Hodpro 50mg Capsule (Procarbazine): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Fever above 100.4°F (38°C) or chills
- Unusual bleeding or bruising
- Blood in vomit or stool
- Severe headache with visual changes or palpitations
- Difficulty breathing or chest pain
- Yellowing of skin or eyes
- Decreased urine output
- Sudden swelling of face, lips, or throat
- Severe abdominal pain
- Confusion or extreme drowsiness
If experiencing severe symptoms, call emergency services immediately.
What is hodpro 50mg capsule used for?
This medicine is a prescription chemotherapy capsule containing procarbazine 50 mg. It is used mainly for Hodgkin lymphoma and some brain tumours. It works by damaging cancer cell DNA. It must be taken under strict specialist supervision because it can cause serious side effects and dangerous interactions with alcohol and certain foods.
- Generic Name: Procarbazine (50mg)
- Manufacturer: Neon Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 hodpro 50mg capsule के बारे में (Hindi Summary)
उपयोग: यह दवा प्रोकार्बाज़ीन 50 मिलीग्राम कैप्सूल है, जिसका उपयोग मुख्य रूप से हॉजकिन लिम्फोमा और कुछ ब्रेन ट्यूमर के इलाज में कीमोथेरेपी के हिस्से के रूप में किया जाता है। यह कैंसर कोशिकाओं के डीएनए को नुकसान पहुंचाकर उनकी वृद्धि को रोकती है। यह दवा केवल कैंसर विशेषज्ञ की देखरेख में ही लेनी चाहिए। इसे शराब, पनीर, प्रोसेस्ड मीट और फर्मेंटेड खाद्य पदार्थों के साथ नहीं लेना चाहिए क्योंकि इससे खतरनाक प्रतिक्रियाएं हो सकती हैं।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, भूख न लगना, थकान और रक्त कोशिकाओं की कमी शामिल हैं। गंभीर दुष्प्रभावों में संक्रमण, आसानी से खून आना, पीलिया, सांस लेने में कठिनाई और एलर्जी शामिल हो सकते हैं। अगर आपको बुखार, गले में दर्द, मुंह के छाले, खून बहना, पेशाब में कमी या आंखों का पीला होना दिखे तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: यह दवा केवल योग्य कैंसर विशेषज्ञ की देखरेख में ही लें। कैप्सूल को पानी के साथ पूरा निगलें, इसे तोड़ें या चबाएं नहीं। इलाज के दौरान शराब बिल्कुल न लें। पनीर, प्रोसेस्ड मीट, सोया सॉस और फर्मेंटेड खाद्य पदार्थों से बचें क्योंकि इनमें टायरामिन होता है जो रक्तचाप को खतरनाक रूप से बढ़ा सकता है। इलाज के दौरान और बाद में भी गर्भनिरोधक उपाय अपनाएं। बुखार, खून बहना या असामान्य थकान होने पर तुरंत डॉक्टर को बताएं।
💊 hodpro 50mg capsule Uses & Benefits
[{"condition":"Hodgkin lymphoma","description":"Used as part of combination chemotherapy regimens such as MOPP or BEACOPP for treating Hodgkin lymphoma under specialist care.","evidence":"Well-established"},{"condition":"Brain tumours (gliomas)","description":"Sometimes included in combination regimens for certain high-grade brain tumours, especially in specialist oncology protocols.","evidence":"Established in selected protocols"},{"condition":"Non-Hodgkin lymphoma","description":"May be used in some combination regimens for selected non-Hodgkin lymphomas when other options are unsuitable.","evidence":"Limited to specialist use"},{"condition":"Other solid tumours","description":"Occasionally used in selected solid tumours as part of investigational or specialist regimens.","evidence":"Limited"}]
Off-label uses: [{"condition":"Refractory mycosis fungoides","description":"Rarely used off-label in some cutaneous T-cell lymphomas under specialist supervision.","evidence":"Limited"},{"condition":"Selected paediatric malignancies","description":"Occasionally included in paediatric oncology protocols for certain tumours, only by paediatric oncologists.","evidence":"Limited"}]
Primary treatment for: Hodgkin lymphoma
Also treats: Brain tumours, Non-Hodgkin lymphoma
📋 Drug Information
| Generic Name(s) | Procarbazine (50mg) |
| Brand Name | hodpro 50mg capsule |
| Manufacturer | Neon Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Anticancer-others |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | Not established from the available information. Check the expiry date on the pack. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Procarbazine is a prodrug that undergoes metabolic activation in the body to form reactive intermediates. These intermediates alkylate DNA, forming cross-links and adducts that interfere with DNA replication and transcription. This damage is most harmful to rapidly dividing cancer cells, which eventually undergo cell cycle arrest and apoptosis. Procarbazine also inhibits monoamine oxidase, which explains several food and drug interactions. Its antineoplastic action is not cell-cycle specific, but it is most effective against actively dividing cells.
Mechanism Steps
💡 How to Take hodpro 50mg capsule
Strength: Procarbazine 50 mg immediate-release capsule
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified oncologist based on the type of cancer, body weight, blood counts, and other medicines in the regimen. It is usually given as part of a combination chemotherapy cycle, often for 10 to 14 days followed by a rest period. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Never adjust the dose without your oncologist's advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially bone marrow suppression and neurological effects. Doses are often reduced and monitoring is more frequent. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Not established from the available information. Dose adjustment may be needed in kidney impairment; consult your specialist. |
| Hepatic Impairment | Not established from the available information. Dose reduction may be required in liver impairment; consult your specialist. |
| Maximum Daily Dose | Not established from the available information. The maximum dose is determined by the treating oncologist based on the specific regimen and patient factors. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of hodpro 50mg capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| Sympathomimetics | Major | |
| Tyramine-rich foods | Major | |
| Alcohol | Major | |
| Live vaccines | Major | |
| Warfarin | Moderate | |
| CNS depressants | Moderate | |
| Phenytoin | Moderate | |
| Antacids | Minor | |
| Caffeine | Minor |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Sympathomimetic amines (e.g., pseudoephedrine, amphetamines)
- Tyramine-rich foods (aged cheese, cured meats, fermented soy)
- Alcohol
- Live vaccines
⚡ Moderate Interactions
- CNS depressants (e.g., sedatives, opioids)
- Anticoagulants (e.g., warfarin)
- Other myelosuppressive chemotherapy
- Phenytoin
🍷 Alcohol Interaction
Alcohol must be completely avoided while taking this medicine. Combining them can cause a disulfiram-like reaction with severe nausea, vomiting, flushing, headache, and low blood pressure. Alcohol may also worsen bone marrow suppression and liver toxicity.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to procarbazine or any component of the formulation","Severe bone marrow suppression","Pregnancy or planning pregnancy","Breastfeeding","Concurrent use of MAO inhibitors","Severe liver disease"]
⚠️ Warnings & Precautions
["This medicine can cause severe bone marrow suppression; regular blood counts are essential.","Avoid all alcohol and tyramine-rich foods to prevent dangerous reactions.","Do not receive live vaccines during treatment.","Use reliable contraception during treatment and for several months after.","Report any fever, sore throat, bleeding, or bruising immediately.","May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Can cause liver injury; report yellowing of eyes or skin.","Long-term use may increase the risk of secondary cancers."]
🤱 Lactation Safety
Not established from the available information. Breastfeeding is not recommended during treatment and for a period after stopping, as this medicine may pass into breast milk and harm the infant.
💊 Overdose Management
Overdose can cause severe bone marrow suppression, nausea, vomiting, and neurological symptoms. There is no specific antidote. Treatment is supportive and may include blood transfusions, antibiotics, and close monitoring in a hospital setting. Seek emergency medical help immediately if an overdose is suspected.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember if it is within a few hours of the scheduled time. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. Inform your oncology team about any missed doses.
Additional Safety Advice
This medicine must only be taken under the supervision of a qualified cancer specialist. Swallow the capsule whole with water, do not crush or open it, and follow the exact schedule given by your oncology team. Avoid alcohol completely during treatment and for some time after, because it can cause severe reactions. Avoid aged cheese, cured meats, fermented foods, soy sauce, and broad bean pods, as these contain tyramine and can raise blood pressure dangerously. Use reliable contraception during treatment and for several months afterwards. Do not receive live vaccines without asking your doctor. Wash hands frequently, avoid crowds during low blood count periods, and report any fever, bleeding, or unusual tiredness immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to bone marrow suppression, infections, and neurological side effects. Doses may need to be reduced, and monitoring should be more frequent. Discuss any concerns with your doctor.
🤰 Pregnancy Planning (TTC)
This medicine can harm the developing baby. Both men and women should use reliable contraception during treatment and for several months after stopping. If you are planning pregnancy, consult your oncologist well in advance.
🏥 Post-Surgery Considerations
Inform your surgeon and anaesthesiologist that you are taking this medicine before any surgery. It may increase the risk of bleeding and infection. Your doctor may advise temporary discontinuation around the time of surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It can increase the risk of bleeding and infection. Your dentist may recommend antibiotics or other precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Mild to moderate exercise like walking may be beneficial, but avoid strenuous activities if you feel tired, dizzy, or have low blood counts. Consult your doctor before starting any exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness, fatigue, and dizziness, which can affect your ability to drive or operate machinery. Avoid driving until you know how it affects you. You may need to take time off work during treatment cycles. Discuss your work schedule with your doctor.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your oncologist. Stopping suddenly may reduce the effectiveness of your treatment. If you experience severe side effects, your doctor may adjust the dose or stop the medicine temporarily. Always follow your specialist's advice.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of secondary cancers such as leukaemia. It can also cause persistent bone marrow suppression, liver injury, and peripheral neuropathy. Regular monitoring of blood counts, liver function, and neurological status is essential. Discuss long-term risks and benefits with your oncologist.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the cancer type and stage, other combination regimens may be used.
Evidence: Well-establishedMay be used alone or in combination with chemotherapy for Hodgkin lymphoma.
Evidence: Well-establishedNewer targeted medicines may be options for some lymphomas.
Evidence: Established in selected cases💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Do not receive live vaccines while taking this medicine due to the risk of serious infection. Inactivated vaccines may be given, but their effectiveness may be reduced. Consult your oncologist before any vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage and store it at room temperature, away from direct sunlight. If travelling across time zones, ask your oncologist how to adjust your dosing schedule. Check customs regulations for carrying prescription medicines. Never pack it in checked baggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The anticancer effect begins after several days, but clinical response may take weeks to become apparent. Your doctor will monitor your progress with regular tests.
A: Yes, you can take it with food to reduce stomach upset. However, avoid tyramine-rich foods and alcohol completely.
A: If you miss a dose, take it as soon as you remember if it is within a few hours. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, this medicine can harm the developing baby and is contraindicated during pregnancy. Use reliable contraception during treatment and for several months after.
A: No, alcohol must be completely avoided as it can cause a severe disulfiram-like reaction.
🤔 Common Patient Concerns
🔄 Substitutes for hodpro 50mg capsule
View AllAlternative brands with exact same active ingredient:
-
p carzine 50mg capsuleAlkem Laboratories Ltd ₹315.95 28% CHEAPER
-
zinocarb 50mg capsuleMiracalus Pharma Pvt Ltd ₹328.13 25.2% CHEAPER
-
neozine 50mg capsuleVhb Life Sciences Inc ₹328.57 25.1% CHEAPER
-
procarb 50mg tabletVhb Life Sciences Inc ₹3,000.00 583.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken like a regular vitamin or tonic.
Fact: This medicine is a powerful chemotherapy drug and must only be taken under specialist supervision. - Myth: Alcohol in small amounts is safe with this medicine.
Fact: Alcohol must be completely avoided because it can cause a severe disulfiram-like reaction. - Myth: You can eat any food while on this medicine.
Fact: Tyramine-rich foods like aged cheese and cured meats must be avoided to prevent a dangerous rise in blood pressure. - Myth: This medicine is safe during pregnancy.
Fact: This medicine can harm the developing baby and is contraindicated during pregnancy.
🔄 Alternative Options
Generic Alternatives
- Procarbazine 50 mg capsule
Brand Alternatives
- Hodpro 50mg capsule