Ignatis-M 100/500 Tablet ER: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Rapid breathing or shortness of breath
- Severe muscle pain or cramps
- Persistent nausea, vomiting, or stomach pain
- Extreme tiredness or weakness
- Yellowing of skin or eyes
- Decreased urine output or swelling in legs
- Severe abdominal pain radiating to the back
- Swelling of face, lips, or throat
- Blistering or peeling skin
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is ignalis-m 100/500 tablet er used for?
This medicine is a combination of Sitagliptin and Metformin used to treat type 2 diabetes. It helps control blood sugar by increasing insulin release and reducing glucose production in the liver. It is taken orally with meals, usually once or twice daily, as prescribed by a doctor.
- Generic Name: Sitagliptin (100mg) + Metformin (500mg)
- Manufacturer: Intas Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ignalis-m 100/500 tablet er के बारे में (Hindi Summary)
उपयोग: यह दवा टाइप 2 डायबिटीज (मधुमेह) के इलाज के लिए इस्तेमाल की जाती है। इसमें सिटाग्लिप्टिन और मेटफॉर्मिन दो दवाएं होती हैं जो मिलकर ब्लड शुगर को कंट्रोल करती हैं। यह खाने के साथ ली जाती है और डॉक्टर की सलाह से ही लेनी चाहिए। यह दवा इंसुलिन के स्तर को बढ़ाने और लिवर में ग्लूकोज बनने को कम करने में मदद करती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में दस्त, जी मिचलाना, पेट में असहजता, सिरदर्द और कम ब्लड शुगर शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन लैक्टिक एसिडोसिस, पैंक्रियाटाइटिस और एलर्जी प्रतिक्रिया हो सकती है। अगर सांस लेने में तकलीफ, मांसपेशियों में तेज दर्द, या चेहरे पर सूजन हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे खाने के साथ निगलें, चबाएं नहीं। शराब का सेवन न करें क्योंकि इससे लैक्टिक एसिडोसिस का खतरा बढ़ सकता है। ब्लड शुगर और किडनी की जांच नियमित रूप से कराते रहें। अगर पेशाब में कमी, पैरों में सूजन, या बहुत ज्यादा थकान महसूस हो तो डॉक्टर को बताएं।
💊 ignalis-m 100/500 tablet er Uses & Benefits
[{"condition":"Type 2 diabetes mellitus","description":"Improves glycemic control in adults when diet and exercise plus single-agent therapy do not achieve target blood sugar levels.","evidence":"Well-established"},{"condition":"Type 2 diabetes with inadequate control on metformin alone","description":"Adding sitagliptin to metformin provides additional HbA1c reduction without weight gain.","evidence":"Well-established"},{"condition":"Type 2 diabetes with inadequate control on sitagliptin alone","description":"Adding metformin improves fasting and postprandial glucose control.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Prediabetes","description":"Sometimes considered to slow progression to diabetes, but not approved for this use.","evidence":"Limited"},{"condition":"Polycystic ovary syndrome with insulin resistance","description":"Metformin component may be used off-label, but the combination is not standard for PCOS.","evidence":"Limited"}]
Primary treatment for: Type 2 diabetes mellitus
Also treats: Obesity, Dyslipidemia, Hypertension
📋 Drug Information
| Generic Name(s) | Sitagliptin (100mg) + Metformin (500mg) |
| Brand Name | ignalis-m 100/500 tablet er |
| Manufacturer | Intas Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Keep in the original container, away from moisture and direct sunlight. Do not refrigerate unless specified. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. Guidelines generally recommend metformin as first-line therapy for type 2 diabetes, with DPP-4 inhibitors as add-on options. |
| ICMR Guideline | Not established from the available information. ICMR guidelines recommend individualized therapy for type 2 diabetes, including metformin and DPP-4 inhibitors as options. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two oral antidiabetic agents with complementary mechanisms. Sitagliptin inhibits dipeptidyl peptidase-4 (DPP-4), the enzyme that breaks down incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). By blocking DPP-4, sitagliptin increases active incretin levels, which stimulate insulin release from pancreatic beta cells when glucose is high and reduce glucagon release from alpha cells. Metformin decreases hepatic glucose production, reduces intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. The combination lowers both fasting and postprandial blood glucose.
Mechanism Steps
💡 How to Take ignalis-m 100/500 tablet er
Strength: Tablet containing Sitagliptin 100 mg and Metformin 500 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken once or twice daily with meals, depending on the prescribed strength and blood sugar control. The dose of sitagliptin and metformin should be individualized by a qualified clinician based on renal function, glycemic targets, and other medicines. Do not exceed the maximum recommended daily dose of sitagliptin 100 mg and metformin 2000 mg. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients should have kidney function assessed before starting and periodically during treatment. Dose adjustments may be needed based on renal function. Close monitoring of blood glucose and kidney function is advised. |
| Renal Impairment | Dose adjustment is required in kidney impairment. Sitagliptin dose should be reduced to 50 mg daily if eGFR is 30 to 45 mL/min/1.73 m2, and to 25 mg daily if eGFR is less than 30 mL/min/1.73 m2. Metformin is contraindicated if eGFR is less than 30 mL/min/1.73 m2. Consult your doctor for personalized dosing. |
| Hepatic Impairment | No specific dose adjustment is established for mild to moderate liver impairment. Use with caution in severe liver disease. Consult your doctor. |
| Maximum Daily Dose | Sitagliptin 100 mg and metformin 2000 mg per day. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ignalis-m 100/500 tablet er
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Insulin | Major | |
| Sulfonylureas | Major | |
| Alcohol | Major | |
| Iodinated contrast media | Major | |
| Cimetidine | Major | |
| Diuretics | Moderate | |
| Corticosteroids | Moderate | |
| ACE inhibitors | Moderate | |
| Digoxin | Moderate | |
| Beta-blockers | Minor |
🚨 Major Interactions
- Insulin or sulfonylureas
- Alcohol
- Iodinated contrast media
- Cationic drugs (e.g., cimetidine, dolutegravir, ranolazine, trimethoprim, vancomycin)
⚡ Moderate Interactions
- Diuretics
- Corticosteroids
- ACE inhibitors
- Digoxin
🍷 Alcohol Interaction
Alcohol should be avoided or limited while taking this medicine. Alcohol increases the risk of lactic acidosis, a rare but serious complication of metformin, and can also cause hypoglycemia. If you drink alcohol, do so in moderation and never on an empty stomach. Discuss with your doctor about safe limits.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe kidney impairment (eGFR less than 30 mL/min/1.73 m2)","Acute or chronic metabolic acidosis, including diabetic ketoacidosis","Hypersensitivity to sitagliptin, metformin, or any component of the formulation","Type 1 diabetes mellitus","Severe liver disease","Acute conditions that may cause kidney impairment (e.g., dehydration, severe infection, shock)"]
⚠️ Warnings & Precautions
["Lactic acidosis is a rare but serious metabolic complication that can occur due to metformin accumulation. Seek immediate medical help for symptoms such as rapid breathing, muscle pain, or extreme tiredness.","Pancreatitis has been reported with sitagliptin. Stop the medicine and seek medical attention if you develop severe abdominal pain.","Hypoglycemia risk increases when used with insulin or sulfonylureas. Monitor blood sugar regularly.","Kidney function should be assessed before starting and periodically during treatment.","Vitamin B12 deficiency may occur with long-term metformin use. Periodic monitoring is advised.","Avoid excessive alcohol intake as it increases the risk of lactic acidosis.","Temporarily discontinue before surgery or imaging with iodinated contrast media as advised by your doctor."]
🤱 Lactation Safety
Not established from the available information. Sitagliptin and metformin are excreted in breast milk in small amounts. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose may cause hypoglycemia, lactic acidosis, or pancreatitis. Seek emergency medical attention immediately. Treatment is supportive and may include dialysis for metformin removal. Do not try to induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Swallow the tablet whole with a meal to reduce stomach upset. Do not crush, chew, or split the tablet unless your doctor advises otherwise. Check your blood sugar regularly as instructed. Inform your doctor if you have kidney problems, liver disease, or a history of pancreatitis. Avoid excessive alcohol because it increases the risk of lactic acidosis. Stop the medicine and contact your doctor immediately if you experience unusual muscle pain, difficulty breathing, severe stomach pain, or signs of an allergic reaction. Do not start or stop any other medicine without consulting your doctor.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function, which can increase the risk of metformin accumulation and lactic acidosis. Kidney function should be assessed before and during treatment. Dose adjustments may be needed. Monitor blood sugar closely to avoid hypoglycemia.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before starting or continuing this medicine. Insulin is generally preferred for managing diabetes during pregnancy. Your doctor will adjust your treatment plan accordingly.
🏥 Post-Surgery Considerations
This medicine may need to be temporarily stopped before surgery, especially if you will be fasting or undergoing procedures with iodinated contrast. Follow your doctor's instructions. Blood sugar levels should be monitored closely during the perioperative period.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. If you are scheduled for a dental procedure that requires fasting or sedation, your doctor may adjust your dose. Maintain good oral hygiene as diabetes can increase the risk of gum disease.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is beneficial for diabetes management, but be cautious if you take insulin or sulfonylureas as exercise can lower blood sugar. Carry fast-acting sugar with you. Stay hydrated and avoid strenuous exercise in extreme heat. Consult your doctor before starting a new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause mild gastrointestinal side effects initially, but most people can continue their daily activities. If you experience hypoglycemia, avoid driving or operating heavy machinery until your blood sugar is stable. Inform your employer about your condition and the medicine you take.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience serious side effects such as lactic acidosis, pancreatitis, or severe allergic reactions, stop the medicine and seek immediate medical attention. Your doctor may adjust or change your treatment based on your condition.
📅 Long-Term Use Effects
Long-term use of this medicine may require periodic monitoring of kidney function, vitamin B12 levels, and blood sugar control. Metformin can cause vitamin B12 deficiency over time, which may lead to anemia or nerve problems. Sitagliptin is generally well-tolerated long-term. Regular follow-up with your doctor is essential to adjust the dose and monitor for any complications.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet and exercise are the cornerstone of diabetes management and can complement medicine.
Evidence: Well-establishedSGLT2 inhibitors, sulfonylureas, or insulin may be alternatives based on individual needs.
Evidence: Well-establishedMay be considered for selected patients with obesity and type 2 diabetes.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
People with diabetes are at higher risk of infections. Ensure you are up to date with vaccinations such as influenza, pneumococcal, and hepatitis B. Consult your doctor about the timing of vaccines.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid temperature extremes. If traveling across time zones, adjust the timing of doses gradually as advised by your doctor. Store at room temperature and avoid direct sunlight. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood sugar within the first day, but the full effect on HbA1c may take several weeks. Your doctor will monitor your progress.
A: Yes, but only under your doctor's supervision. Combining with insulin or sulfonylureas may increase the risk of low blood sugar.
A: Take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: Your kidney function will be checked before and during treatment. The dose may need adjustment if your kidney function declines.
A: No, do not stop without consulting your doctor. Stopping suddenly can cause blood sugar to rise again.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can cure diabetes.
Fact: This medicine helps control blood sugar but does not cure diabetes. Lifestyle changes and ongoing treatment are essential. - Myth: This medicine causes weight gain.
Fact: Unlike some other diabetes medicines, this combination is generally weight-neutral or may cause slight weight loss. - Myth: You can stop this medicine once blood sugar is normal.
Fact: Stopping without doctor's advice can cause blood sugar to rise again. Always consult your doctor before stopping. - Myth: This medicine is safe for everyone with diabetes.
Fact: It is not for type 1 diabetes or people with severe kidney disease. A doctor must decide if it is right for you.
🔄 Alternative Options
Generic Alternatives
- Sitagliptin and Metformin combination tablets from other manufacturers
Brand Alternatives
- Janumet
- Janumet XR
- Zita-Met
- Sitamet
- Glyxambi