Isokin 300 Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of skin or eyes (jaundice)
- Dark urine or pale stools
- Severe abdominal pain, especially in the right upper quadrant
- Persistent nausea and vomiting
- Numbness, tingling, or burning in hands or feet
- Seizures or confusion
- Difficulty breathing or swelling of face, lips, or throat
- Unusual fatigue or weakness
If experiencing severe symptoms, call emergency services immediately.
What is inatos 300mg/10mg tablet used for?
This medicine is a combination of isoniazid 300 mg and pyridoxine 10 mg used to treat and prevent tuberculosis. Isoniazid kills the TB bacteria, while pyridoxine prevents nerve damage caused by isoniazid. It must be taken exactly as prescribed, usually once daily with food, and treatment should not be stopped early.
- Generic Name: Isoniazid (300mg) + Vitamin B6 (Pyridoxine) (10mg)
- Manufacturer: TOSC International Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 inatos 300mg/10mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा इंसोनियाजिड 300 मिलीग्राम और पाइरिडॉक्सिन (विटामिन बी6) 10 मिलीग्राम का संयोजन है। इसका उपयोग तपेदिक (टीबी) के इलाज और रोकथाम के लिए किया जाता है। इंसोनियाजिड टीबी के बैक्टीरिया को मारता है, जबकि पाइरिडॉक्सिन इंसोनियाजिड के कारण होने वाली नर्व डैमेज (पेरिफेरल न्यूरोपैथी) को रोकता है। यह दवा सक्रिय टीबी के लिए अन्य दवाओं के साथ और लेटेंट टीबी के लिए अकेले दी जाती है। इसे डॉक्टर के निर्देशानुसार ही लें, बीच में न छोड़ें।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट में असहजता, भूख न लगना और थकान शामिल हैं। गंभीर दुष्प्रभावों में लिवर की सूजन (पीलिया, गहरे रंग का पेशाब), गंभीर एलर्जी, और दौरे पड़ना शामिल हैं। हाथ-पैरों में झुनझुनी या सुन्नपन हो सकता है, लेकिन पाइरिडॉक्सिन इसे कम करता है। कोई भी असामान्य लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक न छोड़ें और इलाज बीच में न रोकें, वरना टीबी दोबारा हो सकती है और दवा का असर कम हो सकता है। शराब न पिएं क्योंकि इससे लिवर को नुकसान हो सकता है। अगर आपको पीलिया, गहरे रंग का पेशाब, या पेट के दाहिने हिस्से में दर्द हो, तो तुरंत डॉक्टर को बताएं। नियमित रूप से लिवर की जांच कराएं। गर्भवती महिलाएं, मधुमेह रोगी और एचआईवी रोगी डॉक्टर से सलाह लें।
💊 inatos 300mg/10mg tablet Uses & Benefits
[{"condition":"Active tuberculosis","description":"Used in combination with other antitubercular drugs (e.g., rifampicin, pyrazinamide, ethambutol) for the treatment of drug-susceptible active TB.","evidence":"Well-established"},{"condition":"Latent tuberculosis infection","description":"Used as monotherapy or in combination with rifampicin to prevent progression to active TB in individuals with latent infection.","evidence":"Well-established"},{"condition":"Tuberculosis prophylaxis in high-risk individuals","description":"Given to close contacts of active TB patients, especially children and immunocompromised persons, to prevent development of active disease.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Not established from the available information.","description":"Not established from the available information.","evidence":"Not established from the available information."}]
Primary treatment for: Tuberculosis
Also treats: Latent tuberculosis infection, Tuberculosis prophylaxis in high-risk individuals
📋 Drug Information
| Generic Name(s) | Isoniazid (300mg) + Vitamin B6 (Pyridoxine) (10mg) |
| Brand Name | inatos 300mg/10mg tablet |
| Manufacturer | TOSC International Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container, tightly closed. |
| Shelf Life | 24 months from the date of manufacture, unless otherwise specified on the packaging. |
| WHO Guideline | The World Health Organization recommends isoniazid as a first-line antitubercular drug for both drug-susceptible active TB and latent TB infection. Pyridoxine supplementation is recommended to prevent neuropathy, especially in malnourished individuals, pregnant women, and those with HIV. |
| ICMR Guideline | The Indian Council of Medical Research recommends isoniazid as part of the standard regimen for tuberculosis under the Revised National Tuberculosis Control Program (RNTCP). Pyridoxine is co-administered to prevent peripheral neuropathy. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Isoniazid is a prodrug that is activated by the mycobacterial catalase-peroxidase enzyme (KatG). The activated form inhibits InhA, an enoyl-acyl carrier protein reductase, which is essential for the synthesis of mycolic acid, a critical component of the mycobacterial cell wall. This leads to disruption of cell wall synthesis and bacterial death. Pyridoxine (vitamin B6) is included to prevent isoniazid-induced peripheral neuropathy by replenishing pyridoxine stores that isoniazid depletes.
Mechanism Steps
💡 How to Take inatos 300mg/10mg tablet
Strength: Each tablet contains isoniazid 300 mg and pyridoxine (vitamin B6) 10 mg.
Dosage Information
| Adult Dosage | The usual adult dose for active tuberculosis is 5 mg/kg/day (up to 300 mg/day) as part of a combination regimen. For latent tuberculosis, 300 mg once daily for 6-9 months is common. The pyridoxine component is fixed at 10 mg. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and acetylator status. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may require dose adjustment due to reduced renal and hepatic function. Monitor liver function closely and watch for signs of neurotoxicity. The dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with severe renal impairment (creatinine clearance <30 mL/min), dose reduction may be necessary. Monitor for toxicity. The dose must be individualized by a qualified clinician. |
| Hepatic Impairment | In patients with hepatic impairment, isoniazid should be used with caution. Dose reduction or discontinuation may be required based on liver function tests. The dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose of isoniazid is 300 mg. The pyridoxine component is fixed at 10 mg. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of inatos 300mg/10mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Rifampicin | Major | |
| Phenytoin | Major | |
| Carbamazepine | Major | |
| Warfarin | Major | |
| Alcohol | Major | |
| Ketoconazole | Moderate | |
| Cycloserine | Moderate | |
| Disulfiram | Moderate | |
| Antacids (aluminum) | Minor | |
| Levodopa | Minor |
🚨 Major Interactions
- Rifampicin
- Phenytoin
- Carbamazepine
- Warfarin
- Alcohol
⚡ Moderate Interactions
- Ketoconazole
- Cycloserine
- Disulfiram
🍷 Alcohol Interaction
Alcohol should be strictly avoided while taking this medicine because it significantly increases the risk of isoniazid-induced hepatitis and can worsen liver damage. Alcohol may also increase the risk of peripheral neuropathy.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to isoniazid or pyridoxine.","Acute liver disease or previous isoniazid-induced hepatitis.","Severe renal impairment (dose adjustment required; use with caution).","Concurrent use with alcohol (relative contraindication).","Patients with a history of seizures (use with caution; pyridoxine may help)."]
⚠️ Warnings & Precautions
["Isoniazid can cause hepatitis; monitor liver function closely.","Peripheral neuropathy may occur; pyridoxine is included to prevent it.","Avoid alcohol consumption to reduce risk of liver damage.","Use with caution in patients with diabetes, as isoniazid may affect blood sugar control.","Isoniazid may interact with many drugs; review all medications with your doctor.","Do not use alone for active tuberculosis; combination therapy is essential to prevent resistance.","In patients with HIV, isoniazid may need dose adjustment and monitoring for interactions with antiretroviral drugs.","Elderly patients are at higher risk of hepatotoxicity; monitor closely."]
🤱 Lactation Safety
Isoniazid and pyridoxine are excreted in breast milk. The amount is generally considered safe for the infant, but monitoring for signs of toxicity (e.g., jaundice, poor feeding) is advised. Pyridoxine supplementation is recommended for the mother to prevent neuropathy. Consult your doctor before breastfeeding while on this medicine.
💊 Overdose Management
Overdose of isoniazid can cause nausea, vomiting, dizziness, slurred speech, seizures, metabolic acidosis, and coma. Immediate medical attention is required. Treatment includes activated charcoal if within 1-2 hours of ingestion, intravenous pyridoxine (high doses), benzodiazepines for seizures, and supportive care. Hemodialysis may be considered in severe cases. Pyridoxine overdose is generally not harmful but may cause nausea and headache.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up. Consistency is important for effective tuberculosis treatment.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop treatment early, as this can lead to treatment failure and drug resistance. Avoid alcohol consumption while on this medicine because it increases the risk of liver damage. Inform your doctor if you have a history of liver disease, kidney disease, diabetes, or HIV. Regular monitoring of liver function tests is recommended. If you experience symptoms of hepatitis (yellowing of skin or eyes, dark urine, nausea, vomiting, loss of appetite), stop the medicine and contact your doctor immediately. Do not take this medicine without pyridoxine supplementation if you are pregnant, malnourished, or have a history of seizures. Keep all appointments for follow-up and laboratory tests.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of isoniazid-induced hepatitis and peripheral neuropathy. Liver function should be monitored closely. Dose adjustment may be needed based on renal and hepatic function. Pyridoxine supplementation is especially important.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before starting or continuing this medicine. Isoniazid is generally considered safe during pregnancy, and pyridoxine is recommended to prevent neuropathy. Treatment should not be stopped without medical advice.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. Isoniazid may interact with certain anesthetic agents. Continue treatment unless advised otherwise by your doctor.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. Isoniazid may cause dry mouth or affect healing. Maintain good oral hygiene and follow your dentist's advice.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but if you experience fatigue, dizziness, or numbness in feet, avoid activities that require balance or coordination. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue or dizziness in some people. If you experience these, avoid driving or operating heavy machinery until you know how the medicine affects you. Most people can continue their normal work activities with appropriate precautions.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Treatment must be completed as prescribed. If you experience serious side effects like hepatitis or severe neuropathy, contact your doctor immediately; they will decide whether to adjust or stop treatment.
📅 Long-Term Use Effects
Long-term use of isoniazid can lead to peripheral neuropathy, which is mitigated by pyridoxine. Rarely, it can cause hepatitis, especially with prolonged use or alcohol consumption. Regular monitoring of liver function is recommended. Pyridoxine is generally safe for long-term use. After completing treatment, follow-up is advised to ensure no relapse.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Alternative regimens for latent TB include rifampicin alone or rifampicin plus isoniazid for shorter durations.
Evidence: Well-establishedAdequate nutrition, including pyridoxine-rich foods, can help prevent neuropathy.
Evidence: Supportive💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Isoniazid may reduce the immune response to certain vaccines, particularly live vaccines. Consult your doctor about vaccination timing while on this medicine. The BCG vaccine is not affected by isoniazid.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, adjust dosing times gradually under medical advice. Check customs regulations for carrying prescription medicines. Do not stop treatment during travel; ensure you have enough supply for the entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Improvement in symptoms may take several weeks. However, you must complete the full course as prescribed, which may last 6 to 9 months for latent TB or longer for active TB.
A: No, you must complete the full course. Stopping early can lead to relapse and drug-resistant tuberculosis.
A: Watch for yellowing of skin or eyes, dark urine, severe abdominal pain, numbness or tingling in hands or feet, and seizures. Report these to your doctor immediately.
A: Isoniazid interacts with many drugs, including phenytoin, warfarin, and rifampicin. Always inform your doctor about all medicines you are taking.
🤔 Common Patient Concerns
🔄 Substitutes for inatos 300mg/10mg tablet
View AllAlternative brands with exact same active ingredient:
-
isocaldin 300 mg/10 mg tabletRetort Pharma Pvt Ltd ₹25.94 791.4% COSTLIER
-
isokin 300 tabletPfizer Ltd ₹31.15 970.4% COSTLIER
-
isocaldin 300 mg/10 mg syrupRetort Pharma Pvt Ltd ₹91.31 3037.8% COSTLIER
-
rifa i 6 tabletConcept Pharmaceuticals Ltd ₹116.25 3894.8% COSTLIER
-
rifa i 6 forte tabletConcept Pharmaceuticals Ltd ₹119.53 4007.6% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Isoniazid alone can cure active tuberculosis.
Fact: Isoniazid must be used in combination with other antitubercular drugs for active TB to prevent resistance. - Myth: You can stop treatment once symptoms improve.
Fact: Treatment must be completed as prescribed to fully eliminate the bacteria and prevent relapse or resistance. - Myth: Pyridoxine is not necessary when taking isoniazid.
Fact: Pyridoxine is essential to prevent peripheral neuropathy caused by isoniazid. - Myth: Isoniazid is safe to take with alcohol.
Fact: Alcohol increases the risk of liver damage and should be avoided.
🔄 Alternative Options
Generic Alternatives
- Isoniazid + Pyridoxine (generic)
Brand Alternatives
- Isokin 300 Tablet