Isolazine Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe dizziness or fainting
- Chest pain or difficulty breathing
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Unusual bruising or bleeding
- Joint pain with fever or rash
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is isolazine tablet used for?
This medicine is a combination of isosorbide dinitrate and hydralazine used to treat heart failure. It works by relaxing blood vessels to reduce the heart's workload and improve blood flow.
- Generic Name: Isosorbide Dinitrate (20mg) + Hydralazine (37.5mg)
- Manufacturer: Lupin Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 isolazine tablet के बारे में (Hindi Summary)
उपयोग: यह दवा हृदय विफलता (हार्ट फेल्योर) के इलाज में उपयोग की जाती है, खासकर उन रोगियों में जो अन्य दवाओं से ठीक से लाभ नहीं उठा पाते। यह रक्त वाहिकाओं को फैलाकर हृदय पर दबाव कम करती है और रक्त प्रवाह में सुधार करती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में सिरदर्द, चक्कर आना, मतली, उल्टी, दस्त, तेज़ धड़कन और चेहरे पर लालिमा शामिल हैं। गंभीर दुष्प्रभावों में गंभीर निम्न रक्तचाप, बेहोशी, सीने में दर्द, अनियमित धड़कन और ल्यूपस जैसे लक्षण हो सकते हैं। किसी भी असामान्य लक्षण पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। शराब से बचें क्योंकि इससे चक्कर आ सकते हैं। अचानक उठने से बचें। अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं और दवाओं के बारे में बताएं। नियमित जांच कराएं।
💊 isolazine tablet Uses & Benefits
[{"condition":"Heart failure with reduced ejection fraction","description":"This medicine is used to improve survival and reduce hospitalizations in patients with heart failure, particularly those of African descent, when added to standard therapy.","evidence":"Well-established"},{"condition":"Hypertension","description":"The combination may be used to lower blood pressure in certain patients, though it is not a first-line treatment.","evidence":"Limited"}]
Off-label uses: [{"condition":"Angina pectoris","description":"Isosorbide dinitrate component may be used to prevent angina attacks, but the combination is not standard for this use.","evidence":"Limited"}]
Primary treatment for: Heart failure with reduced ejection fraction
Also treats: Hypertension
📋 Drug Information
| Generic Name(s) | Isosorbide Dinitrate (20mg) + Hydralazine (37.5mg) |
| Brand Name | isolazine tablet |
| Manufacturer | Lupin Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two vasodilators with complementary actions. Isosorbide Dinitrate is a nitrate that is converted to nitric oxide in the body. Nitric oxide activates guanylate cyclase, increasing cyclic GMP, which leads to relaxation of vascular smooth muscle, especially in veins. This reduces preload and cardiac workload. Hydralazine directly relaxes arterial smooth muscle, reducing peripheral vascular resistance and afterload. Together, they reduce the workload on the heart and improve cardiac output in heart failure.
Mechanism Steps
💡 How to Take isolazine tablet
Strength: Tablet: Isosorbide Dinitrate 20 mg + Hydralazine 37.5 mg
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally two to three times daily, or as prescribed by your doctor. The dose may be adjusted based on your condition and response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the blood pressure-lowering effects. Start with a lower dose and monitor closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose adjustment may be necessary. Consult your doctor. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose adjustment may be necessary. Consult your doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is 3 tablets (60 mg isosorbide dinitrate and 112.5 mg hydralazine) or as prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of isolazine tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Sildenafil | Major | |
| Alcohol | Major | |
| Other antihypertensives | Major | |
| NSAIDs | Moderate | |
| MAOIs | Moderate |
🚨 Major Interactions
- Phosphodiesterase-5 inhibitors (e.g., sildenafil)
- Alcohol
- Other antihypertensives
⚡ Moderate Interactions
- NSAIDs
- Monoamine oxidase inhibitors (MAOIs)
🍷 Alcohol Interaction
Alcohol can intensify the blood pressure-lowering effects of this medicine, leading to dizziness, fainting, or severe hypotension. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to nitrates or hydralazine","Severe hypotension","Severe aortic stenosis","Systemic lupus erythematosus","Concurrent use with phosphodiesterase-5 inhibitors"]
⚠️ Warnings & Precautions
["May cause severe hypotension, especially with alcohol or other antihypertensives.","Can cause lupus-like syndrome; monitor for joint pain, fever, rash.","May cause peripheral neuropathy; report numbness or tingling.","Use with caution in patients with renal or hepatic impairment.","Avoid abrupt withdrawal; taper gradually under medical supervision."]
🤱 Lactation Safety
Not established from the available information. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose can cause severe hypotension, tachycardia, and shock. Seek immediate medical attention. Treatment is supportive and symptomatic. Gastric lavage may be considered if recent ingestion. Monitor vital signs and provide intravenous fluids and vasopressors if needed.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without medical advice. Stand up slowly from a sitting or lying position to avoid dizziness. Avoid alcohol, as it can increase the blood pressure-lowering effect and worsen dizziness. Inform your doctor if you have kidney or liver disease, low blood pressure, or a history of autoimmune disease. Regular monitoring of blood pressure, heart rate, and symptoms is important. Do not use this medicine if you are pregnant or planning pregnancy without consulting your doctor. Keep all follow-up appointments and report any new or worsening symptoms promptly.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the blood pressure-lowering effects. Start with a lower dose and monitor closely for dizziness and falls.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy unless clearly needed. Consult your doctor if you are planning pregnancy or become pregnant.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine, as it can affect blood pressure during surgery. Dose adjustments may be needed.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine, as it can cause dizziness or low blood pressure during dental procedures. Take precautions to avoid sudden position changes.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise until you know how this medicine affects you, as it can cause dizziness. Start slowly and increase activity gradually under your doctor's guidance.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or lightheadedness, especially when standing up. Avoid driving or operating heavy machinery until you know how it affects you. Take breaks and rise slowly.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects, contact your doctor immediately for advice on dose adjustment or alternative treatment.
📅 Long-Term Use Effects
Long-term use may require monitoring for lupus-like syndrome, peripheral neuropathy, and liver function. Regular follow-up with your doctor is essential to adjust the dose and manage any side effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another class of heart failure medicines that may be used instead or in addition.
Evidence: Well-establishedStandard therapy for heart failure that may be combined with this medicine.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If crossing time zones, adjust dosing times gradually as advised by your doctor. Keep enough supply for your trip and carry it in your hand luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 30-60 minutes, but full benefits for heart failure may take several weeks.
A: No, you should not stop without consulting your doctor. Stopping suddenly can worsen your condition.
A: Take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue your regular schedule. Do not double the dose.
🤔 Common Patient Concerns
🔄 Substitutes for isolazine tablet
View AllAlternative brands with exact same active ingredient:
-
sorbitrate hf tabletAbbott ₹58.90 75.2% CHEAPER
-
muzika 20mg/37.5mg tabletAlkem Laboratories Ltd ₹86.50 63.6% CHEAPER
-
nitrohart tabletMankind Pharma Ltd ₹91.02 61.7% CHEAPER
-
vasolazine tabletLenimen Biotech ₹107.81 54.6% CHEAPER
-
apresol plus tabletOrdain Health Care Global Pvt Ltd ₹113.64 52.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure heart failure.
Fact: This medicine helps manage symptoms and improve survival but does not cure heart failure. - Myth: You can stop taking this medicine once you feel better.
Fact: You should not stop without consulting your doctor, as it may worsen your condition.
🔄 Alternative Options
Generic Alternatives
- Isosorbide Dinitrate + Hydralazine generic tablets
Brand Alternatives
- Isolazine Tablet