Zerodol Tablet (Aceclofenac 100 mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or black tarry stools
- Vomiting blood or coffee-ground vomit
- Severe or persistent abdominal pain
- Chest pain, shortness of breath, or difficulty breathing
- Sudden swelling of the face, lips, or throat
- Yellowing of the skin or eyes, or dark urine
- Reduced urine output or sudden ankle swelling
- Severe headache with neck stiffness or sensitivity to light
- Unusual bruising or bleeding
- High fever with a spreading skin rash
If experiencing severe symptoms, call emergency services immediately.
What is if 100mg tablet used for?
This medicine contains aceclofenac 100 mg, an NSAID used to relieve pain and inflammation in conditions such as osteoarthritis, rheumatoid arthritis, and musculoskeletal injuries. It is usually taken as one tablet twice daily with food, and it works by blocking COX enzymes to reduce prostaglandins. It should be used at the lowest effective dose for the shortest duration and avoided in people with active ulcers, severe kidney or liver disease, or uncontrolled heart failure.
- Generic Name: Aceclofenac (100mg)
- Manufacturer: Medisun Pharma
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 if 100mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एसिफेनाक 100 मिलीग्राम की एक टैबलेट है, जो नॉन-स्टेरॉयडल एंटी-इंफ्लेमेटरी ड्रग (NSAID) वर्ग की दवा है। इसका उपयोग मुख्य रूप से जोड़ों के दर्द, सूजन और अकड़न को कम करने के लिए किया जाता है, जैसे घुटनों का ऑस्टियोआर्थराइटिस, रुमेटॉयड आर्थराइटिस, कमर की अकड़न (एंकिलोज़िंग स्पॉन्डिलाइटिस), चोट लगने के बाद होने वाला दर्द, दांत निकालने के बाद का दर्द और मासिक धर्म के दौरान होने वाली ऐंठन। यह दवा शरीर में प्रोस्टाग्लैंडिन नामक रसायन को कम करती है, जिससे दर्द और सूजन कम होती है। यह दवा दर्द को पूरी तरह खत्म नहीं करती और गठिया को ठीक नहीं करती, बल्कि लक्षणों को कम करने में मदद करती है। इसे डॉक्टर की सलाह के अनुसार ही लेना चाहिए, खासकर अगर आपको पेट के अल्सर, गुर्दे या लिवर की बीमारी, हृदय की समस्या या दमा है।
साइड इफेक्ट्स: इस दवा को लेने पर आमतौर पर पेट से जुड़ी समस्याएं हो सकती हैं, जैसे अपच, सीने में जलन, मतली, पेट में दर्द और भूख कम लगना। कुछ लोगों को सिरदर्द, चक्कर आना, नींद आना या हल्के दाने भी हो सकते हैं। ये आमतौर पर हल्के होते हैं और कुछ दिनों में ठीक हो जाते हैं। कभी-कभी गंभीर समस्याएं भी हो सकती हैं, जैसे पेट या आंत में खून आना, अल्सर, गुर्दे की कार्यक्षमता में बदलाव, शरीर में सूजन, रक्तचाप बढ़ना और लिवर की समस्या। बहुत कम मामलों में गंभीर एलर्जी, दमा का दौरा या त्वचा की गंभीर प्रतिक्रिया हो सकती है। अगर काला मल, खून की उल्टी, तेज पेट दर्द, सांस लेने में कठिनाई, चेहरे या गले में सूजन, या आंखों-त्वचा का पीलापन दिखे, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर द्वारा बताई गई मात्रा में और बताई गई अवधि तक ही लें। इसे भोजन या दूध के साथ लें ताकि पेट में जलन न हो। टैबलेट को पानी के साथ पूरा निगलें, चबाएं या तोड़ें नहीं। इस दवा के साथ शराब न लें, क्योंकि इससे पेट में खून आने का खतरा बढ़ जाता है। बिना डॉक्टर की सलाह के कोई अन्य दर्द निवारक दवा न लें। अगर आपको पेट के अल्सर, गुर्दे या लिवर की बीमारी, हृदय की समस्या, उच्च रक्तचाप या दमा है, तो दवा शुरू करने से पहले डॉक्टर को बताएं। गर्भावस्था, गर्भधारण की योजना या स्तनपान के दौरान डॉक्टर से सलाह लें। दवा को मूल डिब्बे में, ठंडी और सूखी जगह पर, धूप से दूर रखें और बच्चों की पहुंच से बाहर रखें।
💊 if 100mg tablet Uses & Benefits
[{"condition":"Osteoarthritis","description":"Relieves joint pain, reduces stiffness, and improves physical function in knee, hip, and hand osteoarthritis.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Helps control pain and inflammation" class="semantic-link" title="Medicines for swelling">swelling in inflamed joints as part of a broader treatment plan that includes disease-modifying drugs.","evidence":"Well-established"},{"condition":"Ankylosing spondylitis","description":"Reduces back pain and morning stiffness associated with this inflammatory spine condition.","evidence":"Well-established"},{"condition":"Acute musculoskeletal injuries","description":"Eases pain and swelling after sprains, strains, and soft tissue injuries.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term relief of mild to moderate pain after surgical procedures, as advised by the treating doctor.","evidence":"Moderate"},{"condition":"Dental pain","description":"Provides short-term relief of pain following dental extraction or other minor dental procedures.","evidence":"Moderate"},{"condition":"Dysmenorrhea","description":"Helps relieve menstrual cramps by reducing prostaglandin-driven uterine contractions.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Acute gout flare","description":"Sometimes used for short-term pain relief during a gout attack when other treatments are not suitable.","evidence":"Limited"},{"condition":"Migraine","description":"Occasionally used for acute migraine pain, but it is not a first-line treatment.","evidence":"Limited"}]
Primary treatment for: Osteoarthritis
Also treats: Rheumatoid arthritis, Ankylosing spondylitis, Acute musculoskeletal injuries, Dysmenorrhea, Post-operative pain, Dental pain
📋 Drug Information
| Generic Name(s) | Aceclofenac (100mg) |
| Brand Name | if 100mg tablet |
| Manufacturer | Medisun Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | NSAID's- Non-Selective COX 1&2 Inhibitors (acetic acid) |
| Route of Administration | Oral. This medicine is taken by mouth as a tablet, usually with a glass of water and food |
| Storage | Store this medicine at room temperature between 15°C and 30°C in a dry place. Keep the tablets in their original blister pack or container, tightly closed, away from direct sunlight, moisture, and heat. Do not store it in the bathroom. Keep it out of reach of children and pets. |
| Shelf Life | The shelf life is typically 24 months from the date of manufacture when stored as directed. Always check the expiry date printed on the pack and do not use the medicine after that date. |
| WHO Guideline | Not established from the available information. International guidelines generally recommend NSAIDs such as this medicine for short-term symptom relief in osteoarthritis and inflammatory arthritis, but specific WHO recommendations for aceclofenac are not established from the available information. |
| ICMR Guideline | Not established from the available information. Indian guidelines generally advise using NSAIDs at the lowest effective dose for the shortest duration, with caution in the elderly and in people with kidney, liver, or heart disease. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by blocking the cyclo-oxygenase (COX) enzymes, which are needed to convert arachidonic acid into prostaglandins and related inflammatory mediators. Prostaglandins sensitize pain nerve endings, cause blood vessels to widen, and promote swelling and fever. By reducing prostaglandin production, this medicine lowers pain and inflammation. Aceclofenac is considered to have relatively greater activity against COX-2 than COX-1 compared with some older NSAIDs, which may translate into a somewhat lower risk of stomach irritation, although the risk is not eliminated. It also reduces the production of certain cytokines and inflammatory substances in the joint lining, which helps improve joint comfort and mobility.
Mechanism Steps
💡 How to Take if 100mg tablet
Strength: Immediate-release tablet containing 100 mg of aceclofenac.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one 100 mg tablet taken twice daily, preferably with food or milk to reduce stomach upset. Some doctors may prescribe one tablet twice daily for chronic conditions such as osteoarthritis or rheumatoid arthritis, while for acute pain a shorter course may be used. The dose and duration must be individualized by a qualified clinician based on the indication, age, weight, kidney function, liver function, and other medicines you are taking. Do not exceed the dose prescribed by your doctor, and do not take this medicine for longer than recommended without medical review. |
| Pediatric Dosage | Pediatric dosing is not established from available information. This medicine is not recommended for children and adolescents below 18 years of age. Consult a pediatrician for safe and appropriate pain relief options for your child. |
| Elderly Dosage | Elderly patients, especially those above 65 years of age, are at higher risk of stomach bleeding, kidney problems, and heart side effects from this medicine. They should use the lowest effective dose for the shortest possible duration. Kidney function and blood pressure should be monitored more closely, and the medicine should be avoided in frail elderly patients with dehydration or multiple medical conditions unless clearly necessary. |
| Renal Impairment | This medicine should be used with caution in people with kidney disease. In mild kidney impairment, no dose adjustment may be needed, but kidney function should be monitored. In moderate to severe kidney impairment, this medicine is generally not recommended because it can worsen kidney function. The dose must be individualized by a qualified clinician based on the degree of kidney impairment and the underlying cause of pain. |
| Hepatic Impairment | This medicine is extensively metabolized in the liver, so people with liver disease may have higher blood levels and a greater risk of side effects. In mild to moderate liver impairment, the dose may need to be reduced and liver function monitored. In severe liver disease, this medicine is contraindicated. The dose must be individualized by a qualified clinician based on liver function tests and the overall clinical picture. |
| Maximum Daily Dose | The maximum recommended adult daily dose is 200 mg per day, usually given as 100 mg twice daily. Doses above this are not recommended because they increase the risk of stomach, kidney, and heart side effects without providing extra benefit. Always follow the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of if 100mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Aspirin | Major | |
| Ibuprofen | Major | |
| Methotrexate | Major | |
| Lithium | Major | |
| Ramipril | Major | |
| Furosemide | Moderate | |
| Sertraline | Moderate | |
| Ciclosporin | Moderate | |
| Prednisolone | Major |
🚨 Major Interactions
- Warfarin and other anticoagulants
- Other NSAIDs including aspirin
- Corticosteroids
- Methotrexate
- Lithium
- ACE inhibitors and angiotensin receptor blockers
⚡ Moderate Interactions
- Diuretics such as furosemide and hydrochlorothiazide
- Selective serotonin reuptake inhibitors (SSRIs)
- Ciclosporin
- Tacrolimus
- Zidovudine
- Antidiabetic medicines
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Both alcohol and this medicine can irritate the stomach lining, and together they increase the risk of stomach ulcers and gastrointestinal bleeding. Alcohol can also add to liver stress and may worsen dizziness or drowsiness. If you drink alcohol regularly, discuss this with your doctor before starting or continuing this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy or hypersensitivity to aceclofenac, diclofenac, or any other ingredient in the tablet","Active or history of peptic ulcer or gastrointestinal bleeding","Severe heart failure or recent heart attack or stroke","Severe kidney disease or severe liver disease","Asthma, urticaria, or allergic reactions triggered by aspirin or other NSAIDs","Third trimester of pregnancy","Children and adolescents below 18 years of age, as safety and effectiveness are not established","Use around the time of coronary artery bypass graft surgery"]
⚠️ Warnings & Precautions
["Take this medicine with food or milk to reduce stomach irritation.","Use the lowest effective dose for the shortest duration that controls your symptoms.","Avoid alcohol and other NSAIDs while taking this medicine.","Tell your doctor if you have a history of stomach ulcers, kidney disease, liver disease, heart failure, or high blood pressure.","This medicine may cause dizziness or drowsiness; avoid driving or operating heavy machinery until you know how it affects you.","Do not use this medicine to treat pain before or after heart bypass surgery.","Elderly patients should use this medicine with extra caution because of a higher risk of stomach, kidney, and heart side effects.","Stop the medicine and seek medical advice if you develop signs of bleeding, allergic reaction, or liver problems."]
🤱 Lactation Safety
This medicine and its active metabolite pass into breast milk in small amounts. Short-term use of a single dose is generally considered acceptable, but regular or high-dose use while breastfeeding is not recommended because of the potential for side effects in the infant, such as stomach upset, drowsiness, or kidney effects. If you need pain relief while breastfeeding, discuss safer options with your doctor.
💊 Overdose Management
Taking more than the prescribed dose of this medicine can cause nausea, vomiting, stomach pain, dizziness, drowsiness, and in severe cases, gastrointestinal bleeding, kidney problems, or liver injury. If you suspect an overdose, contact your doctor or a poison control center immediately, or go to the nearest emergency department. Do not try to vomit unless instructed by a healthcare professional. Treatment is supportive and may include activated charcoal if the overdose is recent, along with monitoring of vital signs, kidney function, liver function, and blood counts.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember, provided there is still a long time before your next scheduled dose. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose, because this increases the risk of side effects. If you miss several doses in a row, contact your doctor for advice rather than doubling up on your own.
Additional Safety Advice
Always take this medicine exactly as your doctor has prescribed, and do not increase the dose or extend the duration on your own. Take the tablet with food or a glass of milk to reduce the chance of stomach upset. Swallow it whole with water; do not crush or chew it. Avoid alcohol while you are taking this medicine because it increases the risk of stomach bleeding. Do not take other pain relievers, including over-the-counter NSAIDs, without checking with your doctor. If you have a history of stomach ulcers, kidney disease, liver disease, heart failure, or high blood pressure, tell your doctor before starting this medicine. Use the lowest effective dose for the shortest possible time. If you are pregnant, planning pregnancy, or breastfeeding, discuss the risks and benefits with your doctor. Keep all follow-up appointments so your doctor can monitor your blood pressure, kidney function, and liver function if needed. Store the tablets in their original container, away from moisture and direct sunlight, and keep them out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
People above 65 years of age are at higher risk of stomach bleeding, kidney impairment, fluid retention, and heart side effects from this medicine. They should use the lowest effective dose for the shortest possible duration. Kidney function and blood pressure should be checked more often. Elderly patients who are dehydrated, frail, or taking multiple medicines should use this medicine only after careful discussion with their doctor, and alternative pain relief options should be considered first.
🤰 Pregnancy Planning (TTC)
If you are trying to conceive, discuss this medicine with your doctor before use. NSAIDs such as this medicine can interfere with ovulation and may reduce fertility in some women, although this effect is usually reversible after stopping the medicine. During pregnancy, especially in the third trimester, this medicine should be avoided because it can harm the baby. If you become pregnant while taking this medicine, stop it and contact your doctor immediately.
🏥 Post-Surgery Considerations
This medicine may be used for short-term pain relief after some surgical procedures, but it should not be used around the time of heart bypass surgery because it increases the risk of heart complications. After any surgery, follow your surgeon's instructions about pain relief, and inform them about all medicines you are taking. This medicine can increase bleeding risk, so it may need to be stopped before certain operations. Do not start or stop it without your surgeon's advice.
🦷 Dental Procedures
This medicine can be used for short-term pain relief after dental extraction or other minor dental procedures. However, because it increases bleeding risk, inform your dentist if you are taking it before any dental surgery or procedure. Your dentist may advise you to stop it for a few days before a procedure that involves bleeding, but only after consulting your doctor. Do not take extra doses for dental pain without medical advice.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may feel less pain and be tempted to overexert yourself. Avoid high-impact activities such as running on hard surfaces or heavy weightlifting until your doctor or physiotherapist says it is safe. If you feel dizzy or drowsy after taking the tablet, avoid exercises that require balance or coordination. Stop exercising and seek medical advice if you develop chest pain, severe shortness of breath, or sudden joint swelling.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people, so avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their usual office or light physical work while taking it. If your job involves heavy lifting or prolonged standing, discuss with your doctor whether you need work modifications. Keep your medicine with you at work so you do not miss a dose, and inform your supervisor if you have any medical condition that could affect your safety at work.
🛑 When to Stop This Medicine
Stop taking this medicine and contact your doctor if you develop black stools, vomiting blood, severe stomach pain, signs of an allergic reaction, yellowing of the eyes or skin, reduced urine output, or sudden ankle swelling. Do not stop this medicine suddenly on your own if you have been taking it for a long time for a chronic condition; instead, discuss a tapering plan or alternative treatment with your doctor. If your pain improves and you no longer need it, you may stop after consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of stomach ulcers and gastrointestinal bleeding, kidney impairment, fluid retention, raised blood pressure, and cardiovascular events such as heart attack or stroke. It may also cause liver enzyme elevations. If long-term treatment is needed, your doctor should review your condition regularly, use the lowest effective dose, and monitor blood pressure, kidney function, and liver function. Do not continue this medicine for months without a medical review.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Strengthening and stretching exercises can reduce pain and improve joint function in osteoarthritis.
Evidence: Well-establishedLosing excess weight reduces load on weight-bearing joints and can significantly improve knee osteoarthritis symptoms.
Evidence: Well-establishedGels and creams containing NSAIDs can provide local pain relief with fewer systemic side effects.
Evidence: Well-establishedApplying heat or cold packs can help reduce pain and stiffness temporarily.
Evidence: ModerateSome patients report pain relief with acupuncture, although evidence is mixed.
Evidence: LimitedA simple pain reliever that may be used when NSAIDs are not suitable, though it has no anti-inflammatory effect.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you have a fever or are unwell, it is better to postpone vaccination until you have recovered. If you are taking this medicine for a long-term condition, inform the healthcare provider before receiving any vaccine. This medicine does not affect the immune response to vaccines.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in the original blister pack or container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children and pets
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your hand luggage so it stays with you and is not exposed to extreme temperatures in checked baggage. Store it at room temperature and away from direct sunlight. If you are crossing time zones, continue taking your doses at the same intervals as prescribed; for twice-daily dosing, try to keep doses about 12 hours apart. Check the customs rules of your destination country for prescription medicines, and carry only the amount you need for the trip plus a small extra supply. If you have kidney, liver, or heart disease, discuss travel plans and hydration with your doctor before you go.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Pain relief usually begins within 30 to 60 minutes after taking a tablet, with peak effects in about 1.5 to 3 hours. The effect of a single dose generally lasts 4 to 6 hours.
A: It is best taken with food or milk to reduce the risk of stomach upset. Taking it on an empty stomach may increase the chance of indigestion and heartburn.
A: Long-term use should only be under medical supervision. It can increase the risk of stomach ulcers, kidney problems, and heart side effects. Your doctor may monitor your blood pressure, kidney function, and liver function.
A: It is best to avoid alcohol because it increases the risk of stomach bleeding and liver irritation.
A: If you remember soon after the missed dose, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: This medicine should be avoided during pregnancy, especially in the third trimester, unless your doctor advises otherwise. Discuss safer options with your doctor.
A: Yes, it can reduce the effectiveness of ACE inhibitors, angiotensin receptor blockers, and diuretics, and may increase the risk of kidney problems. Your doctor may need to monitor your blood pressure and kidney function.
A: In some cases, your doctor may allow this combination for short-term pain relief, but you should not combine them without medical advice because of the risk of liver and kidney strain.
🤔 Common Patient Concerns
🔄 Substitutes for if 100mg tablet
View AllAlternative brands with exact same active ingredient:
-
asozen 100 tabletZeelab Pharmacy Pvt Ltd ₹6.00 82.7% CHEAPER
-
aclonac tabletPCI Pharmaceuticals ₹7.36 78.8% CHEAPER
-
ac1 tabletPharmasynth Formulations Ltd ₹9.38 73% CHEAPER
-
atofen 100mg tabletZota Health care Ltd ₹10.81 68.8% CHEAPER
-
acetal 100mg tabletTalent Healthcare ₹12.00 65.4% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure arthritis.
Fact: This medicine only relieves pain and inflammation; it does not cure arthritis or stop joint damage. - Myth: More tablets mean faster relief.
Fact: Taking more than the prescribed dose increases the risk of serious side effects without giving extra benefit. - Myth: This medicine is safe for everyone.
Fact: It is not safe for people with active ulcers, severe kidney or liver disease, uncontrolled heart failure, or aspirin-sensitive asthma. - Myth: You can take this medicine with any other painkiller.
Fact: Combining it with other NSAIDs increases the risk of stomach bleeding and kidney problems. - Myth: This medicine can be taken without food.
Fact: Taking it with food or milk reduces stomach irritation and is generally recommended.
🔄 Alternative Options
Generic Alternatives
- Aceclofenac 100 mg tablet
Brand Alternatives
- Zerodol tablet