Isorifazin S 100 mg/50 mg/300 mg Tablet: Complete Information
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of skin or eyes (jaundice)
- Dark urine or pale stools
- Severe abdominal pain
- Persistent nausea and vomiting
- Tingling or numbness in hands and feet
- Vision changes
- Rash or skin peeling
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is isorifazin s 100 mg/50 mg/300 mg tablet used for?
This medicine is a combination of isoniazid and pyrazinamide used to treat tuberculosis. It works by killing the bacteria that cause TB. It must be taken exactly as prescribed for the full duration to prevent resistance.
- Generic Name: Isoniazid (100mg) + Pyrazinamide (50mg)
- Manufacturer: PCI Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 isorifazin s 100 mg/50 mg/300 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा तपेदिक (टीबी) के इलाज के लिए इस्तेमाल की जाती है। इसमें आइसोनियाजिड और पायराजिनामाइड दो सक्रिय तत्व होते हैं जो टीबी के बैक्टीरिया को मारते हैं। यह दवा अकेले नहीं ली जाती, बल्कि अन्य टीबी की दवाओं के साथ मिलकर इलाज का हिस्सा होती है। डॉक्टर के बताए अनुसार पूरा कोर्स करना बहुत जरूरी है, वरना बीमारी दोबारा हो सकती है और दवा का असर कम हो सकता है।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में जी मिचलाना, उल्टी, पेट दर्द, भूख न लगना और थकान शामिल हैं। कुछ लोगों में हाथ-पैरों में झनझनाहट या सुन्नपन हो सकता है। गंभीर दुष्प्रभावों में लिवर को नुकसान, त्वचा पर गंभीर रैश, और खून की बीमारियां शामिल हैं। अगर आपको पीलिया, गहरे रंग का पेशाब, या त्वचा पर चकत्ते दिखें तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। कोर्स पूरा करें, बीच में न छोड़ें। शराब न पिएं क्योंकि इससे लिवर को नुकसान हो सकता है। नियमित रूप से लिवर की जांच कराएं। अगर आपको मधुमेह, गाउट, या लिवर की बीमारी है तो डॉक्टर को बताएं। बिना डॉक्टर की सलाह के यह दवा न लें।
💊 isorifazin s 100 mg/50 mg/300 mg tablet Uses & Benefits
[{"condition":"Active Tuberculosis","description":"Used as part of a combination regimen for the treatment of active tuberculosis caused by susceptible strains of Mycobacterium tuberculosis.","evidence":"Well-established"},{"condition":"Latent Tuberculosis Infection","description":"Isoniazid alone is used for latent TB, but this combination is not typically used for latent TB.","evidence":"Not established from the available information."}]
Off-label uses: []
Primary treatment for: Tuberculosis
Also treats: Latent tuberculosis infection (isoniazid component)
📋 Drug Information
| Generic Name(s) | Isoniazid (100mg) + Pyrazinamide (50mg) |
| Brand Name | isorifazin s 100 mg/50 mg/300 mg tablet |
| Manufacturer | PCI Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization recommends isoniazid and pyrazinamide as part of standard antitubercular regimens for drug-susceptible tuberculosis. |
| ICMR Guideline | The Indian Council of Medical Research recommends similar regimens for tuberculosis treatment in India. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antitubercular agents with distinct mechanisms. Isoniazid is a prodrug activated by the bacterial catalase-peroxidase enzyme KatG. It inhibits the synthesis of mycolic acid, a vital component of the mycobacterial cell wall, leading to cell death. Pyrazinamide is also a prodrug converted to pyrazinoic acid by the bacterial enzyme pyrazinamidase. It disrupts membrane transport and energy production, particularly in acidic environments. Together, they are bactericidal against Mycobacterium tuberculosis.
Mechanism Steps
💡 How to Take isorifazin s 100 mg/50 mg/300 mg tablet
Strength: Tablet containing isoniazid 100 mg and pyrazinamide 50 mg.
Dosage Information
| Adult Dosage | The dosage of this medicine is individualized based on the patient's weight, age, renal and hepatic function, and the specific treatment regimen for tuberculosis. It is typically used as part of a combination therapy. The standard adult dose of isoniazid is 5 mg/kg/day (usual range 4-6 mg/kg/day) and pyrazinamide is 15-30 mg/kg/day. However, this fixed-dose combination may not provide the exact required doses for all patients. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal and hepatic function; dose adjustment may be necessary. Monitor closely for side effects. |
| Renal Impairment | Dose adjustment may be required in patients with severe renal impairment (creatinine clearance <30 mL/min). Monitor renal function and adjust dose as needed. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose reduction may be necessary. Contraindicated in severe liver disease. |
| Maximum Daily Dose | The maximum daily dose depends on the individual patient's weight and clinical response. For isoniazid, the usual maximum is 300 mg/day; for pyrazinamide, the usual maximum is 2 g/day. However, this fixed-dose combination may not be suitable for all patients. Follow your doctor's prescription. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of isorifazin s 100 mg/50 mg/300 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Rifampicin | Major | |
| Phenytoin | Major | |
| Warfarin | Major | |
| Carbamazepine | Major | |
| Alcohol | Major | |
| Ketoconazole | Moderate | |
| Cycloserine | Moderate | |
| Ethionamide | Moderate | |
| Antacids | Minor | |
| Tyramine-rich foods | Major |
🚨 Major Interactions
- Rifampicin
- Alcohol
- Phenytoin
- Carbamazepine
- Warfarin
⚡ Moderate Interactions
- Ketoconazole
- Cycloserine
- Ethionamide
🍷 Alcohol Interaction
Avoid alcohol consumption while taking this medicine. Alcohol increases the risk of hepatotoxicity and may reduce the effectiveness of treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to isoniazid or pyrazinamide","Severe liver disease","Acute gout","Previous isoniazid-induced hepatitis"]
⚠️ Warnings & Precautions
["Monitor liver function closely; discontinue if signs of hepatotoxicity occur.","Use with caution in patients with diabetes, as isoniazid may affect blood sugar control.","Pyridoxine (vitamin B6) supplementation may be needed to prevent peripheral neuropathy, especially in malnourished patients, diabetics, and those with HIV.","Avoid alcohol consumption.","Use with caution in patients with renal impairment; dose adjustment may be required.","May interfere with urine glucose tests; use enzymatic methods instead."]
🤱 Lactation Safety
Isoniazid and pyrazinamide are excreted in breast milk in small amounts. They are generally considered compatible with breastfeeding, but monitoring for infant side effects is advised. Consult your doctor.
💊 Overdose Management
Overdose can cause nausea, vomiting, dizziness, slurred speech, hallucinations, and seizures. Seek immediate medical attention. Treatment is supportive and symptomatic. Hemodialysis may be considered in severe cases.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop treatment early, as this can lead to treatment failure and drug resistance. Regular monitoring of liver function tests, uric acid levels, and complete blood counts is recommended. Avoid alcohol consumption while taking this medicine, as it increases the risk of liver damage. Inform your doctor if you have a history of liver disease, gout, diabetes, or kidney problems. If you experience symptoms of liver injury such as nausea, vomiting, dark urine, or yellowing of the eyes, seek medical attention immediately. Do not take this medicine without a prescription. Keep all appointments with your healthcare provider for monitoring and follow-up.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to side effects, especially hepatotoxicity and peripheral neuropathy. Regular monitoring of liver and kidney function is advised. Dose adjustment may be necessary.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor. This medicine is considered safe during pregnancy when used for TB. Untreated TB is more dangerous to both mother and baby.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist about this medicine before any surgery. It may interact with other medications used during surgery.
🦷 Dental Procedures
Inform your dentist about this medicine before any dental procedure. It may interact with certain antibiotics or anesthetics.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but if you experience fatigue or dizziness, avoid strenuous activities. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue in some patients. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal activities, but take precautions.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects such as jaundice, severe rash, or persistent vomiting, contact your doctor immediately. Your doctor will decide whether to adjust the dose or stop treatment.
📅 Long-Term Use Effects
Long-term use of this medicine is generally well-tolerated when monitored appropriately. However, prolonged use can increase the risk of peripheral neuropathy and hepatotoxicity. Regular monitoring of liver function and clinical assessments are necessary. Most side effects are reversible upon discontinuation.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A strategy to ensure patients take their TB medicines regularly under supervision.
Evidence: Well-establishedAdequate nutrition helps improve treatment outcomes.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
BCG vaccination is used to prevent severe forms of TB in children. This medicine is used for treatment, not prevention. Inform your doctor about your vaccination status.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Ensure you have enough supply for the entire trip. Store at room temperature and protect from direct sunlight. If crossing time zones, consult your doctor about adjusting the timing of doses. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within days, but full treatment for tuberculosis usually takes 6 months or more. You may start feeling better within a few weeks, but it is crucial to complete the full course.
A: No, you must complete the full course as prescribed. Stopping early can lead to relapse and drug-resistant tuberculosis.
A: Take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
🤔 Common Patient Concerns
🔄 Substitutes for isorifazin s 100 mg/50 mg/300 mg tablet
View AllAlternative brands with exact same active ingredient:
-
Rhz Kid 100 mg/50 mg/300 mg TabletOverseas Healthcare Pvt Ltd ₹18.89 76.7% CHEAPER
-
montorip kid 100mg/50mg/300mg tabletShreya Life Sciences Pvt Ltd ₹20.42 74.8% CHEAPER
-
vicox 3 kid tabletShrinivas Gujarat Laboratories Pvt Ltd ₹32.81 59.6% CHEAPER
-
r-cinex z kid tabletLupin Ltd ₹43.64 46.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: TB treatment can be stopped once symptoms improve.
Fact: Treatment must be completed for the full duration to prevent relapse and drug resistance. - Myth: This medicine can be taken without monitoring.
Fact: Regular monitoring of liver function and other parameters is essential.
🔄 Alternative Options
Generic Alternatives
- Isoniazid and Pyrazinamide combination tablets from other manufacturers