Indolpara 37.5mg/350mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Slow, shallow, or difficult breathing
- Extreme drowsiness or confusion
- Seizures or convulsions
- Severe abdominal pain or vomiting blood
- Yellowing of the skin or eyes
- Signs of an allergic reaction such as rash, swelling of face, lips, or throat
- Chest pain or irregular heartbeat
If experiencing severe symptoms, call emergency services immediately.
What is indolpara 37.5mg/350mg tablet used for?
This medicine is a combination of tramadol and paracetamol used for short-term relief of moderate to severe acute pain. It works by reducing pain signals in the brain and spinal cord. It should be taken exactly as prescribed and for the shortest duration necessary.
- Generic Name: Tramadol (37.5mg) + Paracetamol (350mg)
- Manufacturer: Oxytech
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 indolpara 37.5mg/350mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा ट्रामाडोल और पैरासिटामोल का संयोजन है, जिसका उपयोग मध्यम से गंभीर तीव्र दर्द के अल्पकालिक उपचार के लिए किया जाता है। यह सर्जरी, दांत निकालने, या मांसपेशियों की चोट के बाद होने वाले दर्द में राहत देती है। यह दवा केवल डॉक्टर के परामर्श से और निर्धारित अवधि तक ही लेनी चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, चक्कर आना, नींद आना, कब्ज, सिरदर्द और मुंह सूखना शामिल हैं। गंभीर दुष्प्रभावों में सांस लेने में कठिनाई, दौरे, गंभीर पेट दर्द, पीलिया, और एलर्जी की प्रतिक्रिया शामिल हैं। यदि कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक न बढ़ाएं और न ही अधिक बार लें। इस दवा के साथ शराब का सेवन पूरी तरह से बंद कर दें। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन न चलाएं। यदि आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर से सलाह लें। बिना डॉक्टर की सलाह के दवा अचानक बंद न करें।
💊 indolpara 37.5mg/350mg tablet Uses & Benefits
[{"condition":"Acute moderate to severe pain","description":"Short-term relief of pain following surgery, dental procedures, or musculoskeletal injuries.","evidence":"Well-established"},{"condition":"Postoperative pain","description":"Management of pain after surgical procedures when non-opioid analgesics are insufficient.","evidence":"Well-established"},{"condition":"Dental pain","description":"Relief of moderate to severe dental pain, including after tooth extraction.","evidence":"Well-established"},{"condition":"Musculoskeletal pain","description":"Short-term relief of pain from strains, sprains, and other musculoskeletal injuries.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Chronic pain syndromes","description":"Sometimes used off-label for chronic pain conditions like osteoarthritis or neuropathic pain, but not recommended for long-term use due to dependence risk.","evidence":"Limited"}]
Primary treatment for: Acute moderate to severe pain
Also treats: Postoperative pain, Dental pain, Musculoskeletal pain
📋 Drug Information
| Generic Name(s) | Tramadol (37.5mg) + Paracetamol (350mg) |
| Brand Name | indolpara 37.5mg/350mg tablet |
| Manufacturer | Oxytech |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two analgesics with complementary mechanisms. Tramadol is a centrally acting opioid analgesic that binds to mu-opioid receptors and also inhibits the reuptake of serotonin and norepinephrine, which enhances descending inhibitory pain pathways. Paracetamol acts primarily in the central nervous system to reduce pain and fever, though its exact mechanism is not fully established; it may involve inhibition of prostaglandin synthesis in the brain and modulation of pain perception. Together, they provide effective pain relief through both opioid and non-opioid pathways.
Mechanism Steps
💡 How to Take indolpara 37.5mg/350mg tablet
Strength: Tablet containing Tramadol 37.5 mg and Paracetamol 350 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally every 4 to 6 hours as needed for pain. The maximum recommended dose is 8 tablets in 24 hours. However, the dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. Use for the shortest duration necessary. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of tramadol and paracetamol. Start with a lower dose and monitor closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Dose adjustment may be required in patients with renal impairment. Consult your doctor for individualized dosing. |
| Hepatic Impairment | Dose adjustment may be required in patients with hepatic impairment. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | Maximum 8 tablets in 24 hours (equivalent to 300 mg tramadol and 2800 mg paracetamol). Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of indolpara 37.5mg/350mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| CNS depressants | Major | |
| Warfarin | Major | |
| Carbamazepine | Major | |
| SSRIs/SNRIs | Moderate | |
| CYP2D6 inhibitors | Moderate | |
| CYP3A4 inducers | Moderate | |
| Diuretics | Moderate | |
| Anticholinergics | Minor | |
| Metoclopramide | Minor |
🚨 Major Interactions
- MAO inhibitors
- CNS depressants (e.g., alcohol, benzodiazepines, opioids)
- Warfarin
- Carbamazepine
⚡ Moderate Interactions
- SSRIs, SNRIs, TCAs
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
- CYP3A4 inducers (e.g., rifampin, St. John's wort)
- Diuretics
🍷 Alcohol Interaction
Avoid alcohol completely while taking this medicine. Alcohol increases the risk of severe drowsiness, respiratory depression, and liver damage, and can worsen the side effects of both tramadol and paracetamol.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe respiratory depression","Acute or severe asthma","Severe liver disease","Known hypersensitivity to tramadol or paracetamol","Concurrent use of MAO inhibitors or within 14 days of their discontinuation","Children under 12 years of age","Post-operative pain management in children under 18 following tonsillectomy or adenoidectomy"]
⚠️ Warnings & Precautions
["May cause drowsiness and dizziness. Avoid driving or operating machinery until you know how it affects you.","Risk of respiratory depression, especially with high doses or in combination with other CNS depressants.","Risk of seizures, particularly in patients with a history of seizures or those taking other seizure-threshold-lowering drugs.","Risk of serotonin syndrome when used with serotonergic drugs.","Risk of dependence and withdrawal with prolonged use.","Do not exceed the recommended dose of paracetamol to avoid liver damage.","Use with caution in elderly patients and those with kidney or liver impairment.","Avoid alcohol while taking this medicine."]
🤱 Lactation Safety
Tramadol and paracetamol are excreted in breast milk. Use with caution during breastfeeding. Consult your doctor to weigh benefits and risks.
💊 Overdose Management
Overdose can cause severe respiratory depression, seizures, liver damage, and coma. Seek immediate medical attention. Treatment includes supportive care, administration of naloxone for opioid effects, and acetylcysteine for paracetamol toxicity. Do not attempt to manage overdose at home.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not increase the dose or take it more frequently than directed. Avoid alcohol completely while taking this medicine, as it can increase drowsiness and the risk of serious breathing problems. Do not drive or operate heavy machinery until you know how this medicine affects you. Inform your doctor if you have a history of liver or kidney disease, seizures, breathing problems, or substance abuse. Do not take other products containing paracetamol while on this medicine to avoid liver damage. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Keep this medicine out of reach of children and store it in a secure place to prevent misuse. Do not stop this medicine suddenly without consulting your doctor, as withdrawal symptoms may occur.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of tramadol and paracetamol. They are at higher risk of respiratory depression, falls, and confusion. Dose adjustment and close monitoring are recommended.
🤰 Pregnancy Planning (TTC)
Consult your doctor before taking this medicine if you are planning pregnancy. Tramadol and paracetamol may not be suitable during pregnancy. Discuss alternative pain management options.
🏥 Post-Surgery Considerations
This medicine may be prescribed for post-surgical pain. Follow your surgeon's instructions carefully. Do not exceed the prescribed dose and avoid alcohol.
🦷 Dental Procedures
This medicine can be used for dental pain after procedures like tooth extraction. Inform your dentist about all medications you are taking. Do not take additional paracetamol-containing products.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that may worsen your pain while taking this medicine. Consult your doctor or physiotherapist for appropriate exercise modifications.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness and dizziness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also impact your concentration and coordination.
🛑 When to Stop This Medicine
Stop this medicine when your pain is adequately controlled or as advised by your doctor. Do not stop suddenly if you have been taking it for more than a few days, as withdrawal symptoms may occur. Consult your doctor for a tapering schedule.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to dependence, tolerance, and withdrawal symptoms. It may also increase the risk of liver and kidney damage. Regular monitoring of liver and kidney function is recommended if used for extended periods. Consult your doctor for alternative pain management strategies if long-term use is required.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain management.
Evidence: Well-establishedMay help with certain types of pain.
Evidence: LimitedHelps in managing chronic pain and reducing reliance on medications.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. Consult your doctor for routine vaccinations.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and away from direct sunlight. If crossing time zones, consult your doctor for dose timing adjustments. Check local customs regulations regarding opioid medications before traveling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Pain relief typically begins within 30 to 60 minutes after taking this medicine.
A: This medicine is for short-term use only. Consult your doctor for the appropriate duration based on your condition.
A: Yes, prolonged use can lead to dependence. It should be used only as prescribed and for the shortest duration necessary.
A: No, alcohol should be completely avoided as it increases the risk of serious side effects.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is safe for long-term use.
Fact: This medicine is intended for short-term use only. Prolonged use can lead to dependence and other serious side effects. - Myth: It is okay to drink alcohol while taking this medicine.
Fact: Alcohol should be completely avoided as it increases the risk of drowsiness, respiratory depression, and liver damage. - Myth: This medicine can be taken for any type of pain.
Fact: It is only for moderate to severe acute pain and should not be used for mild pain or without a prescription.
🔄 Alternative Options
Generic Alternatives
- Tramadol 37.5 mg + Paracetamol 350 mg tablet