disease. Liver function should be monitored, and the dose may need to be reduced or the medicine avoided in severe liver impairment. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum daily dose of this medicine depends on the indication and is determined by a qualified clinician. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of it-mac sb capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Simvastatin | Major | |
| Midazolam | Major | |
| Rifampicin | Major | |
| Omeprazole | Moderate | |
| Amlodipine | Moderate | |
| Cyclosporine | Moderate | |
| Metformin | Moderate | |
| Paracetamol | Minor | |
| Loratadine | Minor |
🚨 Major Interactions
- Cisapride, pimozide, quinidine, and other QT-prolonging drugs
- Midazolam and triazolam
- HMG-CoA reductase inhibitors (statins) such as simvastatin and lovastatin
- Ergot alkaloids such as ergotamine and dihydroergotamine
- Rifampicin, rifabutin, and carbamazepine
⚡ Moderate Interactions
- Warfarin
- Proton pump inhibitors and antacids
- Calcium channel blockers such as nifedipine and amlodipine
- Oral hypoglycemics and insulin
- Cyclosporine and tacrolimus
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because both are processed by the liver and combining them increases the risk of liver injury. Alcohol can also worsen nausea, stomach pain, and dizziness. If you drink regularly, discuss this with your doctor before starting treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to itraconazole or any other ingredient in this medicine","Heart failure or a history of heart failure","Pregnancy or planning to become pregnant","Use with certain medicines that are contraindicated with this medicine, such as cisapride, pimozide, quinidine, ergot alkaloids, simvastatin, and lovastatin","Severe liver disease"]
⚠️ Warnings & Precautions
["Tell your doctor if you have heart failure, liver disease, kidney disease, or any heart rhythm problem.","Avoid grapefruit and grapefruit juice while taking this medicine.","Do not drink alcohol during treatment.","Use effective contraception during treatment and for at least two months after the last dose.","Tell your doctor about all other medicines, supplements, and herbal products you take.","Do not stop this medicine without consulting your doctor, even if you feel better.","Report any signs of liver problems, such as yellowing of the eyes or skin, dark urine, or severe tiredness, immediately."]
🤱 Lactation Safety
This medicine passes into breast milk in small amounts. Because of the potential for serious side effects in a nursing infant, breastfeeding is generally not recommended while taking this medicine. Discuss alternative feeding options with your doctor.
💊 Overdose Management
If you take more than the prescribed dose of this medicine, contact your doctor or a poison control center immediately. There is no specific antidote for this medicine. Treatment is supportive and may include monitoring of vital signs, liver function, and heart rhythm. Do not try to vomit unless instructed by a medical professional.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember if there is still a long time before your next dose. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed and complete the full course even if you feel better. Swallow the capsule whole with a full glass of water, ideally after a meal, because food improves absorption. Avoid grapefruit and grapefruit juice while taking this medicine, as they can raise drug levels in your body. Do not drink alcohol, because it increases the risk of liver problems. Tell your doctor about all other medicines, supplements, and herbal products you use, especially those for heartburn, cholesterol, or heart rhythm. If you have heart failure, liver disease, or kidney disease, your doctor may need to adjust or avoid this medicine. Do not take this medicine if you are pregnant or trying to conceive. Use effective contraception during treatment and for at least two months after the last dose. Keep all follow-up appointments so your doctor can monitor your liver and heart health.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have heart and liver problems and to take other medicines. This medicine should be used with caution, and liver and heart function should be monitored. The dose may need to be individualized by a qualified clinician.
🤰 Pregnancy Planning (TTC)
This medicine should not be used if you are pregnant or planning to become pregnant. Use effective contraception during treatment and for at least two months after the last dose. If you become pregnant while taking this medicine, contact your doctor immediately.
🏥 Post-Surgery Considerations
Tell your surgeon and anesthesiologist that you are taking this medicine before any surgery. This medicine can interact with many medicines used during and after surgery, and it may need to be stopped temporarily. Do not stop it without your doctor's advice.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. This medicine can interact with some medicines used in dentistry, and it may affect bleeding risk if you take blood thinners. Your dentist may need to consult your doctor before the procedure.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you. Mild exercise is usually fine, but if you have heart failure or feel short of breath, stop and seek medical advice.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
Most people can continue their normal work and daily activities while taking this medicine. However, if you feel dizzy or unusually tired, avoid driving or operating machinery until you feel better. Keep your doctor informed if your work involves heavy machinery or if you need to travel.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. Complete the full course prescribed by your doctor, even if you feel better. If you experience serious side effects such as yellowing of the eyes or skin, severe tiredness, shortness of breath, or swelling of the legs, stop the medicine and seek medical help immediately. Your doctor will decide whether to stop or change the treatment.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of liver injury, heart failure, and nerve problems. Your doctor may monitor your liver function and heart health during prolonged treatment. If you need long-term therapy, regular follow-up is important to detect side effects early and to adjust the dose if needed.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Creams and ointments may be enough for mild skin fungal infections.
Evidence: Well-establishedAn alternative oral antifungal for skin and nail infections with fewer drug interactions.
Evidence: Well-establishedAnother oral antifungal often used for yeast infections.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and routine vaccines. However, if you are immunocompromised, discuss vaccination timing with your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage so it stays at room temperature and does not get lost. If you are crossing time zones, ask your doctor how to adjust the timing of your doses. Avoid grapefruit and alcohol during travel. Check the customs rules of your destination for prescription medicines, and carry enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Skin infections may start improving within one to two weeks. Nail infections can take several months because the infected nail must grow out.
A: Yes, take it with a meal, preferably one that contains some fat, because food improves absorption.
A: No, alcohol should be avoided because it increases the risk of liver problems and stomach side effects.
A: No, this medicine should not be used during pregnancy because it can harm the developing baby. Use effective contraception during treatment and for at least two months after the last dose.
A: If you remember soon after the missed dose, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and continue your regular schedule. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for it-mac sb capsule
View AllAlternative brands with exact same active ingredient:
-
itgo 50dt tabletSalsim Pharma Pvt Ltd ₹83.44 18.3% CHEAPER
-
subitral 50mg capsuleIndoco Remedies Ltd ₹84.38 17.3% CHEAPER
-
candiforce-sb 50 capsuleMankind Pharma Ltd ₹98.44 3.6% CHEAPER
-
flucos itz 50 capsuleOaknet Healthcare Pvt Ltd ₹110.00 7.7% COSTLIER
-
itaspor-sb capsuleIntas Pharmaceuticals Ltd ₹112.50 10.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any skin rash.
Fact: This medicine only treats fungal infections. It does not work for bacterial, viral, or allergic rashes. - Myth: You can stop this medicine as soon as the symptoms go away.
Fact: Stopping too early can allow the fungal infection to return. Always complete the full course prescribed by your doctor. - Myth: This medicine is safe to take with any other medicine.
Fact: This medicine interacts with many medicines and can cause serious problems. Always tell your doctor about everything you take. - Myth: This medicine is safe during pregnancy.
Fact: This medicine should not be used during pregnancy because it can harm the developing baby.
🔄 Alternative Options
Generic Alternatives
- Itraconazole 50 mg capsule
Brand Alternatives
- Afitra-SB 50 Capsule