Terlipressin 1mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe chest pain or difficulty breathing
- Sudden swelling of face, lips, or throat
- Pain, numbness, or colour changes in fingers or toes
- Severe abdominal pain or worsening bleeding
- Confusion, seizures, or extreme drowsiness
- Very high blood pressure or irregular heartbeat
- Decreased urine output or swelling in legs
If experiencing severe symptoms, call emergency services immediately.
What is interli 1mg injection used for?
This medicine is a vasopressin analogue given by intravenous injection to control bleeding from oesophageal varices in patients with liver cirrhosis. It works by narrowing blood vessels in the abdomen to reduce pressure in the portal vein.
- Generic Name: Terlipressin (1mg)
- Manufacturer: Integrated Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 interli 1mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा टेरलिप्रेसिन 1 मिलीग्राम इंजेक्शन के रूप में उपलब्ध है और इसका उपयोग अस्पताल में डॉक्टर द्वारा किया जाता है। यह मुख्य रूप से लिवर सिरोसिस वाले मरीजों में अन्नप्रणाली की नसों से होने वाले गंभीर रक्तस्राव को रोकने के लिए दी जाती है। यह दवा खून की नसों को सिकोड़कर पोर्टल वेन का दबाव कम करती है, जिससे रक्तस्राव रुकता है। कुछ देशों में यह हेपेटोरेनल सिंड्रोम के इलाज में भी इस्तेमाल होती है। यह दवा केवल नस में इंजेक्शन द्वारा दी जाती है और घर पर खुद से नहीं लगाई जानी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में त्वचा का पीला पड़ना, पेट में ऐंठन, जी मिचलाना, दस्त, सिरदर्द और रक्तचाप में अस्थायी वृद्धि शामिल हैं। गंभीर दुष्प्रभावों में उंगलियों या पैरों की नसों में खून का प्रवाह कम होना, सूजन, सोडियम की कमी और दिल की धड़कन में गड़बड़ी हो सकती है। किसी भी असामान्य लक्षण को तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल अस्पताल में डॉक्टर या नर्स द्वारा ही दी जानी चाहिए। इसे घर पर खुद से न लगाएं। अगर आपको दिल की बीमारी, हाई ब्लड प्रेशर, दमा या किडनी की समस्या है तो डॉक्टर को पहले बताएं। इलाज के दौरान ब्लड प्रेशर, दिल की धड़कन और शरीर में पानी की मात्रा की निगरानी की जाएगी। उंगलियों या पैरों में दर्द, सुन्नपन या रंग बदलने पर तुरंत डॉक्टर को बताएं। इलाज के दौरान शराब न पिएं।
💊 interli 1mg injection Uses & Benefits
[{"condition":"Bleeding oesophageal varices","description":"This medicine is used to control acute bleeding from enlarged veins in the food pipe in patients with liver cirrhosis by reducing portal pressure.","evidence":"Well-established"},{"condition":"Hepatorenal syndrome","description":"In some countries, this medicine is used to improve kidney function in patients with advanced liver disease and kidney failure, often in combination with albumin.","evidence":"Established in specific regions"}]
Off-label uses: [{"condition":"Refractory ascites","description":"Occasionally used in specialist centres to manage fluid accumulation in the abdomen due to liver disease, but evidence is limited.","evidence":"Limited"}]
Primary treatment for: Bleeding oesophageal varices
Also treats: Hepatorenal syndrome, Cirrhosis with portal hypertension
📋 Drug Information
| Generic Name(s) | Terlipressin (1mg) |
| Brand Name | interli 1mg injection |
| Manufacturer | Integrated Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | HORMONES |
| Action Class | Vasopressin analogues |
| Route of Administration | Parenteral (intravenous injection) |
| Storage | Store in a refrigerator at 2°C to 8°C. Do not freeze. Keep the vial in its original carton to protect from light. |
| Shelf Life | Refer to the expiry date on the vial or carton. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by mimicking the natural hormone vasopressin. It binds selectively to vasopressin V1 receptors on smooth muscle cells in blood vessels, especially in the splanchnic circulation. This binding triggers a cascade that increases intracellular calcium, leading to contraction of the muscle cells and narrowing of the blood vessels. As a result, blood flow to the portal vein is reduced, which lowers the pressure inside the portal system and helps stop bleeding from varices. The effect on V2 receptors is minimal, so it causes less water retention than natural vasopressin.
Mechanism Steps
💡 How to Take interli 1mg injection
Strength: Terlipressin 1 mg injection
Dosage Information
| Adult Dosage | The dose of this medicine is determined by the treating doctor based on the condition being treated, the patient's weight, kidney and liver function, and response to therapy. For bleeding oesophageal varices, an initial intravenous dose is given, followed by doses every 4 to 6 hours for up to 48 hours or as clinically indicated. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially on blood pressure and heart rhythm. Doses should be carefully adjusted by the doctor, and monitoring should be more frequent. |
| Renal Impairment | Dose adjustment may be needed in patients with kidney impairment. The doctor will decide the appropriate dose based on kidney function tests. |
| Hepatic Impairment | No specific dose adjustment is established for liver impairment, but this medicine is often used in patients with liver disease. Close monitoring is required. |
| Maximum Daily Dose | The maximum daily dose is not fixed and depends on the indication and clinical response. The doctor will determine the appropriate dose and duration. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of interli 1mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Adrenaline | Major | |
| Noradrenaline | Major | |
| Beta-blockers | Major | |
| Diuretics | Moderate | |
| NSAIDs | Moderate | |
| Antidiabetic medicines | Minor |
🚨 Major Interactions
- Other vasoconstrictors (e.g., adrenaline, noradrenaline)
- Beta-blockers
⚡ Moderate Interactions
- Diuretics
- Non-steroidal anti-inflammatory drugs (NSAIDs)
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine because it can worsen liver disease and increase the risk of bleeding and other complications.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to terlipressin or any component of the formulation","Severe uncontrolled high blood pressure","Severe heart disease including recent heart attack or unstable angina","Severe asthma or chronic obstructive pulmonary disease","Peripheral vascular disease","Pregnancy (unless clearly needed and prescribed by a specialist)"]
⚠️ Warnings & Precautions
["This medicine must be given only by a healthcare professional in a hospital setting.","Monitor blood pressure and heart rate continuously during administration.","Use with caution in patients with kidney disease, heart disease, or asthma.","Avoid use in patients with severe peripheral vascular disease.","Report any pain, numbness, or colour changes in fingers or toes immediately.","Do not use if the solution is discoloured or contains particles.","Keep out of reach of children."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Breastfeeding should be avoided during treatment unless advised otherwise by a doctor.
💊 Overdose Management
Overdose of this medicine can cause severe vasoconstriction, dangerously high blood pressure, and reduced blood flow to vital organs. Treatment is supportive and symptomatic, with close monitoring of vital signs and organ perfusion. There is no specific antidote. In case of overdose, stop the infusion immediately and seek emergency medical care.
⏰ Missed Dose
This medicine is given by a healthcare professional in a hospital setting, so missed doses are unlikely. If a dose is missed, the medical team will determine the appropriate timing for the next dose based on your condition.
Additional Safety Advice
This medicine must only be given by a qualified healthcare professional in a hospital or clinic setting. Do not attempt to self-administer this injection. Inform your doctor if you have a history of heart disease, high blood pressure, asthma, or kidney problems before receiving this medicine. Your doctor will monitor your blood pressure, heart rate, and fluid balance closely during treatment. Report any pain, numbness, or colour changes in your fingers or toes right away. Avoid alcohol during treatment because it can worsen liver and blood vessel problems. Do not drive or operate heavy machinery immediately after receiving this medicine, as it may cause dizziness or low blood pressure. Keep all follow-up appointments for blood tests and clinical review.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine, especially on blood pressure and heart rhythm. Close monitoring is required, and doses should be adjusted by the doctor.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss with your doctor before receiving this medicine. It should be used during pregnancy only if clearly needed and prescribed by a specialist.
🏥 Post-Surgery Considerations
This medicine may be used before or after certain surgical procedures to control bleeding. Inform your surgeon and anaesthetist if you have received this medicine recently.
🦷 Dental Procedures
Inform your dentist if you have received this medicine recently, as it may affect bleeding and blood pressure. Dental procedures may need to be postponed until you are stable.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise during treatment and recovery. Light activity may be allowed as advised by your doctor. Do not start any new exercise routine without consulting your healthcare provider.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital, so it will not affect your work directly. After treatment, you may need rest and follow-up. Do not drive or operate heavy machinery until you feel fully recovered and your doctor approves.
🛑 When to Stop This Medicine
This medicine is stopped by the doctor based on your clinical response and condition. Do not stop or adjust the dose yourself. If you experience severe side effects, inform your doctor immediately.
📅 Long-Term Use Effects
This medicine is usually given for a short duration in a hospital setting. Long-term effects are not well established because it is not intended for prolonged use. Monitoring of blood pressure, heart rhythm, kidney function, and fluid balance is required during treatment. Follow-up care should focus on the underlying liver disease.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Endoscopic band ligation or sclerotherapy can be used to control variceal bleeding.
Evidence: Well-establishedAnother vasoactive medicine that can reduce portal pressure.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions known with this medicine. However, patients with liver disease should discuss vaccination against hepatitis A and B with their doctor.
📦 Storage Guide
✅ DO
Store in a refrigerator at 2°C to 8°C
❌ DON'T
Do not freeze
✅ DO
Keep the vial in its original carton to protect from light
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Check the expiry date before use
❌ DON'T
Do not use if the solution is discoloured or contains particles
✈️ Traveling with This Medicine
This medicine is given in a hospital setting, so travel advice is not applicable for self-administration. If you are travelling after treatment, carry a copy of your prescription and medical records. Inform your doctor before travelling. Store the medicine as advised by the hospital pharmacy. Do not carry or use this medicine without medical supervision.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within a few minutes after intravenous injection.
A: No, this medicine is given only by intravenous injection in a hospital setting.
A: Common side effects include pale skin, abdominal cramps, nausea, headache, and a temporary rise in blood pressure.
A: This medicine should be used during pregnancy only if clearly needed and prescribed by a specialist.
🤔 Common Patient Concerns
🔄 Substitutes for interli 1mg injection
View AllAlternative brands with exact same active ingredient:
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pressin 1mg injectionProhealth Vitamins Pvt Ltd ₹74.06 95.9% CHEAPER
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Tresil 1mg InjectionSerum Institute Of India Ltd ₹585.94 67.5% CHEAPER
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gi-pres injectionAhen Pharmaceuticals ₹1,125.00 37.6% CHEAPER
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triprez 1mg injectionJ B Chemicals and Pharmaceuticals Ltd ₹1,236.91 31.4% CHEAPER
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Terlibax 1mg InjectionEmcure Pharmaceuticals Ltd ₹1,370.03 24% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken orally.
Fact: This medicine is given only by intravenous injection in a hospital setting. - Myth: This medicine is safe for everyone with liver disease.
Fact: It is contraindicated in certain heart and lung conditions and must be used under medical supervision.