Autadol 50mg/325mg Tablet: Comprehensive Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Seizures or convulsions
- Difficulty breathing or slow, shallow breathing
- Severe allergic reaction (rash, swelling of face, lips, or throat)
- Signs of serotonin syndrome (agitation, hallucinations, fast heartbeat, fever)
- Yellowing of skin or eyes, dark urine, or severe abdominal pain
- Extreme drowsiness or confusion
- Chest pain or irregular heartbeat
If experiencing severe symptoms, call emergency services immediately.
What is inodol p 50mg/325mg tablet used for?
This medicine is a combination of tramadol (an opioid pain reliever) and paracetamol (an analgesic and antipyretic). It is used for short-term relief of moderate to moderately severe pain. It works by blocking pain signals in the brain and reducing fever. It should be taken exactly as prescribed and is not for long-term use without medical supervision.
- Generic Name: Tramadol (50mg) + Paracetamol (325mg)
- Manufacturer: H.L Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 inodol p 50mg/325mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा ट्रामाडोल और पैरासिटामोल का संयोजन है, जिसका उपयोग मध्यम से गंभीर दर्द के इलाज के लिए किया जाता है। यह सर्जरी, दांत निकालने, चोट या मांसपेशियों के दर्द में राहत देती है। यह दर्द के संकेतों को मस्तिष्क तक पहुंचने से रोकती है और बुखार को भी कम करती है। इसका उपयोग केवल डॉक्टर की सलाह पर और सीमित समय के लिए करना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, चक्कर आना, नींद आना, कब्ज, सूखा मुँह और सिरदर्द शामिल हैं। गंभीर दुष्प्रभावों में दौरे, सांस लेने में कठिनाई, एलर्जी, और सेरोटोनिन सिंड्रोम हो सकते हैं। यदि आपको कोई भी गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। शराब का सेवन बिल्कुल न करें। गाड़ी चलाने या मशीन चलाने से बचें जब तक आपको पता न चल जाए कि यह दवा आप पर कैसा असर करती है। यदि आपको लीवर या किडनी की बीमारी है, दौरे पड़ते हैं, या नशे की लत है, तो डॉक्टर को बताएं। बच्चों की पहुंच से दूर रखें।
💊 inodol p 50mg/325mg tablet Uses & Benefits
[{"condition":"Acute moderate to severe pain","description":"Used for short-term relief of pain that is not controlled by non-opioid analgesics alone, such as post-operative pain, dental pain, or musculoskeletal injury pain.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Provides effective analgesia following surgical procedures when used as part of a multimodal pain management plan.","evidence":"Well-established"},{"condition":"Dental pain","description":"Relieves moderate to severe dental pain, including pain after tooth extraction or other dental procedures.","evidence":"Well-established"},{"condition":"Musculoskeletal pain","description":"Used for short-term management of moderate pain from strains, sprains, or other musculoskeletal injuries.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Chronic pain","description":"Sometimes prescribed off-label for chronic pain conditions such as osteoarthritis or neuropathic pain, but long-term use is generally discouraged due to risks of dependence and tolerance.","evidence":"Limited"},{"condition":"Migraine","description":"May be used off-label for acute migraine attacks, but not as a first-line treatment.","evidence":"Limited"}]
Primary treatment for: Acute moderate to severe pain
Also treats: Post-operative pain, Dental pain, Musculoskeletal pain, Back pain
📋 Drug Information
| Generic Name(s) | Tramadol (50mg) + Paracetamol (325mg) |
| Brand Name | inodol p 50mg/325mg tablet |
| Manufacturer | H.L Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture, heat, and direct sunlight. Do not refrigerate unless specified by the manufacturer. |
| Shelf Life | 24 months from the date of manufacture, unless otherwise stated on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two analgesics with different mechanisms. Tramadol is a centrally acting opioid analgesic that binds to mu-opioid receptors and also inhibits the reuptake of norepinephrine and serotonin, which contributes to its pain-relieving effects. Paracetamol acts primarily in the central nervous system to reduce pain and fever, though its exact mechanism is not fully understood; it may involve inhibition of prostaglandin synthesis in the brain and spinal cord. Together, they provide additive pain relief.
Mechanism Steps
💡 How to Take inodol p 50mg/325mg tablet
Strength: Each immediate-release tablet contains tramadol hydrochloride 50 mg and paracetamol 325 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet (tramadol 50 mg and paracetamol 325 mg) taken orally every 4 to 6 hours as needed for pain, not to exceed 8 tablets in 24 hours. The maximum daily dose of tramadol should not exceed 400 mg and paracetamol should not exceed 4000 mg from all sources. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not use for more than 5 days without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. This medicine is contraindicated in children under 12 years and in children under 18 years following tonsillectomy or adenoidectomy. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the effects of tramadol, especially respiratory depression, sedation, and confusion. The dose should be reduced and individualized by a clinician. The maximum daily dose of tramadol should not exceed 300 mg in patients over 75 years. Use with caution and monitor closely. |
| Renal Impairment | In patients with renal impairment, dose adjustment is required. For creatinine clearance less than 30 mL/min, the dosing interval should be increased to every 12 hours, and the maximum daily dose of tramadol should not exceed 200 mg. This medicine is contraindicated in severe renal impairment. Consult a clinician for individualized dosing. |
| Hepatic Impairment | In patients with hepatic impairment, dose reduction and longer dosing intervals are recommended. In severe hepatic impairment, this medicine is contraindicated. For mild to moderate impairment, the maximum daily dose of tramadol should not exceed 200 mg, and paracetamol dose should be limited. Consult a clinician for individualized dosing. |
| Maximum Daily Dose | Maximum daily dose: 8 tablets (tramadol 400 mg and paracetamol 2600 mg) per 24 hours. However, the total daily dose of paracetamol from all sources should not exceed 4000 mg, and tramadol should not exceed 400 mg. In elderly or patients with renal/hepatic impairment, lower maximum doses apply. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of inodol p 50mg/325mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| Warfarin | Major | |
| CNS depressants | Major | |
| SSRIs/SNRIs | Major | |
| Carbamazepine | Major | |
| CYP2D6 inhibitors | Moderate | |
| CYP3A4 inducers | Moderate | |
| Anticholinergics | Moderate | |
| Diuretics | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- CNS depressants (e.g., alcohol, benzodiazepines, opioids)
- Warfarin
- Carbamazepine
- SSRIs, SNRIs, TCAs
⚡ Moderate Interactions
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
- CYP3A4 inducers (e.g., rifampin, St. John's wort)
- Anticholinergic drugs
- Diuretics
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of liver damage from paracetamol and enhances the sedative and respiratory depressant effects of tramadol. It can also increase the risk of seizures and other serious side effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to tramadol, paracetamol, or any component of the formulation","Severe respiratory depression or acute severe asthma","Concurrent use of monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping MAOIs","Severe hepatic impairment","Severe renal impairment (creatinine clearance
⚠️ Warnings & Precautions
["May cause seizures, especially in patients with a history of seizures, head trauma, or metabolic disorders.","Risk of serotonin syndrome when used with other serotonergic drugs.","May cause respiratory depression, especially in elderly or debilitated patients.","Can cause physical and psychological dependence; use with caution in patients with a history of substance abuse.","Avoid abrupt discontinuation after prolonged use to prevent withdrawal symptoms.","Use with caution in patients with liver or kidney disease; dose adjustment may be required.","May impair mental and physical abilities; avoid driving or operating machinery until effects are known.","Do not exceed the recommended dose of paracetamol to avoid liver damage.","Not recommended for use in children under 12 years.","Use with caution in elderly patients due to increased risk of falls and confusion."]
🤱 Lactation Safety
Tramadol and paracetamol are excreted in breast milk. Tramadol may cause serious adverse effects in a nursing infant, including excessive sleepiness, difficulty breathing, and poor feeding. This medicine is not recommended during breastfeeding. Consult your doctor for alternative pain management options.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage from paracetamol, respiratory depression, seizures, and coma from tramadol. Seek emergency medical attention immediately. Treatment includes supportive care, activated charcoal if within 1-2 hours of ingestion, and administration of N-acetylcysteine for paracetamol toxicity. Naloxone may be used for tramadol-induced respiratory depression, but it may not reverse all effects. Do not attempt to manage overdose at home.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Avoid alcohol while taking this medicine as it can increase the risk of liver damage and drowsiness. Do not drive or operate heavy machinery until you know how this medicine affects you. Inform your doctor if you have a history of liver or kidney disease, seizures, or substance abuse. Do not take other products containing paracetamol while on this medicine to avoid overdose. Keep out of reach of children. Store at room temperature away from moisture and heat. If you miss a dose, take it as soon as you remember unless it is almost time for the next dose; do not double the dose.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at increased risk of side effects such as drowsiness, confusion, falls, and respiratory depression. The dose should be reduced, and the medicine should be used with caution. The maximum daily dose of tramadol should not exceed 300 mg in patients over 75 years. Regular monitoring is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Tramadol is not recommended during pregnancy, especially in the third trimester, due to the risk of neonatal opioid withdrawal syndrome. Discuss alternative pain management options with your healthcare provider.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative pain management, but it should be used with caution, especially in patients with a history of respiratory depression or those receiving other sedatives. It is contraindicated in children under 18 years following tonsillectomy or adenoidectomy. Close monitoring is required.
🦷 Dental Procedures
This medicine can be used for dental pain, but it should be taken only as prescribed by your dentist or doctor. Inform your dentist if you are taking this medicine before any dental procedure, as it may interact with anesthetics or other medications used during the procedure.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that may worsen your pain while taking this medicine. This medicine can cause drowsiness and dizziness, so avoid activities that require alertness, such as driving or operating machinery, until you know how it affects you. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, dizziness, and difficulty concentrating, which may affect your ability to work or perform daily activities. Avoid driving, operating heavy machinery, or engaging in activities that require mental alertness until you know how this medicine affects you. Inform your employer if your job requires such activities.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your pain is not relieved, if you experience serious side effects, or if you have taken it for more than 5 days without improvement. Do not stop abruptly after long-term use; consult your doctor for a tapering plan to avoid withdrawal symptoms.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to tolerance, dependence, and withdrawal symptoms. It may also increase the risk of liver damage from paracetamol and kidney impairment. Regular monitoring of liver and kidney function is advised. This medicine should generally not be used for more than a few weeks without specialist supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help strengthen muscles, improve flexibility, and reduce pain for musculoskeletal conditions.
Evidence: Well-establishedMay be effective for mild to moderate pain and inflammation, but have their own risks.
Evidence: Well-establishedMay provide pain relief for some chronic pain conditions.
Evidence: ModerateHelps manage chronic pain by changing thought patterns and behaviors.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled to receive a live vaccine, inform your doctor that you are taking this medicine, as it may affect your immune response. Generally, this medicine does not require postponement of vaccinations.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Check the laws of your destination country regarding opioid medications, as some countries have strict regulations. Store it in a cool, dry place away from direct sunlight. If crossing time zones, adjust dosing intervals as advised by your doctor. Do not pack it in checked luggage; keep it in your carry-on bag.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it orally.
A: Yes, you can take it with or without food. Taking it with food may help reduce nausea.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: This medicine is not recommended during pregnancy, especially in the third trimester, due to risk of neonatal opioid withdrawal syndrome. Consult your doctor for alternative pain relief.
A: Do not stop suddenly after long-term use as it can cause withdrawal symptoms. Consult your doctor for a tapering plan.
🤔 Common Patient Concerns
🔄 Substitutes for inodol p 50mg/325mg tablet
View AllAlternative brands with exact same active ingredient:
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hoxatram plus 50mg/325mg tabletHochest Biotech India ₹37.00 59.7% CHEAPER
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trox-p 50mg/325mg tabletLifekyor Pharmaceuticals ₹37.50 59.2% CHEAPER
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dolnac p 50mg/325mg tabletHilbert Healthcare ₹39.38 57.1% CHEAPER
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yorodol p 50mg/325mg tabletMediyork Pharma Pvt Ltd ₹39.38 57.1% CHEAPER
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Trick-T TabletVatican Life Sciences Pvt Ltd ₹39.50 57% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is safe to take for any type of pain.
Fact: This medicine is only for moderate to severe pain and should not be used for mild pain or without a prescription. - Myth: You can take this medicine with alcohol without any problems.
Fact: Alcohol increases the risk of liver damage and severe sedation. It should be avoided completely. - Myth: This medicine is not addictive.
Fact: Tramadol can cause dependence and withdrawal symptoms, especially with long-term use. - Myth: You can stop this medicine suddenly after long-term use.
Fact: Abrupt discontinuation can cause withdrawal symptoms. Always consult your doctor for a tapering plan.
🔄 Alternative Options
Generic Alternatives
- Tramadol 50 mg + Paracetamol 325 mg tablet (generic)
Brand Alternatives
- Autadol 50mg/325mg Tablet