Inapure 2.5mg Tablet (Ivabradine): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Fainting or loss of consciousness
- Very slow pulse, usually below 50 beats per minute, with dizziness or weakness
- New or worsening shortness of breath or swelling of the legs
- Chest pain that is new, worsening, or lasts longer than usual
- Palpitations or irregular heartbeat
- Severe allergic reaction with swelling of the face, lips, or throat
- Yellowing of the skin or eyes
- Decreased urine output or severe fatigue
If experiencing severe symptoms, call emergency services immediately.
What is inapure 2.5mg tablet used for?
This medicine contains ivabradine 2.5 mg, an oral tablet that slows the heart rate by blocking the I(f) current in the sinoatrial node. It is used in selected patients with stable angina or chronic heart failure when the heart rate is too fast despite other treatments. It must only be taken under specialist supervision.
- Generic Name: Ivabradine (2.5mg)
- Manufacturer: Sun Pharmaceutical Industries Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 inapure 2.5mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा इवाब्राडीन 2.5 मिलीग्राम की गोली है, जिसका उपयोग कुछ हृदय रोगों में किया जाता है। यह दिल की धड़कन की गति को धीमा करती है और हृदय की ऑक्सीजन की मांग को कम करती है। इसका उपयोग मुख्य रूप से उन रोगियों में किया जाता है जिन्हें स्थिर एनजाइना है और बीटा-ब्लॉकर दवाएं ठीक से काम नहीं करतीं या सहन नहीं होतीं। इसके अलावा, कुछ प्रकार के दिल की विफलता में भी यह दवा विशेषज्ञ की सलाह पर दी जाती है, जब दिल की धड़कन की गति तेज बनी रहती है। यह दवा केवल डॉक्टर की सलाह से ही लेनी चाहिए और इसका सेवन भोजन के साथ करना चाहिए। धड़कन बहुत धीमी होने, गंभीर जिगर या गुर्दे की बीमारी, या कुछ विशेष दवाओं के साथ इसका उपयोग नहीं करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में रोशनी में चमक या हैलो दिखना, धड़कन का धीमा हो जाना, सिरदर्द, चक्कर आना और धुंधला दिखना शामिल हैं। ये लक्षण अक्सर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं, लेकिन इन्हें डॉक्टर को बताना जरूरी है। कभी-कभी धड़कन बहुत धीमी हो सकती है, बेहोशी आ सकती है, या दिल की विफलता के लक्षण बढ़ सकते हैं। अगर सांस लेने में तकलीफ, सीने में दर्द, या बेहोशी जैसी समस्या हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, आमतौर पर भोजन के साथ दिन में दो बार। अपनी धड़कन, ब्लड प्रेशर और दिल की धड़कन की जांच के लिए नियमित रूप से डॉक्टर के पास जाएं। अपने डॉक्टर को अपनी सभी दवाओं के बारे में बताएं, खासकर वेरापामिल, डिल्टियाजेम, कुछ एंटीबायोटिक्स और एंटीफंगल दवाएं। इस दवा के साथ अंगूर या अंगूर का जूस न लें। जब तक आपको पता न चले कि यह दवा आपको कैसे प्रभावित करती है, वाहन न चलाएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। दवा को सूखी जगह पर कमरे के तापमान पर रखें।
💊 inapure 2.5mg tablet Uses & Benefits
[{"condition":"Stable angina in patients with sinus rhythm and elevated heart rate","description":"This medicine reduces heart rate and myocardial oxygen demand, which can decrease the frequency of angina attacks in selected patients who cannot take beta-blockers or whose symptoms are not fully controlled by them.","evidence":"Well-established in selected patients"},{"condition":"Chronic heart failure with reduced ejection fraction and elevated resting heart rate","description":"When the resting heart rate remains high despite optimized standard therapy, this medicine may be added to reduce heart rate and improve outcomes in carefully selected patients.","evidence":"Well-established in selected patients"},{"condition":"Inappropriate sinus tachycardia","description":"This medicine is sometimes used to reduce abnormally fast sinus heart rates when other measures have not worked, but this use requires specialist assessment.","evidence":"Limited"}]
Off-label uses: [{"condition":"Postural orthostatic tachycardia syndrome","description":"This medicine has been tried in some patients with postural orthostatic tachycardia syndrome to reduce heart rate, but evidence is limited and it is not a standard treatment.","evidence":"Limited"},{"condition":"Microvascular angina","description":"This medicine may be considered in some patients with chest pain related to small heart blood vessels, but this is not a widely established use.","evidence":"Limited"}]
Primary treatment for: Stable angina and chronic heart failure with reduced ejection fraction in selected patients
Also treats: Inappropriate sinus tachycardia, Postural orthostatic tachycardia syndrome, Microvascular angina
📋 Drug Information
| Generic Name(s) | Ivabradine (2.5mg) |
| Brand Name | inapure 2.5mg tablet |
| Manufacturer | Sun Pharmaceutical Industries Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | I F sodium channel (sinoatrial node) current blockers |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature between 15°C and 30°C in its original packaging, away from moisture, heat, and direct sunlight. Keep it out of reach of children. |
| Shelf Life | The shelf life is typically 24 months from the date of manufacture, but you should always check the expiry date printed on the pack. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine selectively blocks the hyperpolarization-activated cyclic nucleotide-gated funny current, known as the I(f) current, in the sinoatrial node of the heart. By entering the channel from the inside of the cell and reducing the slope of the diastolic depolarization, it slows the rate at which the sinoatrial node fires. This leads to a lower resting heart rate and a lower heart rate during exercise, while preserving myocardial contractility and blood pressure. The effect is use-dependent, meaning it works more strongly at higher heart rates, which helps control heart rate without causing excessive bradycardia at rest in most patients.
Mechanism Steps
💡 How to Take inapure 2.5mg tablet
Strength: Immediate-release tablet containing 2.5 mg of ivabradine.
Dosage Information
| Adult Dosage | The usual starting dose of this medicine is 5 mg twice daily with meals, and the dose may be adjusted by your doctor based on your heart rate and symptoms. For some patients, especially the elderly or those with a lower heart rate, a starting dose of 2.5 mg twice daily may be used. The maximum recommended dose is 7.5 mg twice daily. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and heart rate response. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric cardiologist. |
| Elderly Dosage | Elderly patients may be more sensitive to the heart rate-lowering effects of this medicine. A lower starting dose, often 2.5 mg twice daily, may be used, and heart rate should be monitored closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No dose adjustment is usually needed for mild to moderate kidney impairment. In severe kidney impairment, this medicine should be used with caution and the dose may need to be reduced. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | This medicine is contraindicated in severe liver impairment. In mild to moderate liver impairment, no dose adjustment is usually needed, but caution is advised. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended total daily dose is 15 mg, given as 7.5 mg twice daily, but this must only be used if prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of inapure 2.5mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Clarithromycin | Major | |
| Verapamil | Major | |
| Diltiazem | Major | |
| Ritonavir | Major | |
| Fluconazole | Moderate | |
| Beta-blockers | Moderate | |
| St John's wort | Minor | |
| Grapefruit juice | Minor | |
| QT-prolonging medicines | Moderate |
🚨 Major Interactions
- Strong CYP3A4 inhibitors such as ketoconazole, itraconazole, clarithromycin, ritonavir, and nefazodone
- Verapamil and diltiazem
⚡ Moderate Interactions
- Moderate CYP3A4 inhibitors such as grapefruit juice, fluconazole, and some macrolide antibiotics
- Beta-blockers
- QT-prolonging medicines
🍷 Alcohol Interaction
Alcohol may worsen dizziness and low blood pressure and can add to the heart rate-lowering effect of this medicine. It is best to avoid alcohol or keep it to a minimum while taking this medicine, and to discuss your alcohol intake with your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Very slow heart rate before starting treatment, generally below 60 beats per minute","Sick sinus syndrome, sinoatrial block, or complete heart block unless a functioning pacemaker is in place","Severe liver impairment","Severe kidney impairment requiring dialysis","Use of strong CYP3A4 inhibitors such as ketoconazole, clarithromycin, or ritonavir","Use of verapamil or diltiazem","Pregnancy and breastfeeding","Known allergy to ivabradine or any ingredient in the tablet"]
⚠️ Warnings & Precautions
["This medicine should only be started by a doctor experienced in treating heart conditions.","Your heart rate should be checked before starting and regularly during treatment.","Tell your doctor if you have a pacemaker, as the settings may need review.","Avoid grapefruit and grapefruit juice while taking this medicine.","Do not stop this medicine suddenly without medical advice.","Use with caution in elderly patients, who may be more sensitive to heart rate effects.","Report any new visual symptoms, especially if they affect your ability to drive.","Tell your doctor about all other medicines, including herbal products, before starting this medicine."]
🤱 Lactation Safety
This medicine passes into breast milk in animal studies, and it is not known whether it passes into human breast milk. Because of the potential for serious heart rate effects in a breastfed infant, breastfeeding is not recommended while taking this medicine unless a specialist advises otherwise.
💊 Overdose Management
An overdose of this medicine can cause severe bradycardia, low blood pressure, and fainting. If you suspect an overdose, seek emergency medical care immediately. Treatment is supportive and may include intravenous fluids and, in severe cases, medicines to increase heart rate. Do not try to treat an overdose at home.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember if less than half the usual dosing interval has passed. If more than half the interval has passed, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed, usually twice daily with meals, and do not change the dose on your own. Keep all follow-up appointments so your doctor can check your heart rate, blood pressure, and heart rhythm. Tell your doctor about all other medicines you take, especially calcium channel blockers such as verapamil or diltiazem, macrolide antibiotics, antifungal medicines, and HIV medicines, because some of these can raise the level of this medicine in your body. Avoid grapefruit and grapefruit juice while taking this medicine. Do not drive or operate heavy machinery until you know how this medicine affects your vision and alertness. If you are pregnant, planning pregnancy, or breastfeeding, speak to your doctor before continuing this medicine. Store the tablets in their original packaging at room temperature, away from moisture and direct sunlight, and keep them out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the heart rate-lowering effects of this medicine. A lower starting dose, often 2.5 mg twice daily, may be used, and heart rate should be monitored closely. The risk of atrial fibrillation is also higher in this age group.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or when planning pregnancy. Women of childbearing potential should use effective contraception while taking this medicine. If you are planning pregnancy, speak to your doctor well in advance to discuss alternative treatments.
🏥 Post-Surgery Considerations
This medicine may affect heart rate during and after surgery. Inform your surgeon and anesthesiologist that you are taking this medicine. Your doctor may advise temporary adjustment or monitoring around the time of surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine, as it can affect heart rate and may interact with certain medicines used in dental procedures. Local anesthetics containing adrenaline should be used with caution.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine slows your heart rate, so your maximum exercise heart rate may be lower than usual. Avoid sudden strenuous activity until you know how the medicine affects you. If you feel dizzy, breathless, or have chest pain during exercise, stop and seek medical advice. Discuss your exercise plan with your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause visual symptoms such as increased brightness of lights, which can affect driving and operating machinery, especially at night. It may also cause dizziness or fatigue. Avoid driving or operating heavy machinery until you know how this medicine affects you. Most people can continue their usual work activities, but discuss any concerns with your doctor.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. Your doctor may decide to stop or adjust it if your heart rate becomes too slow, if you develop atrial fibrillation, or if your condition changes. If you experience severe side effects, contact your doctor immediately for advice.
📅 Long-Term Use Effects
Long-term use of this medicine requires regular monitoring of heart rate, blood pressure, and heart rhythm. Some patients may develop atrial fibrillation over time, especially if they are elderly or have heart failure. Visual symptoms may persist in a small number of patients. The medicine should be reviewed periodically to ensure it is still appropriate and effective. Do not stop it on your own; your doctor will decide if and when to adjust or stop treatment.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
These are often first-line for angina and heart failure but may not be tolerated by some patients.
Evidence: Well-establishedThese can be used for angina but may interact with this medicine.
Evidence: Well-establishedThese can complement medicine and improve heart health.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known vaccine interactions with this medicine. However, always inform your healthcare provider about all medicines you take before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in the original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging with the prescription label visible. Keep a copy of your prescription and a doctor's note with you, especially for international travel. Store the tablets at room temperature and protect them from extreme heat or moisture. If you are crossing time zones, discuss with your doctor how to adjust the timing of your doses. Do not pack this medicine in checked luggage; keep it in your hand baggage. Check local customs rules for carrying prescription medicines before you travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The heart rate-lowering effect begins within a few hours after the first dose, but the full clinical benefit for angina or heart failure may take days to weeks to become apparent.
A: Yes, this medicine should be taken with meals to reduce variability in absorption and improve tolerability.
A: Avoid grapefruit and grapefruit juice, strong CYP3A4 inhibitors, and verapamil or diltiazem. Also avoid driving until you know how this medicine affects your vision.
A: No, do not stop this medicine suddenly without talking to your doctor, as it can worsen your condition.
A: This medicine is not recommended during pregnancy unless a specialist clearly determines that the benefit outweighs the risk.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is a general blood pressure medicine.
Fact: This medicine mainly slows the heart rate and is not used as a routine blood pressure medicine. - Myth: This medicine can be taken without any heart monitoring.
Fact: Regular heart rate and rhythm monitoring are important while taking this medicine. - Myth: This medicine can be stopped as soon as symptoms improve.
Fact: This medicine should only be stopped on your doctor's advice, as sudden stopping can worsen your condition.
🔄 Alternative Options
Generic Alternatives
- Ivabradine 2.5 mg tablet
Brand Alternatives
- Inapure 2.5 mg tablet