Isorifazin Forte 300 mg/200 mg Tablet: Complete Guide to Uses, Dosage, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of skin or eyes (jaundice)
- Dark urine or pale stools
- Severe abdominal pain
- Persistent nausea and vomiting
- Sudden severe joint pain, especially in the big toe
- Numbness, tingling, or burning in hands or feet
- Blurred vision or loss of color vision
- Seizures
- Difficulty breathing or swelling of face, lips, or throat
- Unusual bruising or bleeding
If experiencing severe symptoms, call emergency services immediately.
What is isorifazin forte 300 mg/200 mg/750 mg tablet used for?
This medicine is a combination of isoniazid and pyrazinamide, two antibiotics used to treat tuberculosis. It works by killing the bacteria that cause TB. It is taken orally, usually once daily, as part of a multi-drug regimen. It must be taken exactly as prescribed to prevent resistance.
- Generic Name: Isoniazid (300mg) + Pyrazinamide (200mg)
- Manufacturer: PCI Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 isorifazin forte 300 mg/200 mg/750 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा इशोनियाजिड और पायराजिनामाइड का संयोजन है, जिसका उपयोग तपेदिक (टीबी) के इलाज के लिए किया जाता है। यह बैक्टीरिया को मारकर काम करती है और आमतौर पर अन्य टीबी दवाओं के साथ दी जाती है। इसे डॉक्टर के निर्देशानुसार नियमित रूप से लेना बहुत जरूरी है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, उल्टी, भूख न लगना, पेट दर्द और थकान शामिल हैं। कुछ लोगों को चक्कर आना, सिरदर्द या त्वचा पर दाने हो सकते हैं। गंभीर दुष्प्रभावों में लिवर को नुकसान, पैरों में झनझनाहट, और गाउट का दौरा शामिल है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे रोज एक ही समय पर लें। इलाज के दौरान शराब बिल्कुल न पिएं क्योंकि इससे लिवर को गंभीर नुकसान हो सकता है। अगर आपको पहले से लिवर की बीमारी, गाउट या मधुमेह है तो डॉक्टर को बताएं। नियमित रूप से लिवर की जांच कराते रहें। दवा को बच्चों की पहुंच से दूर रखें।
💊 isorifazin forte 300 mg/200 mg/750 mg tablet Uses & Benefits
[{"condition":"Active pulmonary tuberculosis","description":"Used as part of a combination regimen during the intensive phase to rapidly kill Mycobacterium tuberculosis and reduce transmission.","evidence":"Well-established"},{"condition":"Extrapulmonary tuberculosis","description":"Effective in treating tuberculosis affecting lymph nodes, pleura, bones, joints, and other sites when combined with other antitubercular drugs.","evidence":"Well-established"},{"condition":"Tuberculous meningitis","description":"Included in initial therapy for tuberculous meningitis due to its ability to penetrate the cerebrospinal fluid, especially when inflammation is present.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Latent tuberculosis infection","description":"Isoniazid alone is standard for latent TB, but this combination is not typically used for latent infection.","evidence":"Not established from the available information."}]
Primary treatment for: Tuberculosis
Also treats: Tuberculous meningitis, Extrapulmonary tuberculosis, Pulmonary tuberculosis
📋 Drug Information
| Generic Name(s) | Isoniazid (300mg) + Pyrazinamide (200mg) |
| Brand Name | isorifazin forte 300 mg/200 mg/750 mg tablet |
| Manufacturer | PCI Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture and direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization recommends isoniazid and pyrazinamide as part of first-line treatment for drug-susceptible tuberculosis. The standard regimen includes a 2-month intensive phase with isoniazid, rifampicin, pyrazinamide, and ethambutol, followed by a continuation phase with isoniazid and rifampicin. |
| ICMR Guideline | The Indian Council of Medical Research and the Revised National Tuberculosis Control Program (RNTCP) recommend isoniazid and pyrazinamide in the intensive phase of tuberculosis treatment, in combination with rifampicin and ethambutol, followed by a continuation phase. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antitubercular agents with distinct mechanisms. Isoniazid is a prodrug activated by the mycobacterial catalase-peroxidase enzyme (KatG). The activated form inhibits InhA, an enoyl-acyl carrier protein reductase, blocking mycolic acid synthesis and disrupting the bacterial cell wall. Pyrazinamide is also a prodrug converted by mycobacterial pyrazinamidase to pyrazinoic acid, which disrupts membrane transport and energy production, particularly in acidic environments within macrophages. Together, they inhibit growth and kill Mycobacterium tuberculosis.
Mechanism Steps
💡 How to Take isorifazin forte 300 mg/200 mg/750 mg tablet
Strength: Each tablet contains isoniazid 300 mg and pyrazinamide 200 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet daily, but the exact dose and duration depend on the type and severity of tuberculosis, patient weight, and other medications in the regimen. This medicine is typically part of a combination regimen that may include rifampicin, ethambutol, and/or streptomycin. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced liver and kidney function, increasing the risk of toxicity. Dose adjustment may be necessary based on renal and hepatic function. Close monitoring is recommended. |
| Renal Impairment | In patients with severe renal impairment (creatinine clearance <30 mL/min), dose reduction or extended dosing intervals may be required. Consult a nephrologist or clinical pharmacist for guidance. |
| Hepatic Impairment | Use with extreme caution in patients with pre-existing liver disease. Dose reduction or alternative regimens may be necessary. Regular monitoring of liver function is essential. |
| Maximum Daily Dose | The maximum daily dose is typically one tablet of this strength, but the exact maximum depends on the prescribed regimen. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of isorifazin forte 300 mg/200 mg/750 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Rifampicin | Major | |
| Alcohol | Major | |
| Phenytoin | Major | |
| Carbamazepine | Major | |
| Warfarin | Major | |
| Acetaminophen | Moderate | |
| Ketoconazole | Moderate | |
| Probenecid | Moderate | |
| Antacids | Minor | |
| Caffeine | Minor |
🚨 Major Interactions
- Rifampicin
- Alcohol
- Phenytoin
- Carbamazepine
- Warfarin
⚡ Moderate Interactions
- Acetaminophen (paracetamol)
- Ketoconazole
- Probenecid
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Both isoniazid and pyrazinamide can cause liver damage, and alcohol significantly increases this risk. Alcohol may also worsen peripheral neuropathy caused by isoniazid.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to isoniazid or pyrazinamide","Severe liver disease (e.g., acute hepatitis, decompensated cirrhosis)","Acute gout","Previous isoniazid-induced liver injury","Severe renal impairment (creatinine clearance
⚠️ Warnings & Precautions
["Monitor liver function closely; discontinue if signs of hepatotoxicity occur.","Use with caution in patients with diabetes, alcohol use disorder, or malnutrition due to risk of peripheral neuropathy.","May cause hyperuricemia; monitor uric acid levels and manage gout appropriately.","Patients should avoid alcohol completely during treatment.","Use effective contraception during treatment; consult doctor if pregnancy occurs.","May interact with many drugs; review all medications with your doctor.","Do not use for latent TB without specialist advice.","Complete the full course to prevent resistance."]
🤱 Lactation Safety
Isoniazid and pyrazinamide are excreted in breast milk in small amounts. The American Academy of Pediatrics considers isoniazid compatible with breastfeeding. Pyrazinamide is also generally considered safe. However, monitor the infant for jaundice or unusual drowsiness. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause severe liver toxicity, seizures, and metabolic acidosis. If overdose is suspected, seek emergency medical care immediately. Treatment is supportive and may include activated charcoal if within 1-2 hours of ingestion, management of seizures, and monitoring of liver and kidney function. Hemodialysis may be considered in severe cases.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, usually once daily with or without food. Do not skip doses or stop treatment early, even if you feel better, because incomplete treatment can lead to drug-resistant tuberculosis. Avoid alcohol completely while taking this medicine, as it increases the risk of liver damage. Inform your doctor if you have a history of liver disease, gout, diabetes, or alcohol use. Your doctor will monitor your liver function and uric acid levels regularly. Use effective contraception during treatment if you are of childbearing age. If you miss a dose, take it as soon as you remember unless it is almost time for the next dose; do not double the dose. Keep this medicine out of reach of children and store it in a cool, dry place.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of liver toxicity and peripheral neuropathy. Dose adjustment may be needed based on liver and kidney function. Close monitoring is recommended. They should also be monitored for falls due to dizziness.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting this medicine. Tuberculosis treatment is essential during pregnancy, but the regimen may need adjustment. Use effective contraception while taking this medicine and consult your doctor if you become pregnant.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents. Your doctor may advise temporary adjustment of the dose. Do not stop the medicine without medical advice.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may interact with certain antibiotics or anesthetics. Maintain good oral hygiene to prevent infections.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may feel tired or dizzy. Avoid heavy lifting or strenuous exercise until you know how the medicine affects you. Light exercise like walking is generally safe if you feel up to it. Consult your doctor before starting any new exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, tiredness, or nausea, which can affect your ability to drive or operate machinery. Avoid driving until you know how it affects you. You may need to take time off work during the initial phase of treatment, especially if you have active TB and are infectious. Once you are no longer contagious, you can usually return to work. Discuss with your doctor about when it is safe to resume normal activities.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Stopping early can lead to treatment failure, relapse, and drug-resistant tuberculosis. If you experience severe side effects, contact your doctor immediately; they may adjust your treatment. Only stop if your doctor advises you to do so.
📅 Long-Term Use Effects
Long-term use of this medicine is typically limited to the duration of tuberculosis treatment, usually 6 to 9 months. Prolonged use beyond this period is not recommended without specialist guidance. Potential long-term effects include liver damage, peripheral neuropathy, and hyperuricemia. Regular monitoring of liver function, uric acid levels, and neurological symptoms is essential. Most side effects are reversible upon discontinuation.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A healthcare worker observes the patient taking each dose to ensure adherence.
Evidence: Well-establishedAdequate nutrition helps improve treatment outcomes and reduce side effects.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Patients with active tuberculosis should complete treatment before receiving live vaccines. Inactivated vaccines can be given as needed. BCG vaccination is not a treatment for active TB. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If crossing time zones, continue taking your dose at the same interval as prescribed; consult your doctor for specific advice. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within a few weeks, but the full course must be completed to cure the infection and prevent resistance.
A: No, you must complete the full course as prescribed. Stopping early can lead to relapse and drug-resistant tuberculosis.
A: Avoid alcohol, and limit tyramine-rich foods. Also, inform your doctor about all other medicines you are taking.
A: It can cause liver damage in some people. Your doctor will monitor your liver function regularly. Report any symptoms like yellowing of eyes or skin.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: Tuberculosis treatment can be stopped once symptoms improve.
Fact: Treatment must be completed as prescribed to prevent relapse and drug resistance. - Myth: This medicine can be taken with alcohol.
Fact: Alcohol increases the risk of liver damage and should be avoided completely. - Myth: Isoniazid and pyrazinamide are safe for everyone.
Fact: They are contraindicated in certain conditions like severe liver disease and gout.
🔄 Alternative Options
Generic Alternatives
- Isoniazid 300 mg + Pyrazinamide 200 mg tablet
Brand Alternatives
- Isorifazin Forte 300 mg/200 mg Tablet