Duotrol 2.5mg/500mg Tablet SR: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe hypoglycemia (unconsciousness, seizures, confusion)
- Symptoms of lactic acidosis (muscle pain, breathing difficulty, extreme fatigue)
- Yellowing of skin or eyes (jaundice)
- Severe abdominal pain with nausea and vomiting
- Unusual bleeding or bruising
- Sudden fever with sore throat or mouth ulcers
- Decreased urine output or swelling in legs
If experiencing severe symptoms, call emergency services immediately.
What is iscept 2.5mg/500mg tablet used for?
This medicine is a combination of Glibenclamide 2.5 mg and Metformin 500 mg used to treat type 2 diabetes. It lowers blood sugar by increasing insulin release and improving insulin sensitivity. It should be taken with meals as prescribed by your doctor.
- Generic Name: Glibenclamide (2.5mg) + Metformin (500mg)
- Manufacturer: Strides shasun Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 iscept 2.5mg/500mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा ग्लिबेंक्लामाइड 2.5 मिलीग्राम और मेटफॉर्मिन 500 मिलीग्राम का संयोजन है, जिसका उपयोग टाइप 2 डायबिटीज (मधुमेह) के इलाज के लिए किया जाता है। यह रक्त शर्करा को कम करने में मदद करती है। ग्लिबेंक्लामाइड अग्न्याशय से इंसुलिन निकालने में मदद करता है, जबकि मेटफॉर्मिन शरीर में इंसुलिन की कार्यक्षमता को बढ़ाता है और लीवर में ग्लूकोज बनने को कम करता है। यह दवा उन वयस्कों के लिए है जिनका मधुमेह आहार, व्यायाम और अन्य दवाओं से नियंत्रित नहीं हो रहा है। इसे डॉक्टर के निर्देशानुसार भोजन के साथ लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में कम रक्त शर्करा (हाइपोग्लाइसीमिया), जी मिचलाना, दस्त, पेट दर्द, धातु जैसा स्वाद और वजन बढ़ना शामिल हैं। गंभीर दुष्प्रभावों में लैक्टिक एसिडोसिस (मांसपेशियों में दर्द, सांस लेने में कठिनाई, अत्यधिक थकान), गंभीर हाइपोग्लाइसीमिया, पीलिया और रक्त विकार शामिल हैं। यदि आपको कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा भोजन के साथ लें ताकि कम रक्त शर्करा और पेट की परेशानी से बचा जा सके। कभी भी भोजन न छोड़ें। अपने साथ हमेशा ग्लूकोज या मिठाई रखें। शराब का सेवन बिल्कुल न करें। डॉक्टर की सलाह के बिना दवा बंद या डोज न बदलें। नियमित रूप से रक्त शर्करा, गुर्दे की कार्यप्रणाली और रक्त की जांच कराएं। यदि आप गर्भवती हैं या स्तनपान करा रही हैं तो डॉक्टर से सलाह लें।
💊 iscept 2.5mg/500mg tablet Uses & Benefits
[{"condition":"Type 2 diabetes mellitus","description":"Used as an add-on therapy in adults whose blood sugar is not controlled by metformin alone or other single oral agents, along with diet and exercise.","evidence":"Well-established"},{"condition":"Secondary sulfonylurea failure","description":"May be used when a patient no longer responds adequately to a single sulfonylurea or metformin, to improve glycemic control.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Polycystic ovary syndrome (PCOS)","description":"Metformin component is sometimes used off-label in PCOS to improve insulin resistance, but the combination with glibenclamide is not standard for this purpose.","evidence":"Limited"}]
Primary treatment for: Type 2 diabetes mellitus
Also treats: Insulin resistance, Metabolic syndrome
📋 Drug Information
| Generic Name(s) | Glibenclamide (2.5mg) + Metformin (500mg) |
| Brand Name | iscept 2.5mg/500mg tablet |
| Manufacturer | Strides shasun Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F) in a dry place. Protect from light and moisture. Keep in the original container. Do not refrigerate unless specified. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. Do not use after the expiry date printed on the pack. |
| WHO Guideline | Not established from the available information. Guidelines generally recommend metformin as first-line therapy for type 2 diabetes, with sulfonylureas as add-on options. The combination may be used when monotherapy fails. |
| ICMR Guideline | Not established from the available information. ICMR guidelines for type 2 diabetes recommend individualized therapy, with metformin as first-line and sulfonylureas as add-on. The combination is used when dual therapy is needed. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antidiabetic agents with complementary mechanisms. Glibenclamide binds to ATP-sensitive potassium channels on pancreatic beta cells, causing depolarization and calcium influx, which triggers insulin release. Metformin decreases hepatic glucose production, reduces intestinal glucose absorption, and enhances peripheral insulin sensitivity by activating AMP-activated protein kinase. The combined effect lowers blood glucose levels more effectively than either agent alone.
Mechanism Steps
💡 How to Take iscept 2.5mg/500mg tablet
Strength: Tablet containing Glibenclamide 2.5 mg and Metformin 500 mg (sustained release).
Dosage Information
| Adult Dosage | The dosage of this medicine must be individualized by a qualified clinician based on your blood sugar levels, kidney and liver function, and other medications you are taking. Typically, it is taken once or twice daily with meals. The starting dose is usually one tablet daily, and the dose may be gradually increased based on response. Do not adjust the dose yourself. Always follow your doctor's prescription exactly. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) are more sensitive to the effects of this medicine, especially the risk of hypoglycemia and lactic acidosis. The dose should be started at the lower end and adjusted cautiously based on renal function. Regular monitoring of blood glucose and kidney function is essential. |
| Renal Impairment | This medicine is contraindicated in severe renal impairment (eGFR <30 mL/min/1.73 m²). In mild to moderate renal impairment, dose adjustment or alternative therapy may be needed. Metformin should be used with caution when eGFR is between 30-45 mL/min/1.73 m². Regular monitoring of kidney function is required. |
| Hepatic Impairment | This medicine should be used with caution in patients with hepatic impairment due to increased risk of hypoglycemia and lactic acidosis. In severe hepatic impairment, it is contraindicated. Dose adjustment may be necessary in mild to moderate impairment, as advised by your doctor. |
| Maximum Daily Dose | The maximum daily dose of this combination is not fixed and depends on the individual patient's response and tolerance. Generally, the maximum recommended dose of glibenclamide is 20 mg per day and metformin is 2000-2550 mg per day. However, the combination should not exceed the maximum recommended doses of individual components. Always follow your doctor's prescription. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of iscept 2.5mg/500mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Alcohol | Major | |
| Contrast media | Major | |
| Diuretics | Major | |
| Corticosteroids | Major | |
| Beta-blockers | Major | |
| ACE inhibitors | Moderate | |
| NSAIDs | Moderate | |
| Warfarin | Moderate | |
| Cimetidine | Moderate | |
| Rifampicin | Moderate |
🚨 Major Interactions
- Alcohol
- Contrast media (iodinated)
- Diuretics (e.g., furosemide)
- Corticosteroids
- Beta-blockers
⚡ Moderate Interactions
- ACE inhibitors
- NSAIDs
- Warfarin
- Cimetidine
- Rifampicin
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Alcohol increases the risk of lactic acidosis, a rare but serious complication of metformin, and can also cause severe hypoglycemia by interfering with glucose production in the liver. Even moderate drinking can be dangerous.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Type 1 diabetes mellitus","Diabetic ketoacidosis","Severe renal impairment (eGFR
⚠️ Warnings & Precautions
["Risk of hypoglycemia, especially with skipped meals, alcohol, or intense exercise.","Risk of lactic acidosis, a rare but serious complication; seek immediate help if symptoms occur.","Not for use in type 1 diabetes or diabetic ketoacidosis.","May cause weight gain; monitor weight and lifestyle.","Use with caution in elderly patients and those with renal or hepatic impairment.","Temporarily discontinue before surgery or contrast imaging as advised.","May increase risk of cardiovascular events; monitor patients with heart disease.","Regular monitoring of blood glucose, kidney function, and blood counts is required.","Avoid alcohol completely.","Inform your doctor about all other medications you are taking."]
🤱 Lactation Safety
Glibenclamide is excreted in breast milk in small amounts, and metformin is also excreted in breast milk. The effects on the nursing infant are not well established. Breastfeeding is not recommended while taking this medicine unless advised by a doctor. Consult your healthcare provider to discuss alternatives.
💊 Overdose Management
Overdose of this medicine can cause severe hypoglycemia and lactic acidosis. Symptoms of hypoglycemia include sweating, shakiness, confusion, and unconsciousness. Lactic acidosis may present with muscle pain, breathing difficulty, and extreme fatigue. If overdose is suspected, seek emergency medical attention immediately. Treatment may include intravenous glucose for hypoglycemia and supportive care for lactic acidosis, including hemodialysis if necessary. Do not try to treat yourself at home.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember, provided it is not almost time for your next dose. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Always take this medicine with meals to reduce the risk of low blood sugar and stomach upset. Never skip meals while on this medicine, as that can trigger hypoglycemia. Carry a fast-acting sugar source like glucose tablets or candy with you at all times. Inform your doctor about all other medicines, supplements, or herbal products you are taking, as many can interact with this medicine. Avoid alcohol completely, as it can increase the risk of lactic acidosis and low blood sugar. Do not drive or operate heavy machinery if you feel dizzy or shaky. Get your blood sugar, kidney function, and blood counts checked regularly as advised. Do not stop or change the dose without consulting your doctor. If you are scheduled for surgery, a contrast X-ray, or dental work, tell your doctor you are taking this medicine. Pregnant or breastfeeding women should consult their doctor before using this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the effects of this medicine, especially hypoglycemia and lactic acidosis. The dose should be started low and adjusted cautiously based on kidney function. Regular monitoring of blood sugar, kidney function, and blood counts is essential. Falls and fractures due to hypoglycemia are a concern.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy. If you are planning pregnancy, consult your doctor to switch to a safer alternative, usually insulin. Good blood sugar control before and during pregnancy is crucial to prevent complications for both mother and baby.
🏥 Post-Surgery Considerations
This medicine may need to be temporarily stopped before surgery due to the risk of lactic acidosis and hypoglycemia. Your doctor will advise on when to stop and when to restart. Blood sugar levels will be monitored closely during the perioperative period, and insulin may be used instead.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. Dental procedures can cause stress and may affect blood sugar levels. You may need to adjust your dose or monitor blood sugar more closely. If you are having a procedure that requires fasting, consult your doctor about dose adjustments.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise can lower blood sugar and increase the risk of hypoglycemia, especially when combined with this medicine. Check your blood sugar before exercising and carry a fast-acting sugar source. Avoid intense exercise if your blood sugar is low. Stay hydrated. Consult your doctor before starting a new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause low blood sugar, which can affect your ability to drive or operate machinery. If you experience symptoms like dizziness, shakiness, or confusion, do not drive or operate heavy machinery. Inform your employer about your condition and medication. Carry a fast-acting sugar source at work. With proper management, most people can continue their normal work activities.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects like lactic acidosis, severe hypoglycemia, or allergic reactions, seek immediate medical attention and your doctor may advise stopping the medicine. Your doctor may also stop it temporarily before surgery or contrast imaging. Always follow your doctor's guidance.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to vitamin B12 deficiency due to metformin, requiring periodic monitoring and supplementation if needed. It can also cause weight gain and increase the risk of hypoglycemia. Regular monitoring of kidney function, liver function, and blood counts is important. The risk of lactic acidosis, though rare, persists with long-term use, especially in patients with kidney impairment. Cardiovascular risk may be increased with glibenclamide. Lifestyle modifications and regular follow-up are essential for optimal outcomes.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet and exercise are the cornerstone of diabetes management and can reduce the need for medication.
Evidence: Well-establishedDPP-4 inhibitors, SGLT2 inhibitors, or GLP-1 receptor agonists may be alternatives with different side effect profiles.
Evidence: Well-establishedMay be needed if oral agents fail to control blood sugar.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, patients with diabetes are at higher risk of infections, so routine vaccinations such as influenza and pneumococcal vaccines are recommended. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss or temperature extremes. If crossing time zones, consult your doctor about adjusting the timing of doses to prevent low blood sugar. Store at room temperature and avoid direct sunlight. Carry extra medication in case of delays. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The effect on blood sugar starts within a few hours, but it may take several days to weeks to see the full benefit. Your doctor will monitor your blood sugar and adjust the dose as needed.
A: This medicine is not recommended in severe kidney disease. In mild to moderate kidney disease, your doctor may adjust the dose or choose a different medicine. Regular monitoring of kidney function is essential.
A: If you feel symptoms like sweating, shakiness, or confusion, immediately take a fast-acting sugar source like glucose tablets, candy, or fruit juice. If symptoms persist or you become unconscious, seek emergency medical help.
A: No, do not stop without consulting your doctor. Stopping suddenly can cause your blood sugar to rise again. Your doctor will decide if and when to adjust or stop the medicine.
🤔 Common Patient Concerns
🔄 Substitutes for iscept 2.5mg/500mg tablet
View AllAlternative brands with exact same active ingredient:
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Ree Mef 2.5mg/500mg TabletSunre Healthcare ₹19.69 46.1% CHEAPER
-
bencomet 2.5mg/500mg tabletSunniva Life Science ₹24.00 34.4% CHEAPER
-
duotrol 2.5mg/500mg tablet srUSV Ltd ₹44.50 21.7% COSTLIER
-
geben m 2.5mg/500mg tabletShinto Organics (P) Limited ₹92.81 153.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure diabetes.
Fact: This medicine helps manage blood sugar but does not cure diabetes. Lifestyle changes and medication are needed lifelong. - Myth: You can stop taking this medicine once your sugar levels are normal.
Fact: Do not stop without consulting your doctor. Stopping suddenly can cause blood sugar to rise again. - Myth: This medicine can be taken without food.
Fact: It should be taken with meals to reduce the risk of low blood sugar and stomach upset. - Myth: Alcohol is safe while taking this medicine.
Fact: Alcohol should be avoided completely as it increases the risk of lactic acidosis and hypoglycemia.
🔄 Alternative Options
Generic Alternatives
- Glibenclamide + Metformin combination tablets from other manufacturers
Brand Alternatives
- Glibenclamide + Metformin tablets (various brands)