Intraval Sodium Injection (Thiopental Sodium 1000mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or stopped breathing
- Severe chest pain or irregular heartbeat
- Sudden swelling of face, lips, or throat
- Severe dizziness or fainting
- Persistent vomiting or inability to wake up
- Redness, swelling, or pain at injection site that worsens
- Yellowing of skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is intraval sodium injection used for?
This medicine is a short-acting intravenous anesthetic used to induce general anesthesia. It works quickly, usually within 30 to 60 seconds, and its effects last for about 5 to 20 minutes after a single dose. It must be given by a trained anesthesiologist in a hospital setting with continuous monitoring.
- Generic Name: Thiopental Sodium (1000mg)
- Manufacturer: Rhone-Poulenc India Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 intraval sodium injection के बारे में (Hindi Summary)
उपयोग: यह दवा थायोपेंटल सोडियम का इंजेक्शन है, जिसका उपयोग सामान्य एनेस्थीसिया (बेहोशी) शुरू करने के लिए किया जाता है। यह दवा बहुत तेजी से काम करती है और मरीज को 30 से 60 सेकंड में बेहोश कर देती है। इसका उपयोग सर्जरी से पहले किया जाता है ताकि मरीज को दर्द और बेचैनी महसूस न हो। यह दवा केवल अस्पताल में प्रशिक्षित एनेस्थेसियोलॉजिस्ट द्वारा ही दी जाती है। इसे घर पर या बिना डॉक्टर की निगरानी में कभी नहीं लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, जी मिचलाना और उल्टी शामिल हैं। कुछ मरीजों को इंजेक्शन लगाने की जगह पर दर्द या सूजन हो सकती है। गंभीर दुष्प्रभावों में सांस लेने में कठिनाई, बहुत कम रक्तचाप और धड़कन धीमी होना शामिल है। एलर्जी की प्रतिक्रिया बहुत कम होती है लेकिन गंभीर हो सकती है। इन सभी प्रभावों की निगरानी अस्पताल में डॉक्टर द्वारा की जाती है।
सुरक्षा सलाह: यह दवा केवल अस्पताल में प्रशिक्षित डॉक्टर द्वारा ही दी जानी चाहिए। इसे घर पर कभी न लें। अगर आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर को बताएं। इस दवा को लेने से पहले अपने सभी दवाओं के बारे में डॉक्टर को जानकारी दें। शराब और अन्य नींद लाने वाली दवाओं से बचें। इंजेक्शन के बाद 24 घंटे तक गाड़ी न चलाएं और मशीन न चलाएं।
💊 intraval sodium injection Uses & Benefits
[{"condition":"Induction of general anesthesia","description":"This medicine is used to rapidly induce unconsciousness before other anesthetic agents are given.","evidence":"Well-established"},{"condition":"Short surgical procedures","description":"It can provide anesthesia for brief procedures when used alone or with other agents.","evidence":"Well-established"},{"condition":"Control of convulsive states","description":"It may be used to terminate certain seizures when other treatments are ineffective or unavailable.","evidence":"Limited"},{"condition":"Cerebral protection","description":"In some neurosurgical situations, it is used to reduce brain metabolic demand and intracranial pressure.","evidence":"Limited"}]
Off-label uses: [{"condition":"Refractory status epilepticus","description":"Occasionally used in intensive care for seizures that do not respond to standard therapy.","evidence":"Limited"},{"condition":"Sedation in intensive care","description":"Rarely used for prolonged sedation in critically ill patients, though not a first-line choice.","evidence":"Limited"}]
Primary treatment for: Induction of general anesthesia
Also treats: Convulsive states, Cerebral protection in neurosurgery
📋 Drug Information
| Generic Name(s) | Thiopental Sodium (1000mg) |
| Brand Name | intraval sodium injection |
| Manufacturer | Rhone-Poulenc India Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Barbiturate |
| Route of Administration | Parenteral (intravenous) |
| Storage | Store below 25°C, protected from light. Do not freeze. Keep the vial in its original carton until use. Reconstituted solutions should be used immediately and any unused portion discarded. |
| Shelf Life | 24 months from the date of manufacture, unless otherwise specified on the label. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine acts by binding to the barbiturate site on the gamma-aminobutyric acid type A (GABAA) receptor complex in the brain. This binding enhances the inhibitory effect of GABA, leading to increased chloride ion flow into neurons and hyperpolarization. The result is a dose-dependent depression of the central nervous system, ranging from sedation to deep unconsciousness and coma. At higher doses, it can also directly activate the receptor even without GABA. The rapid onset and short duration are due to its high lipid solubility, which allows quick entry into the brain and subsequent redistribution to other tissues.
Mechanism Steps
💡 How to Take intraval sodium injection
Strength: Injection: 1000mg vial
Dosage Information
| Adult Dosage | The dose of this medicine is highly individualized and must be determined by a qualified anesthesiologist based on the patient's age, weight, cardiovascular status, and the procedure. For induction of anesthesia, a typical adult dose is 3 to 5 mg per kg of body weight given intravenously over 10 to 15 seconds. For maintenance, additional small doses may be given as needed. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician or pediatric anesthesiologist for appropriate dosing. |
| Elderly Dosage | Elderly patients are more sensitive to the effects of this medicine. Reduced doses are recommended, and the dose must be individualized by a qualified clinician based on the patient's condition and response. |
| Renal Impairment | Renal impairment does not significantly affect the elimination of this medicine, but caution is advised because hypotension can worsen renal function. Dose adjustment is not typically required, but close monitoring is essential. |
| Hepatic Impairment | In patients with hepatic impairment, the metabolism of this medicine is reduced, leading to prolonged effects. Reduced doses and extended monitoring are recommended. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum daily dose is not fixed and depends on the clinical situation. It must be determined by a qualified anesthesiologist. Repeated doses can lead to accumulation. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of intraval sodium injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Opioids | Major | |
| Benzodiazepines | Major | |
| Alcohol | Major | |
| MAOIs | Major | |
| Antihypertensives | Major | |
| Cimetidine | Moderate | |
| Valproic acid | Moderate | |
| Probenecid | Moderate | |
| Rifampicin | Minor | |
| St. John's wort | Minor |
🚨 Major Interactions
- Other central nervous system depressants (e.g., opioids, benzodiazepines, alcohol)
- Monoamine oxidase inhibitors (MAOIs)
- Antihypertensive agents
⚡ Moderate Interactions
- Cimetidine
- Valproic acid
- Probenecid
🍷 Alcohol Interaction
Alcohol should be strictly avoided before and after receiving this medicine. Combining alcohol with thiopental sodium can cause severe respiratory depression, profound sedation, and dangerously low blood pressure. Even small amounts of alcohol can intensify the effects and increase the risk of complications.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to barbiturates","Severe cardiovascular disease","Porphyria","Severe respiratory depression or airway obstruction","Status asthmaticus","Severe hepatic impairment","Use without appropriate resuscitation equipment"]
⚠️ Warnings & Precautions
["This medicine must be administered only by trained anesthesia personnel.","Continuous monitoring of vital signs is mandatory.","Rapid injection can cause severe hypotension and respiratory depression.","Tolerance and dependence can develop with prolonged use.","Use with caution in the elderly, debilitated, and obese patients.","Avoid extravasation to prevent tissue necrosis.","Do not use if solution is discolored or contains particles.","Inform patients not to drive or operate machinery for at least 24 hours after anesthesia."]
🤱 Lactation Safety
This medicine is excreted in breast milk in small amounts. It is generally not recommended during breastfeeding because of the potential for infant sedation. If it must be used, breastfeeding should be withheld for at least 24 hours after administration, and the infant should be monitored for drowsiness.
💊 Overdose Management
Overdose of this medicine causes profound central nervous system depression, respiratory failure, and cardiovascular collapse. Management includes immediate airway support, mechanical ventilation, oxygen therapy, and intravenous fluids. There is no specific antidote. Hemodialysis or hemoperfusion may be considered in severe cases. Supportive care in an intensive care unit is essential until the drug is eliminated.
⏰ Missed Dose
This medicine is given as a single dose or a series of doses in a controlled medical setting. Missed doses are not applicable because administration is supervised by a healthcare professional. If a scheduled dose is missed, the medical team will determine the appropriate action based on the clinical situation.
Additional Safety Advice
This medicine must only be administered by a qualified anesthesia professional in a hospital or surgical center with continuous monitoring of heart rate, blood pressure, oxygen saturation, and breathing. Do not attempt to use this medicine at home or in any non-medical setting. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding, as this medicine can affect the baby. Tell your healthcare provider about all medicines you take, especially sedatives, pain relievers, and blood pressure medicines, because they can increase the depressant effects. Avoid alcohol and other central nervous system depressants before and after receiving this medicine. After administration, do not drive, operate machinery, or make important decisions until fully alert. Keep all follow-up appointments and report any unusual symptoms such as difficulty breathing, persistent dizziness, or skin rash.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the effects of this medicine due to decreased metabolism and reduced cardiovascular reserve. Lower doses are recommended, and close monitoring is essential. The risk of confusion, prolonged sedation, and falls is higher in this age group.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss with your doctor before receiving this medicine. It crosses the placenta and may affect the fetus. It should only be used during pregnancy if clearly needed and under strict medical supervision. Effective contraception is advised during treatment if not pregnant.
🏥 Post-Surgery Considerations
After surgery, you will be monitored in a recovery area until you are fully awake. You may feel drowsy, dizzy, or nauseated. Follow your surgeon's instructions regarding activity, diet, and medications. Do not drive or operate machinery for at least 24 hours. Report any unusual symptoms to your doctor promptly.
🦷 Dental Procedures
This medicine is not typically used for dental procedures. If you are scheduled for dental work and have received this medicine recently, inform your dentist. You may need to postpone non-urgent dental procedures until you have fully recovered from the anesthesia.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid exercise and strenuous activities for at least 24 hours after receiving this medicine. Your coordination and judgment may be impaired. Gradually resume normal activities as you feel able, but consult your doctor before starting intense exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine causes profound drowsiness and impairs coordination and judgment. You should not drive, operate machinery, or make important decisions for at least 24 hours after receiving it. Plan to take the day off work and arrange for someone to stay with you for the first few hours after the procedure.
🛑 When to Stop This Medicine
This medicine is given as a single dose or a short series of doses in a controlled medical setting. You do not need to stop it yourself. If you experience any severe side effects, the medical team will manage them immediately. After discharge, if you have concerns, contact your doctor before taking any other medications.
📅 Long-Term Use Effects
Long-term effects of this medicine are not well established because it is typically used for short-term anesthesia. Prolonged or repeated use can lead to tolerance, dependence, and accumulation in body fat, resulting in prolonged sedation. Regular monitoring of liver and kidney function may be advised in cases of prolonged use. When used appropriately in a controlled setting, the risks are minimized.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another intravenous anesthetic with rapid onset and shorter duration.
Evidence: Well-establishedIntravenous anesthetic with minimal cardiovascular effects.
Evidence: Well-establishedAlternative to general anesthesia for certain procedures.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, if you are scheduled for surgery, inform your doctor about any recent vaccinations. Live vaccines should be avoided around the time of surgery if immunosuppression is expected, but this medicine itself does not require changes to vaccination schedules.
📦 Storage Guide
✅ DO
Store below 25°C
❌ DON'T
Do not freeze
✅ DO
Keep in original carton
❌ DON'T
Do not expose to light
✅ DO
Use immediately after reconstitution
❌ DON'T
Do not store reconstituted solution
✈️ Traveling with This Medicine
This medicine is administered only in a hospital setting and is not for self-administration. If you are traveling after a procedure that used this medicine, carry a copy of your medical records and discharge summary. Do not drive or operate machinery for at least 24 hours. If you need to fly, inform the airline about your recent anesthesia. Keep any prescribed medications in their original packaging with a copy of the prescription. Store this medicine as directed by the healthcare provider; it should not be stored at home.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine works very quickly, usually within 30 to 60 seconds after injection.
A: No, this medicine induces deep unconsciousness, so you will not feel pain during the procedure.
A: No, you should not drive or operate machinery for at least 24 hours after receiving this medicine.
A: Pediatric dosing is not established from available information. Consult a pediatric anesthesiologist.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: Thiopental sodium is a painkiller.
Fact: Thiopental sodium is an anesthetic agent that induces unconsciousness; it does not provide pain relief. - Myth: Thiopental sodium can be taken at home.
Fact: This medicine must only be administered by trained professionals in a hospital setting. - Myth: Thiopental sodium is safe for everyone.
Fact: It is contraindicated in certain conditions such as porphyria and severe cardiovascular disease.
🔄 Alternative Options
Generic Alternatives
- Thiopental Sodium
Brand Alternatives
- Intraval Sodium