Imipramine 25mg Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Irregular or fast heartbeat
- Severe dizziness or fainting
- Seizures
- Chest pain or difficulty breathing
- Yellowing of skin or eyes
- Unusual bleeding or bruising
- Severe confusion or hallucinations
- Suicidal thoughts or behavior
If experiencing severe symptoms, call emergency services immediately.
What is imipam 25mg tablet used for?
This medicine contains Imipramine 25 mg, a tricyclic antidepressant used to treat depression and bedwetting in children. It works by increasing serotonin and norepinephrine in the brain. It is taken orally, usually 1-3 times daily, and must be used exactly as prescribed. Common side effects include dry mouth, drowsiness, and dizziness. Do not stop suddenly without medical advice.
- Generic Name: Imipramine (25mg)
- Manufacturer: Manas Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 imipam 25mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा इमिप्रामिन 25 मिलीग्राम की एक गोली है, जिसका उपयोग अवसाद (डिप्रेशन) के इलाज के लिए किया जाता है। यह ट्राइसाइक्लिक एंटीडिप्रेसेंट वर्ग की दवा है और मस्तिष्क में सेरोटोनिन और नॉरएपिनेफ्रिन के स्तर को बढ़ाकर मूड को बेहतर बनाती है। इसका उपयोग बच्चों में बिस्तर गीला करने (नॉक्टर्नल एन्यूरिसिस) के इलाज में भी किया जाता है। यह दवा तुरंत असर नहीं करती; पूरा लाभ पाने में 2 से 4 सप्ताह लग सकते हैं। इसे डॉक्टर के बताए अनुसार ही लें और अचानक बंद न करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मुँह सूखना, नींद आना, चक्कर आना, धुंधली दृष्टि, कब्ज, पेशाब में कठिनाई और वजन बढ़ना शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ दिनों में सुधर जाते हैं। गंभीर दुष्प्रभावों में अनियमित दिल की धड़कन, बेहोशी, दौरे और यकृत की समस्या शामिल हो सकते हैं। यदि आपको सीने में दर्द, सांस लेने में कठिनाई, या त्वचा या आँखों का पीला पड़ना महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। अपनी मर्जी से खुराक न बदलें और न ही अचानक बंद करें। इस दवा के साथ शराब न पिएं क्योंकि इससे नींद और चक्कर बढ़ सकते हैं। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन चलाने या मशीनरी चलाने से बचें। यदि आप गर्भवती हैं, गर्भधारण की योजना बना रही हैं, या स्तनपान करा रही हैं, तो डॉक्टर से सलाह लें। अपनी सभी दवाओं के बारे में डॉक्टर को बताएं।
💊 imipam 25mg tablet Uses & Benefits
- [{"condition":"Major depressive disorder","description":"This medicine is used to treat symptoms of depression such as persistent sadness, loss of interest, sleep changes, and fatigue.
- It is one of the older antidepressants and remains effective for many patients.","evidence":"Well-established"},{"condition":"Nocturnal enuresis (bedwetting) in children","description":"This medicine can reduce the frequency of bedwetting in children older than 6 years when other measures have not worked.
- It is usually prescribed at a lower dose than for depression.","evidence":"Well-established"},{"condition":"Panic disorder","description":"This medicine may be prescribed to reduce the frequency and intensity of panic attacks, though it is not a first-line treatment.","evidence":"Moderate"},{"condition":"Neuropathic pain","description":"Sometimes used off-label to relieve nerve pain, such as diabetic neuropathy, based on its effects on pain pathways.","evidence":"Limited"}]
Off-label uses: [{"condition":"Migraine prophylaxis","description":"This medicine is occasionally prescribed to prevent migraines, but it is not approved for this use.","evidence":"Limited"},{"condition":"Attention deficit hyperactivity disorder (ADHD)","description":"Rarely used as an alternative when other treatments are not effective or not tolerated.","evidence":"Limited"}]
Primary treatment for: Major depressive disorder
Also treats: Nocturnal enuresis, Panic disorder, Neuropathic pain
📋 Drug Information
| Generic Name(s) | Imipramine (25mg) |
| Brand Name | imipam 25mg tablet |
| Manufacturer | Manas Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Tricyclic antidepressants |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature between 15°C and 30°C (59°F to 86°F) in a dry place. Keep it in its original container, tightly closed, away from direct sunlight and moisture. Do not store it in the bathroom. Keep out of reach of children and pets. |
| Shelf Life | The shelf life of this medicine is typically 24 to 36 months from the date of manufacture. Check the expiry date on the pack before use. Do not use if expired. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by blocking the reuptake of serotonin and norepinephrine in the brain, which increases their availability in the synaptic cleft. It also blocks certain receptors such as histamine H1, muscarinic acetylcholine, and alpha-1 adrenergic receptors, which explains many of its side effects. Over time, these changes help restore normal mood and reduce depression symptoms.
Mechanism Steps
💡 How to Take imipam 25mg tablet
Strength: Imipramine 25 mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual starting dose of this medicine for depression in adults is 25 mg to 50 mg taken orally one to three times daily, with gradual increases as needed and tolerated. The maintenance dose is typically 50 mg to 150 mg per day, and the maximum recommended dose is 300 mg per day in hospitalized patients. For elderly patients, lower starting doses are used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to treatment. Do not adjust the dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. For nocturnal enuresis, this medicine may be used in children older than 6 years under specialist supervision, but the dose is determined by the doctor based on the child's age and weight. |
| Elderly Dosage | Elderly patients are more sensitive to the effects of this medicine, especially sedation, confusion, orthostatic hypotension, and cardiac effects. Lower starting doses (e.g., 10 mg to 25 mg daily) are recommended, with slow titration. Close monitoring is advised. Dose must be individualized by a qualified clinician. |
| Renal Impairment | This medicine is primarily excreted by the kidneys. In patients with severe renal impairment, dose reduction may be necessary. Consult your doctor for individualized dosing. Monitor renal function periodically. |
| Hepatic Impairment | This medicine is extensively metabolized in the liver. In patients with hepatic impairment, the dose should be reduced and titrated slowly. Regular monitoring of liver function is recommended. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose of this medicine for adults is 300 mg per day in hospitalized patients, but doses above 150 mg per day should be used with caution in outpatients. For elderly patients, the maximum dose is usually lower. Dose must be individualized by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of imipam 25mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| SSRIs | Major | |
| QT-prolonging drugs | Major | |
| Anticholinergics | Moderate | |
| CNS depressants | Moderate | |
| Sympathomimetics | Moderate | |
| CYP2D6 inhibitors | Moderate | |
| Antacids | Minor | |
| Caffeine | Minor | |
| Alcohol | Moderate |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Other tricyclic antidepressants
- Selective serotonin reuptake inhibitors (SSRIs)
- Drugs that prolong QT interval (e.g., quinidine, sotalol, methadone)
⚡ Moderate Interactions
- Anticholinergic drugs (e.g., benztropine, diphenhydramine)
- CNS depressants (e.g., alcohol, benzodiazepines, opioids)
- Sympathomimetic drugs (e.g., pseudoephedrine, amphetamines)
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, bupropion)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can increase sedation, drowsiness, and dizziness, and may worsen depression. It can also increase the risk of liver problems and impair judgment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to imipramine or other tricyclic antidepressants","Recent myocardial infarction","Concurrent use of monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping an MAOI","Severe cardiac arrhythmias, especially heart block","Uncontrolled narrow-angle glaucoma","Acute recovery phase after myocardial infarction","Severe liver disease"]
⚠️ Warnings & Precautions
["This medicine may increase the risk of suicidal thoughts and behaviors, especially in children, adolescents, and young adults during the first few weeks of treatment. Close monitoring is required.","Use with caution in patients with cardiovascular disease, including history of heart attack, heart failure, or arrhythmias.","May cause orthostatic hypotension; advise patients to rise slowly from sitting or lying positions.","May impair mental and physical abilities required for driving or operating machinery. Avoid until you know how it affects you.","Use with caution in patients with a history of seizures, as it may lower the seizure threshold.","May worsen symptoms of psychosis or mania in patients with bipolar disorder. Screen for bipolar disorder before starting treatment.","Do not stop this medicine abruptly, as withdrawal symptoms such as nausea, headache, and malaise may occur. Taper gradually under medical supervision.","Use with caution in elderly patients due to increased risk of confusion, falls, and cardiac effects.","This medicine may interact with many other drugs; always inform your doctor about all medicines you are taking."]
🤱 Lactation Safety
This medicine passes into breast milk and may cause drowsiness, poor feeding, or other effects in the nursing infant. Breastfeeding is not recommended while taking this medicine unless advised by a doctor. Consult your doctor to discuss the risks and benefits.
💊 Overdose Management
Overdose of this medicine is a medical emergency and can be fatal. Symptoms include irregular heartbeat, severe low blood pressure, seizures, coma, and respiratory depression. If you suspect an overdose, call emergency services immediately. Treatment is supportive and may include activated charcoal, sodium bicarbonate for cardiac toxicity, and management of seizures and arrhythmias. There is no specific antidote. Hospitalization and close monitoring are essential.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you are unsure, contact your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop suddenly without medical advice. Avoid alcohol while taking this medicine because it can worsen drowsiness and dizziness. Be careful while driving or operating machinery until you know how this medicine affects you. Inform your doctor if you have heart disease, glaucoma, thyroid problems, diabetes, or liver or kidney disease. Tell your doctor about all other medicines, supplements, and herbal products you are taking, especially MAOIs, other antidepressants, and drugs that affect heart rhythm. If you are pregnant, planning pregnancy, or breastfeeding, talk to your doctor before using this medicine. Keep all follow-up appointments and laboratory tests as advised. Store this medicine in its original container away from moisture and direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the side effects of this medicine, especially sedation, confusion, orthostatic hypotension, and cardiac effects. Lower starting doses and slow titration are recommended. Regular monitoring for falls and cognitive changes is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting or continuing this medicine. The risks and benefits should be carefully weighed. Alternative treatments may be considered.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may interact with anesthetic agents and affect blood pressure and heart rhythm. Your doctor may advise you to stop the medicine temporarily before surgery.
🦷 Dental Procedures
This medicine can cause dry mouth, which may increase the risk of dental cavities and gum disease. Inform your dentist that you are taking this medicine. Maintain good oral hygiene and regular dental check-ups.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness, dizziness, or orthostatic hypotension, which can increase the risk of falls during exercise. Start with light activities and avoid sudden changes in position. Stay hydrated. Consult your doctor before starting a new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, dizziness, and blurred vision, which may affect your ability to drive, operate machinery, or perform tasks requiring alertness. It may also affect concentration. Avoid these activities until you know how the medicine affects you. Discuss with your employer if you need accommodations.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Your doctor will decide when and how to stop based on your condition and response to treatment. If you experience severe side effects, contact your doctor immediately. Abrupt discontinuation can cause withdrawal symptoms such as nausea, headache, and malaise.
📅 Long-Term Use Effects
Long-term use of this medicine may require periodic monitoring of heart function, liver function, and blood counts. Some patients may experience weight gain, sexual dysfunction, or dental problems due to dry mouth. Regular follow-up with your doctor is important to assess continued need and adjust the dose. Do not stop the medicine without medical advice.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Cognitive behavioral therapy (CBT) can be effective for depression and may be used alone or with medication.
Evidence: Well-establishedRegular exercise, healthy diet, and good sleep hygiene can help improve mood.
Evidence: Well-establishedSSRIs, SNRIs, and other classes may be alternatives if this medicine is not effective or not tolerated.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, adjust your dosing schedule gradually in consultation with your doctor. Carry enough supply for the entire trip and a few extra days in case of delays. Check local customs regulations for controlled substances, as some countries may have restrictions.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine may start to improve sleep and appetite within 1 to 2 weeks, but full antidepressant effects usually take 4 to 6 weeks. For bedwetting, improvement may be seen within a few days.
A: No, you should not stop without consulting your doctor. Stopping suddenly can cause withdrawal symptoms and increase the risk of relapse. Your doctor will guide you on tapering off safely.
A: Avoid alcohol, driving or operating machinery until you know how it affects you, and taking other medications without consulting your doctor. Also avoid grapefruit juice and limit tyramine-rich foods.
A: This medicine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult your doctor if you are pregnant or planning to become pregnant.
🤔 Common Patient Concerns
🔄 Substitutes for imipam 25mg tablet
View AllAlternative brands with exact same active ingredient:
-
imipra 25mg tabletCyril Pharmaceuticals ₹5.53 58.1% CHEAPER
-
imikon 25mg tabletKonark Lifesciences Pvt Ltd ₹6.56 50.3% CHEAPER
-
impramine 25mg tabletSun Pharmaceutical Industries Ltd ₹7.00 47% CHEAPER
-
imprin 25mg tabletOsho Pharma Pvt Ltd ₹7.00 47% CHEAPER
-
eldep 25mg tabletPsychotropics India Ltd ₹7.50 43.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is addictive.
Fact: This medicine is not considered addictive in the way that opioids or benzodiazepines are. However, it can cause dependence, and stopping suddenly can lead to withdrawal symptoms. It should be tapered gradually under medical supervision. - Myth: This medicine works immediately.
Fact: This medicine does not work immediately. It may take 1 to 2 weeks for initial effects and 4 to 6 weeks for full antidepressant benefits. - Myth: You can stop taking this medicine once you feel better.
Fact: You should not stop taking this medicine without consulting your doctor. Stopping suddenly can cause withdrawal symptoms and increase the risk of relapse. Your doctor will guide you on how to taper off safely.
🔄 Alternative Options
Generic Alternatives
- Imipramine hydrochloride
Brand Alternatives
- Depsol