Depsin Plus 2mg/25mg Tablet: Complete Information
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe drowsiness or difficulty breathing
- Confusion or hallucinations
- Irregular heartbeat or chest pain
- Seizures
- Yellowing of eyes or skin
- Unusual bleeding or bruising
- Severe allergic reaction (swelling of face, lips, throat)
- Suicidal thoughts or behavior
If experiencing severe symptoms, call emergency services immediately.
What is imizep tablet used for?
This medicine is a combination of Diazepam 2 mg and Imipramine 25 mg used for short-term treatment of anxiety with depressive features. It works by calming the brain and balancing mood chemicals. It can cause drowsiness and dependence, so it must be used exactly as prescribed.
- Generic Name: Diazepam (2mg) + Imipramine (25mg)
- Manufacturer: Nusearch Organic
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 imizep tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डायजेपाम 2 मिलीग्राम और इमिप्रामिन 25 मिलीग्राम का संयोजन है। इसका उपयोग चिंता और अवसाद के लक्षणों के इलाज के लिए किया जाता है। यह मस्तिष्क को शांत करने और मूड को संतुलित करने में मदद करती है। यह दवा केवल डॉक्टर के पर्चे पर ही लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, मुँह सूखना, कब्ज, और थकान शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, रक्त विकार, और हृदय की समस्याएं हो सकती हैं। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे अचानक बंद न करें। शराब का सेवन बिल्कुल न करें। गाड़ी चलाने या मशीन चलाने से बचें। अन्य दवाओं के साथ लेने से पहले डॉक्टर से सलाह लें।
💊 imizep tablet Uses & Benefits
[{"condition":"Anxiety with depressive features","description":"Used for short-term management of anxiety disorders when depressive symptoms are also present.","evidence":"Limited"},{"condition":"Chronic pain syndromes with emotional component","description":"Sometimes prescribed for chronic pain conditions where anxiety and depression contribute to the pain experience.","evidence":"Limited"},{"condition":"Tension-type headache with anxiety","description":"May be used in selected patients with tension headaches and significant anxiety.","evidence":"Limited"}]
Off-label uses: [{"condition":"Irritable bowel syndrome with anxiety","description":"Occasionally prescribed off-label for IBS when anxiety is a major trigger.","evidence":"Limited"},{"condition":"Insomnia with depressive symptoms","description":"Rarely used off-label for short-term management of insomnia associated with depression.","evidence":"Limited"}]
Primary treatment for: Anxiety with depressive features
Also treats: Chronic pain syndromes, Tension-type headache, Irritable bowel syndrome
📋 Drug Information
| Generic Name(s) | Diazepam (2mg) + Imipramine (25mg) |
| Brand Name | imizep tablet |
| Manufacturer | Nusearch Organic |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture, heat, and direct sunlight. Keep in the original container, tightly closed. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different mechanisms. Diazepam enhances the inhibitory neurotransmitter GABA at GABA-A receptors, leading to sedation, anxiety relief, muscle relaxation, and anticonvulsant effects. Imipramine inhibits the reuptake of serotonin and norepinephrine in the brain, increasing their availability and helping to improve mood and reduce anxiety. The combination aims to address both anxiety and depressive symptoms simultaneously.
Mechanism Steps
💡 How to Take imizep tablet
Strength: Tablet containing Diazepam 2 mg and Imipramine 25 mg.
Dosage Information
| Adult Dosage | The dosage of this medicine must be individualized by a qualified clinician based on the specific condition being treated, the patient's age, weight, renal and hepatic function, and response to therapy. Typically, treatment is started at a low dose and gradually increased. The usual adult dose is one tablet taken orally one to three times daily, but this can vary. Do not adjust the dose without medical advice. Follow your doctor's instructions exactly. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are more sensitive to the effects of this medicine, especially drowsiness, dizziness, and confusion. Lower doses are usually recommended, and the dose should be carefully individualized by a clinician. Regular monitoring for falls and cognitive impairment is advised. |
| Renal Impairment | Dose adjustment may be needed in patients with renal impairment. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Dose adjustment is recommended in patients with hepatic impairment. Use with caution and monitor liver function. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose should not exceed what is prescribed by your doctor. Typically, the maximum daily dose of diazepam is 40 mg and imipramine is 150 mg, but this combination should not exceed the prescribed limit. Do not self-increase the dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of imizep tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| Opioids | Major | |
| Alcohol | Major | |
| Fluoxetine | Major | |
| Warfarin | Moderate | |
| Antihypertensives | Moderate | |
| Cimetidine | Moderate | |
| Anticholinergics | Moderate | |
| Caffeine | Minor | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- MAO inhibitors
- CNS depressants (opioids, alcohol, barbiturates)
- CYP2D6 inhibitors (fluoxetine, paroxetine, quinidine)
⚡ Moderate Interactions
- Antihypertensives
- Anticholinergics
- Cimetidine
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Both diazepam and imipramine can cause drowsiness, and alcohol significantly increases this effect, leading to severe sedation, respiratory depression, and impaired judgment. This combination can be dangerous.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to diazepam, imipramine, or any component of the formulation","Concurrent use of MAO inhibitors","Acute narrow-angle glaucoma","Severe liver disease","Myasthenia gravis","Severe respiratory insufficiency","Acute porphyria","Pregnancy and breastfeeding (unless clearly needed)"]
⚠️ Warnings & Precautions
["This medicine can cause drowsiness and impair ability to drive or operate machinery.","Do not stop this medicine abruptly, as it can cause withdrawal symptoms.","Long-term use can lead to dependence and tolerance.","Avoid alcohol and other CNS depressants.","Use with caution in elderly patients due to increased risk of falls and confusion.","May worsen depression or cause suicidal thoughts; monitor closely.","Can cause anticholinergic effects such as dry mouth, constipation, and urinary retention.","Use with caution in patients with cardiovascular disease, epilepsy, or thyroid disorders."]
🤱 Lactation Safety
Both diazepam and imipramine pass into breast milk and may cause sedation in the infant. Breastfeeding is not recommended while taking this medicine unless advised by a doctor.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, confusion, coma, respiratory depression, seizures, and cardiac arrhythmias. If overdose is suspected, seek emergency medical attention immediately. Treatment is supportive and may include activated charcoal, gastric lavage, and monitoring of vital signs. There is no specific antidote for imipramine; flumazenil may be used for benzodiazepine toxicity but is contraindicated in mixed overdose with tricyclics due to risk of seizures.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once to make up for a missed dose.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not increase or decrease the dose without medical advice. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it can cause drowsiness and slow your reactions. Do not drink alcohol while taking this medicine, as it can increase drowsiness and dangerous side effects. Inform your doctor about all other medicines you are taking, including over-the-counter drugs and herbal supplements. Do not stop this medicine suddenly, especially if you have been taking it for a long time, as this can cause withdrawal symptoms. Keep this medicine out of reach of children. Store it at room temperature, away from moisture and direct sunlight. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor before using this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the sedative and anticholinergic effects of this medicine. Lower doses are recommended, and regular monitoring for falls, confusion, and cognitive impairment is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Both diazepam and imipramine may pose risks to the fetus. Alternative treatments may be considered.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents and increase the risk of complications. Your doctor may advise temporary discontinuation before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may interact with local anesthetics or sedatives used during dental procedures. Your dentist may need to adjust the treatment plan.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness and dizziness, which may affect your coordination. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you. Light to moderate exercise is generally safe.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and impair concentration, which may affect your ability to work, especially if your job requires operating machinery or driving. Discuss with your doctor about adjusting the dose or timing to minimize impact on your daily activities.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Your doctor will gradually reduce the dose to prevent withdrawal symptoms. If you experience severe side effects or allergic reactions, seek immediate medical attention.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to tolerance, dependence, and withdrawal symptoms upon discontinuation. It may also cause cognitive impairment, especially in the elderly. Regular monitoring of liver function, blood counts, and mental status is recommended. The need for continued therapy should be reassessed periodically.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can be effective for anxiety and depression without medication.
Evidence: Well-establishedMay help reduce anxiety and improve mood.
Evidence: ModerateCan help alleviate symptoms of anxiety and depression.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. Consult your doctor regarding vaccinations while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, consult your doctor about adjusting the dosing schedule. Check local customs regulations for controlled substances.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Diazepam works within 30-60 minutes for anxiety, while imipramine may take 1-2 weeks for full antidepressant effect.
A: No, stopping suddenly can cause withdrawal symptoms. Always taper gradually under medical supervision.
A: This medicine can cause drowsiness and impair your ability to drive. Avoid driving until you know how it affects you.
🤔 Common Patient Concerns
🔄 Substitutes for imizep tablet
View AllAlternative brands with exact same active ingredient:
-
sycodep 2 mg/25 mg tabletGujarat Terce Laboratories Ltd ₹8.12 24.7% CHEAPER
-
imip 2mg/25mg tabletAan Pharma Pvt Ltd ₹8.44 21.8% CHEAPER
-
prazep 2 mg/25 mg tabletSun Pharmaceutical Industries Ltd ₹8.58 20.5% CHEAPER
-
imidep 2mg/25mg tabletSunrise Remedies Pvt Ltd ₹8.91 17.4% CHEAPER
-
d prim 2mg/25mg tabletPifer Pharmaceuticals Pvt Ltd ₹9.38 13.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a sleeping pill.
Fact: It is not a sleeping pill. It is a combination of an anxiolytic and an antidepressant used for specific conditions. - Myth: You can stop this medicine whenever you feel better.
Fact: You should never stop this medicine suddenly. It must be tapered gradually under medical supervision to avoid withdrawal symptoms. - Myth: This medicine is safe to take with alcohol.
Fact: Alcohol should be completely avoided as it can cause dangerous sedation and respiratory depression.
🔄 Alternative Options
Generic Alternatives
- Diazepam 2 mg + Imipramine 25 mg tablet (various manufacturers)
Brand Alternatives
- Depsin Plus 2mg/25mg tablet