Gestofit 300mg SR Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Sudden swelling of the face, lips, tongue, or throat, or difficulty breathing.
- Chest pain, shortness of breath, or coughing up blood.
- Pain, swelling, or redness in one leg.
- Severe headache with vision changes or confusion.
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain.
- Heavy or prolonged vaginal bleeding.
- Severe mood changes or thoughts of self-harm.
If experiencing severe symptoms, call emergency services immediately.
What is isogest 300mg tablet sr used for?
This medicine is a sustained-release oral tablet of natural micronized progesterone 300 mg. It is used to support the uterine lining in fertility treatments, prevent miscarriage due to progesterone deficiency, and regulate menstrual problems. It works by binding to progesterone receptors and is taken once daily as prescribed, usually at bedtime.
- Generic Name: Progesterone (Natural Micronized) (300mg)
- Manufacturer: Innovative Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 isogest 300mg tablet sr के बारे में (Hindi Summary)
उपयोग: यह दवा प्राकृतिक माइक्रोनाइज़्ड प्रोजेस्टेरोन 300 मिलीग्राम की सस्टेन्ड-रिलीज़ गोली है। इसका उपयोग मुख्य रूप से महिलाओं में प्रोजेस्टेरोन की कमी को पूरा करने के लिए किया जाता है। यह आईवीएफ जैसे फर्टिलिटी उपचारों में गर्भाशय की परत को सहारा देने, गर्भपात के खतरे को कम करने, और अनियमित मासिक धर्म को नियंत्रित करने में मदद करती है। यह गर्भाशय में प्रोजेस्टेरोन रिसेप्टर्स से जुड़कर काम करती है। इसे डॉक्टर की सलाह के अनुसार ही लें, आमतौर पर रात में सोने से पहले।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में नींद आना, चक्कर आना, सिरदर्द, स्तनों में कोमलता, मतली, पेट फूलना और मासिक धर्म में बदलाव शामिल हैं। ये आमतौर पर हल्के होते हैं और शरीर के सामान्य होने पर कम हो जाते हैं। कभी-कभी गंभीर एलर्जी, खून के थक्के, या लिवर की समस्या हो सकती है। अगर कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। गोली को पानी के साथ पूरा निगलें, चबाएं या तोड़ें नहीं। इसे भोजन के साथ या बिना भोजन के लिया जा सकता है, लेकिन मतली से बचने के लिए भोजन के साथ लेना बेहतर है। अगर आपको नींद या चक्कर आते हैं तो वाहन चलाने या मशीन चलाने से बचें। गर्भावस्था, स्तनपान, या लिवर/किडनी की बीमारी हो तो डॉक्टर को बताएं। कोई भी असामान्य लक्षण होने पर तुरंत डॉक्टर से मिलें।
💊 isogest 300mg tablet sr Uses & Benefits
[{"condition":"Luteal phase support in assisted reproductive technology (ART)","description":"This medicine is used to support the luteal phase after IVF or other fertility treatments, helping to maintain the endometrial lining and improve the chance of implantation and ongoing pregnancy.","evidence":"Well-established"},{"condition":"Threatened or recurrent miscarriage due to luteal phase deficiency","description":"Progesterone supplementation can help support early pregnancy when the body does not produce enough progesterone on its own.","evidence":"Well-established"},{"condition":"Secondary amenorrhea (absence of periods)","description":"This medicine can help restore menstrual bleeding in women with progesterone deficiency after estrogen has been given.","evidence":"Well-established"},{"condition":"Abnormal uterine bleeding due to hormonal imbalance","description":"It helps stabilize the endometrial lining and regulate bleeding in certain non-cancerous hormonal conditions.","evidence":"Established"},{"condition":"Endometrial protection during estrogen therapy","description":"In women with a uterus who take estrogen, this medicine is added to reduce the risk of endometrial hyperplasia.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Preterm birth prevention","description":"Sometimes used in selected women with a short cervix or history of preterm birth, but evidence is mixed and it is not universally recommended.","evidence":"Limited"},{"condition":"Catamenial epilepsy","description":"Occasionally used to reduce seizure frequency linked to the menstrual cycle, but this is not a standard first-line use.","evidence":"Limited"}]
Primary treatment for: Progesterone deficiency
Also treats: Infertility, Luteal phase defect, Threatened miscarriage, Secondary amenorrhea, Abnormal uterine bleeding
📋 Drug Information
| Generic Name(s) | Progesterone (Natural Micronized) (300mg) |
| Brand Name | isogest 300mg tablet sr |
| Manufacturer | Innovative Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GYNAECOLOGICAL |
| Action Class | Natural Progesterone |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Keep away from direct sunlight and moisture. Do not refrigerate unless specified by the manufacturer. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Natural micronized progesterone is chemically identical to the progesterone produced by the human body. It binds to and activates progesterone receptors in the nucleus of target cells, especially in the endometrium, breast, and brain. This binding leads to changes in gene expression that prepare the uterine lining for implantation, maintain pregnancy, and regulate the menstrual cycle. It also has mild anti-mineralocorticoid and anti-androgenic effects, which can influence fluid balance and skin. The sustained-release tablet is designed to release the hormone slowly, aiming for more stable blood levels over the dosing interval.
Mechanism Steps
💡 How to Take isogest 300mg tablet sr
Strength: Sustained-release tablet containing 300 mg of natural micronized progesterone.
Dosage Information
| Adult Dosage | The dose of this medicine must be individualized by a qualified clinician based on the indication, age, weight, and liver function. For luteal support in assisted reproduction, a common dose is 300 mg once daily, but the exact regimen varies. For other uses, doses may range from 200 mg to 400 mg daily, taken as a single dose or divided. Always follow your doctor's prescription exactly. Do not change the dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | There is limited information on the use of this medicine in women over 65 years. It should be used with caution and only under medical supervision, with regular monitoring for side effects. |
| Renal Impairment | No specific dose adjustment is established for kidney impairment. Use with caution and follow your doctor's advice. |
| Hepatic Impairment | This medicine is metabolized in the liver. Women with mild to moderate liver impairment may need a lower dose or careful monitoring. It is contraindicated in severe liver disease. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose depends on the indication and is determined by your doctor. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of isogest 300mg tablet sr
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Rifampicin | Major | |
| Warfarin | Moderate | |
| Diazepam | Moderate | |
| Alcohol | Moderate | |
| Grapefruit juice | Minor | |
| Cimetidine | Minor |
🚨 Major Interactions
- Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir)
- Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin, St. John's wort)
- Anticoagulants (e.g., warfarin)
⚡ Moderate Interactions
- Benzodiazepines (e.g., diazepam, lorazepam)
- Alcohol
- Antihypertensives
🍷 Alcohol Interaction
Alcohol can increase the drowsiness and dizziness caused by this medicine. It is best to avoid alcohol or limit it to very small amounts while taking this medicine, especially if you need to drive or operate machinery.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to progesterone or any ingredient in the tablet","Undiagnosed vaginal bleeding","Known or suspected breast cancer or genital cancer","Active liver disease or history of severe liver disease","History of blood clots (deep vein thrombosis, pulmonary embolism) or stroke","Known or suspected pregnancy loss due to chromosomal abnormalities","Use in children under 18 years for non-approved indications"]
⚠️ Warnings & Precautions
["This medicine may cause drowsiness or dizziness. Avoid driving or operating heavy machinery until you know how it affects you.","Do not crush, chew, or break the sustained-release tablet. Swallow it whole.","Inform your doctor if you have a history of depression, epilepsy, migraine, or heart disease.","Progesterone can cause fluid retention. Use with caution if you have heart failure, kidney disease, or high blood pressure.","Stop the medicine and seek immediate medical help if you experience signs of an allergic reaction or blood clot.","Do not use this medicine if you have undiagnosed vaginal bleeding.","Keep all follow-up appointments and report any unusual symptoms."]
🤱 Lactation Safety
Progesterone is excreted in breast milk. The amount is small and considered unlikely to harm a nursing infant, but it may affect milk production. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine is unlikely to cause serious harm, but it may increase side effects such as drowsiness, dizziness, nausea, and vomiting. If you suspect an overdose, contact your doctor or a poison control center immediately. Treatment is supportive and symptomatic. Do not try to vomit unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember if it is less than half the time until your next dose. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, usually at the same time each day. Swallow the tablet whole with water; do not crush, chew, or break it, because it is a sustained-release formulation. It may be taken with or without food, but taking it with food can reduce nausea. Do not start, stop, or change the dose without medical advice. Inform your doctor if you are pregnant, planning pregnancy, breastfeeding, or have liver, kidney, heart, or clotting problems. Avoid driving or operating heavy machinery if you feel drowsy or dizzy. Keep all follow-up appointments and report any unusual bleeding, severe headache, vision changes, or leg pain immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
There is limited information on the use of this medicine in women over 65 years. It should be used with caution and only under medical supervision, with regular monitoring for side effects.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before starting or continuing this medicine. It is often used to support early pregnancy in women with progesterone deficiency. Your doctor will guide you on the appropriate dose and duration.
🏥 Post-Surgery Considerations
If you are undergoing surgery, inform your surgeon and anesthesiologist that you are taking this medicine. It may need to be stopped temporarily before surgery to reduce the risk of blood clots. Follow your doctor's instructions.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. No specific precautions are usually needed, but it is important for your dentist to know your complete medication list.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness or dizziness. Avoid strenuous exercise or activities that require alertness until you know how it affects you. If you feel dizzy, sit down and rest.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, which may affect your ability to drive or operate machinery. It is best to take it at bedtime. If you experience persistent drowsiness, discuss with your doctor about adjusting the timing or dose. Otherwise, it should not significantly impact your daily work life.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Your doctor will advise you when to stop based on your condition and treatment goals. If you experience serious side effects, contact your doctor immediately.
📅 Long-Term Use Effects
Long-term use of this medicine is generally considered safe when taken under medical supervision. However, prolonged use may increase the risk of blood clots, liver problems, and mood changes. Regular monitoring of liver function, blood pressure, and symptoms is advised. The need for continued use should be reviewed periodically by your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A synthetic progestogen that may cause less drowsiness and can be an alternative for some women.
Evidence: Well-establishedVaginal suppositories or gel may be used for luteal support, often with fewer systemic side effects.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. You can receive vaccinations as recommended by your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss or temperature extremes. Store at room temperature and avoid direct sunlight. If crossing time zones, continue taking your dose at the same interval as prescribed, but consult your doctor for specific advice. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The onset of action depends on the indication. For luteal support, effects begin within hours to days. For menstrual regulation, it may take several days to weeks.
A: Yes, you can take it with or without food. Taking it with food can reduce nausea and improve absorption.
A: If you miss a dose, take it as soon as you remember if it is less than half the time until your next dose. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: Yes, natural progesterone is considered safe when used as prescribed during pregnancy for luteal support and to prevent miscarriage in women with progesterone deficiency. It should only be used under medical supervision.
A: No, do not stop taking this medicine without consulting your doctor, especially during pregnancy. Sudden discontinuation may cause withdrawal bleeding or other complications.
🤔 Common Patient Concerns
🔄 Substitutes for isogest 300mg tablet sr
View AllAlternative brands with exact same active ingredient:
-
endogest 300mg capsuleCipla Ltd ₹102.19 76% CHEAPER
-
StayHappi Progesterone (Natural Micronized) 300mg CapsuleSarvagunaushdhi Pvt Ltd ₹253.13 40.4% CHEAPER
-
Remens 300mg CapsuleManeesh Pharmaceuticals Ltd ₹281.25 33.8% CHEAPER
-
vageston 300mg capsuleBayer Zydus Pharma Pvt Ltd ₹286.88 32.5% CHEAPER
-
lutial 300mg tabletDowell Pharmaceutical ₹301.33 29.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a contraceptive pill.
Fact: This medicine is not a contraceptive. It is used for progesterone support and does not prevent pregnancy. - Myth: This medicine can be taken at any time of day without consequences.
Fact: It is best taken at bedtime because it can cause drowsiness. Taking it at the same time daily is important. - Myth: This medicine is safe to take without a prescription.
Fact: This is a prescription-only medicine. It should only be used under medical supervision.
🔄 Alternative Options
Generic Alternatives
- Natural micronized progesterone 300 mg sustained-release tablets from other manufacturers
Brand Alternatives
- Gestofit 300mg SR Tablet