Folitrax 10 Tablet (Methotrexate 10mg): Comprehensive Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of the skin or eyes (jaundice)
- Severe abdominal pain or vomiting blood
- Blood in stool or black, tarry stools
- Shortness of breath, dry cough, or fever
- Unusual bleeding or bruising
- Severe mouth sores or difficulty swallowing
- Decreased urine output or swelling in legs
- Severe headache with vision changes
- Rash with blisters or peeling skin
- Persistent fever or chills
If experiencing severe symptoms, call emergency services immediately.
What is imutrex 10 tablet used for?
This medicine contains methotrexate, a disease-modifying antirheumatic drug (DMARD) used to treat rheumatoid arthritis, psoriasis, and certain cancers. It works by suppressing the immune system and slowing cell division. It is taken once weekly and requires regular blood tests to monitor for side effects.
- Generic Name: Methotrexate (10mg)
- Manufacturer: Cipla Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 imutrex 10 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मेथोट्रेक्सेट नामक सक्रिय तत्व से बनी है और मुख्य रूप से रूमेटॉइड आर्थराइटिस, सोरायसिस, और कुछ प्रकार के कैंसर के इलाज में उपयोग की जाती है। यह शरीर की प्रतिरक्षा प्रणाली को शांत करके सूजन और दर्द को कम करती है। यह दवा तुरंत असर नहीं करती, बल्कि कई हफ्तों से महीनों में धीरे-धीरे काम करती है। इसे डॉक्टर की सलाह के अनुसार साप्ताहिक रूप से लेना होता है, रोज नहीं। इस दवा को लेते समय नियमित रक्त परीक्षण आवश्यक है ताकि लीवर, किडनी और रक्त कोशिकाओं पर इसके प्रभाव की निगरानी की जा सके। गर्भवती महिलाओं और स्तनपान कराने वाली महिलाओं को यह दवा नहीं लेनी चाहिए। शराब का सेवन पूरी तरह से बंद कर दें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट में परेशानी, भूख न लगना, मुंह में छाले, और थकान शामिल हैं। ये आमतौर पर हल्के होते हैं और शरीर के अभ्यस्त होने पर कम हो जाते हैं। गंभीर दुष्प्रभावों में लीवर को नुकसान, फेफड़ों में सूजन, रक्त कोशिकाओं का कम बनना, और गंभीर त्वचा प्रतिक्रियाएं शामिल हैं। इनके लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें। नियमित रक्त परीक्षण से समस्याओं का जल्दी पता लगाया जा सकता है।
सुरक्षा सलाह: यह दवा एक शक्तिशाली प्रिस्क्रिप्शन दवा है और इसे डॉक्टर के निर्देशानुसार ही लें। अपने आप से खुराक न बदलें। इस दवा को लेते समय नियमित रक्त परीक्षण करवाएं। शराब का सेवन पूरी तरह से बंद कर दें क्योंकि इससे लीवर को नुकसान का खतरा बढ़ जाता है। बिना डॉक्टर की सलाह के कोई भी अन्य दर्द निवारक दवा न लें। गर्भावस्था के दौरान और उसके कुछ समय बाद तक प्रभावी गर्भनिरोधक उपाय अपनाएं। यदि आप कोई खुराक भूल जाएं तो अगली खुराक दोगुनी न करें। किसी भी असामान्य लक्षण के लिए तुरंत डॉक्टर से मिलें।
💊 imutrex 10 tablet Uses & Benefits
[{"condition":"Rheumatoid arthritis","description":"This medicine is a first-line disease-modifying antirheumatic drug (DMARD) used to reduce joint inflammation, pain, and damage in adults with active rheumatoid arthritis.","evidence":"Well-established"},{"condition":"Psoriasis","description":"Used to treat severe plaque psoriasis and psoriatic arthritis that have not responded to other treatments.","evidence":"Well-established"},{"condition":"Juvenile idiopathic arthritis","description":"Prescribed for children with certain forms of juvenile arthritis to control inflammation and prevent joint damage.","evidence":"Well-established"},{"condition":"Crohn's disease","description":"Sometimes used to maintain remission in Crohn's disease, often in combination with other medicines.","evidence":"Moderate"},{"condition":"Ectopic pregnancy","description":"Used in selected cases to stop the growth of an ectopic pregnancy, preserving the fallopian tube.","evidence":"Well-established"},{"condition":"Certain cancers","description":"Used in chemotherapy regimens for cancers such as breast cancer, leukemia, and lymphoma.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Systemic lupus erythematosus","description":"Sometimes prescribed off-label for mild to moderate lupus to reduce steroid use.","evidence":"Limited"},{"condition":"Sarcoidosis","description":"May be used off-label for chronic sarcoidosis affecting the skin, joints, or lungs.","evidence":"Limited"},{"condition":"Myasthenia gravis","description":"Occasionally used as a steroid-sparing agent in myasthenia gravis.","evidence":"Limited"}]
Primary treatment for: Rheumatoid arthritis
Also treats: Psoriasis, Psoriatic arthritis, Juvenile idiopathic arthritis, Crohn's disease, Ectopic pregnancy, Certain cancers
📋 Drug Information
| Generic Name(s) | Methotrexate (10mg) |
| Brand Name | imutrex 10 tablet |
| Manufacturer | Cipla Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Antimetabolite- Methotrexate |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture, heat, and direct sunlight. Store in the original container, tightly closed. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the packaging. |
| WHO Guideline | Methotrexate is recommended by the World Health Organization (WHO) as a first-line disease-modifying antirheumatic drug (DMARD) for rheumatoid arthritis, and it is included in the WHO Model List of Essential Medicines. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) guidelines for the management of rheumatoid arthritis recommend methotrexate as a first-line DMARD, with regular monitoring for toxicity. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Methotrexate works by inhibiting the enzyme dihydrofolate reductase, which is needed to convert folic acid into its active form. This leads to reduced production of thymidylate and purines, which are essential for DNA synthesis and cell division. In inflammatory conditions, this results in decreased proliferation of immune cells and reduced production of inflammatory cytokines. Additionally, methotrexate increases the release of adenosine, which has anti-inflammatory effects. The overall effect is suppression of the immune system and slowing of rapidly dividing cells.
Mechanism Steps
💡 How to Take imutrex 10 tablet
Strength: This medicine is available as a 10 mg immediate-release tablet for oral administration.
Dosage Information
| Adult Dosage | The dose of this medicine is highly individualized and depends on the condition being treated, its severity, and the patient's response. For rheumatoid arthritis, a common starting dose is 7.5 mg to 10 mg taken once weekly, but your doctor may adjust this. For psoriasis, similar weekly doses are used. For cancer, doses are much higher and are determined by a specialist. This medicine is usually taken as a single weekly dose, not daily. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Never change your dose without consulting your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. For juvenile idiopathic arthritis, doses are typically based on body surface area and are determined by a pediatric rheumatologist. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially bone marrow suppression and liver toxicity. Doses may need to be reduced based on kidney and liver function. Close monitoring is recommended. |
| Renal Impairment | In patients with kidney impairment, the dose of this medicine may need to be reduced or the medicine avoided altogether, depending on the degree of impairment. Regular monitoring of kidney function is essential. Consult your doctor for dose adjustments. |
| Hepatic Impairment | In patients with liver impairment, this medicine should be used with caution. Dose reduction or avoidance may be necessary. Regular liver function tests are required. Consult your doctor for guidance. |
| Maximum Daily Dose | The maximum dose varies widely depending on the indication. For inflammatory conditions, the maximum weekly dose is typically 20-25 mg, but higher doses may be used in specialized settings. For cancer, much higher doses are used under close supervision. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of imutrex 10 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ibuprofen | Major | |
| Aspirin | Major | |
| Trimethoprim-sulfamethoxazole | Major | |
| Probenecid | Major | |
| Penicillins | Moderate | |
| Phenytoin | Moderate | |
| Theophylline | Moderate | |
| Live vaccines | Major | |
| Folic acid | Minor |
🚨 Major Interactions
- NSAIDs (e.g., ibuprofen, naproxen)
- Aspirin and other salicylates
- Probenecid
- Trimethoprim-sulfamethoxazole
- Live vaccines
⚡ Moderate Interactions
- Penicillins
- Cephalosporins
- Phenytoin
- Theophylline
- Folic acid antagonists (e.g., trimethoprim)
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Alcohol increases the risk of methotrexate-induced liver damage and can worsen side effects. Even moderate drinking can be harmful.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Pregnancy or breastfeeding","Significant liver disease or cirrhosis","Significant kidney disease or renal impairment","Active infection","Blood disorders such as bone marrow suppression, leukopenia, thrombocytopenia, or anemia","Hypersensitivity to methotrexate","Concurrent use of live vaccines"]
⚠️ Warnings & Precautions
["This medicine should only be used under the supervision of a qualified healthcare professional.","Regular blood tests are required to monitor for liver, kidney, and blood toxicity.","Avoid alcohol completely during treatment.","Use effective contraception during treatment and for a period after stopping.","Do not receive live vaccines while taking this medicine.","Report any signs of infection, unusual bleeding, or bruising immediately.","This medicine may cause dizziness or fatigue; avoid driving or operating machinery until you know how it affects you.","Do not take NSAIDs or aspirin without consulting your doctor.","Inform your doctor if you have a history of liver or kidney disease, diabetes, or obesity.","Keep all appointments for monitoring and follow-up."]
🤱 Lactation Safety
Methotrexate is excreted in breast milk and may harm a nursing infant. Breastfeeding is not recommended during treatment with this medicine.
💊 Overdose Management
Overdose of methotrexate can cause severe bone marrow suppression, liver damage, and kidney failure. If you suspect an overdose, seek emergency medical attention immediately. Treatment may include administration of leucovorin (folinic acid) to rescue normal cells, hydration, and supportive care. Do not attempt to treat yourself.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember if it is within a few hours of the scheduled time. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, contact your doctor or pharmacist.
Additional Safety Advice
This medicine is a powerful prescription drug and must be taken exactly as directed by your doctor. Do not take more or less than prescribed. You will need regular blood tests to check your liver, kidney, and blood cell counts. Avoid alcohol completely while taking this medicine, as it increases the risk of liver damage. Do not take over-the-counter pain relievers or other medicines without asking your doctor, as many can interact with this medicine. Use effective contraception during treatment and for a period after stopping, as this medicine can harm an unborn baby. If you miss a dose, do not double the next dose. Contact your doctor if you experience any side effects or if you become pregnant. Keep all appointments for monitoring. Store this medicine at room temperature, away from moisture and heat.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to side effects, especially bone marrow suppression and liver toxicity. Doses may need to be adjusted based on kidney and liver function. Regular monitoring is crucial.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated in pregnancy. Women planning to become pregnant should stop the medicine at least 3 months before conception, and men should stop at least 3 months before attempting conception. Consult your doctor for a safe treatment plan.
🏥 Post-Surgery Considerations
Inform your surgeon about this medicine before any surgery. It may need to be temporarily stopped due to increased risk of infection and impaired wound healing. Your doctor will advise on when to resume.
🦷 Dental Procedures
Inform your dentist about this medicine before any dental procedure. It may increase the risk of bleeding and infection. Your dentist may recommend antibiotics or temporary discontinuation.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you can exercise, but listen to your body. Avoid high-impact activities if you have joint pain. If you experience fatigue or shortness of breath, stop and consult your doctor. Swimming and walking are generally safe.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue or dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal work and daily activities, but it is important to pace yourself and take breaks when needed. Inform your employer about your condition if necessary.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Stopping suddenly can cause a flare-up of your condition. Your doctor may stop the medicine if you develop serious side effects, become pregnant, or if your disease goes into remission. Always follow your doctor's guidance.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to liver scarring (fibrosis or cirrhosis), especially with alcohol use or pre-existing liver disease. It can also cause bone marrow suppression and increased risk of infections. Regular monitoring of liver and kidney function and blood counts is essential. Some patients may develop lung toxicity. The benefits of long-term use generally outweigh the risks when monitored appropriately.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help improve joint function and reduce pain in rheumatoid arthritis.
Evidence: Well-establishedOther medicines like adalimumab or etanercept may be used if methotrexate is not effective or not tolerated.
Evidence: Well-establishedAnti-inflammatory diet may complement treatment but is not a substitute.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided while taking this medicine due to the risk of infection. Inactivated vaccines are generally safe, but their effectiveness may be reduced. Consult your doctor before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If crossing time zones, maintain your weekly schedule; you may adjust the day gradually with your doctor's advice. Carry enough supply for your entire trip. Check customs regulations for controlled substances in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts to show effects within 3 to 6 weeks, but full benefits may take up to 12 weeks. It is important to continue taking it as prescribed and attend regular follow-ups.
A: Yes, taking it with food can help reduce stomach upset and nausea. However, try to take it at the same time each week.
A: If you miss a dose, take it as soon as you remember if it is within a few days. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, alcohol should be completely avoided as it increases the risk of liver damage.
A: No, this medicine is contraindicated in pregnancy as it can cause birth defects. Use effective contraception during treatment and for a period after stopping.
🤔 Common Patient Concerns
🔄 Substitutes for imutrex 10 tablet
View AllAlternative brands with exact same active ingredient:
-
folitrax 10mg injectionIpca Laboratories Ltd ₹33.00 34.2% CHEAPER
-
duce 10mg tabletChicky Pharma Pvt Ltd ₹53.57 6.8% COSTLIER
-
auratrex 10mg tabletAbbott ₹60.00 19.6% COSTLIER
-
nidtrex 10 tabletNidus Pharma Pvt Ltd ₹108.00 115.3% COSTLIER
-
rhutrex 10mg tabletRhumasafe Pharmaceutical ₹113.70 126.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Methotrexate is a chemotherapy drug, so it must be very dangerous.
Fact: Methotrexate is used in much lower doses for inflammatory conditions than for cancer. At low doses, it is generally safe and effective when monitored properly. - Myth: Methotrexate can be taken daily like other arthritis medicines.
Fact: Methotrexate for inflammatory conditions is taken once weekly, not daily. Taking it daily can lead to severe toxicity. - Myth: You can stop methotrexate as soon as you feel better.
Fact: Methotrexate controls the disease but does not cure it. Stopping suddenly can cause a flare-up. Always consult your doctor before stopping. - Myth: Methotrexate causes birth defects only if taken during pregnancy.
Fact: Methotrexate can affect fertility and cause birth defects if taken by either partner before conception. Both men and women should use contraception during treatment and for a period after.
🔄 Alternative Options
Generic Alternatives
- Methotrexate 10 mg tablet
Brand Alternatives
- Folitrax 10 Tablet
- Methotrexate 10 mg tablets by other manufacturers