Cefepime 1000mg Injection: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of face, lips, or throat
- Severe diarrhea or bloody stools
- Seizures or confusion
- Decreased urine output or swelling in legs
- Severe rash with blistering or peeling skin
- High fever with chills
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is ipacare 1000mg injection used for?
This medicine is a fourth-generation cephalosporin antibiotic used to treat serious bacterial infections. It works by killing bacteria and is given by injection in a hospital setting.
- Generic Name: Cefepime (1000mg)
- Manufacturer: H & Care Incorp
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ipacare 1000mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा सेफेपाइम 1000mg इंजेक्शन है, जिसका उपयोग गंभीर बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है। यह निमोनिया, मूत्र मार्ग संक्रमण, त्वचा संक्रमण और पेट के संक्रमण में प्रभावी है। यह केवल डॉक्टर द्वारा अस्पताल में दी जाती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में इंजेक्शन स्थल पर दर्द, दस्त, मतली, सिरदर्द और दाने शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, दौरे और गुर्दे की समस्या हो सकती है। किसी भी असामान्य लक्षण पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल डॉक्टर की देखरेख में अस्पताल में दी जाती है। अपने आप इंजेक्शन न लगाएं। पूरा कोर्स पूरा करें। गुर्दे की बीमारी, गर्भावस्था या स्तनपान के दौरान डॉक्टर को बताएं। एलर्जी के लक्षण दिखने पर तुरंत मदद लें।
💊 ipacare 1000mg injection Uses & Benefits
[{"condition":"Community-acquired pneumonia","description":"Used to treat moderate to severe pneumonia caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Effective against complicated and uncomplicated UTIs caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Used for serious skin infections like cellulitis and abscesses.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Used in combination with other antibiotics for complicated intra-abdominal infections.","evidence":"Well-established"},{"condition":"Febrile neutropenia","description":"Empiric therapy for febrile neutropenia in cancer patients.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Meningitis","description":"Sometimes used off-label for bacterial meningitis when other options are not suitable.","evidence":"Limited"},{"condition":"Endocarditis","description":"May be used off-label for certain cases of bacterial endocarditis.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Pneumonia, Urinary tract infections, Skin infections, Intra-abdominal infections, Febrile neutropenia
📋 Drug Information
| Generic Name(s) | Cefepime (1000mg) |
| Brand Name | ipacare 1000mg injection |
| Manufacturer | H & Care Incorp |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporins: 4th generation |
| Route of Administration | Parenteral (intravenous or intramuscular) |
| Storage | Store vials at 20°C to 25°C (68°F to 77°F). Protect from light. Reconstituted solutions should be used within specified time frames as per manufacturer instructions. |
| Shelf Life | Typically 24-36 months from the date of manufacture, depending on the manufacturer. Check the expiry date on the vial. |
| WHO Guideline | Cefepime is included in the WHO Model List of Essential Medicines as a fourth-generation cephalosporin for the treatment of serious bacterial infections. |
| ICMR Guideline | ICMR guidelines recommend cefepime for the treatment of hospital-acquired pneumonia and other serious infections based on local susceptibility patterns. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Cefepime exerts its bactericidal effect by binding to penicillin-binding proteins (PBPs) located inside the bacterial cell wall. This binding inhibits the final transpeptidation step of peptidoglycan synthesis, leading to a defective cell wall and ultimately bacterial cell lysis and death. It is stable against many beta-lactamases, including some extended-spectrum beta-lactamases (ESBLs), but not all.
Mechanism Steps
💡 How to Take ipacare 1000mg injection
Strength: 1000mg injection
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 1 to 2 grams intravenously every 8 to 12 hours, depending on the severity of the infection and renal function. For severe infections, 2 grams every 8 hours may be used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have decreased renal function; dose should be adjusted based on creatinine clearance. Monitor renal function closely. |
| Renal Impairment | Dose adjustment is required in patients with renal impairment. For creatinine clearance 30-60 mL/min, the usual dose is 1-2 g every 12 hours; for 11-29 mL/min, 1-2 g every 24 hours; for <10 mL/min, 1-2 g every 48 hours. Consult a clinician for precise dosing. |
| Hepatic Impairment | No specific dosage adjustment is required for hepatic impairment alone. However, if both hepatic and renal impairment are present, dose adjustment may be needed. |
| Maximum Daily Dose | The maximum recommended daily dose is 6 grams per day in adults with normal renal function. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ipacare 1000mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Gentamicin | Major | |
| Furosemide | Major | |
| Warfarin | Major | |
| Probenecid | Moderate | |
| Other beta-lactams | Moderate |
🚨 Major Interactions
- Aminoglycosides (e.g., gentamicin)
- Loop diuretics (e.g., furosemide)
- Warfarin
⚡ Moderate Interactions
- Probenecid
- Other beta-lactams
🍷 Alcohol Interaction
Alcohol may worsen certain side effects such as nausea, dizziness, or drowsiness. It is advisable to avoid alcohol while receiving this medicine and until treatment is completed.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe hypersensitivity to cefepime, other cephalosporins, or penicillins.","Previous anaphylactic reaction to beta-lactam antibiotics."]
⚠️ Warnings & Precautions
["Serious hypersensitivity reactions, including anaphylaxis, can occur. Discontinue immediately if allergic reaction occurs.","Clostridioides difficile-associated diarrhea may occur; evaluate if diarrhea develops.","Seizures have been reported, particularly in patients with renal impairment. Adjust dose in renal insufficiency.","Use with caution in patients with a history of penicillin allergy.","Prolonged use may lead to overgrowth of non-susceptible organisms.","Monitor renal function during therapy, especially in elderly or those on nephrotoxic drugs."]
🤱 Lactation Safety
Cefepime is excreted in human milk in low concentrations. Caution should be exercised when administered to a nursing woman. Consult your doctor.
💊 Overdose Management
Overdose may cause seizures, encephalopathy, and neuromuscular excitability. Treatment is symptomatic and supportive. Cefepime can be removed by hemodialysis. Contact a poison control center or emergency department immediately if overdose is suspected.
⏰ Missed Dose
Since this medicine is administered by a healthcare professional, missed doses are unlikely. If you miss a scheduled dose, contact your healthcare provider as soon as possible. Do not attempt to self-administer.
Additional Safety Advice
This medicine should only be administered by a healthcare professional in a hospital or clinic setting. Inform your doctor if you are allergic to penicillin or other antibiotics, have kidney disease, or are pregnant or breastfeeding. Do not self-administer. Complete the full course as prescribed, even if you feel better. Report any signs of allergic reaction, severe diarrhea, or unusual bleeding. Your doctor may monitor your kidney function and blood counts during treatment.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have decreased renal function and may require dose adjustment. They are also at higher risk of neurotoxicity and should be monitored closely.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before starting this medicine. It is generally considered safe in pregnancy when clearly needed, but the benefits and risks should be discussed.
🏥 Post-Surgery Considerations
This medicine is often used to prevent or treat surgical site infections. It may be given before, during, or after surgery. Follow your surgeon's instructions.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine. It may be used prophylactically for dental procedures in patients at risk of endocarditis.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
You may feel tired or dizzy after receiving this medicine. Avoid strenuous exercise until you feel fully recovered. Consult your doctor before resuming intense physical activity.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital or clinic, so you may need to take time off work for treatment. You may feel tired or dizzy; avoid driving or operating machinery until you know how it affects you.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Complete the full course as prescribed, even if you feel better. Stopping early can lead to recurrence of infection and antibiotic resistance.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance and superinfections. It is generally used for short courses. Prolonged use may require monitoring of kidney function, blood counts, and liver enzymes. If used for more than 10 days, watch for fungal infections or C. difficile diarrhea.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For mild infections, oral antibiotics may be used instead of injections.
Evidence: Well-establishedDepending on the bacteria, other antibiotics like ceftriaxone or meropenem may be used.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interaction with vaccines. However, if you are scheduled for a vaccine, inform your doctor about this medicine. Live vaccines should be avoided during antibiotic therapy.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original packaging
❌ DON'T
Do not use if solution is cloudy or contains particles
✅ DO
Protect from light
❌ DON'T
Do not store in bathroom
✈️ Traveling with This Medicine
This medicine is administered in a healthcare setting, so travel is not applicable. If you are traveling after treatment, carry a copy of your prescription and medical records. Store any remaining medication as directed. Consult your doctor before travel if you have ongoing treatment.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working immediately after administration, but you may start feeling better within 24-48 hours. Complete the full course as prescribed.
A: Inform your doctor about any penicillin allergy. This medicine may be used with caution, but your doctor will decide if it is safe for you.
A: This medicine can rarely affect kidney function. Your doctor will monitor your kidney function and adjust the dose if needed.
🤔 Common Patient Concerns
🔄 Substitutes for ipacare 1000mg injection
View AllAlternative brands with exact same active ingredient:
-
megapime 1000mg injectionAlkem Laboratories Ltd ₹84.38 59.6% CHEAPER
-
biopime 1000mg injectionBiochem Pharmaceutical Industries ₹98.14 53.1% CHEAPER
-
forpar 1000mg injectionCipla Ltd ₹123.75 40.8% CHEAPER
-
cepime 1000mg injectionAlembic Pharmaceuticals Ltd ₹129.91 37.9% CHEAPER
-
corpime 1000mg injectionCoral Pharmaceuticals P Ltd ₹139.69 33.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the flu.
Fact: This medicine is an antibiotic and is only effective against bacterial infections, not viruses. - Myth: You can stop taking this medicine once you feel better.
Fact: You must complete the full course as prescribed to prevent recurrence and resistance.
🔄 Alternative Options
Generic Alternatives
- Cefepime 1000mg injection
Brand Alternatives
- Maxipime
- Cefepime injection