histacare p syrup - Ambroxol (60mg) + Levocetirizine (5mg) medicine

Histacare P Syrup: Complete Guide to Uses, Dosage, and Safety

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🏭 Nri Vision Care India Limited 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 22, 2026
🤰 Pregnancy Category Not established from the available information. Consult your doctor before use. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
12 min read
Evidence: Moderate for the combination in productive cough and allergic rhinitis; individual components are well-established.
Reviewed by
SaathiMed Expert Panel | Oct 22, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Difficulty breathing or shortness of breath
  • Swelling of the face, lips, tongue, or throat
  • Severe rash, blistering, or peeling skin
  • Chest pain or fast, irregular heartbeat
  • Severe dizziness or fainting
  • Blood in sputum or vomit
  • Yellowing of eyes or skin
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is histacare p syrup used for?

This medicine is a combination syrup containing Ambroxol 60 mg and Levocetirizine 5 mg per 5 mL. It is used to treat productive cough with thick mucus and allergic rhinitis. Ambroxol thins mucus, while Levocetirizine reduces allergic symptoms. It is usually taken two to three times daily as prescribed by a doctor.

  • Generic Name: Ambroxol (60mg) + Levocetirizine (5mg)
  • Manufacturer: Nri Vision Care India Limited
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 histacare p syrup के बारे में (Hindi Summary)

उपयोग: यह दवा एम्ब्रोक्सोल 60 मिलीग्राम और लेवोसेटिरिज़िन 5 मिलीग्राम प्रति 5 मिलीलीटर के संयोजन वाली सिरप है। इसका उपयोग गाढ़े बलगम वाली खांसी और एलर्जी से होने वाली नाक बहने, छींक आने और गले में खराश के इलाज के लिए किया जाता है। एम्ब्रोक्सोल बलगम को पतला करता है जिससे खांसी में बलगम आसानी से बाहर निकल आता है। लेवोसेटिरिज़िन एलर्जी के लक्षणों को कम करता है। यह दवा डॉक्टर की सलाह पर ही लेनी चाहिए और निर्धारित मात्रा से ज्यादा नहीं लेनी चाहिए।

साइड इफेक्ट्स: इस दवा से आमतौर पर हल्की नींद आना, मुंह सूखना, सिरदर्द, जी मिचलाना या पेट में हल्की परेशानी हो सकती है। ये लक्षण आमतौर पर कुछ समय में ठीक हो जाते हैं। कभी-कभी चक्कर आना, थकान या दस्त हो सकते हैं। गंभीर एलर्जी प्रतिक्रिया जैसे चेहरे, होंठ या गले में सूजन, सांस लेने में कठिनाई या त्वचा पर चकत्ते बहुत कम होते हैं, लेकिन अगर ऐसा हो तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। मापने वाले कप या चम्मच से सही मात्रा नापें। अगर नींद या चक्कर आएं तो वाहन न चलाएं और मशीन न चलाएं। इस दवा के साथ शराब न लें। अगर आपको किडनी या लीवर की बीमारी है, गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर को बताएं। बिना डॉक्टर की सलाह के दवा की अवधि न बढ़ाएं। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 histacare p syrup Uses & Benefits

[{"condition":"Productive cough with thick mucus","description":"Helps thin and loosen mucus in the airways, making it easier to cough out.","evidence":"Well-established"},{"condition":"Allergic rhinitis","description":"Reduces sneezing, runny nose, itchy eyes, and throat irritation caused by allergies.","evidence":"Well-established"},{"condition":"Cough associated with upper respiratory tract allergies","description":"Combines mucolytic and antihistamine effects to relieve cough triggered by postnasal drip and allergies.","evidence":"Moderate"},{"condition":"Acute bronchitis with thick secretions","description":"May help clear mucus and reduce cough severity when used as an adjunct to other treatments.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Chronic sinusitis with thick mucus","description":"Sometimes prescribed to help thin mucus and reduce congestion, but not a standard approved use.","evidence":"Limited"},{"condition":"Smoker's cough","description":"Occasionally used to help loosen mucus in chronic smokers, but evidence is limited.","evidence":"Limited"}]

Primary treatment for: Productive cough with thick mucus and allergic rhinitis

Also treats: Acute bronchitis, Chronic sinusitis with thick mucus, Upper respiratory tract allergy

📋 Drug Information

Generic Name(s)Ambroxol (60mg) + Levocetirizine (5mg)
Brand Namehistacare p syrup
ManufacturerNri Vision Care India Limited
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C. Protect from direct sunlight and moisture. Keep the bottle tightly closed when not in use.
Shelf Life24 months from the date of manufacture, or as printed on the pack.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always measure the syrup with the provided cup or spoon; household spoons are not accurate.
2
Take this medicine after food if it causes stomach upset.
3
Avoid driving or operating heavy machinery until you know how drowsy it makes you.
4
Do not use this medicine for more than 7 days without consulting your doctor.
5
Stay well hydrated to help loosen mucus naturally.
6
Inform your doctor if you have kidney or liver problems before starting this medicine.
7
Do not combine with other cough syrups or antihistamines without medical advice.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Productive cough with thick mucus
This medicine is commonly prescribed for this.
Likely Use
✅
Runny nose and sneezing due to allergy
Levocetirizine in this medicine helps relieve allergic symptoms.
Likely Use
❌
Dry cough
This medicine is not effective for dry cough without mucus.
Not Primary
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
❌
Chest pain
Chest pain requires urgent medical evaluation, not this medicine.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionAmbroxol is rapidly absorbed from the gastrointestinal tract after oral administration. Levocetirizine is also rapidly and extensively absorbed after oral intake. Food does not significantly affect the absorption of either component.
DistributionAmbroxol distributes widely into body tissues, including lung tissue, and crosses the blood-brain barrier to some extent. Levocetirizine distributes into body tissues with a volume of distribution of approximately 0.4 L/kg.
Protein BindingAmbroxol is approximately 90% bound to plasma proteins. Levocetirizine is about 90% bound to plasma proteins.
MetabolismAmbroxol is metabolized in the liver primarily by conjugation to glucuronic acid and some oxidation. Levocetirizine undergoes minimal metabolism in the liver; it is mainly excreted unchanged.
Half-LifeThe elimination half-life of Ambroxol is approximately 7 to 12 hours. The elimination half-life of Levocetirizine is approximately 6 to 8 hours in adults with normal kidney function.
ExcretionAmbroxol and its metabolites are excreted mainly in the urine. Levocetirizine is excreted primarily unchanged in the urine.
BioavailabilityThe oral bioavailability of Ambroxol is approximately 70% to 80%. Levocetirizine has a high oral bioavailability of approximately 100%.
Onset of ActionAmbroxol begins to thin mucus within 30 to 60 minutes after oral intake. Levocetirizine starts reducing allergic symptoms within 1 hour.
Peak Plasma TimeAmbroxol reaches peak plasma concentration about 1 to 3 hours after oral administration. Levocetirizine reaches peak plasma concentration about 0.9 hours after oral administration.
Duration of ActionThe mucolytic effect of Ambroxol lasts approximately 6 to 8 hours. The antihistamine effect of Levocetirizine lasts about 24 hours.

How It Works

This medicine works through two complementary mechanisms. Ambroxol increases the production of serous fluid in the airways and reduces mucus viscosity by breaking down acidic mucopolysaccharide fibers. It also stimulates surfactant production and enhances ciliary movement, which helps transport mucus out of the lungs. Levocetirizine selectively blocks histamine H1 receptors, reducing allergic responses such as sneezing, itching, and increased mucus secretion. Together, they relieve cough by making mucus easier to expel and by calming allergic triggers.

Mechanism Steps

1
Ambroxol thins mucus: Ambroxol breaks down acidic mucopolysaccharide fibers in mucus, reducing its viscosity and making it easier to cough out.
2
Ambroxol enhances ciliary clearance: It stimulates the cilia in the airways to beat more effectively, helping move loosened mucus upward for expulsion.
3
Levocetirizine blocks histamine: Levocetirizine binds to histamine H1 receptors, preventing histamine from triggering allergic symptoms like sneezing and runny nose.
4
Combined relief: The two actions together reduce cough by clearing mucus and calming allergic airway irritation.

💡 How to Take histacare p syrup

Strength: Each 5 mL of syrup contains Ambroxol 60 mg and Levocetirizine 5 mg.

1Shake the bottle well before each use.
2Measure the prescribed dose using the measuring cup or spoon provided.
3Take the syrup orally, with or without food, as directed by your doctor.
4If it upsets your stomach, take it after a meal.
5Do not mix the syrup with hot liquids, as heat may affect the ingredients.
6Rinse the measuring cup after each use and keep it clean.
7Close the bottle tightly after use and store it as directed.

Dosage Information

Adult DosageThe usual adult dose is 5 mL to 10 mL of this syrup two to three times daily, or as directed by your doctor. The exact dose depends on the severity of your symptoms, your kidney and liver function, and other medicines you may be taking. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. Always use the measuring cup provided.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician. This medicine is not recommended for children below 2 years of age. For older children, the dose is determined by the doctor based on weight and clinical condition.
Elderly DosageElderly patients may be more sensitive to the sedative effects of Levocetirizine. The doctor may start with a lower dose and monitor kidney function, as renal clearance declines with age. Dose must be individualized by a qualified clinician.
Renal ImpairmentIn mild to moderate kidney impairment, dose adjustment may not be needed, but caution is advised. In severe kidney impairment (eGFR < 30 mL/min), this medicine is contraindicated unless specifically approved by a doctor. Dose must be individualized by a qualified clinician based on renal function.
Hepatic ImpairmentNo specific dose adjustment is established for mild to moderate liver impairment. In severe liver disease, use with caution and under medical supervision. Dose must be individualized by a qualified clinician.
Maximum Daily DoseThe maximum recommended daily dose is 30 mL of this syrup (providing 360 mg Ambroxol and 30 mg Levocetirizine) in divided doses, or as prescribed by your doctor. Do not exceed the prescribed dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take after meals
Reduces stomach upset and nausea.
Alcohol
Avoid
Increases drowsiness and dizziness.
Grapefruit juice
Limit intake
May slightly increase levocetirizine levels.
Water
Drink plenty
Helps thin mucus and keeps you hydrated.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of histacare p syrup

✅ Common Side Effects

Drowsiness (Common (5-10%))
Avoid driving or operating machinery until you know how it affects you. Usually settles with continued use.
Dry mouth (Common (5-10%))
Sip water frequently or chew sugar-free gum. Consult doctor if persistent.
Headache (Common (5-10%))
Rest and stay hydrated. Consult doctor if severe or persistent.
Nausea (Uncommon (1-5%))
Take with food to reduce stomach upset. Consult doctor if it continues.
Stomach discomfort (Uncommon (1-5%))
Take after meals. Consult doctor if pain persists.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical help if you notice swelling of face, lips, throat, difficulty breathing, or severe rash.
Fast or irregular heartbeat (Rare (<0.1%))
Contact your doctor immediately if you feel palpitations or chest discomfort.
Severe skin reactions (Very rare (<0.01%))
Stop the medicine and seek urgent medical attention if you develop blistering, peeling skin, or sores in the mouth.

⚠️ Rare Side Effects

Tremors
Report to your doctor if you experience uncontrolled shaking.
Mood changes or agitation
Consult your doctor if you feel unusually restless, anxious, or depressed.
Liver enzyme elevation
Your doctor may monitor liver function if you take this medicine for a long time.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
CNS depressants Major
MAOIs Major
Anticholinergics Moderate
Ritonavir Moderate
Theophylline Minor
Antacids Minor
Alcohol Moderate

🚨 Major Interactions

  • CNS depressants (e.g., benzodiazepines, opioids, alcohol)
  • Monoamine oxidase inhibitors (MAOIs)

⚡ Moderate Interactions

  • Anticholinergic drugs (e.g., atropine, tricyclic antidepressants)
  • Ritonavir

🍷 Alcohol Interaction

Alcohol can increase the sedative effects of Levocetirizine and may worsen drowsiness, dizziness, and difficulty concentrating. It is best to avoid alcohol completely while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known allergy to Ambroxol, Levocetirizine, or any component of this medicine","Severe kidney disease (eGFR < 30 mL/min) unless specifically approved by a doctor","Severe liver disease","Children below 2 years of age","Use in patients with rare hereditary problems of fructose intolerance (due to sorbitol content in some formulations)"]

⚠️ Warnings & Precautions

["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol while taking this medicine.","Do not use for a dry cough or cough without mucus.","Do not exceed the prescribed dose or duration.","Use with caution in elderly patients who may be more sensitive to side effects.","Consult a doctor before use in pregnancy or breastfeeding.","Inform your doctor if you have kidney or liver problems.","Keep out of reach of children.","Do not use if the seal is broken or the syrup is discolored.","Do not share this medicine with others."]

🤱 Lactation Safety

Levocetirizine may pass into breast milk in small amounts. Ambroxol is also likely to pass into breast milk. Consult your doctor before using this medicine while breastfeeding.

💊 Overdose Management

Overdose may cause increased drowsiness, dizziness, nausea, or agitation. If you suspect an overdose, contact your doctor or a poison control center immediately. Treatment is supportive and symptomatic. Do not induce vomiting unless instructed by a medical professional.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not increase or decrease the dose on your own. Measure the syrup with the provided measuring cup or spoon for accuracy. Avoid driving or operating heavy machinery if you feel drowsy. Do not drink alcohol while taking this medicine, as it can increase drowsiness and dizziness. Inform your doctor if you have kidney or liver problems, or if you are pregnant, planning pregnancy, or breastfeeding. Do not use this medicine for more than the recommended duration without medical advice. Keep it away from children. If you miss a dose, follow the missed dose instructions carefully. Do not use this medicine to treat a dry cough or a cough that does not produce mucus, as it may not be effective. Always check with your doctor before starting any new medicine, including over-the-counter products and herbal supplements.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more likely to experience drowsiness, dizziness, and dry mouth. Kidney function declines with age, so the doctor may adjust the dose or monitor kidney function. Falls risk may increase if you feel dizzy. Use with caution and avoid driving.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor before taking this medicine. The safety of this combination in early pregnancy is not well established. Your doctor may recommend alternative treatments if needed.

🏥 Post-Surgery Considerations

If you have recently had surgery, inform your surgeon and anesthesiologist that you are taking this medicine. Levocetirizine may increase sedation when combined with anesthetic agents. Your doctor will advise whether to continue or stop it before surgery.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure. Levocetirizine may cause dry mouth, which can affect your comfort during dental work. It may also interact with sedatives used during dental procedures.

💚 Lifestyle Tips for Better Results

🏃
Drink plenty of warm water throughout the day to help loosen mucus.
🥗
Use a humidifier or take steam inhalation to ease breathing.
😴
Avoid exposure to smoke, dust, and strong fumes.
💧
Get adequate rest to help your body recover.
🧘
Wash your hands frequently to prevent infections.
🌞
Avoid cold drinks and ice cream if they trigger your cough.

🏋️ Exercise Considerations

Avoid strenuous exercise if you feel drowsy or dizzy from this medicine. Light activities like walking are fine if you feel up to it. If you have breathing difficulty, rest and consult your doctor before resuming exercise.

🥗 Diet Recommendations

Include warm soups and broths to soothe your throat.
Eat fruits rich in vitamin C like oranges and amla.
Avoid cold, fried, and processed foods that may worsen cough.
Stay well hydrated with water, herbal tea, or warm water with honey.
Include turmeric and ginger in your diet for their anti-inflammatory properties.

💼 Impact on Daily Work & Life

This medicine may cause drowsiness, which can affect your ability to drive, operate machinery, or concentrate at work. Avoid driving or hazardous tasks until you know how it affects you. If your job requires alertness, inform your doctor so they can adjust the dose or timing.

🛑 When to Stop This Medicine

Stop this medicine when your symptoms improve or as advised by your doctor. Do not stop abruptly if you have been taking it for a long time without consulting your doctor. If you experience any serious side effect, stop immediately and seek medical help.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended without medical supervision. Prolonged use of Levocetirizine may lead to tolerance or increased drowsiness. Ambroxol is generally well tolerated, but rare liver enzyme elevations have been reported. If you need this medicine for more than 7 days, your doctor should reassess your condition and may monitor kidney and liver function.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Steam inhalation

Helps loosen mucus and ease breathing naturally.

Evidence: Well-established
Saline nasal irrigation

Can help clear nasal congestion and reduce allergy symptoms.

Evidence: Moderate
Allergen avoidance

Reducing exposure to dust, pollen, and pet dander can decrease allergic symptoms.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, if you are unwell with a fever or severe cough, your doctor may advise delaying vaccination until you recover.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✅ DO

Keep out of reach of children

❌ DON'T

Do not use after expiry date

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case you need to show it at customs or to a doctor while traveling. Store it in a cool, dry place away from direct sunlight. If traveling across time zones, continue with your regular dosing schedule as close as possible, but do not double dose. Keep it in your carry-on luggage if you need it during the flight. Check the expiry date before you travel.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old teacher with seasonal allergies and productive cough
She was prescribed this medicine for 5 days. She took it after breakfast and dinner as directed. Her cough and runny nose improved within 3 days. She felt mildly sleepy on the first day but it settled. She avoided driving during that time.
💡 Lesson: Taking the medicine consistently after meals and avoiding driving until you know its effects helps manage side effects safely.
👤 A 60-year-old man with chronic bronchitis and thick mucus
He was given this medicine along with antibiotics for acute exacerbation. He noticed his mucus became thinner and easier to cough out. He was advised to drink plenty of water. His kidney function was monitored because of his age.
💡 Lesson: In older adults, monitoring kidney function and staying hydrated are important while taking this medicine.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Ambroxol starts thinning mucus within 30 to 60 minutes, and Levocetirizine begins reducing allergic symptoms within 1 hour. You may notice improvement in cough and runny nose within a few hours to a day.

Q: Can I take this medicine with food?

A: Yes, you can take it with or without food. If it upsets your stomach, take it after a meal.

Q: Is this medicine safe for children?

A: This medicine is not recommended for children below 2 years. For older children, consult a pediatrician for the correct dose.

Q: Can I take this medicine if I am pregnant?

A: Consult your doctor before using this medicine during pregnancy. The safety of this combination in pregnancy is not well established.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Is it safe for my child?
  • Can I take it with antibiotics?

🔄 Substitutes for histacare p syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure any type of cough.
    Fact: This medicine is only for productive cough with thick mucus and allergic cough. It is not effective for dry cough or cough due to bacterial infection alone.
  • Myth: More syrup means faster relief.
    Fact: Taking more than the prescribed dose does not speed up recovery and can increase side effects like drowsiness and stomach upset.
  • Myth: It is safe to take this medicine for months.
    Fact: This medicine is intended for short-term use. Prolonged use should only be under medical supervision.
  • Myth: This medicine can replace antibiotics for chest infections.
    Fact: This medicine is not an antibiotic. If you have a bacterial infection, your doctor may prescribe antibiotics separately.

🔄 Alternative Options

Generic Alternatives

  • Ambroxol + Levocetirizine syrup (generic)

Brand Alternatives

  • Histacare P Syrup

📊 Comparison with Similar Medicines

[{"medicine":"This medicine (Ambroxol + Levocetirizine)","composition":"Ambroxol 60 mg + Levocetirizine 5 mg per 5 mL","primary_use":"Productive cough with allergic rhinitis","sedation":"Moderate","frequency":"2-3 times daily"},{"medicine":"Ambroxol + Cetirizine syrup","composition":"Ambroxol + Cetirizine","primary_use":"Productive cough with allergy","sedation":"Moderate to high","frequency":"2 times daily"},{"medicine":"Levocetirizine syrup alone","composition":"Levocetirizine 5 mg per 5 mL","primary_use":"Allergic rhinitis","sedation":"Mild to moderate","frequency":"Once daily"}]

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