Ibusaan 400 mg/500 mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is ibusaan 400 mg/500 mg tablet used for?
This medicine is a combination of diclofenac and paracetamol used for short-term relief of acute pain and inflammation. It works by reducing prostaglandins that cause pain and swelling. Take it with food to avoid stomach upset and do not exceed 3 tablets in 24 hours.
- Generic Name: Diclofenac (400mg) + Paracetamol (500mg)
- Manufacturer: Sresan Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ibusaan 400 mg/500 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डाइक्लोफेनाक और पैरासिटामोल का संयोजन है, जिसका उपयोग तीव्र दर्द और सूजन के अल्पकालिक उपचार के लिए किया जाता है। यह मांसपेशियों के दर्द, दांत दर्द, मासिक धर्म में होने वाले दर्द, और सर्जरी के बाद के दर्द में राहत देती है। इसे भोजन के साथ लेना चाहिए ताकि पेट में जलन न हो। इस दवा को बिना डॉक्टर की सलाह के लंबे समय तक नहीं लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट में दर्द, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, अल्सर, गुर्दे की समस्या, और यकृत की क्षति शामिल हो सकती है। यदि आपको काला मल, उल्टी में खून, या गंभीर पेट दर्द हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे भोजन के साथ लें ताकि पेट में जलन न हो। इस दवा के साथ शराब का सेवन न करें। यदि आप गर्भवती हैं, स्तनपान करा रही हैं, या आपको गुर्दे या यकृत की बीमारी है, तो डॉक्टर को बताएं। चक्कर आने पर वाहन न चलाएं। दवा को ठंडी और सूखी जगह पर रखें।
💊 ibusaan 400 mg/500 mg tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation associated with muscle strains, sprains, and back pain.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from toothache and pain following dental procedures.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain after surgical procedures.","evidence":"Well-established"},{"condition":"Dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Well-established"},{"condition":"Osteoarthritis","description":"Short-term relief of pain and stiffness in osteoarthritis flare-ups.","evidence":"Established"},{"condition":"Rheumatoid arthritis","description":"May be used for short-term symptomatic relief during acute exacerbations.","evidence":"Established"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but not first-line.","evidence":"Limited"},{"condition":"Renal colic","description":"May be used off-label for pain relief in kidney stones, but requires medical supervision.","evidence":"Limited"}]
Primary treatment for: Acute pain and inflammation
Also treats: Osteoarthritis, Rheumatoid arthritis, Dysmenorrhea, Dental pain, Post-operative pain
📋 Drug Information
| Generic Name(s) | Diclofenac (400mg) + Paracetamol (500mg) |
| Brand Name | ibusaan 400 mg/500 mg tablet |
| Manufacturer | Sresan Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Diclofenac, an NSAID, reversibly inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, leading to decreased synthesis of prostaglandins, prostacyclin, and thromboxane. This results in reduced inflammation, pain, and fever. Paracetamol, although its exact mechanism is not fully elucidated, primarily acts centrally by inhibiting prostaglandin synthesis in the brain and possibly activating descending serotonergic pathways. The combination provides enhanced analgesic and anti-inflammatory effects compared to either agent alone.
Mechanism Steps
💡 How to Take ibusaan 400 mg/500 mg tablet
Strength: Each tablet contains diclofenac 400 mg and paracetamol 500 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally every 6 to 8 hours as needed for pain, not to exceed 3 tablets in 24 hours. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose or duration of treatment without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially gastrointestinal and renal adverse effects. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose reduction may be necessary. Avoid use in severe renal impairment (eGFR <30 mL/min). Consult a clinician for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose reduction may be necessary. Avoid use in severe hepatic impairment. Consult a clinician for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose is 3 tablets in 24 hours. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ibusaan 400 mg/500 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| ACE inhibitors | Major | |
| Methotrexate | Major | |
| Corticosteroids | Moderate | |
| Diuretics | Moderate | |
| Lithium | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor | |
| Alcohol | Major |
🚨 Major Interactions
- Warfarin
- Other NSAIDs
- ACE inhibitors
- Methotrexate
⚡ Moderate Interactions
- Corticosteroids
- Diuretics
- Lithium
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding and can potentiate liver toxicity, especially with paracetamol.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to diclofenac, paracetamol, or any component of the formulation","History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs","Active peptic ulcer disease or history of recurrent peptic ulcer","Severe renal impairment (eGFR
⚠️ Warnings & Precautions
["Cardiovascular risk: NSAIDs may increase the risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke.","Gastrointestinal risk: NSAIDs increase the risk of serious gastrointestinal adverse events, including bleeding, ulceration, and perforation.","Renal effects: Long-term use may lead to renal papillary necrosis and other renal injury.","Hepatic effects: Paracetamol and diclofenac can cause hepatotoxicity. Do not exceed recommended dose.","Skin reactions: Serious skin reactions such as exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis have been reported.","Use in elderly: Increased risk of adverse effects, especially gastrointestinal bleeding and renal impairment.","Use in children: Safety and efficacy not established."]
🤱 Lactation Safety
Diclofenac and paracetamol are excreted in breast milk in small amounts. Short-term use is generally considered compatible with breastfeeding, but consult your doctor before use.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage due to paracetamol and gastrointestinal bleeding, renal failure, and central nervous system effects due to diclofenac. Seek immediate medical attention. Treatment includes activated charcoal if within 1-2 hours of ingestion, N-acetylcysteine for paracetamol toxicity, and supportive care. Monitor liver and renal function, and vital signs.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Always take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it can increase the risk of gastrointestinal bleeding. Do not use this medicine if you have a history of stomach ulcers, bleeding disorders, or severe kidney or liver disease. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. This medicine may interact with blood thinners, antihypertensives, and other NSAIDs. Do not drive or operate heavy machinery if you experience dizziness or drowsiness. Store this medicine in a cool, dry place away from direct sunlight and out of reach of children. If you experience any signs of an allergic reaction or severe side effects, seek medical help immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, renal impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor renal and hepatic function regularly.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Diclofenac may affect ovulation and is not recommended during pregnancy, especially in the third trimester. Paracetamol is generally considered safe but should be used as directed.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative pain relief, but it can increase the risk of bleeding. Inform your surgeon if you are taking this medicine before surgery. It may need to be stopped before certain procedures.
🦷 Dental Procedures
This medicine can be used for dental pain, but it may increase the risk of bleeding during dental procedures. Inform your dentist if you are taking this medicine.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that may increase pain while taking this medicine. Gentle stretching and low-impact exercises are recommended. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is advisable to take it when you can rest if needed.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your pain persists beyond 7 days, if you experience any serious side effects, or if you develop signs of an allergic reaction. Do not stop abruptly if you have been taking it regularly for a long time without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of gastrointestinal bleeding, ulcers, kidney damage, liver toxicity, and cardiovascular events. Regular monitoring of renal and hepatic function, blood counts, and blood pressure is recommended. Use the lowest effective dose for the shortest duration. Consult your doctor if you need to use this medicine for more than 7 days.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain.
Evidence: Well-establishedMay help relieve localized pain and inflammation.
Evidence: EstablishedSome evidence for pain relief in certain conditions.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are established. However, if you are scheduled for vaccination, inform your healthcare provider about this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from direct sunlight and moisture. If crossing time zones, continue taking it as needed for pain, but do not exceed the maximum daily dose. Check local customs regulations regarding prescription medicines. Always keep it in your carry-on luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it orally.
A: It is best to take this medicine with food or milk to reduce the risk of stomach upset.
A: Do not take this medicine with other NSAIDs or paracetamol-containing products without consulting your doctor, as it can increase the risk of side effects.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is safe for long-term use.
Fact: This medicine is intended for short-term use only. Long-term use can increase the risk of gastrointestinal, renal, and cardiovascular side effects. - Myth: It is safe to take this medicine on an empty stomach.
Fact: Taking this medicine with food is recommended to reduce the risk of stomach upset and gastrointestinal bleeding. - Myth: This medicine can be taken with other painkillers.
Fact: Combining with other NSAIDs or paracetamol-containing products can increase the risk of toxicity. Always consult a doctor before combining.
🔄 Alternative Options
Generic Alternatives
- Diclofenac 400 mg + Paracetamol 500 mg tablet
Brand Alternatives
- Ibusaan 400 mg/500 mg tablet