Indivan 400mg Capsule (Indinavir): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe back or side pain, or blood in urine, which may indicate kidney stones.
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain, which may indicate liver problems.
- Unusual bleeding or bruising.
- Sudden swelling of the face, lips, or throat, or difficulty breathing.
- Severe skin rash with blisters or peeling.
- Persistent vomiting or diarrhea leading to dehydration.
- New or worsening symptoms of infections, which may indicate immune reconstitution inflammatory syndrome.
If experiencing severe symptoms, call emergency services immediately.
What is indease 400mg capsule used for?
Indinavir is an antiretroviral medicine used to treat HIV infection. It works by blocking the HIV protease enzyme, preventing the virus from multiplying. It is always used in combination with other HIV medicines and must be taken exactly as prescribed, with plenty of water.
- Generic Name: Indinavir (400mg)
- Manufacturer: Alkem Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 indease 400mg capsule के बारे में (Hindi Summary)
उपयोग: यह दवा इंडिनावीर नामक एंटीरेट्रोवायरल दवा है, जिसका उपयोग एचआईवी संक्रमण के इलाज के लिए अन्य एंटीरेट्रोवायरल दवाओं के साथ किया जाता है। यह एचआईवी वायरस के प्रोटीज एंजाइम को रोककर वायरस को बढ़ने से रोकती है। इसे हमेशा डॉक्टर के बताए अनुसार ही लें, कभी भी अपने आप न लें या बंद न करें। इस दवा को लेते समय भरपूर पानी पिएं और नियमित जांच कराते रहें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, उल्टी, पेट दर्द, दस्त, सिरदर्द, चक्कर आना और थकान शामिल हैं। कुछ लोगों को गुर्दे की पथरी हो सकती है, जिसमें तेज पीठ या कमर दर्द, पेशाब में खून आना या पेशाब करते समय दर्द हो सकता है। अगर आपको ऐसे लक्षण दिखें तो तुरंत डॉक्टर से मिलें। इसके अलावा लिवर में सूजन, ब्लड शुगर और कोलेस्ट्रॉल में बदलाव भी हो सकते हैं।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। रोज कम से कम 1.5 से 2 लीटर पानी पिएं ताकि गुर्दे की पथरी से बचाव हो सके। इसे हल्के भोजन के साथ लें। अपनी सभी दवाओं, सप्लीमेंट्स और हर्बल उत्पादों के बारे में डॉक्टर को बताएं। एचआईवी को दूसरों तक फैलने से रोकने के लिए सुरक्षित यौन संबंध बनाएं। नियमित जांच और डॉक्टर के परामर्श को न छोड़ें।
💊 indease 400mg capsule Uses & Benefits
[{"condition":"HIV-1 infection","description":"Used as part of combination antiretroviral therapy to suppress HIV viral load and improve immune function in adults and children.","evidence":"Well-established"}]
Off-label uses: []
Primary treatment for: Human Immunodeficiency Virus (HIV) infection
Also treats: Acquired Immunodeficiency Syndrome (AIDS), Opportunistic infections in HIV-positive patients
📋 Drug Information
| Generic Name(s) | Indinavir (400mg) |
| Brand Name | indease 400mg capsule |
| Manufacturer | Alkem Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Protease (HIV) inhibitors |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep in the original container, tightly closed, away from moisture and heat. Do not refrigerate. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Indinavir is not recommended as a preferred or alternative first-line antiretroviral agent in current WHO guidelines due to its high pill burden, frequent dosing, and food restrictions. It may be used in certain situations where other options are not available. |
| ICMR Guideline | Indinavir is not included in the preferred first-line or second-line antiretroviral therapy regimens in the current ICMR guidelines for HIV management in India. It may be considered in specific cases under specialist supervision. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Indinavir is a competitive inhibitor of the HIV-1 protease enzyme. It binds to the active site of the protease and prevents the cleavage of viral polyprotein precursors into mature, functional viral proteins. Without this cleavage, new virus particles are immature and non-infectious. This medicine does not kill the virus directly but stops its replication, allowing the immune system to recover and reducing the risk of opportunistic infections.
Mechanism Steps
💡 How to Take indease 400mg capsule
Strength: Indinavir 400 mg immediate-release capsule
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 800 mg (two 400 mg capsules) taken orally every 8 hours. However, the dose may be adjusted by your doctor based on your weight, kidney and liver function, and other medicines you are taking. This medicine must be taken with plenty of water and may be taken with a light meal. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced kidney and liver function. Dose should be selected with caution, and monitoring of kidney and liver function is recommended. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No specific dose adjustment is provided in the available information for renal impairment. Use with caution and monitor kidney function closely. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | In patients with mild to moderate hepatic impairment due to cirrhosis, a dose reduction to 600 mg every 8 hours may be considered. In severe hepatic impairment, use is contraindicated. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is 2400 mg (800 mg every 8 hours). |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of indease 400mg capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Rifampicin | Major | |
| Ritonavir | Major | |
| St John's wort | Major | |
| Ergot derivatives | Major | |
| Midazolam | Major | |
| Ketoconazole | Moderate | |
| Clarithromycin | Moderate | |
| Oral contraceptives | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Rifampicin
- Ritonavir
- St John's wort
- Ergot derivatives
- Midazolam and triazolam
⚡ Moderate Interactions
- Ketoconazole
- Clarithromycin
- Oral contraceptives
🍷 Alcohol Interaction
Alcohol may increase the risk of liver problems and stomach upset. It is best to avoid alcohol while taking this medicine, especially if you have liver disease.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to indinavir or any component of the formulation","Concomitant use with rifampicin","Concomitant use with ergot derivatives","Concomitant use with midazolam or triazolam","Concomitant use with St John's wort","Severe hepatic impairment"]
⚠️ Warnings & Precautions
["This medicine must always be used in combination with other antiretroviral drugs to prevent resistance.","Drink plenty of water to prevent kidney stones.","Use with caution in patients with liver disease; monitor liver enzymes.","Use with caution in patients with kidney disease; monitor kidney function.","May cause changes in blood sugar and lipids; monitor regularly.","May interact with many medicines; always inform your doctor about all drugs you take.","Do not share this medicine with others.","This medicine does not prevent transmission of HIV to others; practice safe sex."]
🤱 Lactation Safety
Indinavir is excreted in human breast milk. Because of the potential for transmission of HIV and serious adverse reactions in the nursing infant, mothers should not breastfeed while taking this medicine. Alternative infant feeding options should be discussed with a healthcare provider.
💊 Overdose Management
There is no specific antidote for indinavir overdose. Treatment should be symptomatic and supportive. Monitor vital signs and liver and kidney function. Contact a poison control center or emergency department immediately if overdose is suspected.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, contact your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed by your HIV specialist. Drink at least 1.5 to 2 liters of water every day to help prevent kidney stones. Take it with food or a light meal if your doctor advises, because food can improve absorption and reduce stomach upset. Do not skip doses or change the schedule without medical advice. Keep all your clinic appointments and blood tests. Tell your doctor about all other medicines, supplements, and herbal products you take, because many drugs interact with this medicine. Use condoms and safe sex practices to prevent passing HIV to others. Do not share needles or personal items that may have blood on them. If you are pregnant, planning pregnancy, or breastfeeding, talk to your doctor about the best treatment for you and your baby. Store this medicine at room temperature away from moisture and heat.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced kidney and liver function, increasing the risk of side effects. Dose adjustments may be necessary. Regular monitoring of kidney and liver function is recommended. Falls and dizziness should be monitored.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss with your doctor to switch to an antiretroviral regimen that is safer during pregnancy. This medicine is not recommended during pregnancy unless clearly needed. Effective contraception should be used while taking this medicine.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine, as it can interact with many drugs used during surgery. Adequate hydration is important before and after surgery to prevent kidney stones.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may interact with certain antibiotics or sedatives used in dental procedures. Maintain good oral hygiene to prevent infections.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but if you experience dizziness or fatigue, avoid strenuous activities until you feel better. Stay hydrated during exercise to reduce the risk of kidney stones.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is important to take the medicine at the same times every day, which may require adjusting your work schedule. Discuss with your employer if you need flexible hours for dosing.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Stopping suddenly can lead to viral rebound and resistance. If you experience severe side effects, contact your doctor immediately to discuss alternative treatment options.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to changes in body fat distribution, increased cholesterol and blood sugar levels, and kidney problems. Regular monitoring of kidney and liver function, blood sugar, and lipids is essential. Some patients may develop resistance if the medicine is not taken consistently. Long-term adherence to combination therapy is crucial to suppress the virus and prevent complications.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Alternative HIV medicines such as integrase inhibitors or NNRTIs may be used based on resistance testing and patient factors.
Evidence: Well-establishedCounseling and support groups can help patients adhere to complex regimens.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Patients with HIV should receive recommended vaccinations, including influenza, pneumococcal, and hepatitis B vaccines, as per guidelines. Live vaccines should be avoided if the immune system is severely compromised. Discuss with your doctor about the best vaccination schedule.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss or temperature extremes. Carry enough for the entire trip plus extra in case of delays. If crossing time zones, adjust dosing times gradually under medical guidance. Store at room temperature and avoid direct sunlight. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts reducing the virus within weeks, but it may take several months to see the full benefit. Regular blood tests will monitor your progress.
A: Yes, it is best taken with a light meal or snack to improve absorption and reduce stomach upset. Avoid high-fat meals.
A: If you miss a dose, take it as soon as you remember if less than 4 hours have passed. If more than 4 hours have passed, skip it and continue with your regular schedule. Do not double dose.
A: This medicine is not recommended during pregnancy unless clearly needed. Discuss with your doctor about alternative HIV medicines that are safer for pregnancy.
A: It is best to avoid alcohol as it may increase the risk of liver problems and stomach upset.
🤔 Common Patient Concerns
🔄 Substitutes for indease 400mg capsule
View AllAlternative brands with exact same active ingredient:
-
virodin 400mg tabletSun Pharmaceutical Industries Ltd ₹360.94 40.2% COSTLIER
-
indivan 400mg capsuleCipla Ltd ₹565.28 119.6% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Indinavir can cure HIV.
Fact: Indinavir does not cure HIV. It controls the virus and must be taken lifelong as part of combination therapy. - Myth: Indinavir can be taken alone.
Fact: Indinavir must always be used with other antiretroviral medicines to prevent resistance. - Myth: Indinavir has no side effects.
Fact: Indinavir can cause kidney stones, nausea, and other side effects. Regular monitoring is important.
🔄 Alternative Options
Generic Alternatives
- Indinavir sulfate
Brand Alternatives
- Indivan 400mg capsule