Hipenox LB 500 Capsule: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Severe or persistent diarrhea, or diarrhea with blood or mucus
- Rash, hives, or blistering of the skin
- Yellowing of the skin or eyes, or dark urine
- Decreased urine output or swelling in the legs
- Unusual bleeding or bruising
- Seizures or severe confusion
If experiencing severe symptoms, call emergency services immediately.
What is hipenox lb 500 capsule used for?
This medicine is a combination antibiotic containing amoxycillin and cloxacillin. It is used to treat bacterial infections of the skin, respiratory tract, urinary tract, and dental infections. It works by killing bacteria and must be taken exactly as prescribed.
- Generic Name: Amoxycillin (500mg) + Cloxacillin (NA)
- Manufacturer: Zydus Cadila
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 hipenox lb 500 capsule के बारे में (Hindi Summary)
उपयोग: यह दवा एक एंटीबायोटिक कैप्सूल है जिसमें अमोक्सिसिलिन और क्लोक्सासिलिन दोनों होते हैं। यह बैक्टीरियल संक्रमणों के इलाज के लिए इस्तेमाल की जाती है, जैसे त्वचा और मुलायम ऊतकों के संक्रमण, श्वसन तंत्र के संक्रमण, मूत्र मार्ग के संक्रमण, दांतों के संक्रमण और हड्डियों तथा जोड़ों के संक्रमण। यह दवा बैक्टीरिया को मारकर काम करती है और इसे डॉक्टर के निर्देशानुसार पूरा कोर्स लेना चाहिए। यह वायरल संक्रमणों जैसे सर्दी-जुकाम या फ्लू के लिए प्रभावी नहीं है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, पेट दर्द और त्वचा पर चकत्ते शामिल हैं। ये आमतौर पर हल्के और अस्थायी होते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें एनाफिलेक्सिस (गंभीर एलर्जी प्रतिक्रिया), गंभीर दस्त, यकृत एंजाइम में वृद्धि और रक्त विकार शामिल हो सकते हैं। यदि आपको सांस लेने में कठिनाई, चेहरे या गले में सूजन, या गंभीर दस्त हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को बताएं कि आपको पेनिसिलिन या सेफलोस्पोरिन से एलर्जी है या नहीं। अपने डॉक्टर को अपनी सभी दवाओं के बारे में बताएं, खासकर रक्त पतला करने वाली दवाएं, मेथोट्रेक्सेट, एलोप्यूरिनॉल और गर्भनिरोधक गोलियां। इस दवा को डॉक्टर के निर्देशानुसार ही लें, भोजन के साथ लेने से पेट की परेशानी कम हो सकती है। पूरा कोर्स पूरा करें, भले ही आप बेहतर महसूस करें। यदि आपको दाने, पित्ती या सांस लेने में कठिनाई हो, तो दवा बंद करें और तुरंत आपातकालीन चिकित्सा सहायता लें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।
💊 hipenox lb 500 capsule Uses & Benefits
[{"condition":"Skin and soft tissue infections","description":"This medicine is used to treat bacterial skin infections such as cellulitis, abscesses, and wound infections caused by susceptible gram-positive bacteria, including penicillinase-producing Staphylococcus aureus.","evidence":"Well-established"},{"condition":"Respiratory tract infections","description":"It is prescribed for upper and lower respiratory tract infections, including sinusitis, pharyngitis, and community-acquired pneumonia, when caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"This combination may be used for urinary tract infections caused by susceptible organisms, though other antibiotics are often preferred based on local resistance patterns.","evidence":"Moderate"},{"condition":"Dental infections","description":"It is effective for dental abscesses and periodontal infections caused by susceptible oral bacteria.","evidence":"Well-established"},{"condition":"Bone and joint infections","description":"This medicine may be used in the treatment of osteomyelitis and septic arthritis caused by susceptible gram-positive bacteria, often in combination with other antibiotics.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Eradication of Helicobacter pylori","description":"Amoxycillin is part of some H. pylori eradication regimens, but cloxacillin is not typically included. This combination is not standard for this indication.","evidence":"Limited"},{"condition":"Lyme disease","description":"Amoxycillin is used for early Lyme disease, but the addition of cloxacillin is not standard and not recommended.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Skin and soft tissue infections, Respiratory tract infections, Urinary tract infections, Dental infections, Bone and joint infections
📋 Drug Information
| Generic Name(s) | Amoxycillin (500mg) + Cloxacillin (NA) |
| Brand Name | hipenox lb 500 capsule |
| Manufacturer | Zydus Cadila |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture and direct sunlight. Do not refrigerate unless specified on the label. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture. Check the expiry date on the packaging before use. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two beta-lactam antibiotics that inhibit bacterial cell wall synthesis. Amoxycillin is a broad-spectrum aminopenicillin that binds to penicillin-binding proteins (PBPs) and inhibits the cross-linking of peptidoglycan chains, leading to bacterial cell lysis. Cloxacillin is a penicillinase-resistant penicillin that also binds to PBPs but is specifically designed to resist hydrolysis by beta-lactamase enzymes produced by certain bacteria, particularly Staphylococcus aureus. Together, they provide coverage against both beta-lactamase-negative and beta-lactamase-producing organisms. The combination is bactericidal, meaning it kills bacteria rather than just inhibiting their growth.
Mechanism Steps
💡 How to Take hipenox lb 500 capsule
Strength: Each capsule contains amoxycillin 500 mg and cloxacillin 500 mg (as sodium salt).
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one capsule (500 mg) taken orally every 6 to 8 hours, depending on the severity of the infection. For skin and soft tissue infections, the typical dose is 500 mg every 6 hours. For respiratory tract infections, 500 mg every 8 hours may be sufficient. The duration of therapy depends on the type of infection and clinical response, usually 7 to 14 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may have reduced renal function, which can increase the risk of side effects. Dose adjustment may be necessary based on creatinine clearance. Monitor renal function closely during therapy. |
| Renal Impairment | In patients with renal impairment, dose adjustment is required. For creatinine clearance between 10 and 30 mL/min, the dose may need to be reduced or the dosing interval extended. For creatinine clearance less than 10 mL/min, the dose should be significantly reduced and the patient monitored closely. Consult a clinician for specific dosing recommendations. |
| Hepatic Impairment | In patients with hepatic impairment, no specific dose adjustment is typically required, but liver function should be monitored during prolonged therapy. Use with caution in patients with severe liver disease. |
| Maximum Daily Dose | The maximum recommended daily dose for adults is 4 grams of amoxycillin and 4 grams of cloxacillin, but this should not be exceeded without medical supervision. The exact maximum dose depends on the indication and patient factors. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of hipenox lb 500 capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| Allopurinol | Major | |
| Oral contraceptives | Moderate | |
| Probenecid | Moderate | |
| Tetracyclines | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Methotrexate
- Allopurinol
⚡ Moderate Interactions
- Oral contraceptives
- Probenecid
- Tetracyclines
🍷 Alcohol Interaction
Alcohol may worsen stomach upset and nausea caused by this medicine. It is advisable to avoid alcohol while taking this medicine to reduce the risk of gastrointestinal side effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to penicillins or cephalosporins","History of severe allergic reaction to beta-lactam antibiotics","Infectious mononucleosis (risk of rash)","Concurrent use with live typhoid vaccine"]
⚠️ Warnings & Precautions
["Serious and occasionally fatal hypersensitivity reactions have been reported. Before starting therapy, inquire about previous hypersensitivity to penicillins, cephalosporins, or other allergens.","Clostridioides difficile-associated diarrhea may occur. If diarrhea develops, evaluate for this condition.","Use with caution in patients with renal impairment. Dose adjustment may be necessary.","Prolonged use may result in overgrowth of non-susceptible organisms, including fungi.","May reduce the efficacy of oral contraceptives. Advise patients to use additional contraception.","Not effective against viral infections. Do not use for colds or flu.","Patients with phenylketonuria should be aware that some formulations may contain phenylalanine."]
🤱 Lactation Safety
Amoxycillin and cloxacillin are excreted in human breast milk in small amounts. This medicine is generally considered safe during breastfeeding, but it may cause diarrhea or thrush in the nursing infant. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine may cause nausea, vomiting, diarrhea, and abdominal pain. In severe cases, especially in patients with renal impairment, seizures may occur. Treatment is symptomatic and supportive. There is no specific antidote. Hemodialysis may be considered to remove amoxycillin from the blood in cases of severe overdose. Contact a poison control center or emergency department immediately if overdose is suspected.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Before taking this medicine, inform your doctor if you are allergic to penicillin, cephalosporins, or any other antibiotics. Tell your doctor about all other medicines you are taking, especially blood thinners, methotrexate, allopurinol, and oral contraceptives. Take this medicine exactly as prescribed, with or without food, but preferably with a meal to reduce stomach upset. Complete the full course even if you feel better after a few days. Do not share this medicine with others. If you develop a rash, hives, or difficulty breathing, stop the medicine and seek emergency care immediately. If you have kidney or liver disease, your doctor may need to adjust your dose. Avoid alcohol while taking this medicine as it may worsen stomach side effects. If you are pregnant or breastfeeding, consult your doctor before using this medicine. Do not use this medicine for viral infections like colds or flu.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function, which can increase the risk of side effects from this medicine. Dose adjustment may be necessary based on creatinine clearance. Monitor renal function closely during therapy. Elderly patients may also be more susceptible to severe diarrhea and should report any changes in bowel habits to their doctor.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It is classified as Pregnancy Category B, meaning animal studies have not shown a risk to the fetus, but there are no adequate studies in pregnant women. Use only if clearly needed and prescribed by your doctor. Discuss any concerns with your healthcare provider.
🏥 Post-Surgery Considerations
This medicine may be prescribed after surgery to prevent or treat surgical site infections. Take it exactly as directed by your surgeon. Inform your surgeon if you have any allergies to penicillin or cephalosporins. Complete the full course to prevent infection. Monitor the surgical site for signs of infection, such as redness, swelling, or discharge.
🦷 Dental Procedures
This medicine is often prescribed for dental infections and may be used prophylactically before certain dental procedures in patients at risk of infective endocarditis. Inform your dentist if you are taking this medicine or have any allergies. Take the full course as prescribed to prevent recurrence of infection.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause dizziness or fatigue in some people. Avoid strenuous exercise if you feel unwell or dizzy. Listen to your body and rest when needed. If you experience joint pain or swelling, consult your doctor before resuming exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, fatigue, or stomach upset in some people. If you experience these effects, avoid driving or operating heavy machinery until you know how the medicine affects you. Most people can continue their normal daily activities, but take it easy if you feel unwell. Inform your employer if you need to take time off for rest.
🛑 When to Stop This Medicine
Stop taking this medicine only after completing the full prescribed course, unless your doctor advises otherwise. If you experience a severe allergic reaction, severe diarrhea, or any other serious side effect, stop the medicine and seek immediate medical attention. Do not stop early even if you feel better, as this can lead to recurrence of infection and antibiotic resistance.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to overgrowth of non-susceptible organisms, including fungi, and may increase the risk of antibiotic resistance. Prolonged therapy may also rarely cause blood dyscrasias, liver enzyme abnormalities, or kidney issues. Regular monitoring of renal and hepatic function is recommended during extended treatment. Do not use this medicine for longer than prescribed without medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Regular hand washing and wound care can help prevent bacterial infections.
Evidence: Well-establishedMay help reduce the risk of antibiotic-associated diarrhea when taken alongside antibiotics.
Evidence: ModerateOver-the-counter pain relievers can help manage pain and fever while the antibiotic takes effect.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the efficacy of live bacterial vaccines, such as the typhoid vaccine. Avoid receiving live vaccines during treatment and for several days after completing the course. Inactivated vaccines are generally safe to administer. Consult your doctor for specific timing recommendations.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case you need to show it at customs or to a healthcare provider. Store it at room temperature and protect it from extreme heat or moisture. If you are crossing time zones, adjust your dosing schedule to maintain even intervals, but consult your doctor for specific advice. Do not pack it in checked luggage; keep it in your carry-on bag.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start to feel better within 24 to 48 hours, but it is important to complete the full course as prescribed.
A: Yes, you can take it with food to reduce stomach upset, but avoid high-fat meals as they may delay absorption.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: It is classified as Pregnancy Category B. Use only if clearly needed and prescribed by your doctor.
A: It is advisable to avoid alcohol as it may worsen stomach upset and nausea.
🤔 Common Patient Concerns
🔄 Substitutes for hipenox lb 500 capsule
View AllAlternative brands with exact same active ingredient:
-
woclox lb capsuleWockhardt Ltd ₹21.52 11.2% CHEAPER
-
zeclox capsuleA. Menarini India Pvt Ltd ₹23.65 2.4% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the common cold.
Fact: This medicine is an antibiotic and is only effective against bacterial infections. It does not treat viral infections. - Myth: You can stop taking this medicine as soon as you feel better.
Fact: You must complete the full course as prescribed, even if symptoms improve, to prevent recurrence and antibiotic resistance. - Myth: This medicine is safe to take without a prescription.
Fact: This is a prescription antibiotic and should only be taken under the guidance of a qualified clinician.
🔄 Alternative Options
Generic Alternatives
- Amoxycillin and Cloxacillin Capsules
Brand Alternatives
- Hipenox LB 500 Capsule